AR088844A1 - Formulacion de liberacion inmediata de 4-metil-3-[[4-(3-piridinil)-2-pirimidinil]-amino]-n-[5-(4-metil-1h-imidazol-1-il)-3-(trifluoro-metil)-fenil]-benzamida - Google Patents

Formulacion de liberacion inmediata de 4-metil-3-[[4-(3-piridinil)-2-pirimidinil]-amino]-n-[5-(4-metil-1h-imidazol-1-il)-3-(trifluoro-metil)-fenil]-benzamida

Info

Publication number
AR088844A1
AR088844A1 ARP120104259A ARP120104259A AR088844A1 AR 088844 A1 AR088844 A1 AR 088844A1 AR P120104259 A ARP120104259 A AR P120104259A AR P120104259 A ARP120104259 A AR P120104259A AR 088844 A1 AR088844 A1 AR 088844A1
Authority
AR
Argentina
Prior art keywords
methyl
imidazol
trifluoro
pyrimidinyl
amino
Prior art date
Application number
ARP120104259A
Other languages
English (en)
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of AR088844A1 publication Critical patent/AR088844A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Se da a conocer una forma de dosificación sólida del nilotinib que comprende: (i) un núcleo que comprende la 4-metil-3-[[4-(3-piridinil)-2-pirimidinil]-amino]-N-[5-(4-metil-1H-imidazol-1-il)-3-(trifluoro-metil)-fenil]-benzamida, o una sal farmacéuticamente aceptable de la misma, y excipientes; y (ii) cuando menos un polímero, recubriendo este polímero al núcleo, en donde se demora la desintegración de la forma de dosificación sólida mencionada.
ARP120104259A 2011-11-14 2012-11-12 Formulacion de liberacion inmediata de 4-metil-3-[[4-(3-piridinil)-2-pirimidinil]-amino]-n-[5-(4-metil-1h-imidazol-1-il)-3-(trifluoro-metil)-fenil]-benzamida AR088844A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161559281P 2011-11-14 2011-11-14

Publications (1)

Publication Number Publication Date
AR088844A1 true AR088844A1 (es) 2014-07-10

Family

ID=47324402

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP120104259A AR088844A1 (es) 2011-11-14 2012-11-12 Formulacion de liberacion inmediata de 4-metil-3-[[4-(3-piridinil)-2-pirimidinil]-amino]-n-[5-(4-metil-1h-imidazol-1-il)-3-(trifluoro-metil)-fenil]-benzamida

Country Status (22)

Country Link
EP (1) EP2779995A1 (es)
JP (1) JP6275645B2 (es)
KR (1) KR20140093230A (es)
CN (1) CN103930094A (es)
AR (1) AR088844A1 (es)
BR (1) BR112014011518A2 (es)
CA (1) CA2855503A1 (es)
CL (1) CL2014001247A1 (es)
CO (1) CO6960546A2 (es)
EA (1) EA201490960A1 (es)
GT (1) GT201400094A (es)
HK (1) HK1197025A1 (es)
IL (1) IL232480A0 (es)
IN (1) IN2014DN03416A (es)
MA (1) MA35636B1 (es)
MX (1) MX2014005874A (es)
PE (1) PE20141337A1 (es)
SG (2) SG11201401476TA (es)
TN (1) TN2014000177A1 (es)
TW (1) TWI574690B (es)
WO (1) WO2013074432A1 (es)
ZA (1) ZA201402756B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2792360A1 (en) 2013-04-18 2014-10-22 IP Gesellschaft für Management mbH (1aR,12bS)-8-cyclohexyl-11-fluoro-N-((1-methylcyclopropyl)sulfonyl)-1a-((3-methyl-3,8-diazabicyclo[3.2.1]oct-8-yl)carbonyl)-1,1a,2,2b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide for use in treating HCV
CZ2017821A3 (cs) 2017-12-20 2019-07-03 Zentiva, K.S. Léková forma obsahující krystalický nilotinib
JP7378279B2 (ja) 2019-11-18 2023-11-13 日本化薬株式会社 ニロチニブを有効成分とする医薬錠剤及びその製造方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0215676D0 (en) * 2002-07-05 2002-08-14 Novartis Ag Organic compounds
GT200600315A (es) 2005-07-20 2007-03-19 Formas cristalinas de 4-metilo-n-[3-(4-metilo-imidazol-1-ilo)-5-trifluorometilo-fenilo]-3-(4-pyridina-3-ilo-pirimidina-2-iloamino)-benzamida
GT200600316A (es) 2005-07-20 2007-04-02 Sales de 4-metilo-n-(3-(4-metilo-imidazol-1-ilo)-5-trifluorometilo-fenilo)-3-(4-piridina-3-ilo-pirimidina-2-iloamino)- benzamida.
EP1923053A1 (en) * 2006-09-27 2008-05-21 Novartis AG Pharmaceutical compositions comprising nilotinib or its salt
US20100136097A1 (en) * 2008-12-02 2010-06-03 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Systems for modulating inflammation
IN2011CH01887A (es) * 2011-06-02 2012-12-14

Also Published As

Publication number Publication date
EA201490960A1 (ru) 2014-08-29
HK1197025A1 (en) 2015-01-02
ZA201402756B (en) 2015-04-29
AU2012339829A1 (en) 2014-05-29
CA2855503A1 (en) 2013-05-23
JP2014533283A (ja) 2014-12-11
EP2779995A1 (en) 2014-09-24
CN103930094A (zh) 2014-07-16
WO2013074432A1 (en) 2013-05-23
IL232480A0 (en) 2014-06-30
TW201325594A (zh) 2013-07-01
SG10201707768RA (en) 2017-10-30
IN2014DN03416A (es) 2015-06-26
PE20141337A1 (es) 2014-10-16
SG11201401476TA (en) 2014-10-30
NZ623844A (en) 2016-09-30
GT201400094A (es) 2017-09-28
CO6960546A2 (es) 2014-05-30
KR20140093230A (ko) 2014-07-25
MA35636B1 (fr) 2014-11-01
TWI574690B (zh) 2017-03-21
BR112014011518A2 (pt) 2017-05-16
AU2012339829B2 (en) 2016-05-12
JP6275645B2 (ja) 2018-02-07
CL2014001247A1 (es) 2014-10-17
MX2014005874A (es) 2014-06-23
TN2014000177A1 (en) 2015-09-30

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