HRP20100293T1 - Formulacije za benzimidazolil piridil etere - Google Patents
Formulacije za benzimidazolil piridil etere Download PDFInfo
- Publication number
- HRP20100293T1 HRP20100293T1 HR20100293T HRP20100293T HRP20100293T1 HR P20100293 T1 HRP20100293 T1 HR P20100293T1 HR 20100293 T HR20100293 T HR 20100293T HR P20100293 T HRP20100293 T HR P20100293T HR P20100293 T1 HRP20100293 T1 HR P20100293T1
- Authority
- HR
- Croatia
- Prior art keywords
- formulation
- mixture
- formulation according
- compound
- formula
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract 42
- 238000009472 formulation Methods 0.000 title claims abstract 29
- SYLABBNLHCTJEF-UHFFFAOYSA-N 2-pyridin-2-yloxy-1h-benzimidazole Chemical class N=1C2=CC=CC=C2NC=1OC1=CC=CC=N1 SYLABBNLHCTJEF-UHFFFAOYSA-N 0.000 title 1
- 239000002904 solvent Substances 0.000 claims abstract 13
- 150000001875 compounds Chemical class 0.000 claims abstract 8
- 239000004615 ingredient Substances 0.000 claims abstract 5
- 150000003839 salts Chemical class 0.000 claims abstract 5
- 239000003995 emulsifying agent Substances 0.000 claims abstract 4
- 239000007787 solid Substances 0.000 claims abstract 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 4
- 239000002202 Polyethylene glycol Substances 0.000 claims 4
- 229920001223 polyethylene glycol Polymers 0.000 claims 4
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 3
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 2
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 claims 2
- 239000002775 capsule Substances 0.000 claims 2
- CTPDSKVQLSDPLC-UHFFFAOYSA-N 2-(oxolan-2-ylmethoxy)ethanol Chemical compound OCCOCC1CCCO1 CTPDSKVQLSDPLC-UHFFFAOYSA-N 0.000 claims 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 1
- XXJWXESWEXIICW-UHFFFAOYSA-N diethylene glycol monoethyl ether Chemical group CCOCCOCCO XXJWXESWEXIICW-UHFFFAOYSA-N 0.000 claims 1
- 229940075557 diethylene glycol monoethyl ether Drugs 0.000 claims 1
- 235000011187 glycerol Nutrition 0.000 claims 1
- 239000012669 liquid formulation Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 150000003904 phospholipids Chemical class 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- RUOJZAUFBMNUDX-UHFFFAOYSA-N propylene carbonate Chemical compound CC1COC(=O)O1 RUOJZAUFBMNUDX-UHFFFAOYSA-N 0.000 claims 1
- 238000001179 sorption measurement Methods 0.000 claims 1
- 239000007788 liquid Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Dispersion Chemistry (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Inorganic Chemistry (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US83271506P | 2006-07-21 | 2006-07-21 | |
PCT/US2007/016469 WO2008011154A2 (en) | 2006-07-21 | 2007-07-20 | Formulations for benzimidazolyl pyridyl ethers |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20100293T1 true HRP20100293T1 (hr) | 2010-06-30 |
Family
ID=38819293
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HR20100293T HRP20100293T1 (hr) | 2006-07-21 | 2010-05-25 | Formulacije za benzimidazolil piridil etere |
Country Status (20)
Country | Link |
---|---|
US (1) | US8455662B2 (el) |
EP (1) | EP2046292B1 (el) |
JP (1) | JP2009544617A (el) |
KR (1) | KR20090033904A (el) |
CN (1) | CN101516335B (el) |
AT (1) | ATE459338T1 (el) |
AU (1) | AU2007275634B2 (el) |
BR (1) | BRPI0715423A2 (el) |
CA (1) | CA2657346A1 (el) |
CY (1) | CY1110037T1 (el) |
DE (1) | DE602007005139D1 (el) |
DK (1) | DK2046292T3 (el) |
ES (1) | ES2340631T3 (el) |
HR (1) | HRP20100293T1 (el) |
MX (1) | MX2009000770A (el) |
PL (1) | PL2046292T3 (el) |
PT (1) | PT2046292E (el) |
RU (2) | RU2452469C2 (el) |
SI (1) | SI2046292T1 (el) |
WO (1) | WO2008011154A2 (el) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PE20070427A1 (es) * | 2005-08-30 | 2007-04-21 | Novartis Ag | Compuestos derivados de benzimidazoles sustituidos como inhibidores de tirosina quinasas |
PE20080766A1 (es) * | 2006-08-30 | 2008-06-15 | Novartis Ag | Sales de benzimidazolil piridil eteres y formulaciones que las contienen |
US8324389B2 (en) * | 2007-03-02 | 2012-12-04 | Novartis Ag | Solid forms of a Raf kinase inhibitor |
WO2010040055A2 (en) * | 2008-10-03 | 2010-04-08 | Intekrin Therapeutics, Inc. | Oral pharmaceutical formulations for antidiabetic compounds |
JO3434B1 (ar) * | 2009-07-31 | 2019-10-20 | Millennium Pharm Inc | مركبات صيدلانية لمعالجة السرطان وامراض واضطرابات اخري |
AU2011276552B2 (en) | 2010-06-29 | 2015-09-03 | Verastem, Inc. | Oral formulation of kinase inhibitors |
CA2803005A1 (en) | 2010-06-30 | 2012-01-26 | Poniard Pharmaceuticals, Inc. | Synthesis and use of kinase inhibitors |
CN102336740B (zh) * | 2010-07-27 | 2013-07-24 | 中国科学院上海药物研究所 | 一类咪唑类化合物及其用途 |
CN103301067B (zh) * | 2012-03-15 | 2018-09-11 | 苏州泽璟生物制药有限公司 | 一种改善吸收性能的固体分散体及其制备 |
EP2976086B1 (en) | 2013-03-22 | 2020-10-14 | Millennium Pharmaceuticals, Inc. | Combination of catalytic mtorc 1/2 inhibitors and selective inhibitors of aurora a kinase |
US10561627B2 (en) * | 2014-12-31 | 2020-02-18 | Eric Morrison | Ibuprofen nanoparticle carriers encapsulated with hermetic surfactant films |
JP2018507914A (ja) | 2015-03-09 | 2018-03-22 | インテクリン・セラピューティクス・インコーポレイテッド | 非アルコール性脂肪肝疾患および/またはリポジストロフィーの処置のための方法 |
BR112019020485A2 (pt) | 2017-04-03 | 2020-05-12 | Coherus Biosciences, Inc. | Agonista ppary para tratamento de paralisia supranuclear progressiva |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9401090D0 (en) | 1994-01-21 | 1994-03-16 | Glaxo Lab Sa | Chemical compounds |
KR0179401B1 (ko) * | 1994-02-28 | 1999-03-20 | 송택선 | 신규한 5-피롤릴-2-피리딜메틸설피닐벤즈이미다졸 유도체 |
US6358932B1 (en) | 1994-05-31 | 2002-03-19 | Isis Pharmaceticals, Inc. | Antisense oligonucleotide inhibition of raf gene expression |
US6391636B1 (en) | 1994-05-31 | 2002-05-21 | Isis Pharmaceuticals, Inc. | Antisense oligonucleotide modulation of raf gene expression |
US6037136A (en) | 1994-10-24 | 2000-03-14 | Cold Spring Harbor Laboratory | Interactions between RaF proto-oncogenes and CDC25 phosphatases, and uses related thereto |
US5717100A (en) | 1995-10-06 | 1998-02-10 | Merck & Co., Inc. | Substituted imidazoles having anti-cancer and cytokine inhibitory activity |
WO1997044058A1 (en) | 1996-05-23 | 1997-11-27 | Applied Research Systems Ars Holding N.V. | Compounds that inhibit the binding of raf-1 or 14-3-3 proteins to the beta chain of il-2 receptor, and pharmaceutical compositions containing same |
AR012634A1 (es) | 1997-05-02 | 2000-11-08 | Sugen Inc | Compuesto basado en quinazolina, composicion famaceutica que lo comprende, metodo para sintetizarlo, su uso, metodos de modulacion de la funcion deserina/treonina proteinaquinasa con dicho compuesto y metodo in vitro para identificar compuestos que modulan dicha funcion |
US6187799B1 (en) | 1997-05-23 | 2001-02-13 | Onyx Pharmaceuticals | Inhibition of raf kinase activity using aryl ureas |
GB9716557D0 (en) | 1997-08-06 | 1997-10-08 | Glaxo Group Ltd | Benzylidene-1,3-dihydro-indol-2-one derivatives having anti-cancer activity |
US6022884A (en) | 1997-11-07 | 2000-02-08 | Amgen Inc. | Substituted pyridine compounds and methods of use |
US6204467B1 (en) | 1998-03-24 | 2001-03-20 | Ford Global Technologies, Inc. | Method and apparatus for resistive welding |
ME00275B (me) | 1999-01-13 | 2011-02-10 | Bayer Corp | ω-KARBOKSIARIL SUPSTITUISANI DIFENIL KARBAMIDI KAO INHIBITORI RAF KINAZE |
US6391683B1 (en) * | 2000-06-21 | 2002-05-21 | Siliconware Precision Industries Co., Ltd. | Flip-chip semiconductor package structure and process for fabricating the same |
WO2002018654A1 (en) | 2000-08-30 | 2002-03-07 | The Board Of Trustees Of The University Of Arkansas | Induction of ldl receptor expression by extracellular-signal regulated kinase, erk-1/2 |
DE60129573T2 (de) * | 2000-09-20 | 2008-04-17 | Jagotec Ag | Verfahren zur sprühtrocknung von zusammensetzungen enthaltend fenofibrat |
US20040131670A1 (en) * | 2001-04-17 | 2004-07-08 | Ping Gao | Pellicle-resistant gelatin capsule |
US20030198666A1 (en) * | 2002-01-07 | 2003-10-23 | Richat Abbas | Oral insulin therapy |
GB0205693D0 (en) * | 2002-03-09 | 2002-04-24 | Astrazeneca Ab | Chemical compounds |
EP1499311B1 (en) | 2002-03-29 | 2009-11-04 | Novartis Vaccines and Diagnostics, Inc. | Substituted benzazoles and use thereof as raf kinase inhibitors |
US8299108B2 (en) | 2002-03-29 | 2012-10-30 | Novartis Ag | Substituted benzazoles and methods of their use as inhibitors of raf kinase |
US20050082192A1 (en) * | 2002-06-17 | 2005-04-21 | Eric Smarr | End cap support for jumbo rolls of material |
EP1751124A4 (en) * | 2004-05-07 | 2010-04-14 | Exelixis Inc | RAF MODULATORS AND METHODS OF USE |
PE20070427A1 (es) | 2005-08-30 | 2007-04-21 | Novartis Ag | Compuestos derivados de benzimidazoles sustituidos como inhibidores de tirosina quinasas |
US20100231394A1 (en) * | 2009-03-11 | 2010-09-16 | Bobby Eugene Finchum | Carbon monoxide detection and dissipation apparatus |
-
2007
- 2007-07-20 BR BRPI0715423-2A patent/BRPI0715423A2/pt not_active IP Right Cessation
- 2007-07-20 PT PT07810647T patent/PT2046292E/pt unknown
- 2007-07-20 DE DE602007005139T patent/DE602007005139D1/de active Active
- 2007-07-20 MX MX2009000770A patent/MX2009000770A/es active IP Right Grant
- 2007-07-20 AT AT07810647T patent/ATE459338T1/de active
- 2007-07-20 SI SI200730219T patent/SI2046292T1/sl unknown
- 2007-07-20 RU RU2009105819/15A patent/RU2452469C2/ru not_active IP Right Cessation
- 2007-07-20 JP JP2009520854A patent/JP2009544617A/ja not_active Ceased
- 2007-07-20 EP EP07810647A patent/EP2046292B1/en active Active
- 2007-07-20 PL PL07810647T patent/PL2046292T3/pl unknown
- 2007-07-20 US US12/374,383 patent/US8455662B2/en not_active Expired - Fee Related
- 2007-07-20 KR KR1020097003547A patent/KR20090033904A/ko not_active Application Discontinuation
- 2007-07-20 CA CA002657346A patent/CA2657346A1/en not_active Abandoned
- 2007-07-20 CN CN200780035017.9A patent/CN101516335B/zh not_active Expired - Fee Related
- 2007-07-20 AU AU2007275634A patent/AU2007275634B2/en not_active Ceased
- 2007-07-20 WO PCT/US2007/016469 patent/WO2008011154A2/en active Application Filing
- 2007-07-20 DK DK07810647.3T patent/DK2046292T3/da active
- 2007-07-20 ES ES07810647T patent/ES2340631T3/es active Active
-
2010
- 2010-05-14 CY CY20101100427T patent/CY1110037T1/el unknown
- 2010-05-25 HR HR20100293T patent/HRP20100293T1/hr unknown
-
2012
- 2012-02-28 RU RU2012107218/15A patent/RU2012107218A/ru not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
US8455662B2 (en) | 2013-06-04 |
AU2007275634B2 (en) | 2011-01-20 |
RU2009105819A (ru) | 2010-08-27 |
DE602007005139D1 (de) | 2010-04-15 |
CN101516335B (zh) | 2014-01-08 |
BRPI0715423A2 (pt) | 2013-07-02 |
SI2046292T1 (sl) | 2010-06-30 |
RU2452469C2 (ru) | 2012-06-10 |
CY1110037T1 (el) | 2015-01-14 |
ES2340631T3 (es) | 2010-06-07 |
CA2657346A1 (en) | 2008-01-24 |
CN101516335A (zh) | 2009-08-26 |
EP2046292A2 (en) | 2009-04-15 |
PL2046292T3 (pl) | 2010-08-31 |
ATE459338T1 (de) | 2010-03-15 |
KR20090033904A (ko) | 2009-04-06 |
US20100040677A1 (en) | 2010-02-18 |
AU2007275634A1 (en) | 2008-01-24 |
EP2046292B1 (en) | 2010-03-03 |
JP2009544617A (ja) | 2009-12-17 |
PT2046292E (pt) | 2010-04-26 |
WO2008011154A2 (en) | 2008-01-24 |
RU2012107218A (ru) | 2013-09-10 |
DK2046292T3 (da) | 2010-06-07 |
MX2009000770A (es) | 2009-01-28 |
WO2008011154A3 (en) | 2008-06-26 |
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