JP2009534368A5 - - Google Patents
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- Publication number
- JP2009534368A5 JP2009534368A5 JP2009505983A JP2009505983A JP2009534368A5 JP 2009534368 A5 JP2009534368 A5 JP 2009534368A5 JP 2009505983 A JP2009505983 A JP 2009505983A JP 2009505983 A JP2009505983 A JP 2009505983A JP 2009534368 A5 JP2009534368 A5 JP 2009534368A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- propoxyethyl
- pyrido
- alkyl
- hydroxyethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 CC(**)=C(*)C(*)=C(*)NC Chemical compound CC(**)=C(*)C(*)=C(*)NC 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US79397106P | 2006-04-21 | 2006-04-21 | |
| PCT/IB2007/001001 WO2007122466A1 (en) | 2006-04-21 | 2007-04-10 | Pyridine[3,4-b]pyrazinones |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009534368A JP2009534368A (ja) | 2009-09-24 |
| JP2009534368A5 true JP2009534368A5 (https=) | 2009-11-05 |
| JP4436892B2 JP4436892B2 (ja) | 2010-03-24 |
Family
ID=38431249
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009505983A Expired - Fee Related JP4436892B2 (ja) | 2006-04-21 | 2007-04-10 | ピリジン［３，４−ｂ］ピラジノン |
Country Status (41)
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2007242555B2 (en) | 2006-04-21 | 2010-12-16 | Pfizer Products Inc. | Pyridine[3,4-b]pyrazinones |
| HUE025355T2 (en) | 2006-12-12 | 2016-02-29 | Gilead Sciences Inc | Composition for treating pulmonary hypertension |
| PT2247292T (pt) | 2008-03-05 | 2017-07-17 | Merck Patent Gmbh | Derivados de piridopirazinonas como estimulantes da secreção de insulina, procedimentos para a sua obtenção e a sua utilização no tratamento da diabetes |
| WO2010041711A1 (ja) * | 2008-10-09 | 2010-04-15 | 杏林製薬株式会社 | イソキノリン誘導体及びそれらを有効成分とするｐｄｅ阻害剤 |
| SG10201500511TA (en) * | 2009-10-26 | 2015-03-30 | Signal Pharm Llc | Methods Of Synthesis And Purification Of Heteroaryl Compounds |
| MX346730B (es) | 2010-10-15 | 2017-03-30 | Gilead Sciences Inc | Composiciones y metodos para el tratamiento de la hipertension pulmonar. |
| CA2830027C (en) | 2011-03-31 | 2016-04-26 | Pfizer Inc. | Novel bicyclic pyridinones |
| WO2012172449A1 (en) | 2011-06-13 | 2012-12-20 | Pfizer Inc. | Lactams as beta secretase inhibitors |
| JP6043355B2 (ja) | 2011-08-31 | 2016-12-14 | ファイザー・インク | ヘキサヒドロピラノ［３，４−ｄ］［１，３］チアジン−２−アミン化合物 |
| WO2013164730A1 (en) | 2012-05-04 | 2013-11-07 | Pfizer Inc. | Heterocyclic substituted hexahydropyrano [3,4-d] [1,3] thiazin- 2 -amine compounds as inhibitors of app, bace1 and bace 2. |
| EP2897964A1 (en) | 2012-09-20 | 2015-07-29 | Pfizer Inc. | Alkyl-substituted hexahydropyrano [3,4-d][1,3]thiazin-2-amine compounds |
| UA110688C2 (uk) | 2012-09-21 | 2016-01-25 | Пфайзер Інк. | Біциклічні піридинони |
| EP2931731A1 (en) | 2012-12-11 | 2015-10-21 | Pfizer Inc. | Hexahydropyrano [3,4-d][1,3]thiazin-2-amine compounds as inhibitors of bace1 |
| US9403846B2 (en) | 2012-12-19 | 2016-08-02 | Pfizer Inc. | Carbocyclic- and heterocyclic-substituted hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds |
| EP2956458B1 (en) | 2013-02-13 | 2017-08-09 | Pfizer Inc | Heteroaryl-substituted hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds |
| US9233981B1 (en) | 2013-02-15 | 2016-01-12 | Pfizer Inc. | Substituted phenyl hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds |
| BR112015019276A2 (pt) | 2013-02-19 | 2017-07-18 | Pfizer | compostos de azabenzimidazol como inibidores de isoenzimas de pde4 para o tratamento de distúrbios do snc e outros distúrbios |
| JP6425717B2 (ja) | 2013-10-04 | 2018-11-21 | ファイザー・インク | ガンマセクレターゼモジュレーターとしての新規二環式ピリジノン |
| JO3466B1 (ar) * | 2013-12-20 | 2020-07-05 | Takeda Pharmaceuticals Co | مواد ضابطة لتترا هيدرو بيريدوبيرازينات من gpr6 |
| AP2016009465A0 (en) | 2014-04-01 | 2016-09-30 | Pfizer | Chromene and 1,1 a,2,7b-tetrahydrocyclopropa[c]chromene pyridopyrazinediones as gamma-secretase modulators |
| CN106459088A (zh) | 2014-04-10 | 2017-02-22 | 辉瑞公司 | 2‑氨基‑6‑甲基‑4，4a，5，6‑四氢吡喃并[3，4‑d][1，3]噻嗪‑8a(8H)‑基‑1，3‑噻唑‑4‑基酰胺 |
| WO2016012896A1 (en) | 2014-07-24 | 2016-01-28 | Pfizer Inc. | Pyrazolopyrimidine compounds |
| MD20170011A2 (ro) | 2014-08-06 | 2017-08-31 | Pfizer Inc. | Compuşi imidazopiridazinici |
| MX368391B (es) | 2015-02-03 | 2019-09-30 | Pfizer | Ciclopropabenzofuranil-piridopirazindionas novedosas. |
| CN107787322B (zh) | 2015-06-17 | 2023-07-07 | 辉瑞大药厂 | 三环化合物以及它们作为磷酸二酯酶抑制剂的用途 |
| JP2018531923A (ja) | 2015-09-24 | 2018-11-01 | ファイザー・インク | Ｎ−［２−（２−アミノ−６，６−二置換−４，４ａ，５，６−テトラヒドロピラノ［３，４−ｄ］［１，３］チアジン−８ａ（８Ｈ）−イル）−１，３−チアゾール−４−イル］アミド |
| WO2017051303A1 (en) | 2015-09-24 | 2017-03-30 | Pfizer Inc. | Tetrahydropyrano[3,4-d][1,3]oxazin derivatives and their use as bace inhibitors |
| JP2018534251A (ja) | 2015-09-24 | 2018-11-22 | ファイザー・インク | Ｂａｃｅ阻害剤として有用なｎ−［２−（３−アミノ−２，５−ジメチル−１，１−ジオキシド−５，６−ジヒドロ−２ｈ−１，２，４−チアジアジン−５−イル）−１，３−チアゾール−４−イル］アミド |
| CN113332292A (zh) | 2016-02-23 | 2021-09-03 | 辉瑞公司 | 6,7-二氢-5H-吡唑并[5,1-b][1,3]噁嗪-2-甲酰胺化合物 |
| PT3478679T (pt) | 2016-07-01 | 2021-06-30 | Pfizer | Derivados de 5,7-dihidro-pirrolo-piridina para o tratamento de doenças neurológicas e neurodegenerativas |
| IL271290B2 (en) | 2017-06-22 | 2023-11-01 | Pfizer | Dihydro-pyrrolo-pyridine derivatives |
| US11382918B2 (en) * | 2017-06-28 | 2022-07-12 | Ptc Therapeutics, Inc. | Methods for treating Huntington's Disease |
| PT3768669T (pt) | 2018-03-23 | 2023-04-24 | Pfizer | Derivados de piperazina azaspiro |
| US12144815B2 (en) | 2021-02-23 | 2024-11-19 | Hoth Therapeutics, Inc. | Use of aprepitant for treating Alzheimer's disease |
| WO2024118524A1 (en) | 2022-11-28 | 2024-06-06 | Cerevel Therapeutics, Llc | Azaindole compounds and their use as phosphodiesterase inhibitors |
| WO2025145091A1 (en) | 2023-12-29 | 2025-07-03 | Pfizer Inc. | Crystalline forms of a muscarinic m4 receptor modulator and methods of treating diseases |
| WO2025160132A1 (en) * | 2024-01-23 | 2025-07-31 | Maplight Therapeutics, Inc. | Gpr6 inverse agonists |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1361652A (fr) | 1963-06-21 | 1964-05-22 | Ciba Geigy | Procédé de préparation de diazines, entre autres de la 2-méthyl-6-hydroxy-7-morpholino-ptéridine |
| HU221425B (en) | 1990-11-06 | 2002-10-28 | Yamanouchi Pharma Co Ltd | Condensed pyrazine derivatives, process for their production and pharmaceutical preparations containing these compounds |
| TW274550B (https=) | 1992-09-26 | 1996-04-21 | Hoechst Ag | |
| JP2000154139A (ja) | 1998-09-16 | 2000-06-06 | Kyowa Hakko Kogyo Co Ltd | 縮環ピラジン誘導体 |
| US6369056B1 (en) | 1999-05-04 | 2002-04-09 | American Home Products Corporation | Cyclic urea and cyclic amide derivatives |
| US6465465B1 (en) * | 2000-03-14 | 2002-10-15 | Arzneimittelwerk Dresden Gmbh | Process for the treatment of erectile dysfunction and product therefor |
| JP4166991B2 (ja) * | 2001-02-26 | 2008-10-15 | 田辺三菱製薬株式会社 | ピリドピリミジンまたはナフチリジン誘導体 |
| WO2002076954A1 (en) | 2001-03-23 | 2002-10-03 | Smithkline Beecham Corporation | Compounds useful as kinase inhibitors for the treatment of hyperproliferative diseases |
| US20030114469A1 (en) * | 2001-09-27 | 2003-06-19 | Cohen David Saul | Combinations |
| US7067658B2 (en) | 2002-09-30 | 2006-06-27 | Bristol-Myers Squibb Company | Pyridino and pyrimidino pyrazinones |
| JP2007504283A (ja) | 2003-05-20 | 2007-03-01 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | β−アミロイド斑に作用物質を結合させる方法 |
| EP1641423B1 (en) | 2003-06-26 | 2010-03-17 | Merck Sharp & Dohme Corp. | Benzodiazepine cgrp receptor antagonists |
| DE102004033670A1 (de) | 2004-07-09 | 2006-02-02 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Pyridodihydropyrazinone, Verfahren zu Ihrer Herstellung und Ihre Verwendung als Arzneimittel |
| EP1833803A4 (en) | 2005-01-03 | 2009-08-05 | Myriad Genetics Inc | PHARMACEUTICAL COMPOUNDS AS ACTIVATORS OF CASPASES AND INDUCTORS OF APOPTOSIS AND THEIR USE |
| CA2608672A1 (en) * | 2005-05-24 | 2006-11-30 | Pharmacia & Upjohn Company Llc | Pyridine [3,4-b] pyrazinones as pde-5 inhibitors |
| JP2009509923A (ja) | 2005-08-26 | 2009-03-12 | メシルジーン、インコーポレイテッド | ヒストンデアセチラーゼのベンゾジアゼピン及びベンゾピペラジン類似体阻害薬 |
| WO2007112347A1 (en) | 2006-03-28 | 2007-10-04 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| AU2007242555B2 (en) | 2006-04-21 | 2010-12-16 | Pfizer Products Inc. | Pyridine[3,4-b]pyrazinones |
-
2007
- 2007-04-10 AU AU2007242555A patent/AU2007242555B2/en not_active Ceased
- 2007-04-10 CN CN2007800198932A patent/CN101454320B/zh not_active Expired - Fee Related
- 2007-04-10 ES ES07734320T patent/ES2366239T3/es active Active
- 2007-04-10 EP EP07734320A patent/EP2013208B1/en active Active
- 2007-04-10 MX MX2008012456A patent/MX2008012456A/es active IP Right Grant
- 2007-04-10 DK DK07734320.0T patent/DK2013208T3/da active
- 2007-04-10 PL PL07734320T patent/PL2013208T3/pl unknown
- 2007-04-10 SI SI200730675T patent/SI2013208T1/sl unknown
- 2007-04-10 RS RS20110363A patent/RS51885B/sr unknown
- 2007-04-10 ME MEP-238/08A patent/MEP23808A/xx unknown
- 2007-04-10 JP JP2009505983A patent/JP4436892B2/ja not_active Expired - Fee Related
- 2007-04-10 AT AT07734320T patent/ATE513831T1/de active
- 2007-04-10 KR KR1020087028465A patent/KR101061328B1/ko not_active Expired - Fee Related
- 2007-04-10 WO PCT/IB2007/001001 patent/WO2007122466A1/en not_active Ceased
- 2007-04-10 HR HR20110539T patent/HRP20110539T1/hr unknown
- 2007-04-10 EA EA200801998A patent/EA014919B1/ru not_active IP Right Cessation
- 2007-04-10 BR BRPI0710658-0A patent/BRPI0710658A2/pt not_active IP Right Cessation
- 2007-04-10 RS RSP-2008/0484A patent/RS20080484A/sr unknown
- 2007-04-10 MY MYPI20084131A patent/MY148583A/en unknown
- 2007-04-10 CA CA2649775A patent/CA2649775C/en not_active Expired - Fee Related
- 2007-04-10 AP AP2008004640A patent/AP2408A/xx active
- 2007-04-10 NZ NZ571540A patent/NZ571540A/en not_active IP Right Cessation
- 2007-04-11 NL NL2000583A patent/NL2000583C2/nl not_active IP Right Cessation
- 2007-04-18 AR ARP070101657A patent/AR060525A1/es not_active Application Discontinuation
- 2007-04-18 UY UY30291A patent/UY30291A1/es not_active Application Discontinuation
- 2007-04-19 PE PE2007000483A patent/PE20080192A1/es not_active Application Discontinuation
- 2007-04-19 GT GT200700035A patent/GT200700035A/es unknown
- 2007-04-20 US US11/737,966 patent/US7902195B2/en not_active Expired - Fee Related
- 2007-04-20 PA PA20078724201A patent/PA8724201A1/es unknown
- 2007-04-20 DO DO2007000080A patent/DOP2007000080A/es unknown
- 2007-04-20 TW TW096114037A patent/TWI337609B/zh not_active IP Right Cessation
- 2007-10-04 UA UAA200812397A patent/UA92637C2/ru unknown
-
2008
- 2008-09-29 ZA ZA200808283A patent/ZA200808283B/xx unknown
- 2008-09-29 NO NO20084129A patent/NO20084129L/no not_active Application Discontinuation
- 2008-09-30 CR CR10327A patent/CR10327A/es unknown
- 2008-10-07 IL IL194591A patent/IL194591A/en not_active IP Right Cessation
- 2008-10-08 EC EC2008008803A patent/ECSP088803A/es unknown
- 2008-10-17 TN TNP2008000408A patent/TNSN08408A1/fr unknown
- 2008-10-17 CU CU20080194A patent/CU23777B7/es active IP Right Grant
- 2008-10-21 SV SV2008003074A patent/SV2008003074A/es unknown
- 2008-10-21 MA MA31321A patent/MA30352B1/fr unknown
-
2011
- 2011-07-25 CY CY20111100731T patent/CY1111739T1/el unknown
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