HRP20100259T1 - Derivati 1,2,4,5-tetrahidro-3h-benzazepina, postupak za njihovu pripravu i farmaceutske smjese koje ih sadrže - Google Patents

Derivati 1,2,4,5-tetrahidro-3h-benzazepina, postupak za njihovu pripravu i farmaceutske smjese koje ih sadrže Download PDF

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Publication number
HRP20100259T1
HRP20100259T1 HR20100259T HRP20100259T HRP20100259T1 HR P20100259 T1 HRP20100259 T1 HR P20100259T1 HR 20100259 T HR20100259 T HR 20100259T HR P20100259 T HRP20100259 T HR P20100259T HR P20100259 T1 HRP20100259 T1 HR P20100259T1
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HR
Croatia
Prior art keywords
formula
group
compound
branched
straight
Prior art date
Application number
HR20100259T
Other languages
English (en)
Croatian (hr)
Inventor
Peglion Jean-Louis
Goument Bertrand
Dessinges Aime
Caignard Pascal
Vilaine Jean-Paul
Thollon Catherine
Villeneuve Nicole
Chimenti Stefano
Original Assignee
Les Laboratoires Servier
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39323822&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HRP20100259(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Les Laboratoires Servier filed Critical Les Laboratoires Servier
Publication of HRP20100259T1 publication Critical patent/HRP20100259T1/hr

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D223/00Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16Benzazepines; Hydrogenated benzazepines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/10Drugs for disorders of the urinary system of the bladder
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/06Antiarrhythmics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B55/00Racemisation; Complete or partial inversion
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07Optical isomers
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs
HR20100259T 2007-09-11 2010-05-11 Derivati 1,2,4,5-tetrahidro-3h-benzazepina, postupak za njihovu pripravu i farmaceutske smjese koje ih sadrže HRP20100259T1 (hr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0706346A FR2920773B1 (fr) 2007-09-11 2007-09-11 Derives de 1,2,4,5-tetrahydro-3h-benzazepines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
HRP20100259T1 true HRP20100259T1 (hr) 2010-06-30

Family

ID=39323822

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20100259T HRP20100259T1 (hr) 2007-09-11 2010-05-11 Derivati 1,2,4,5-tetrahidro-3h-benzazepina, postupak za njihovu pripravu i farmaceutske smjese koje ih sadrže

Country Status (45)

Country Link
US (1) US8076325B2 (de)
EP (1) EP2036892B1 (de)
JP (1) JP4932805B2 (de)
KR (1) KR101078076B1 (de)
CN (1) CN101386594B (de)
AP (1) AP2384A (de)
AR (1) AR068386A1 (de)
AT (1) ATE460401T1 (de)
AU (1) AU2008207585B2 (de)
BR (1) BRPI0804091B8 (de)
CA (1) CA2639349C (de)
CL (1) CL2008002654A1 (de)
CO (1) CO6020016A1 (de)
CR (1) CR10229A (de)
CU (1) CU23706B7 (de)
CY (1) CY1110034T1 (de)
DE (1) DE602008000786D1 (de)
DK (1) DK2036892T3 (de)
EA (1) EA014756B1 (de)
EC (1) ECSP088731A (de)
ES (1) ES2342511T3 (de)
FR (1) FR2920773B1 (de)
HK (1) HK1129667A1 (de)
HN (1) HN2008001393A (de)
HR (1) HRP20100259T1 (de)
JO (1) JO2652B1 (de)
MA (1) MA30315B1 (de)
ME (1) ME00981B (de)
MX (1) MX2008011164A (de)
MY (1) MY143079A (de)
NI (1) NI200800247A (de)
NZ (1) NZ571143A (de)
PA (1) PA8795301A1 (de)
PE (1) PE20090620A1 (de)
PL (1) PL2036892T3 (de)
PT (1) PT2036892E (de)
RS (1) RS51305B (de)
SA (1) SA08290567B1 (de)
SG (1) SG151172A1 (de)
SI (1) SI2036892T1 (de)
TW (1) TWI374029B (de)
UA (1) UA100003C2 (de)
UY (1) UY31305A1 (de)
WO (1) WO2009066041A2 (de)
ZA (1) ZA200807586B (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2961105B1 (fr) 2010-06-15 2013-02-08 Servier Lab Utilisation de l'association d'un inhibiteur du courant if sinusal et d'un inhibiteur de l'enzyme de conversion de l'angiotensine pour le traitement de l'insuffisance cardiaque
EP2567959B1 (de) 2011-09-12 2014-04-16 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridin-4-carbonsäureamid-derivate als kinaseinhibitoren
FR2984320B1 (fr) * 2011-12-20 2013-11-29 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2984319B1 (fr) * 2011-12-20 2013-12-27 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2988720B1 (fr) * 2012-03-27 2014-03-14 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
TWI654180B (zh) 2012-06-29 2019-03-21 美商艾佛艾姆希公司 殺真菌之雜環羧醯胺
FR3003859B1 (fr) * 2013-03-26 2015-03-13 Servier Lab "procede de synthese de derives de la 7,8-dimethoxy-1,3-dihydro-2h-3-benzazepin-2-one et application a la synthese de l'ivabradine"
WO2015009534A2 (en) 2013-07-16 2015-01-22 Allergan, Inc. Hcn inhibitors affecting ganglion cell function and visual function
FR3020810B1 (fr) * 2014-05-06 2016-05-06 Servier Lab Nouveau sel de l'ivabradine et son procede de preparation.
FR3046793B1 (fr) * 2016-01-14 2018-01-05 Les Laboratoires Servier Nouveaux derives de phosphinanes et azaphosphinanes, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EP3615052B1 (de) * 2017-04-27 2023-01-25 The University of Hong Kong Verwendung von hcn-inhibitoren zur behandlung von krebs
CN112724001B (zh) * 2019-10-28 2022-12-13 鲁南制药集团股份有限公司 一种伊伐布雷定手性中间体化合物
CN113372274B (zh) * 2020-03-10 2023-03-24 鲁南制药集团股份有限公司 一种伊伐布雷定的制备方法
CN113372273B (zh) * 2020-03-10 2023-05-09 鲁南制药集团股份有限公司 一种伊伐布雷定中间体化合物iv
IL310339A (en) 2021-08-31 2024-03-01 Eisai R&D Man Co Ltd A method for the production of a monocyclic pyridine derivative

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3119874A1 (de) * 1981-05-19 1982-12-09 Dr. Karl Thomae Gmbh, 7950 Biberach "benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel"
DE3418270A1 (de) * 1984-05-17 1985-11-21 Dr. Karl Thomae Gmbh, 7950 Biberach Neue aminotetralinderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
GB8707120D0 (en) * 1987-03-25 1987-04-29 Pfizer Ltd Antiarrhythmic agents
JPH02193971A (ja) * 1989-01-20 1990-07-31 Yamanouchi Pharmaceut Co Ltd トリ置換―2,3,4,5―テトラヒドロベンズアゼピン誘導体とその中間体
FR2681862B1 (fr) * 1991-09-27 1993-11-12 Adir Cie Nouvelles (benzocycloalkyl)alkylamines, leur procede de preparation, et les compositions pharmaceutiques qui les contiennent.
AU6971894A (en) * 1993-05-27 1994-12-20 Smithkline Beecham Laboratoires Pharmaceutiques Anti-arrhythmic n-substituted 3-benzazepines or isoquinolines
TW527355B (en) * 1997-07-02 2003-04-11 Bristol Myers Squibb Co Inhibitors of farnesyl protein transferase
US6514964B1 (en) * 1999-09-27 2003-02-04 Amgen Inc. Fused cycloheptane and fused azacycloheptane compounds and their methods of use
FR2882554B1 (fr) * 2005-02-28 2007-05-04 Servier Lab Forme critalline beta d du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
FR2894826B1 (fr) 2005-12-21 2010-10-22 Servier Lab Nouvelle association d'un inhibiteur du courant if sinusal et d'un inhibiteur calcique et les compositions pharmaceutiques qui la contiennent

Also Published As

Publication number Publication date
EP2036892A1 (de) 2009-03-18
SG151172A1 (en) 2009-04-30
US8076325B2 (en) 2011-12-13
MY143079A (en) 2011-02-28
BRPI0804091A2 (pt) 2009-05-05
EA200801828A3 (ru) 2009-08-28
SA08290567B1 (ar) 2011-06-22
DE602008000786D1 (de) 2010-04-22
KR101078076B1 (ko) 2011-10-28
WO2009066041A3 (fr) 2009-12-17
CY1110034T1 (el) 2015-01-14
CU23706B7 (es) 2011-10-05
CA2639349A1 (fr) 2009-03-11
UA100003C2 (ru) 2012-11-12
PL2036892T3 (pl) 2010-08-31
MA30315B1 (fr) 2009-04-01
DK2036892T3 (da) 2010-06-07
FR2920773B1 (fr) 2009-10-23
FR2920773A1 (fr) 2009-03-13
TW200918076A (en) 2009-05-01
CR10229A (es) 2008-11-26
EA014756B1 (ru) 2011-02-28
BRPI0804091B8 (pt) 2021-05-25
KR20090027164A (ko) 2009-03-16
EA200801828A2 (ru) 2009-04-28
PT2036892E (pt) 2010-05-10
JP4932805B2 (ja) 2012-05-16
AU2008207585A1 (en) 2009-03-26
ZA200807586B (en) 2011-04-28
BRPI0804091B1 (pt) 2020-09-29
AP2008004589A0 (en) 2008-08-31
CN101386594A (zh) 2009-03-18
NI200800247A (es) 2011-01-10
PE20090620A1 (es) 2009-05-30
NZ571143A (en) 2010-04-30
CU20080165A7 (es) 2011-03-21
RS51305B (sr) 2010-12-31
ATE460401T1 (de) 2010-03-15
JO2652B1 (en) 2012-06-17
SI2036892T1 (sl) 2010-06-30
ES2342511T3 (es) 2010-07-07
TWI374029B (en) 2012-10-11
CL2008002654A1 (es) 2009-03-20
US20090069296A1 (en) 2009-03-12
AU2008207585B2 (en) 2013-08-22
ECSP088731A (es) 2008-10-31
EP2036892B1 (de) 2010-03-10
AR068386A1 (es) 2009-11-11
WO2009066041A2 (fr) 2009-05-28
CA2639349C (fr) 2011-03-22
HK1129667A1 (de) 2009-12-04
PA8795301A1 (es) 2009-04-23
CO6020016A1 (es) 2009-03-31
MX2008011164A (es) 2009-03-10
UY31305A1 (es) 2008-10-31
AP2384A (en) 2012-03-21
CN101386594B (zh) 2012-05-16
HN2008001393A (es) 2011-05-11
ME00981B (me) 2012-06-20
JP2009108032A (ja) 2009-05-21

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