HK1116778A1 - - Google Patents

Info

Publication number
HK1116778A1
HK1116778A1 HK08107504.6A HK08107504A HK1116778A1 HK 1116778 A1 HK1116778 A1 HK 1116778A1 HK 08107504 A HK08107504 A HK 08107504A HK 1116778 A1 HK1116778 A1 HK 1116778A1
Authority
HK
Hong Kong
Application number
HK08107504.6A
Inventor
Paul W Manley
Wen-Chung Shieh
Paul Allen Sutton
Piotr H Karpinski
Raeann Wu
Stephanie Monnier
Joerg Brozio
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37398525&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1116778(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of HK1116778A1 publication Critical patent/HK1116778A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
HK08107504.6A 2005-07-20 2008-07-08 HK1116778A1 (xx)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US70140605P 2005-07-20 2005-07-20
US71621305P 2005-09-12 2005-09-12
PCT/US2006/027878 WO2007015871A1 (en) 2005-07-20 2006-07-18 Salts of 4-methyl-n-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide

Publications (1)

Publication Number Publication Date
HK1116778A1 true HK1116778A1 (xx) 2009-01-02

Family

ID=37398525

Family Applications (1)

Application Number Title Priority Date Filing Date
HK08107504.6A HK1116778A1 (xx) 2005-07-20 2008-07-08

Country Status (34)

Country Link
US (4) US8163904B2 (xx)
EP (2) EP2186808B1 (xx)
JP (1) JP5129132B2 (xx)
KR (3) KR20140047737A (xx)
CN (1) CN102267981A (xx)
AR (1) AR057467A1 (xx)
AT (1) ATE514689T1 (xx)
AU (2) AU2006276205B2 (xx)
BR (1) BRPI0613605A2 (xx)
CA (2) CA2615669C (xx)
CY (1) CY1111772T1 (xx)
DK (1) DK1910336T3 (xx)
EC (1) ECSP088118A (xx)
ES (1) ES2634291T3 (xx)
GT (1) GT200600316A (xx)
HK (1) HK1116778A1 (xx)
HR (1) HRP20110639T1 (xx)
IL (1) IL187787A (xx)
JO (1) JO2757B1 (xx)
MA (1) MA29686B1 (xx)
MX (1) MX2008000892A (xx)
MY (1) MY149889A (xx)
NO (1) NO341313B1 (xx)
NZ (2) NZ564182A (xx)
PE (1) PE20070241A1 (xx)
PL (1) PL1910336T3 (xx)
PT (1) PT1910336E (xx)
RU (4) RU2434864C2 (xx)
SG (1) SG170772A1 (xx)
SI (1) SI1910336T1 (xx)
TN (1) TNSN08028A1 (xx)
TW (1) TWI455934B (xx)
UY (1) UY29683A1 (xx)
WO (1) WO2007015871A1 (xx)

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GT200600315A (es) 2005-07-20 2007-03-19 Formas cristalinas de 4-metilo-n-[3-(4-metilo-imidazol-1-ilo)-5-trifluorometilo-fenilo]-3-(4-pyridina-3-ilo-pirimidina-2-iloamino)-benzamida
GT200600316A (es) * 2005-07-20 2007-04-02 Sales de 4-metilo-n-(3-(4-metilo-imidazol-1-ilo)-5-trifluorometilo-fenilo)-3-(4-piridina-3-ilo-pirimidina-2-iloamino)- benzamida.
EP2010182A2 (en) * 2006-04-07 2009-01-07 Novartis AG Use of c-src inhibitors in combination with a pyrimidylaminobenzamide compound for the treatment of leukemia
EP1923053A1 (en) 2006-09-27 2008-05-21 Novartis AG Pharmaceutical compositions comprising nilotinib or its salt
EP2305667A3 (en) 2008-07-17 2011-05-11 Teva Pharmaceutical Industries Ltd. Nilotinib intermediates and preparation thereof
EP2262793B1 (en) * 2008-11-05 2012-10-03 Teva Pharmaceutical Industries Ltd. Nilotinib hci crystalline forms
EP2186514B1 (en) 2008-11-14 2016-06-29 Kinki University Treatment of Malignant Peripheral Nerve Sheath Tumors
BRPI1013366A2 (pt) 2009-03-06 2016-03-29 Novartis Ag uso de derivados de pirimidilaminobenzamida para o tratamento de distúrbios mediados pela quinase contendo zíper de leucina e quinase contendo motivo alfa estéril (zak).
TW201102068A (en) 2009-06-02 2011-01-16 Novartis Ag Treatment of ophthalmologic disorders mediated by alpha-carbonic anhydrase isoforms
US20110053968A1 (en) 2009-06-09 2011-03-03 Auspex Pharmaceuticals, Inc. Aminopyrimidine inhibitors of tyrosine kinase
WO2011033307A1 (en) 2009-09-17 2011-03-24 Generics [Uk] Limited Nilotinib dihydrochloride salt
RU2012120901A (ru) 2009-10-23 2013-12-10 Новартис Аг Способ лечения пролиферативных расстройств и других патологических состояний, опосредованных действием киназ bcr-abl, c-kit, ddr1, ddr2 или pdgf-r
JO3634B1 (ar) 2009-11-17 2020-08-27 Novartis Ag طريقة لعلاج اضطرابات تكاثرية وحالات مرضية أخرى متوسطة بنشاط كيناز bcr-abl، c-kit، ddr1، ddr2، أو pdgf-r
WO2011086541A1 (en) 2010-01-15 2011-07-21 Generics [Uk] Limited Novel polymorph of nilotinib monohydrochloride monohydrate
JP2013525296A (ja) 2010-04-16 2013-06-20 ノバルティス アーゲー 内分泌療法抵抗性乳癌の処置
EP2382976A1 (en) 2010-04-30 2011-11-02 Hiroshima University Use of pdgf-r inhibitors for the treatment of lymph node metastasis of gastric cancer
JP5894153B2 (ja) * 2010-06-21 2016-03-23 テバ ファーマシューティカル インダストリーズ リミティド ニロチニブ塩及びそれらの結晶性形態
WO2012014127A1 (en) 2010-07-30 2012-02-02 Ranbaxy Laboratories Limited 5-lipoxygenase inhibitors
CN102453024B (zh) * 2010-10-27 2014-09-03 浙江九洲药业股份有限公司 一种尼罗替尼盐酸盐晶型及其制备方法
IN2010CH03577A (xx) * 2010-11-26 2012-07-20 Hetero Research Foundation
AR086913A1 (es) 2011-06-14 2014-01-29 Novartis Ag 4-metil-3-[[4-(3-piridinil)-2-pirimidinil]-amino]-n-[5-(4-metil-1h-imidazol-1-il)-3-(trifluoro-metil)-fenil]-benzamida amorfa, forma de dosificacion que la contiene y metodo para prepararlas
WO2013063003A1 (en) 2011-10-28 2013-05-02 Novartis Ag Method of treating gastrointestinal stromal tumors
WO2013063000A1 (en) 2011-10-28 2013-05-02 Novartis Ag Method of treating gastrointestinal stromal tumors
AR088844A1 (es) 2011-11-14 2014-07-10 Novartis Ag Formulacion de liberacion inmediata de 4-metil-3-[[4-(3-piridinil)-2-pirimidinil]-amino]-n-[5-(4-metil-1h-imidazol-1-il)-3-(trifluoro-metil)-fenil]-benzamida
IN2014DN10801A (xx) 2012-07-11 2015-09-04 Novartis Ag
EP2906554A4 (en) 2012-10-15 2016-06-29 Apotex Inc SOLID FORMS OF NILOTINIB HYDROCHLORIDE
AU2013333953B2 (en) * 2012-10-19 2017-08-31 Basf Se Multicomponent crystalline system comprising nilotinib and selected co-crystal formers
EP2792360A1 (en) 2013-04-18 2014-10-22 IP Gesellschaft für Management mbH (1aR,12bS)-8-cyclohexyl-11-fluoro-N-((1-methylcyclopropyl)sulfonyl)-1a-((3-methyl-3,8-diazabicyclo[3.2.1]oct-8-yl)carbonyl)-1,1a,2,2b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide for use in treating HCV
EP3461818A1 (en) 2013-04-24 2019-04-03 Dr. Reddy's Laboratories Ltd. Polymorphic forms of nilotinib hydrochloride
RU2551359C9 (ru) * 2013-11-28 2021-08-20 Общество с ограниченной ответственностью "Мамонт Фарм" Наноразмерная слабо закристаллизованная модификация 4-метил-N-[3-(4-метилимидазол-1-ил)-5-(трифторметил)фенил]-3-[(4-пиридин-3-илпиримидин-2-ил)амино]бензамида гидрохлорида моногидрата, способ ее получения и фармацевтическая композиция на ее основе
WO2015092624A1 (en) 2013-12-16 2015-06-25 Ranbaxy Laboratories Limited Nilotinib mono-oxalate and its crystalline form
US9926296B2 (en) 2014-08-08 2018-03-27 Dr. Reddy's Laboratories Limited Process for the preparation of polymorphic forms of nilotinib hydrochloride
WO2016024289A2 (en) 2014-08-11 2016-02-18 Sun Pharmaceutical Industries Ltd Novel salts of nilotinib and polymorphs thereof
EP3271351A1 (en) 2015-03-20 2018-01-24 Cipla Limited Novel polymorphic form x of nilotinib dihydrochloride hydrate
EP3408264B1 (en) 2016-01-26 2020-03-11 Farma GRS, d.o.o. Nilotinib dinitrate (v) and crystalline forms thereof
WO2017149550A1 (en) * 2016-03-02 2017-09-08 Msn Laboratories Private Limited Amorphous form of 4-methyl-n-[3-(4-methyl-1h-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-benzamide
ES2814499T3 (es) 2016-03-14 2021-03-29 Pliva Hrvatska D O O Formas en estado sólido de sales de Nilotinib
EP3404025B1 (en) 2017-05-16 2019-12-04 F.I.S.- Fabbrica Italiana Sintetici S.p.A. Process for the preparation of pure nilotinib and its salt
CZ2017821A3 (cs) 2017-12-20 2019-07-03 Zentiva, K.S. Léková forma obsahující krystalický nilotinib
AU2019285066B2 (en) 2018-06-15 2024-06-13 Handa Pharmaceuticals, Inc. Kinase inhibitor salts and compositions thereof
EP3877379A4 (en) * 2018-11-05 2022-08-31 Laurus Labs Limited CRYSTALLINE FORM OF NILOTINIB HYDROCHLORIDE, METHOD FOR PREPARING IT AND PHARMACEUTICAL COMPOSITION CONTAINING IT
WO2020172120A1 (en) 2019-02-18 2020-08-27 Slayback Pharma Llc Pharmaceutical compositions of nilotinib
IL295007A (en) 2020-01-31 2022-09-01 Nanocopoeia Llc Amorphous nilotinib microparticles and uses thereof
EP4103560A1 (en) 2020-02-15 2022-12-21 Cipla Limited Novel salts of nilotinib and polymorphic forms thereof
WO2021222739A1 (en) 2020-04-30 2021-11-04 Nanocopoeia, Llc Orally disintegrating tablet comprising amorphous solid dispersion of nilotinib
CN114133378B (zh) * 2020-09-04 2023-08-15 成都苑东生物制药股份有限公司 一种盐酸尼洛替尼共晶及其制备方法
EP4260848A1 (en) 2022-04-11 2023-10-18 Lotus Pharmaceutical Co., Ltd. Pharmaceutical composition for solid dosage form containing nilotinib and process for its preparation

Family Cites Families (11)

* Cited by examiner, † Cited by third party
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RU2081108C1 (ru) * 1991-10-16 1997-06-10 Циба-Гейги АГ Аддитивные соли кислот с основанием и фармацевтическая композиция, обладающая противоопухолевой активностью
US5516775A (en) * 1992-08-31 1996-05-14 Ciba-Geigy Corporation Further use of pyrimidine derivatives
EP0672041B1 (en) 1993-10-01 2001-11-14 Novartis AG Pharmacologically active pyridine derivatives and processes for the preparation thereof
CO4940418A1 (es) * 1997-07-18 2000-07-24 Novartis Ag Modificacion de cristal de un derivado de n-fenil-2- pirimidinamina, procesos para su fabricacion y su uso
CN1190423C (zh) * 1999-12-14 2005-02-23 日本新药株式会社 杂环衍生物和药物
GB0215676D0 (en) * 2002-07-05 2002-08-14 Novartis Ag Organic compounds
GB2398565A (en) * 2003-02-18 2004-08-25 Cipla Ltd Imatinib preparation and salts
AR047530A1 (es) 2004-02-04 2006-01-25 Novartis Ag Formas de sal de 4-(4-metilpiperazin-1-ilmetil)-n-(4-metil-3-(4-piridin-3-il)pirimidin-2-ilamino)fenil)-benzamida
SA06270147B1 (ar) * 2005-06-09 2009-12-22 نوفارتيس ايه جي عملية لتخليق 5-(مثيل–1h–إيميدازول–1-يل )–3-(ثلاثي فلـورو مثيل)–بنزامـين
GT200600316A (es) * 2005-07-20 2007-04-02 Sales de 4-metilo-n-(3-(4-metilo-imidazol-1-ilo)-5-trifluorometilo-fenilo)-3-(4-piridina-3-ilo-pirimidina-2-iloamino)- benzamida.
GT200600315A (es) 2005-07-20 2007-03-19 Formas cristalinas de 4-metilo-n-[3-(4-metilo-imidazol-1-ilo)-5-trifluorometilo-fenilo]-3-(4-pyridina-3-ilo-pirimidina-2-iloamino)-benzamida

Also Published As

Publication number Publication date
US8580806B2 (en) 2013-11-12
MY149889A (en) 2013-10-31
AU2010241419B2 (en) 2012-03-29
AU2010241419C1 (en) 2024-05-23
SI1910336T1 (sl) 2011-10-28
CA2823946C (en) 2015-12-29
US20130137712A1 (en) 2013-05-30
EP1910336A1 (en) 2008-04-16
ES2634291T3 (es) 2017-09-27
US8163904B2 (en) 2012-04-24
WO2007015871A1 (en) 2007-02-08
GT200600316A (es) 2007-04-02
KR101755137B1 (ko) 2017-07-06
RU2509767C1 (ru) 2014-03-20
AU2006276205B2 (en) 2010-08-19
IL187787A (en) 2012-07-31
PE20070241A1 (es) 2007-03-22
MX2008000892A (es) 2008-03-18
IL187787A0 (en) 2008-08-07
CA2615669A1 (en) 2007-02-08
ECSP088118A (es) 2008-02-20
SG170772A1 (en) 2011-05-30
KR20150100946A (ko) 2015-09-02
KR20140047737A (ko) 2014-04-22
AU2010241419A1 (en) 2010-12-02
CA2823946A1 (en) 2007-02-08
RU2013101749A (ru) 2014-07-27
TWI455934B (zh) 2014-10-11
PL1910336T3 (pl) 2011-11-30
RU2434864C2 (ru) 2011-11-27
RU2605551C2 (ru) 2016-12-20
JP5129132B2 (ja) 2013-01-23
UY29683A1 (es) 2007-02-28
NZ564182A (en) 2011-03-31
EP1910336B1 (en) 2011-06-29
US9163005B2 (en) 2015-10-20
RU2008105827A (ru) 2009-08-27
EP2186808B1 (en) 2017-04-19
TNSN08028A1 (en) 2009-07-14
NO341313B1 (no) 2017-10-09
PT1910336E (pt) 2011-09-05
EP2186808A1 (en) 2010-05-19
TW200800950A (en) 2008-01-01
CN102267981A (zh) 2011-12-07
JO2757B1 (en) 2014-03-15
ATE514689T1 (de) 2011-07-15
CY1111772T1 (el) 2015-10-07
AR057467A1 (es) 2007-12-05
US20120270891A1 (en) 2012-10-25
JP2009502796A (ja) 2009-01-29
HRP20110639T1 (hr) 2011-10-31
US8389537B2 (en) 2013-03-05
RU2483065C2 (ru) 2013-05-27
NZ591142A (en) 2012-09-28
BRPI0613605A2 (pt) 2011-01-18
DK1910336T3 (da) 2011-10-03
KR20080027855A (ko) 2008-03-28
NO20080897L (no) 2008-02-20
MA29686B1 (fr) 2008-08-01
RU2011120363A (ru) 2012-11-27
US20080200487A1 (en) 2008-08-21
AU2006276205A1 (en) 2007-02-08
CA2615669C (en) 2013-11-12
US20140038994A1 (en) 2014-02-06

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