HRP20110539T1 - PIRIDINO[3,4-b]PIRAZINONI - Google Patents

PIRIDINO[3,4-b]PIRAZINONI Download PDF

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Publication number
HRP20110539T1
HRP20110539T1 HR20110539T HRP20110539T HRP20110539T1 HR P20110539 T1 HRP20110539 T1 HR P20110539T1 HR 20110539 T HR20110539 T HR 20110539T HR P20110539 T HRP20110539 T HR P20110539T HR P20110539 T1 HRP20110539 T1 HR P20110539T1
Authority
HR
Croatia
Prior art keywords
group
substituents
propoxyethyl
alkyl
pyrido
Prior art date
Application number
HR20110539T
Other languages
English (en)
Croatian (hr)
Inventor
O. Hughes Robert
Simon Bell Andrew
Graham Brown David
Rhys Owen Dafydd
John Palmer Michael
Phillips Christopher
Louis Brown David
Marlene Fobian Yvette
Nicholas Freskos John
Edward Heasley Steven
Jon Jacobsen Eric
Michael Maddux Todd
Virgil Mischke Brent
Major Molyneaux John
Blair Moon Joseph
Joseph Jr. Rogier Donald
Brent Tollefson Michael
Keith Walker John
Original Assignee
Pfizer Products Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Products Inc. filed Critical Pfizer Products Inc.
Publication of HRP20110539T1 publication Critical patent/HRP20110539T1/hr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Separation Of Suspended Particles By Flocculating Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Epoxy Compounds (AREA)
HR20110539T 2006-04-21 2007-04-10 PIRIDINO[3,4-b]PIRAZINONI HRP20110539T1 (hr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US79397106P 2006-04-21 2006-04-21
PCT/IB2007/001001 WO2007122466A1 (en) 2006-04-21 2007-04-10 Pyridine[3,4-b]pyrazinones

Publications (1)

Publication Number Publication Date
HRP20110539T1 true HRP20110539T1 (hr) 2011-08-31

Family

ID=38431249

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20110539T HRP20110539T1 (hr) 2006-04-21 2007-04-10 PIRIDINO[3,4-b]PIRAZINONI

Country Status (41)

Country Link
US (1) US7902195B2 (https=)
EP (1) EP2013208B1 (https=)
JP (1) JP4436892B2 (https=)
KR (1) KR101061328B1 (https=)
CN (1) CN101454320B (https=)
AP (1) AP2408A (https=)
AR (1) AR060525A1 (https=)
AT (1) ATE513831T1 (https=)
AU (1) AU2007242555B2 (https=)
BR (1) BRPI0710658A2 (https=)
CA (1) CA2649775C (https=)
CR (1) CR10327A (https=)
CU (1) CU23777B7 (https=)
CY (1) CY1111739T1 (https=)
DK (1) DK2013208T3 (https=)
DO (1) DOP2007000080A (https=)
EA (1) EA014919B1 (https=)
EC (1) ECSP088803A (https=)
ES (1) ES2366239T3 (https=)
GT (1) GT200700035A (https=)
HR (1) HRP20110539T1 (https=)
IL (1) IL194591A (https=)
MA (1) MA30352B1 (https=)
ME (1) MEP23808A (https=)
MX (1) MX2008012456A (https=)
MY (1) MY148583A (https=)
NL (1) NL2000583C2 (https=)
NO (1) NO20084129L (https=)
NZ (1) NZ571540A (https=)
PA (1) PA8724201A1 (https=)
PE (1) PE20080192A1 (https=)
PL (1) PL2013208T3 (https=)
RS (2) RS20080484A (https=)
SI (1) SI2013208T1 (https=)
SV (1) SV2008003074A (https=)
TN (1) TNSN08408A1 (https=)
TW (1) TWI337609B (https=)
UA (1) UA92637C2 (https=)
UY (1) UY30291A1 (https=)
WO (1) WO2007122466A1 (https=)
ZA (1) ZA200808283B (https=)

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NZ610012A (en) 2010-10-15 2015-05-29 Gilead Sciences Inc Compositions and methods of treating pulmonary hypertension
EP2691393B1 (en) 2011-03-31 2016-09-14 Pfizer Inc Novel bicyclic pyridinones
WO2012172449A1 (en) 2011-06-13 2012-12-20 Pfizer Inc. Lactams as beta secretase inhibitors
ES2605565T3 (es) 2011-08-31 2017-03-15 Pfizer Inc Compuestos de hexahidropirano [3,4-D][1,3]tiazin-2-amina
ES2585262T3 (es) 2012-05-04 2016-10-04 Pfizer Inc Compuestos heterocíclicos de hexahidropiran[3,4-d][1,3]tiazin-2-amina sustituidos como inhibidores de PPA, BACE1 y BACE2
CA2882389A1 (en) 2012-09-20 2014-03-27 Pfizer Inc. Alkyl-substituted hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds
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WO2014091352A1 (en) 2012-12-11 2014-06-19 Pfizer Inc. Hexahydropyrano [3,4-d][1,3]thiazin-2-amine compounds as inhibitors of bace1
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WO2014125394A1 (en) 2013-02-13 2014-08-21 Pfizer Inc. HETEROARYL-SUBSTITUTED HEXAHYDROPYRANO [3,4-d][1,3] THIAZIN-2-AMINE COMPOUNDS
US9233981B1 (en) 2013-02-15 2016-01-12 Pfizer Inc. Substituted phenyl hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds
CN105121439A (zh) 2013-02-19 2015-12-02 辉瑞公司 作为pde4亚型抑制剂用于治疗cns和其他病症的氮杂苯并咪唑化合物
ES2742078T3 (es) 2013-10-04 2020-02-13 Pfizer Piridonas bicíclicas novedosas como moduladores de gamma-secretasa
JO3466B1 (ar) * 2013-12-20 2020-07-05 Takeda Pharmaceuticals Co مواد ضابطة لتترا هيدرو بيريدوبيرازينات من gpr6
DK3126361T3 (da) 2014-04-01 2020-01-02 Pfizer Chromen og 1,1a,2,7b-tetrahydrocyclopropa[c]chromen- pyridopyrazindioner som gamma-sekretase-modulatorer
PE20170327A1 (es) 2014-04-10 2017-04-21 Pfizer 2-AMINO-6-METIL-4,4a,5,6-TETRAHIDROPIRANO[3,4d] [1,3] TIAZIN-8a(8H)-IL-1,3-TIAZOL-4-ILAMIDAS
WO2016012896A1 (en) 2014-07-24 2016-01-28 Pfizer Inc. Pyrazolopyrimidine compounds
PL3177624T3 (pl) 2014-08-06 2019-09-30 Pfizer Inc. Związki imidazopirydazynowe
MX368391B (es) 2015-02-03 2019-09-30 Pfizer Ciclopropabenzofuranil-piridopirazindionas novedosas.
EP3766885B1 (en) 2015-06-17 2022-05-25 Pfizer Inc. Tricyclic compounds and their use as phosphodiesterase inhibitors
WO2017051276A1 (en) 2015-09-24 2017-03-30 Pfizer Inc. N-[2-(2-amino-6,6-disubstituted-4, 4a, 5, 6-tetrahydropyrano [3,4-d][1,3] thiazin-8a (8h)-yl) -1, 3-thiazol-4-yl] amides
WO2017051294A1 (en) 2015-09-24 2017-03-30 Pfizer Inc. N-[2-(3-amino-2,5-dimethyl-1,1-dioxido-5,6-dihydro-2h-1,2,4-thiadiazin-5-yl)-1,3-thiazol-4-yl] amides useful as bace inhibitors
EP3353182A1 (en) 2015-09-24 2018-08-01 Pfizer Inc Tetrahydropyrano[3,4-d][1,3]oxazin derivatives and their use as bace inhibitors
SG11201806383TA (en) 2016-02-23 2018-09-27 Pfizer 6,7-dihydro-5h-pyrazolo[5,1-b][1,3]oxazine-2-carboxamide compounds
WO2018002760A1 (en) 2016-07-01 2018-01-04 Pfizer Inc. 5,7-dihydro-pyrrolo-pyridine derivatives for treating neurological and neurodegenerative diseases
BR112019026955A2 (pt) 2017-06-22 2020-06-30 Pfizer Inc. derivados de di-hidro-pirrolo-piridina
CN111182898B (zh) * 2017-06-28 2024-04-16 Ptc医疗公司 用于治疗亨廷顿氏病的方法
EP4219464A1 (en) 2018-03-23 2023-08-02 Pfizer Inc. Piperazine azaspiro derivaves
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Also Published As

Publication number Publication date
EP2013208B1 (en) 2011-06-22
TWI337609B (en) 2011-02-21
IL194591A (en) 2012-07-31
PA8724201A1 (es) 2009-08-26
CA2649775A1 (en) 2007-11-01
PE20080192A1 (es) 2008-03-01
NL2000583C2 (nl) 2007-12-14
UA92637C2 (en) 2010-11-25
GT200700035A (es) 2008-02-05
KR101061328B1 (ko) 2011-08-31
CR10327A (es) 2008-10-21
DK2013208T3 (da) 2011-08-15
MX2008012456A (es) 2008-10-10
AP2408A (en) 2012-05-30
CN101454320B (zh) 2012-12-19
NZ571540A (en) 2010-10-29
CN101454320A (zh) 2009-06-10
CA2649775C (en) 2011-05-31
CU20080194A7 (es) 2011-03-21
TW200808794A (en) 2008-02-16
DOP2007000080A (es) 2007-11-15
CU23777B7 (es) 2012-02-15
SV2008003074A (es) 2010-01-12
UY30291A1 (es) 2007-11-30
AP2008004640A0 (en) 2008-10-31
NO20084129L (no) 2008-10-29
ES2366239T3 (es) 2011-10-18
KR20080110930A (ko) 2008-12-19
AR060525A1 (es) 2008-06-25
ZA200808283B (en) 2009-11-25
US20070249615A1 (en) 2007-10-25
RS20080484A (sr) 2009-07-15
NL2000583A1 (nl) 2007-10-23
MY148583A (en) 2013-04-30
US7902195B2 (en) 2011-03-08
WO2007122466A1 (en) 2007-11-01
CY1111739T1 (el) 2015-10-07
MA30352B1 (fr) 2009-04-01
EA200801998A1 (ru) 2009-04-28
PL2013208T3 (pl) 2011-10-31
EP2013208A1 (en) 2009-01-14
RS51885B (sr) 2012-02-29
SI2013208T1 (sl) 2011-09-30
ATE513831T1 (de) 2011-07-15
JP2009534368A (ja) 2009-09-24
JP4436892B2 (ja) 2010-03-24
AU2007242555B2 (en) 2010-12-16
MEP23808A (en) 2010-06-10
EA014919B1 (ru) 2011-04-29
BRPI0710658A2 (pt) 2011-08-16
TNSN08408A1 (fr) 2010-04-14
AU2007242555A1 (en) 2007-11-01
ECSP088803A (es) 2008-11-27
HK1133875A1 (en) 2010-04-09

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