CN103930094A - 即释4-甲基-3[[4-(3-吡啶基)-2-嘧啶基]氨基]-n-[5-(4-甲基-1h-咪唑-1-基)-3-(三氟甲基)苯基]苯甲酰胺剂型 - Google Patents

即释4-甲基-3[[4-(3-吡啶基)-2-嘧啶基]氨基]-n-[5-(4-甲基-1h-咪唑-1-基)-3-(三氟甲基)苯基]苯甲酰胺剂型 Download PDF

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Publication number
CN103930094A
CN103930094A CN201280055937.8A CN201280055937A CN103930094A CN 103930094 A CN103930094 A CN 103930094A CN 201280055937 A CN201280055937 A CN 201280055937A CN 103930094 A CN103930094 A CN 103930094A
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CN
China
Prior art keywords
methyl
dosage forms
solid dosage
amino
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201280055937.8A
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English (en)
Chinese (zh)
Inventor
U·巴德瓦杰
M·S·博尔达维卡
A·R·康福特
P·李
李守峰
A·马卡洛夫
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Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis AG filed Critical Novartis AG
Publication of CN103930094A publication Critical patent/CN103930094A/zh
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN201280055937.8A 2011-11-14 2012-11-12 即释4-甲基-3[[4-(3-吡啶基)-2-嘧啶基]氨基]-n-[5-(4-甲基-1h-咪唑-1-基)-3-(三氟甲基)苯基]苯甲酰胺剂型 Pending CN103930094A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161559281P 2011-11-14 2011-11-14
US61/559,281 2011-11-14
PCT/US2012/064610 WO2013074432A1 (en) 2011-11-14 2012-11-12 Immediate release 4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-n-[5-(4-methyl- 1h-imidazol-1-yl)-3-(trifluoromethyl)phenyl] benzamide formulation

Publications (1)

Publication Number Publication Date
CN103930094A true CN103930094A (zh) 2014-07-16

Family

ID=47324402

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201280055937.8A Pending CN103930094A (zh) 2011-11-14 2012-11-12 即释4-甲基-3[[4-(3-吡啶基)-2-嘧啶基]氨基]-n-[5-(4-甲基-1h-咪唑-1-基)-3-(三氟甲基)苯基]苯甲酰胺剂型

Country Status (22)

Country Link
EP (1) EP2779995A1 (es)
JP (1) JP6275645B2 (es)
KR (1) KR20140093230A (es)
CN (1) CN103930094A (es)
AR (1) AR088844A1 (es)
BR (1) BR112014011518A2 (es)
CA (1) CA2855503A1 (es)
CL (1) CL2014001247A1 (es)
CO (1) CO6960546A2 (es)
EA (1) EA201490960A1 (es)
GT (1) GT201400094A (es)
HK (1) HK1197025A1 (es)
IL (1) IL232480A0 (es)
IN (1) IN2014DN03416A (es)
MA (1) MA35636B1 (es)
MX (1) MX2014005874A (es)
PE (1) PE20141337A1 (es)
SG (2) SG10201707768RA (es)
TN (1) TN2014000177A1 (es)
TW (1) TWI574690B (es)
WO (1) WO2013074432A1 (es)
ZA (1) ZA201402756B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2792360A1 (en) 2013-04-18 2014-10-22 IP Gesellschaft für Management mbH (1aR,12bS)-8-cyclohexyl-11-fluoro-N-((1-methylcyclopropyl)sulfonyl)-1a-((3-methyl-3,8-diazabicyclo[3.2.1]oct-8-yl)carbonyl)-1,1a,2,2b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide for use in treating HCV
CZ2017821A3 (cs) 2017-12-20 2019-07-03 Zentiva, K.S. Léková forma obsahující krystalický nilotinib
JP7378279B2 (ja) * 2019-11-18 2023-11-13 日本化薬株式会社 ニロチニブを有効成分とする医薬錠剤及びその製造方法
JP7489849B2 (ja) 2020-07-20 2024-05-24 日本化薬株式会社 ニロチニブ錠剤

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101516344A (zh) * 2006-09-27 2009-08-26 诺瓦提斯公司 包含尼罗替尼或其盐的药物组合物
US20100136097A1 (en) * 2008-12-02 2010-06-03 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Systems for modulating inflammation

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0215676D0 (en) * 2002-07-05 2002-08-14 Novartis Ag Organic compounds
GT200600316A (es) 2005-07-20 2007-04-02 Sales de 4-metilo-n-(3-(4-metilo-imidazol-1-ilo)-5-trifluorometilo-fenilo)-3-(4-piridina-3-ilo-pirimidina-2-iloamino)- benzamida.
GT200600315A (es) 2005-07-20 2007-03-19 Formas cristalinas de 4-metilo-n-[3-(4-metilo-imidazol-1-ilo)-5-trifluorometilo-fenilo]-3-(4-pyridina-3-ilo-pirimidina-2-iloamino)-benzamida
WO2012164578A1 (en) * 2011-06-02 2012-12-06 Hetero Research Foundation Compositions and methods for preparing immediate release formulations of nilotinib

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101516344A (zh) * 2006-09-27 2009-08-26 诺瓦提斯公司 包含尼罗替尼或其盐的药物组合物
US20100136097A1 (en) * 2008-12-02 2010-06-03 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Systems for modulating inflammation

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
L. ZEMA. A.等: "Different HPMC viscosity grades as coating agents for an oral time and/or site-controlled delivery system: An investigation into the mechanisms governing drug release", 《JOURNAL OF PHARMACEUTICAL SCIENCES》 *
PETER KLEINEBUDDE: "Roll compaction/dry granulation: Pharmaceutical applications", 《EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS》 *

Also Published As

Publication number Publication date
CO6960546A2 (es) 2014-05-30
KR20140093230A (ko) 2014-07-25
CL2014001247A1 (es) 2014-10-17
ZA201402756B (en) 2015-04-29
EA201490960A1 (ru) 2014-08-29
GT201400094A (es) 2017-09-28
NZ623844A (en) 2016-09-30
TWI574690B (zh) 2017-03-21
CA2855503A1 (en) 2013-05-23
MX2014005874A (es) 2014-06-23
TN2014000177A1 (en) 2015-09-30
SG11201401476TA (en) 2014-10-30
SG10201707768RA (en) 2017-10-30
AR088844A1 (es) 2014-07-10
BR112014011518A2 (pt) 2017-05-16
TW201325594A (zh) 2013-07-01
AU2012339829A1 (en) 2014-05-29
IL232480A0 (en) 2014-06-30
JP2014533283A (ja) 2014-12-11
IN2014DN03416A (es) 2015-06-26
HK1197025A1 (en) 2015-01-02
MA35636B1 (fr) 2014-11-01
JP6275645B2 (ja) 2018-02-07
PE20141337A1 (es) 2014-10-16
AU2012339829B2 (en) 2016-05-12
EP2779995A1 (en) 2014-09-24
WO2013074432A1 (en) 2013-05-23

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