TN2013000440A1 - Modified release of 4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-n-5-(4-methyl-1h-imidazol-1-yl)-3-(trifluoromethyl)phenyl] benzamide solubilized using organic acids - Google Patents

Modified release of 4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-n-5-(4-methyl-1h-imidazol-1-yl)-3-(trifluoromethyl)phenyl] benzamide solubilized using organic acids

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Publication number
TN2013000440A1
TN2013000440A1 TNP2013000440A TN2013000440A TN2013000440A1 TN 2013000440 A1 TN2013000440 A1 TN 2013000440A1 TN P2013000440 A TNP2013000440 A TN P2013000440A TN 2013000440 A TN2013000440 A TN 2013000440A TN 2013000440 A1 TN2013000440 A1 TN 2013000440A1
Authority
TN
Tunisia
Prior art keywords
methyl
organic acids
imidazol
pyridinyl
pyrimidinyl
Prior art date
Application number
TNP2013000440A
Other languages
French (fr)
Inventor
Shoufeng Li
Saran Kumar
Nikhil Javant Kavimandan
Enxian Lu
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2012/042205 external-priority patent/WO2012174082A1/en
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of TN2013000440A1 publication Critical patent/TN2013000440A1/en

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  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Soluble pharmaceutical compositions of amorphous nilotinib or a pharmaceutically acceptable salt thereof were invented using one or more organic acids that function as a solubilizing agent, increasing the bioavailability of nilotinib and supressing the food effect associated with certain compositions of nilotinib. The pharmaceutical compositions are in th form of solid oral dosage forms, including capsules and tablets.
TNP2013000440A 2011-09-30 2013-10-29 Modified release of 4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-n-5-(4-methyl-1h-imidazol-1-yl)-3-(trifluoromethyl)phenyl] benzamide solubilized using organic acids TN2013000440A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161541306P 2011-09-30 2011-09-30
PCT/US2012/042205 WO2012174082A1 (en) 2011-06-14 2012-06-13 Modified release of 4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-n-5-(4-methyl-1h-imidazol-1-yl)-3-(trifluoromethyl)phenyl] benzamide solubilized using organic acids

Publications (1)

Publication Number Publication Date
TN2013000440A1 true TN2013000440A1 (en) 2015-03-30

Family

ID=52394773

Family Applications (1)

Application Number Title Priority Date Filing Date
TNP2013000440A TN2013000440A1 (en) 2011-09-30 2013-10-29 Modified release of 4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-n-5-(4-methyl-1h-imidazol-1-yl)-3-(trifluoromethyl)phenyl] benzamide solubilized using organic acids

Country Status (2)

Country Link
CU (1) CU20130165A7 (en)
TN (1) TN2013000440A1 (en)

Also Published As

Publication number Publication date
CU20130165A7 (en) 2014-04-24

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