HRP20110085T1 - Fotostabilni farmaceutski pripravci za tretman herpesnog keratitisa koji sadrže brivudin - Google Patents
Fotostabilni farmaceutski pripravci za tretman herpesnog keratitisa koji sadrže brivudin Download PDFInfo
- Publication number
- HRP20110085T1 HRP20110085T1 HR20110085T HRP20110085T HRP20110085T1 HR P20110085 T1 HRP20110085 T1 HR P20110085T1 HR 20110085 T HR20110085 T HR 20110085T HR P20110085 T HRP20110085 T HR P20110085T HR P20110085 T1 HRP20110085 T1 HR P20110085T1
- Authority
- HR
- Croatia
- Prior art keywords
- preparation according
- preparation
- amount
- film
- coating agent
- Prior art date
Links
- 229960001169 brivudine Drugs 0.000 title claims abstract 4
- ODZBBRURCPAEIQ-PIXDULNESA-N helpin Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(\C=C\Br)=C1 ODZBBRURCPAEIQ-PIXDULNESA-N 0.000 title claims abstract 4
- 208000005100 Herpetic Keratitis Diseases 0.000 title 1
- 206010073938 Ophthalmic herpes simplex Diseases 0.000 title 1
- 201000010884 herpes simplex virus keratitis Diseases 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 239000004372 Polyvinyl alcohol Substances 0.000 claims abstract 6
- 229920000058 polyacrylate Polymers 0.000 claims abstract 6
- 229920002451 polyvinyl alcohol Polymers 0.000 claims abstract 6
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims abstract 6
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims abstract 6
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims abstract 6
- 239000003795 chemical substances by application Substances 0.000 claims abstract 5
- 239000007888 film coating Substances 0.000 claims abstract 5
- 238000009501 film coating Methods 0.000 claims abstract 5
- 239000004480 active ingredient Substances 0.000 claims abstract 2
- 238000002360 preparation method Methods 0.000 claims 17
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims 3
- 239000003963 antioxidant agent Substances 0.000 claims 2
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 claims 2
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims 2
- 239000003755 preservative agent Substances 0.000 claims 2
- 230000002335 preservative effect Effects 0.000 claims 2
- 208000003809 Herpes Zoster Ophthalmicus Diseases 0.000 claims 1
- 206010030865 Ophthalmic herpes zoster Diseases 0.000 claims 1
- LRJOMUJRLNCICJ-JZYPGELDSA-N Prednisolone acetate Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)COC(=O)C)(O)[C@@]1(C)C[C@@H]2O LRJOMUJRLNCICJ-JZYPGELDSA-N 0.000 claims 1
- 230000003078 antioxidant effect Effects 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 208000030533 eye disease Diseases 0.000 claims 1
- 239000003889 eye drop Substances 0.000 claims 1
- 229940012356 eye drops Drugs 0.000 claims 1
- FAOZLTXFLGPHNG-KNAQIMQKSA-N fluorometholone Chemical compound C([C@@]12C)=CC(=O)C=C1[C@@H](C)C[C@@H]1[C@]2(F)[C@@H](O)C[C@]2(C)[C@@](O)(C(C)=O)CC[C@H]21 FAOZLTXFLGPHNG-KNAQIMQKSA-N 0.000 claims 1
- 229960001048 fluorometholone Drugs 0.000 claims 1
- SYTBZMRGLBWNTM-UHFFFAOYSA-N flurbiprofen Chemical group FC1=CC(C(C(O)=O)C)=CC=C1C1=CC=CC=C1 SYTBZMRGLBWNTM-UHFFFAOYSA-N 0.000 claims 1
- 229960002390 flurbiprofen Drugs 0.000 claims 1
- 239000000499 gel Substances 0.000 claims 1
- 206010023332 keratitis Diseases 0.000 claims 1
- 239000002674 ointment Substances 0.000 claims 1
- 229960002800 prednisolone acetate Drugs 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 230000003637 steroidlike Effects 0.000 claims 1
- 150000003431 steroids Chemical class 0.000 claims 1
- 208000025889 stromal keratitis Diseases 0.000 claims 1
- 239000004094 surface-active agent Substances 0.000 claims 1
- UEUXEKPTXMALOB-UHFFFAOYSA-J tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O UEUXEKPTXMALOB-UHFFFAOYSA-J 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Virology (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Ophthalmology & Optometry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Biotechnology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102005046769A DE102005046769A1 (de) | 2005-09-29 | 2005-09-29 | Lichtstabile, brivudinhaltige pharmazeutische Formulierung zur Behandlung von Augenherpes (Herpes Ophthalmicus) |
| PCT/EP2006/009383 WO2007039201A2 (en) | 2005-09-29 | 2006-09-27 | Photostable pharmaceutical composition containing brivudine for the treatment of herpetic keratitis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20110085T1 true HRP20110085T1 (hr) | 2011-03-31 |
Family
ID=37561306
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20110085T HRP20110085T1 (hr) | 2005-09-29 | 2011-02-03 | Fotostabilni farmaceutski pripravci za tretman herpesnog keratitisa koji sadrže brivudin |
Country Status (33)
| Country | Link |
|---|---|
| US (1) | US20080249061A1 (de) |
| EP (1) | EP1940353B1 (de) |
| JP (1) | JP2009509993A (de) |
| KR (1) | KR20080053319A (de) |
| CN (1) | CN101272765A (de) |
| AP (1) | AP2008004394A0 (de) |
| AR (1) | AR056551A1 (de) |
| AT (1) | ATE489076T1 (de) |
| AU (1) | AU2006299115A1 (de) |
| BR (1) | BRPI0616449A2 (de) |
| CA (1) | CA2624111A1 (de) |
| CR (1) | CR9839A (de) |
| CY (1) | CY1111059T1 (de) |
| DE (2) | DE102005046769A1 (de) |
| DK (1) | DK1940353T3 (de) |
| EA (1) | EA012975B1 (de) |
| EC (1) | ECSP088310A (de) |
| ES (1) | ES2356774T3 (de) |
| HN (1) | HN2008000497A (de) |
| HR (1) | HRP20110085T1 (de) |
| IL (1) | IL190466A0 (de) |
| MA (1) | MA29887B1 (de) |
| NO (1) | NO20081488L (de) |
| PE (1) | PE20070767A1 (de) |
| PL (1) | PL1940353T3 (de) |
| PT (1) | PT1940353E (de) |
| RS (1) | RS51615B (de) |
| SI (1) | SI1940353T1 (de) |
| TN (1) | TNSN08094A1 (de) |
| TW (1) | TW200744664A (de) |
| UA (1) | UA90911C2 (de) |
| WO (1) | WO2007039201A2 (de) |
| ZA (1) | ZA200802729B (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009006130A2 (en) * | 2007-06-28 | 2009-01-08 | Bausch & Lomb Incorporated | Salt free hyaluronate ophthalmic solution |
| US20090196833A1 (en) * | 2008-02-06 | 2009-08-06 | Adherex Technologies Inc. | Compositions comprising topical dpd inhibitors and methods of using same in the treatment of hand-foot syndrome |
| DE102009003942A1 (de) * | 2009-01-07 | 2010-07-08 | D2O Biosience Group Ltd., Hamilton | Verwendung von Deuteriumoxid zur Behandlung Virus-basierter Erkrankungen des Auges |
| ES2734269T3 (es) | 2014-01-22 | 2019-12-05 | Visufarma B V | Composición que comprende carragenina tipo iota contra conjuntivitis viral |
| WO2017192944A1 (en) * | 2016-05-06 | 2017-11-09 | SaCSh Corp. | Ophthalmic compositions |
| CN113712928A (zh) * | 2021-09-29 | 2021-11-30 | 重庆市力扬医药开发有限公司 | 经口腔粘膜吸收的溴夫定药物 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY136633A (en) * | 2001-01-17 | 2008-11-28 | Berlin Chemie Ag | Stabilized brivudine topical formulations |
| DE10162593A1 (de) * | 2001-12-19 | 2003-07-03 | Menarini Ricerche Spa | Stabilisierte topische Brivudin-Formulierungen |
-
2005
- 2005-09-29 DE DE102005046769A patent/DE102005046769A1/de not_active Withdrawn
-
2006
- 2006-09-27 DK DK06805904.7T patent/DK1940353T3/da active
- 2006-09-27 US US12/088,397 patent/US20080249061A1/en not_active Abandoned
- 2006-09-27 ES ES06805904T patent/ES2356774T3/es active Active
- 2006-09-27 PT PT06805904T patent/PT1940353E/pt unknown
- 2006-09-27 TW TW095135667A patent/TW200744664A/zh unknown
- 2006-09-27 PL PL06805904T patent/PL1940353T3/pl unknown
- 2006-09-27 ZA ZA200802729A patent/ZA200802729B/xx unknown
- 2006-09-27 JP JP2008532659A patent/JP2009509993A/ja not_active Withdrawn
- 2006-09-27 AU AU2006299115A patent/AU2006299115A1/en not_active Abandoned
- 2006-09-27 DE DE602006018505T patent/DE602006018505D1/de active Active
- 2006-09-27 KR KR1020087007483A patent/KR20080053319A/ko not_active Application Discontinuation
- 2006-09-27 AT AT06805904T patent/ATE489076T1/de active
- 2006-09-27 CN CNA2006800356965A patent/CN101272765A/zh active Pending
- 2006-09-27 SI SI200630913T patent/SI1940353T1/sl unknown
- 2006-09-27 CA CA002624111A patent/CA2624111A1/en not_active Abandoned
- 2006-09-27 BR BRPI0616449-8A patent/BRPI0616449A2/pt not_active IP Right Cessation
- 2006-09-27 WO PCT/EP2006/009383 patent/WO2007039201A2/en active Application Filing
- 2006-09-27 RS RS20110016A patent/RS51615B/en unknown
- 2006-09-27 EP EP06805904A patent/EP1940353B1/de active Active
- 2006-09-27 EA EA200800646A patent/EA012975B1/ru not_active IP Right Cessation
- 2006-09-27 AP AP2008004394A patent/AP2008004394A0/xx unknown
- 2006-09-27 UA UAA200802782A patent/UA90911C2/ru unknown
- 2006-09-28 PE PE2006001181A patent/PE20070767A1/es not_active Application Discontinuation
- 2006-09-28 AR ARP060104294A patent/AR056551A1/es unknown
-
2008
- 2008-02-28 TN TNP2008000094A patent/TNSN08094A1/en unknown
- 2008-03-25 EC EC2008008310A patent/ECSP088310A/es unknown
- 2008-03-26 NO NO20081488A patent/NO20081488L/no not_active Application Discontinuation
- 2008-03-27 HN HN2008000497A patent/HN2008000497A/es unknown
- 2008-03-27 CR CR9839A patent/CR9839A/es not_active Application Discontinuation
- 2008-03-27 IL IL190466A patent/IL190466A0/en unknown
- 2008-04-24 MA MA30877A patent/MA29887B1/fr unknown
-
2010
- 2010-12-23 CY CY20101101189T patent/CY1111059T1/el unknown
-
2011
- 2011-02-03 HR HR20110085T patent/HRP20110085T1/hr unknown
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