NZ591142A - Salts of 4-methyl-N-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide - Google Patents

Salts of 4-methyl-N-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide

Info

Publication number
NZ591142A
NZ591142A NZ591142A NZ59114206A NZ591142A NZ 591142 A NZ591142 A NZ 591142A NZ 591142 A NZ591142 A NZ 591142A NZ 59114206 A NZ59114206 A NZ 59114206A NZ 591142 A NZ591142 A NZ 591142A
Authority
NZ
New Zealand
Prior art keywords
methyl
salts
ylamino
imidazol
pyrimidin
Prior art date
Application number
NZ591142A
Inventor
Paul W Manley
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37398525&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NZ591142(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of NZ591142A publication Critical patent/NZ591142A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Disclosed are salts of the compound 4-methyl-N-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide represented by the structural formula shown herein, namely the salts are hydrochloride, monophosphate, diphosphate, sulphate, methane sulfonate, ethane sulfonate, benzene sulfonate, and p-toluene sulfonate salt of said compound. Also disclosed is a method of preparing these salts, and the use of the salt to treat diseases which respond to an inhibition of protein kinase activity.
NZ591142A 2005-07-20 2006-07-18 Salts of 4-methyl-N-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide NZ591142A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US70140605P 2005-07-20 2005-07-20
US71621305P 2005-09-12 2005-09-12
NZ564182A NZ564182A (en) 2005-07-20 2006-07-18 Salts of 4-methyl-N-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide

Publications (1)

Publication Number Publication Date
NZ591142A true NZ591142A (en) 2012-09-28

Family

ID=37398525

Family Applications (2)

Application Number Title Priority Date Filing Date
NZ591142A NZ591142A (en) 2005-07-20 2006-07-18 Salts of 4-methyl-N-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide
NZ564182A NZ564182A (en) 2005-07-20 2006-07-18 Salts of 4-methyl-N-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide

Family Applications After (1)

Application Number Title Priority Date Filing Date
NZ564182A NZ564182A (en) 2005-07-20 2006-07-18 Salts of 4-methyl-N-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide

Country Status (34)

Country Link
US (4) US8163904B2 (en)
EP (2) EP1910336B1 (en)
JP (1) JP5129132B2 (en)
KR (3) KR20080027855A (en)
CN (1) CN102267981A (en)
AR (1) AR057467A1 (en)
AT (1) ATE514689T1 (en)
AU (2) AU2006276205C1 (en)
BR (1) BRPI0613605A2 (en)
CA (2) CA2823946C (en)
CY (1) CY1111772T1 (en)
DK (1) DK1910336T3 (en)
EC (1) ECSP088118A (en)
ES (1) ES2634291T3 (en)
GT (1) GT200600316A (en)
HK (1) HK1116778A1 (en)
HR (1) HRP20110639T1 (en)
IL (1) IL187787A (en)
JO (1) JO2757B1 (en)
MA (1) MA29686B1 (en)
MX (1) MX2008000892A (en)
MY (1) MY149889A (en)
NO (1) NO341313B1 (en)
NZ (2) NZ591142A (en)
PE (1) PE20070241A1 (en)
PL (1) PL1910336T3 (en)
PT (1) PT1910336E (en)
RU (4) RU2483065C2 (en)
SG (1) SG170772A1 (en)
SI (1) SI1910336T1 (en)
TN (1) TNSN08028A1 (en)
TW (1) TWI455934B (en)
UY (1) UY29683A1 (en)
WO (1) WO2007015871A1 (en)

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GT200600316A (en) 2005-07-20 2007-04-02 SALTS OF 4-METHYL-N- (3- (4-METHYL-IMIDAZOL-1-ILO) -5-TRIFLUOROMETILO-PHENYL) -3- (4-PIRIDINA-3-ILO-PIRIMIDINA-2-ILOAMINO) - BENZAMIDA.
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AU2012328979B2 (en) 2011-10-28 2016-04-21 Novartis Ag Method of treating gastrointestinal stromal tumors
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Also Published As

Publication number Publication date
HK1116778A1 (en) 2009-01-02
AR057467A1 (en) 2007-12-05
CA2615669C (en) 2013-11-12
AU2010241419B2 (en) 2012-03-29
AU2010241419A1 (en) 2010-12-02
RU2011120363A (en) 2012-11-27
AU2006276205C1 (en) 2024-08-01
MA29686B1 (en) 2008-08-01
KR20150100946A (en) 2015-09-02
US20140038994A1 (en) 2014-02-06
EP1910336A1 (en) 2008-04-16
JO2757B1 (en) 2014-03-15
AU2010241419C1 (en) 2024-05-23
TWI455934B (en) 2014-10-11
RU2008105827A (en) 2009-08-27
PE20070241A1 (en) 2007-03-22
US8580806B2 (en) 2013-11-12
KR101755137B1 (en) 2017-07-06
EP2186808B1 (en) 2017-04-19
TW200800950A (en) 2008-01-01
RU2483065C2 (en) 2013-05-27
UY29683A1 (en) 2007-02-28
CA2823946C (en) 2015-12-29
US20130137712A1 (en) 2013-05-30
JP5129132B2 (en) 2013-01-23
ECSP088118A (en) 2008-02-20
CA2823946A1 (en) 2007-02-08
DK1910336T3 (en) 2011-10-03
EP1910336B1 (en) 2011-06-29
US8389537B2 (en) 2013-03-05
US20120270891A1 (en) 2012-10-25
PL1910336T3 (en) 2011-11-30
US9163005B2 (en) 2015-10-20
JP2009502796A (en) 2009-01-29
CY1111772T1 (en) 2015-10-07
AU2006276205B2 (en) 2010-08-19
ES2634291T3 (en) 2017-09-27
CN102267981A (en) 2011-12-07
TNSN08028A1 (en) 2009-07-14
NO20080897L (en) 2008-02-20
KR20080027855A (en) 2008-03-28
RU2434864C2 (en) 2011-11-27
RU2605551C2 (en) 2016-12-20
MX2008000892A (en) 2008-03-18
US20080200487A1 (en) 2008-08-21
SI1910336T1 (en) 2011-10-28
WO2007015871A1 (en) 2007-02-08
SG170772A1 (en) 2011-05-30
CA2615669A1 (en) 2007-02-08
NZ564182A (en) 2011-03-31
ATE514689T1 (en) 2011-07-15
IL187787A0 (en) 2008-08-07
BRPI0613605A2 (en) 2011-01-18
EP2186808A1 (en) 2010-05-19
HRP20110639T1 (en) 2011-10-31
GT200600316A (en) 2007-04-02
IL187787A (en) 2012-07-31
KR20140047737A (en) 2014-04-22
RU2013101749A (en) 2014-07-27
NO341313B1 (en) 2017-10-09
PT1910336E (en) 2011-09-05
AU2006276205A1 (en) 2007-02-08
MY149889A (en) 2013-10-31
US8163904B2 (en) 2012-04-24
RU2509767C1 (en) 2014-03-20

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