HRP20110639T1 - 4-metil-n-[3-4(-metil-imidazol-1-il)-5-trifluorometil-fenil]-3-(4-piridin-3-il-pirimidin-2-ilamino)-benzamid-monohidroklorid-monohidratna sol - Google Patents
4-metil-n-[3-4(-metil-imidazol-1-il)-5-trifluorometil-fenil]-3-(4-piridin-3-il-pirimidin-2-ilamino)-benzamid-monohidroklorid-monohidratna sol Download PDFInfo
- Publication number
- HRP20110639T1 HRP20110639T1 HR20110639T HRP20110639T HRP20110639T1 HR P20110639 T1 HRP20110639 T1 HR P20110639T1 HR 20110639 T HR20110639 T HR 20110639T HR P20110639 T HRP20110639 T HR P20110639T HR P20110639 T1 HRP20110639 T1 HR P20110639T1
- Authority
- HR
- Croatia
- Prior art keywords
- methyl
- ylamino
- imidazol
- pyridin
- trifluoromethyl
- Prior art date
Links
- HHZIURLSWUIHRB-UHFFFAOYSA-N nilotinib Chemical compound C1=NC(C)=CN1C1=CC(NC(=O)C=2C=C(NC=3N=C(C=CN=3)C=3C=NC=CC=3)C(C)=CC=2)=CC(C(F)(F)F)=C1 HHZIURLSWUIHRB-UHFFFAOYSA-N 0.000 title claims abstract 4
- DKAGJZJALZXOOV-UHFFFAOYSA-N hydrate;hydrochloride Chemical compound O.Cl DKAGJZJALZXOOV-UHFFFAOYSA-N 0.000 title 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 4
- YCBPQSYLYYBPDW-UHFFFAOYSA-N 4-methyl-n-[3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]benzamide;hydrate;hydrochloride Chemical group O.Cl.C1=NC(C)=CN1C1=CC(NC(=O)C=2C=C(NC=3N=C(C=CN=3)C=3C=NC=CC=3)C(C)=CC=2)=CC(C(F)(F)F)=C1 YCBPQSYLYYBPDW-UHFFFAOYSA-N 0.000 claims 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 3
- 238000001816 cooling Methods 0.000 claims 3
- 239000011541 reaction mixture Substances 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 239000007787 solid Substances 0.000 claims 3
- 238000003756 stirring Methods 0.000 claims 3
- 239000000725 suspension Substances 0.000 claims 3
- 238000001914 filtration Methods 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 1
- 102000001253 Protein Kinase Human genes 0.000 claims 1
- 230000008878 coupling Effects 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000001035 drying Methods 0.000 claims 1
- 239000012458 free base Substances 0.000 claims 1
- 238000010438 heat treatment Methods 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 238000002156 mixing Methods 0.000 claims 1
- 238000010899 nucleation Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 108060006633 protein kinase Proteins 0.000 claims 1
- 238000005406 washing Methods 0.000 claims 1
- -1 4-methyl-imidazol-1-yl Chemical group 0.000 abstract 1
- JEGUKCSWCFPDGT-UHFFFAOYSA-N h2o hydrate Chemical compound O.O JEGUKCSWCFPDGT-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Sol od 4-metil-N-[3-(4-metil-imidazol-1-il)-5-trifluorometil-fenil]-3-(4-piridin-3-il-pirimidin-2-ilamino)-benzamida, naznačena time, da je to monohidroklorid monohidrat 4-metil-N-[3-(4-metil-imidazol-1-il)-5-trifluorometil-fenil]-3-(4-piridin-3-il-pirimidin-2-ilamino)-benzamida. Patent sadrži još 3 patentna zahtjeva.
Claims (4)
1. Sol od 4-metil-N-[3-(4-metil-imidazol-1-il)-5-trifluorometil-fenil]-3-(4-piridin-3-il-pirimidin-2-ilamino)-benzamida, naznačena time, da je to monohidroklorid monohidrat 4-metil-N-[3-(4-metil-imidazol-1-il)-5-trifluorometil-fenil]-3-(4-piridin-3-il-pirimidin-2-ilamino)-benzamida.
2. Postupak za pripravljanje 4-metil-N-[3-(4-metil-imidazol-1-il)-5-trifluorometil-fenil]-3-(4-piridin-3-il-pirimidin-2-ilamino)-benzamid-monohidroklorid monohidrata, naznačen time, da obuhvaća sljedeće korake:
(a) povezivanje slobodne baze 4-metil-N-[3-(4-metil-imidazol-1-il)-5-trifluorometil-fenil]-3-(4-piridin-3-il-pirimidin-2-ilamino)-benzamida i klorovodične kiseline u metanolu pod dušikovim zračnim omotačem;
(b) zagrijavanje reakcijske smjese na temperaturi u rasponu od oko 42-50°C;
(c) miješanje reakcijske smjese;
(d) filtriranje reakcijske smjese dok se održava temperatura iznad 40°C da se dobije bistra otopina;
(e) hlađenje bistre otopine na oko 30°C dok se ona miješa pod dušikovim zračnim omotačem;
(f) zasijavanje otopine;
(g) hlađenje zasijane otopine na oko 23°C;
(h) miješanje otopine da se dobije suspenzija;
(i) hlađenje suspenzije na oko -10°C;
(j) miješanje suspenzije;
(k) filtriranje krutina;
(l) ispiranje krutina hladnim metanolom; i
(m) sušenje krutina na oko 50-55°C i 10-20 tora da se dobije 4-metil-N-[3-(4-metil-imidazol-1-il)-5-trifluorometil-fenil]-3-(4-piridin-3-il-pirimidin-2-ilamino)-benzamid-monohidroklorid monohidratna sol.
3. Farmaceutski sastav, naznačen time, da obuhvaća:
(a) terapeutski učinkovitu količinu soli prema zahtjevu 1; i
(b) barem jedan(no) farmaceutski prihvatljiv(o) nosač, razrjeđivač, prijenosno sredstvo ili pomoćno sredstvo.
4. Uporaba terapeutski učinkovite količine soli prema zahtjevu 1, naznačena time, da je za proizvodnju lijeka za liječenje bolesti koja odgovara inhibiciji djelovanja proteinske kinaze.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US70140605P | 2005-07-20 | 2005-07-20 | |
US71621305P | 2005-09-12 | 2005-09-12 | |
PCT/US2006/027878 WO2007015871A1 (en) | 2005-07-20 | 2006-07-18 | Salts of 4-methyl-n-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20110639T1 true HRP20110639T1 (hr) | 2011-10-31 |
Family
ID=37398525
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HR20110639T HRP20110639T1 (hr) | 2005-07-20 | 2011-09-07 | 4-metil-n-[3-4(-metil-imidazol-1-il)-5-trifluorometil-fenil]-3-(4-piridin-3-il-pirimidin-2-ilamino)-benzamid-monohidroklorid-monohidratna sol |
Country Status (34)
Country | Link |
---|---|
US (4) | US8163904B2 (hr) |
EP (2) | EP1910336B1 (hr) |
JP (1) | JP5129132B2 (hr) |
KR (3) | KR20080027855A (hr) |
CN (1) | CN102267981A (hr) |
AR (1) | AR057467A1 (hr) |
AT (1) | ATE514689T1 (hr) |
AU (2) | AU2006276205B2 (hr) |
BR (1) | BRPI0613605A2 (hr) |
CA (2) | CA2823946C (hr) |
CY (1) | CY1111772T1 (hr) |
DK (1) | DK1910336T3 (hr) |
EC (1) | ECSP088118A (hr) |
ES (1) | ES2634291T3 (hr) |
GT (1) | GT200600316A (hr) |
HK (1) | HK1116778A1 (hr) |
HR (1) | HRP20110639T1 (hr) |
IL (1) | IL187787A (hr) |
JO (1) | JO2757B1 (hr) |
MA (1) | MA29686B1 (hr) |
MX (1) | MX2008000892A (hr) |
MY (1) | MY149889A (hr) |
NO (1) | NO341313B1 (hr) |
NZ (2) | NZ564182A (hr) |
PE (1) | PE20070241A1 (hr) |
PL (1) | PL1910336T3 (hr) |
PT (1) | PT1910336E (hr) |
RU (4) | RU2434864C2 (hr) |
SG (1) | SG170772A1 (hr) |
SI (1) | SI1910336T1 (hr) |
TN (1) | TNSN08028A1 (hr) |
TW (1) | TWI455934B (hr) |
UY (1) | UY29683A1 (hr) |
WO (1) | WO2007015871A1 (hr) |
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GT200600316A (es) * | 2005-07-20 | 2007-04-02 | Sales de 4-metilo-n-(3-(4-metilo-imidazol-1-ilo)-5-trifluorometilo-fenilo)-3-(4-piridina-3-ilo-pirimidina-2-iloamino)- benzamida. | |
GT200600315A (es) | 2005-07-20 | 2007-03-19 | Formas cristalinas de 4-metilo-n-[3-(4-metilo-imidazol-1-ilo)-5-trifluorometilo-fenilo]-3-(4-pyridina-3-ilo-pirimidina-2-iloamino)-benzamida |
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2006
- 2006-07-14 GT GT200600316A patent/GT200600316A/es unknown
- 2006-07-18 SG SG201102150-8A patent/SG170772A1/en unknown
- 2006-07-18 DK DK06787733.2T patent/DK1910336T3/da active
- 2006-07-18 MY MYPI20063405A patent/MY149889A/en unknown
- 2006-07-18 AR ARP060103071A patent/AR057467A1/es unknown
- 2006-07-18 NZ NZ564182A patent/NZ564182A/en unknown
- 2006-07-18 KR KR1020087001461A patent/KR20080027855A/ko not_active Application Discontinuation
- 2006-07-18 US US11/995,898 patent/US8163904B2/en active Active
- 2006-07-18 CN CN2011102503529A patent/CN102267981A/zh active Pending
- 2006-07-18 RU RU2008105827/04A patent/RU2434864C2/ru active
- 2006-07-18 BR BRPI0613605-2A patent/BRPI0613605A2/pt not_active Application Discontinuation
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