HRP20110449T1 - Derivati piridina kao modulatori receptora s1p1/edg1 - Google Patents
Derivati piridina kao modulatori receptora s1p1/edg1 Download PDFInfo
- Publication number
- HRP20110449T1 HRP20110449T1 HR20110449T HRP20110449T HRP20110449T1 HR P20110449 T1 HRP20110449 T1 HR P20110449T1 HR 20110449 T HR20110449 T HR 20110449T HR P20110449 T HRP20110449 T HR P20110449T HR P20110449 T1 HRP20110449 T1 HR P20110449T1
- Authority
- HR
- Croatia
- Prior art keywords
- alkyl
- methyl
- pyridine
- pyridinyl
- ethyl
- Prior art date
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- 101000693265 Homo sapiens Sphingosine 1-phosphate receptor 1 Proteins 0.000 title 1
- 102100025750 Sphingosine 1-phosphate receptor 1 Human genes 0.000 title 1
- 150000003222 pyridines Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 31
- 239000001257 hydrogen Substances 0.000 claims abstract 29
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract 29
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims abstract 26
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract 23
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims abstract 22
- 150000003839 salts Chemical class 0.000 claims abstract 17
- 125000006527 (C1-C5) alkyl group Chemical group 0.000 claims abstract 10
- WJJMNDUMQPNECX-UHFFFAOYSA-N dipicolinic acid Chemical compound OC(=O)C1=CC=CC(C(O)=O)=N1 WJJMNDUMQPNECX-UHFFFAOYSA-N 0.000 claims abstract 10
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims abstract 10
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims abstract 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract 5
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims abstract 4
- FBFDPDWTCGQHPO-UHFFFAOYSA-N 3,5-bis(2-ethylpyridin-4-yl)-1,2,4-oxadiazole Chemical compound C1=NC(CC)=CC(C=2N=C(ON=2)C=2C=C(CC)N=CC=2)=C1 FBFDPDWTCGQHPO-UHFFFAOYSA-N 0.000 claims abstract 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims abstract 2
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical group C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
- 201000010099 disease Diseases 0.000 claims 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 208000015181 infectious disease Diseases 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 125000006274 (C1-C3)alkoxy group Chemical group 0.000 claims 1
- ICAMXPDSOYKTLR-UHFFFAOYSA-N 2-(2,6-dimethylpyridin-4-yl)-5-(2-methyl-6-pentan-3-ylpyridin-4-yl)-1,3,4-thiadiazole Chemical compound CC1=NC(C(CC)CC)=CC(C=2SC(=NN=2)C=2C=C(C)N=C(C)C=2)=C1 ICAMXPDSOYKTLR-UHFFFAOYSA-N 0.000 claims 1
- OEFPHQSZXAIHHA-UHFFFAOYSA-N 2-(2-ethyl-6-methylpyridin-4-yl)-5-(2-methyl-6-pentan-3-ylpyridin-4-yl)-1,3,4-thiadiazole Chemical compound CC1=NC(C(CC)CC)=CC(C=2SC(=NN=2)C=2C=C(CC)N=C(C)C=2)=C1 OEFPHQSZXAIHHA-UHFFFAOYSA-N 0.000 claims 1
- HTGUHIFSMITKAZ-UHFFFAOYSA-N 3,5-bis(2-ethyl-6-methylpyridin-4-yl)-1,2,4-oxadiazole Chemical compound CC1=NC(CC)=CC(C=2N=C(ON=2)C=2C=C(CC)N=C(C)C=2)=C1 HTGUHIFSMITKAZ-UHFFFAOYSA-N 0.000 claims 1
- DGHQHTVURCHARU-UHFFFAOYSA-N 3-(2,6-dimethylpyridin-4-yl)-5-(2-ethyl-6-methylpyridin-4-yl)-1,2,4-oxadiazole Chemical compound CC1=NC(CC)=CC(C=2ON=C(N=2)C=2C=C(C)N=C(C)C=2)=C1 DGHQHTVURCHARU-UHFFFAOYSA-N 0.000 claims 1
- PKFIOWUDLWFDRQ-UHFFFAOYSA-N 3-(2,6-dimethylpyridin-4-yl)-5-(2-methyl-6-pentan-3-ylpyridin-4-yl)-1,2,4-oxadiazole Chemical compound CC1=NC(C(CC)CC)=CC(C=2ON=C(N=2)C=2C=C(C)N=C(C)C=2)=C1 PKFIOWUDLWFDRQ-UHFFFAOYSA-N 0.000 claims 1
- UXEPPMPTMGSDFS-UHFFFAOYSA-N 3-(2,6-dimethylpyridin-4-yl)-5-(2-methyl-6-propylpyridin-4-yl)-1,2,4-oxadiazole Chemical compound CC1=NC(CCC)=CC(C=2ON=C(N=2)C=2C=C(C)N=C(C)C=2)=C1 UXEPPMPTMGSDFS-UHFFFAOYSA-N 0.000 claims 1
- GMNYRUZXHQVCQR-UHFFFAOYSA-N 3-(2,6-dimethylpyridin-4-yl)-5-[2-ethyl-6-(2-methylpropyl)pyridin-4-yl]-1,2,4-oxadiazole Chemical compound CC(C)CC1=NC(CC)=CC(C=2ON=C(N=2)C=2C=C(C)N=C(C)C=2)=C1 GMNYRUZXHQVCQR-UHFFFAOYSA-N 0.000 claims 1
- HWGIXLDYPAQRDP-UHFFFAOYSA-N 3-(2,6-dimethylpyridin-4-yl)-5-[2-methyl-6-(2-methylpropyl)pyridin-4-yl]-1,2,4-oxadiazole Chemical compound CC1=NC(CC(C)C)=CC(C=2ON=C(N=2)C=2C=C(C)N=C(C)C=2)=C1 HWGIXLDYPAQRDP-UHFFFAOYSA-N 0.000 claims 1
- VHIWEDUDPFELNB-UHFFFAOYSA-N 3-(2-ethyl-6-methylpyridin-4-yl)-5-(2-methoxy-6-pentan-3-ylpyridin-4-yl)-1,2,4-oxadiazole Chemical compound COC1=NC(C(CC)CC)=CC(C=2ON=C(N=2)C=2C=C(CC)N=C(C)C=2)=C1 VHIWEDUDPFELNB-UHFFFAOYSA-N 0.000 claims 1
- ALHBLSYGZQMVNI-UHFFFAOYSA-N 3-(2-ethyl-6-methylpyridin-4-yl)-5-(2-methyl-6-pentan-3-ylpyridin-4-yl)-1,2,4-oxadiazole Chemical compound CC1=NC(C(CC)CC)=CC(C=2ON=C(N=2)C=2C=C(CC)N=C(C)C=2)=C1 ALHBLSYGZQMVNI-UHFFFAOYSA-N 0.000 claims 1
- TYBVLPOAZRULRP-UHFFFAOYSA-N 3-(2-ethyl-6-methylpyridin-4-yl)-5-(2-methyl-6-propan-2-yloxypyridin-4-yl)-1,2,4-oxadiazole Chemical compound CC1=NC(CC)=CC(C=2N=C(ON=2)C=2C=C(OC(C)C)N=C(C)C=2)=C1 TYBVLPOAZRULRP-UHFFFAOYSA-N 0.000 claims 1
- XQEGXKNSMQCFPR-UHFFFAOYSA-N 3-(2-ethyl-6-methylpyridin-4-yl)-5-(2-methyl-6-propylpyridin-4-yl)-1,2,4-oxadiazole Chemical compound CC1=NC(CCC)=CC(C=2ON=C(N=2)C=2C=C(CC)N=C(C)C=2)=C1 XQEGXKNSMQCFPR-UHFFFAOYSA-N 0.000 claims 1
- NPNNHSXQVNILOA-UHFFFAOYSA-N 3-(2-ethyl-6-methylpyridin-4-yl)-5-[2-methoxy-6-(2-methylpropyl)pyridin-4-yl]-1,2,4-oxadiazole Chemical compound CC1=NC(CC)=CC(C=2N=C(ON=2)C=2C=C(OC)N=C(CC(C)C)C=2)=C1 NPNNHSXQVNILOA-UHFFFAOYSA-N 0.000 claims 1
- WVYRAQWHFQYZNX-UHFFFAOYSA-N 3-(2-ethyl-6-methylpyridin-4-yl)-5-[2-methyl-6-(2-methylpropyl)pyridin-4-yl]-1,2,4-oxadiazole Chemical compound CC1=NC(CC)=CC(C=2N=C(ON=2)C=2C=C(CC(C)C)N=C(C)C=2)=C1 WVYRAQWHFQYZNX-UHFFFAOYSA-N 0.000 claims 1
- SLBBYPWXVVSBTA-UHFFFAOYSA-N 3-methyl-5-[5-[2-methyl-6-(2-methylpropyl)pyridin-4-yl]-1,2,4-oxadiazol-3-yl]-n-propan-2-ylpyridin-2-amine Chemical compound CC1=NC(CC(C)C)=CC(C=2ON=C(N=2)C=2C=C(C)C(NC(C)C)=NC=2)=C1 SLBBYPWXVVSBTA-UHFFFAOYSA-N 0.000 claims 1
- ZANJNBAXROIEMU-UHFFFAOYSA-N 4-[3-(2-ethyl-6-methylpyridin-4-yl)-1,2,4-oxadiazol-5-yl]-6-methyl-n-propan-2-ylpyridin-2-amine Chemical compound CC1=NC(CC)=CC(C=2N=C(ON=2)C=2C=C(NC(C)C)N=C(C)C=2)=C1 ZANJNBAXROIEMU-UHFFFAOYSA-N 0.000 claims 1
- VJJGBGPLCFMQSQ-UHFFFAOYSA-N 4-[3-(2-ethyl-6-methylpyridin-4-yl)-1,2,4-oxadiazol-5-yl]-n,6-dimethylpyridin-2-amine Chemical compound CC1=NC(CC)=CC(C=2N=C(ON=2)C=2C=C(NC)N=C(C)C=2)=C1 VJJGBGPLCFMQSQ-UHFFFAOYSA-N 0.000 claims 1
- IESJZDOUFILRLJ-UHFFFAOYSA-N 5-(2,6-diethylpyridin-4-yl)-3-(2,6-dimethylpyridin-4-yl)-1,2,4-oxadiazole Chemical compound CCC1=NC(CC)=CC(C=2ON=C(N=2)C=2C=C(C)N=C(C)C=2)=C1 IESJZDOUFILRLJ-UHFFFAOYSA-N 0.000 claims 1
- NRBDXWUCRQKLGS-UHFFFAOYSA-N 5-(2,6-diethylpyridin-4-yl)-3-(2-ethyl-6-methylpyridin-4-yl)-1,2,4-oxadiazole Chemical compound CC1=NC(CC)=CC(C=2N=C(ON=2)C=2C=C(CC)N=C(CC)C=2)=C1 NRBDXWUCRQKLGS-UHFFFAOYSA-N 0.000 claims 1
- RQIFKHVRTFYXNI-UHFFFAOYSA-N 5-(2-cyclopentyl-6-methoxypyridin-4-yl)-3-(2-ethyl-6-methylpyridin-4-yl)-1,2,4-oxadiazole Chemical compound CC1=NC(CC)=CC(C=2N=C(ON=2)C=2C=C(N=C(OC)C=2)C2CCCC2)=C1 RQIFKHVRTFYXNI-UHFFFAOYSA-N 0.000 claims 1
- GRWOKQVBOVHBMH-UHFFFAOYSA-N 5-(2-cyclopentyl-6-methylpyridin-4-yl)-3-(2,6-dimethylpyridin-4-yl)-1,2,4-oxadiazole Chemical compound CC1=NC(C)=CC(C=2N=C(ON=2)C=2C=C(N=C(C)C=2)C2CCCC2)=C1 GRWOKQVBOVHBMH-UHFFFAOYSA-N 0.000 claims 1
- FJTWFKBPXMAFHZ-UHFFFAOYSA-N 5-(2-ethyl-6-methylpyridin-4-yl)-3-[2-methyl-6-(2-methylpropyl)pyridin-4-yl]-1,2,4-oxadiazole Chemical compound CC1=NC(CC)=CC(C=2ON=C(N=2)C=2C=C(CC(C)C)N=C(C)C=2)=C1 FJTWFKBPXMAFHZ-UHFFFAOYSA-N 0.000 claims 1
- MUAZUGTWXWRBFN-UHFFFAOYSA-N 5-[2-ethyl-6-(2-methylpropyl)pyridin-4-yl]-3-(2-ethyl-6-methylpyridin-4-yl)-1,2,4-oxadiazole Chemical compound CC1=NC(CC)=CC(C=2N=C(ON=2)C=2C=C(CC(C)C)N=C(CC)C=2)=C1 MUAZUGTWXWRBFN-UHFFFAOYSA-N 0.000 claims 1
- 208000012657 Atopic disease Diseases 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- 206010010741 Conjunctivitis Diseases 0.000 claims 1
- 201000004624 Dermatitis Diseases 0.000 claims 1
- 206010018364 Glomerulonephritis Diseases 0.000 claims 1
- 208000030836 Hashimoto thyroiditis Diseases 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 206010027476 Metastases Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 201000001263 Psoriatic Arthritis Diseases 0.000 claims 1
- 208000036824 Psoriatic arthropathy Diseases 0.000 claims 1
- 206010038910 Retinitis Diseases 0.000 claims 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 1
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 230000001363 autoimmune Effects 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 210000004087 cornea Anatomy 0.000 claims 1
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 210000002216 heart Anatomy 0.000 claims 1
- 150000002431 hydrogen Chemical group 0.000 claims 1
- 210000000987 immune system Anatomy 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 210000004185 liver Anatomy 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- RGOCOPQXPMOWMH-UHFFFAOYSA-N n,6-dimethyl-4-[5-[2-methyl-6-(2-methylpropyl)pyridin-4-yl]-1,2,4-oxadiazol-3-yl]pyridin-2-amine Chemical compound CC1=NC(NC)=CC(C=2N=C(ON=2)C=2C=C(CC(C)C)N=C(C)C=2)=C1 RGOCOPQXPMOWMH-UHFFFAOYSA-N 0.000 claims 1
- HHNLFPMRSAXIKN-UHFFFAOYSA-N n,n-diethyl-4-[3-(2-ethyl-6-methylpyridin-4-yl)-1,2,4-oxadiazol-5-yl]-6-methylpyridin-2-amine Chemical compound CC1=NC(N(CC)CC)=CC(C=2ON=C(N=2)C=2C=C(CC)N=C(C)C=2)=C1 HHNLFPMRSAXIKN-UHFFFAOYSA-N 0.000 claims 1
- KQXRPPPNJZILCP-UHFFFAOYSA-N n-ethyl-4-[3-(2-ethyl-6-methylpyridin-4-yl)-1,2,4-oxadiazol-5-yl]-6-methylpyridin-2-amine Chemical compound CC1=NC(NCC)=CC(C=2ON=C(N=2)C=2C=C(CC)N=C(C)C=2)=C1 KQXRPPPNJZILCP-UHFFFAOYSA-N 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 210000000496 pancreas Anatomy 0.000 claims 1
- 201000003068 rheumatic fever Diseases 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 206010039083 rhinitis Diseases 0.000 claims 1
- 210000003491 skin Anatomy 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 238000011476 stem cell transplantation Methods 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 206010043778 thyroiditis Diseases 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Endocrinology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- Otolaryngology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Obesity (AREA)
- Transplantation (AREA)
- Psychiatry (AREA)
- Ophthalmology & Optometry (AREA)
- Emergency Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IB2007053293 | 2007-08-17 | ||
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| PT2970236T (pt) | 2013-03-15 | 2017-11-30 | Idorsia Pharmaceuticals Ltd | Derivados de piridin-4-ilo |
| HUE047646T2 (hu) | 2015-05-20 | 2020-05-28 | Idorsia Pharmaceuticals Ltd | Az (S)-3-{4-[5-(2-ciklopentil-6-metoxi-piridin-4-il)-[1,2,4]oxadiazol-3-il]-2-etil-6-metil-fenoxi} -propán-1,2-diol vegyület kristályformája |
| US10111841B2 (en) | 2015-06-19 | 2018-10-30 | University Of South Florida | Stabilization of alcohol intoxication-induced cardiovascular instability |
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| CA3226824A1 (en) | 2016-03-07 | 2017-09-14 | The Global Alliance For Tb Drug Development, Inc. | Antibacterial compounds and uses thereof |
| EP3429997A1 (de) | 2016-03-16 | 2019-01-23 | Bayer CropScience Aktiengesellschaft | N-(cyanbenzyl)-6-(cyclopropylcarbonylamino)-4-(phenyl)-pyridin-2-carboxamid-derivate und verwandte verbindungen als pestizide pflanzenschutzmittel |
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