HRP20100020T1 - Novi derivati hidantoina za liječenje opstruktivnih bolesti dišnih putova - Google Patents
Novi derivati hidantoina za liječenje opstruktivnih bolesti dišnih putova Download PDFInfo
- Publication number
- HRP20100020T1 HRP20100020T1 HR20100020T HRP20100020T HRP20100020T1 HR P20100020 T1 HRP20100020 T1 HR P20100020T1 HR 20100020 T HR20100020 T HR 20100020T HR P20100020 T HRP20100020 T HR P20100020T HR P20100020 T1 HRP20100020 T1 HR P20100020T1
- Authority
- HR
- Croatia
- Prior art keywords
- formula
- compound
- pharmaceutically acceptable
- acceptable salt
- image
- Prior art date
Links
- 230000000414 obstructive effect Effects 0.000 title claims 3
- 208000023504 respiratory system disease Diseases 0.000 title claims 2
- 229940053195 antiepileptics hydantoin derivative Drugs 0.000 title 1
- 150000001469 hydantoins Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 20
- 150000003839 salts Chemical class 0.000 claims abstract 10
- 125000000217 alkyl group Chemical group 0.000 claims abstract 9
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims abstract 7
- 125000001153 fluoro group Chemical group F* 0.000 claims abstract 4
- ITMCEJHCFYSIIV-UHFFFAOYSA-M triflate Chemical compound [O-]S(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-M 0.000 claims 3
- 239000000654 additive Substances 0.000 claims 2
- 230000000996 additive effect Effects 0.000 claims 2
- 239000002131 composite material Substances 0.000 claims 2
- 150000004820 halides Chemical class 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 125000006239 protecting group Chemical group 0.000 claims 2
- 239000002904 solvent Substances 0.000 claims 2
- NLQVGZDJKWLKJC-LJQANCHMSA-N (5s)-5-[[4-[2-(2-cyclopropylpyrimidin-5-yl)ethynyl]-3,6-dihydro-2h-pyridin-1-yl]sulfonylmethyl]-5-methylimidazolidine-2,4-dione Chemical compound C1CC(C#CC=2C=NC(=NC=2)C2CC2)=CCN1S(=O)(=O)C[C@@]1(C)NC(=O)NC1=O NLQVGZDJKWLKJC-LJQANCHMSA-N 0.000 claims 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
- 150000001502 aryl halides Chemical class 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0401762A SE0401762D0 (sv) | 2004-07-05 | 2004-07-05 | Novel compounds |
| PCT/SE2005/001092 WO2006004532A1 (en) | 2004-07-05 | 2005-07-04 | Novel hydantoin derivatives for the treatment of obstructive airway diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20100020T1 true HRP20100020T1 (hr) | 2010-02-28 |
Family
ID=32768773
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20100020T HRP20100020T1 (hr) | 2004-07-05 | 2010-01-11 | Novi derivati hidantoina za liječenje opstruktivnih bolesti dišnih putova |
Country Status (33)
| Country | Link |
|---|---|
| US (1) | US7989620B2 (ru) |
| EP (1) | EP1778673B1 (ru) |
| JP (1) | JP4390833B2 (ru) |
| KR (1) | KR101222736B1 (ru) |
| CN (1) | CN100543024C (ru) |
| AR (1) | AR049578A1 (ru) |
| AT (1) | ATE448219T1 (ru) |
| AU (1) | AU2005260142B2 (ru) |
| BR (1) | BRPI0512974A (ru) |
| CA (1) | CA2569716C (ru) |
| CY (1) | CY1109728T1 (ru) |
| DE (1) | DE602005017636D1 (ru) |
| DK (1) | DK1778673T3 (ru) |
| ES (1) | ES2335424T3 (ru) |
| HK (1) | HK1102814A1 (ru) |
| HR (1) | HRP20100020T1 (ru) |
| IL (1) | IL179906A (ru) |
| MX (1) | MXPA06014661A (ru) |
| MY (1) | MY145613A (ru) |
| NO (1) | NO20070576L (ru) |
| NZ (1) | NZ552101A (ru) |
| PL (1) | PL1778673T3 (ru) |
| PT (1) | PT1778673E (ru) |
| RS (1) | RS51280B (ru) |
| RU (1) | RU2386629C2 (ru) |
| SA (1) | SA05260192B1 (ru) |
| SE (1) | SE0401762D0 (ru) |
| SI (1) | SI1778673T1 (ru) |
| TW (1) | TWI353985B (ru) |
| UA (1) | UA86977C2 (ru) |
| UY (1) | UY29002A1 (ru) |
| WO (1) | WO2006004532A1 (ru) |
| ZA (1) | ZA200610698B (ru) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0100902D0 (sv) | 2001-03-15 | 2001-03-15 | Astrazeneca Ab | Compounds |
| SE0202539D0 (sv) | 2002-08-27 | 2002-08-27 | Astrazeneca Ab | Compounds |
| SE0401762D0 (sv) | 2004-07-05 | 2004-07-05 | Astrazeneca Ab | Novel compounds |
| US7648992B2 (en) | 2004-07-05 | 2010-01-19 | Astrazeneca Ab | Hydantoin derivatives for the treatment of obstructive airway diseases |
| SE0401763D0 (sv) * | 2004-07-05 | 2004-07-05 | Astrazeneca Ab | Compounds |
| US7776869B2 (en) * | 2004-10-18 | 2010-08-17 | Amgen Inc. | Heteroaryl-substituted alkyne compounds and method of use |
| SE0403085D0 (sv) | 2004-12-17 | 2004-12-17 | Astrazeneca Ab | Novel componds |
| SE0403086D0 (sv) | 2004-12-17 | 2004-12-17 | Astrazeneca Ab | Compounds |
| TW200740769A (en) | 2006-03-16 | 2007-11-01 | Astrazeneca Ab | Novel process |
| TW200831488A (en) * | 2006-11-29 | 2008-08-01 | Astrazeneca Ab | Novel compounds |
| GB0702456D0 (en) | 2007-02-08 | 2007-03-21 | Astrazeneca Ab | New combination |
| WO2009007747A2 (en) * | 2007-07-11 | 2009-01-15 | Astrazeneca Ab | Hydantoin derivatives used as mmp12 inhibitors |
| GB0913345D0 (en) | 2009-07-31 | 2009-09-16 | Astrazeneca Ab | New combination 802 |
| WO2011061527A1 (en) | 2009-11-17 | 2011-05-26 | Astrazeneca Ab | Combinations comprising a glucocorticoid receptor modulator for the treatment of respiratory diseases |
| WO2011073662A1 (en) | 2009-12-17 | 2011-06-23 | Astrazeneca Ab | Combination of a benzoxazinone and a further agent for treating respiratory diseases |
| GB201021992D0 (en) | 2010-12-23 | 2011-02-02 | Astrazeneca Ab | Compound |
| GB201021979D0 (en) | 2010-12-23 | 2011-02-02 | Astrazeneca Ab | New compound |
| EP2907512A1 (en) | 2014-02-14 | 2015-08-19 | Commissariat A L'energie Atomique Et Aux Energies Alternatives | Inhibitors of MMP-12 as antiviral Agents |
| RU2555341C1 (ru) * | 2014-04-29 | 2015-07-10 | Федеральное бюджетное учреждение науки "Федеральный научный центр медико-профилактических технологий управления рисками здоровью населения" (ФБУН "ФНЦ медико-профилактических технологий управления рисками здоровью населения") | Способ профилактики развития у детей старше 5 лет неконтролируемых форм бронхиальной астмы, обусловленных воздействием марганца и ванадия |
| MX2017009843A (es) | 2015-01-30 | 2017-11-02 | Basf Se | Fenilpirimidinas herbicidas. |
| BR112018076642A2 (pt) | 2016-07-25 | 2019-03-26 | Basf Se | compostos de pirimidina, compostos de pirimidina de fórmula e seu uso, composições herbicidas, método de controle de vegetação indesejada e uso das composições |
| CA3030082A1 (en) | 2016-07-25 | 2018-02-01 | Basf Se | Herbicidal pyrimidine compounds |
| EP3638033A1 (en) | 2017-06-14 | 2020-04-22 | Basf Se | Herbicidal pyrimidine compounds |
| WO2019121408A1 (en) | 2017-12-20 | 2019-06-27 | Basf Se | Herbicidal pyrimidine compounds |
| KR20210035092A (ko) | 2018-07-16 | 2021-03-31 | 헤파레게닉스 게엠베하 | 간 재생 촉진, 또는 간세포 사멸의 감소 또는 예방용 단백질 키나제 억제제 |
| US20220033363A1 (en) | 2018-09-19 | 2022-02-03 | Bayer Aktiengesellschaft | Herbicidally active substituted phenylpyrimidine hydrazides |
| WO2021260387A1 (en) | 2020-06-26 | 2021-12-30 | The University Of Birmingham | Mmp-9 and mmp-12 inhibition for treating spinal cord injury or related injury to neurological tissue |
Family Cites Families (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2327890A (en) | 1940-04-17 | 1943-08-24 | Parke Davis & Co | Substituted phenoxyalkyl ethers |
| US2745875A (en) | 1953-06-30 | 1956-05-15 | Hoechst Ag | Preparation of nu-acylamino-phenylpropane diols |
| US3452040A (en) | 1966-01-05 | 1969-06-24 | American Home Prod | 5,5-disubstituted hydantoins |
| US3529019A (en) | 1968-04-23 | 1970-09-15 | Colgate Palmolive Co | Alkylaryloxy alanines |
| US3849574A (en) | 1971-05-24 | 1974-11-19 | Colgate Palmolive Co | Alpha-substituted-beta-arylthioalkyl amino-acids,for increasing heart rate |
| US4315031A (en) | 1977-09-01 | 1982-02-09 | Science Union Et Cie | Thiosubstituted amino acids |
| GB1601310A (en) | 1978-05-23 | 1981-10-28 | Lilly Industries Ltd | Aryl hydantoins |
| JPS6172762A (ja) | 1984-09-17 | 1986-04-14 | Kanegafuchi Chem Ind Co Ltd | 光学活性ヒダントイン類の製造法 |
| JPS61212292A (ja) | 1985-03-19 | 1986-09-20 | Mitsui Toatsu Chem Inc | Ｄ−α−アミノ酸の製造方法 |
| CA1325222C (en) | 1985-08-23 | 1993-12-14 | Lederle (Japan), Ltd. | Process for producing 4-biphenylylacetic acid |
| GB8618559D0 (en) | 1986-07-30 | 1986-09-10 | Genetics Int Inc | Rhodococcus bacterium |
| US4983771A (en) | 1989-09-18 | 1991-01-08 | Hexcel Corporation | Method for resolution of D,L-alpha-phenethylamine with D(-)mandelic acid |
| NL9000386A (nl) | 1990-02-16 | 1991-09-16 | Stamicarbon | Werkwijze voor de bereiding van optisch aktief aminozuuramide. |
| DK161690D0 (da) | 1990-07-05 | 1990-07-05 | Novo Nordisk As | Fremgangsmaade til fremstilling af enantiomere forbindelser |
| IL99957A0 (en) | 1990-11-13 | 1992-08-18 | Merck & Co Inc | Piperidinylcamphorsulfonyl oxytocin antagonists and pharmaceutical compositions containing them |
| PH31245A (en) | 1991-10-30 | 1998-06-18 | Janssen Pharmaceutica Nv | 1,3-Dihydro-2H-imidazoÄ4,5-BÜ-quinolin-2-one derivatives. |
| US5308853A (en) | 1991-12-20 | 1994-05-03 | Warner-Lambert Company | Substituted-5-methylidene hydantoins with AT1 receptor antagonist properties |
| US5246943A (en) | 1992-05-19 | 1993-09-21 | Warner-Lambert Company | Substituted 1,2,3,4-tetahydroisoquinolines with angiotensin II receptor antagonist properties |
| NL9201230A (nl) | 1992-07-09 | 1994-02-01 | Dsm Nv | Werkwijze voor de bereiding van optisch aktief methionineamide. |
| EP0640594A1 (en) | 1993-08-23 | 1995-03-01 | Fujirebio Inc. | Hydantoin derivative as metalloprotease inhibitor |
| CA2174650A1 (en) | 1993-11-16 | 1995-05-26 | Mark G. Bock | Piperidinyl camphorsulfonyl oxytocin antagonists |
| EP0709375B1 (en) | 1994-10-25 | 2005-05-18 | AstraZeneca AB | Therapeutic heterocycles |
| ZA96211B (en) | 1995-01-12 | 1996-07-26 | Teva Pharma | Compositions containing and methods of using 1- aminoindan and derivatives thereof and process for preparing optically active 1-aminoindan derivatives |
| US5863949A (en) | 1995-03-08 | 1999-01-26 | Pfizer Inc | Arylsulfonylamino hydroxamic acid derivatives |
| US6166041A (en) | 1995-10-11 | 2000-12-26 | Euro-Celtique, S.A. | 2-heteroaryl and 2-heterocyclic benzoxazoles as PDE IV inhibitors for the treatment of asthma |
| NZ322565A (en) | 1995-11-22 | 1999-11-29 | Darwin Discovery Ltd | Mercaptoalkykpeptidyl compounds having an imidazole substitutent and their use as inhibitors of matrix metalloproteinases and tumor necrosis factor |
| GB9616643D0 (en) | 1996-08-08 | 1996-09-25 | Chiroscience Ltd | Compounds |
| US5919790A (en) | 1996-10-11 | 1999-07-06 | Warner-Lambert Company | Hydroxamate inhibitors of interleukin-1β converting enzyme |
| ES2171905T3 (es) | 1996-10-22 | 2002-09-16 | Upjohn Co | Acidos alfa-amino sulfonilo hidroxamicos como inhibidores de metaloproteinasa de matriz. |
| HUP0003362A3 (en) | 1997-05-06 | 2001-04-28 | Novo Nordisk As | Piperidine derivatives and pharmaceutical compositions containing them |
| DK0877019T3 (da) | 1997-05-09 | 2002-04-08 | Hoechst Ag | Substituerede diaminocarboxylsyrer |
| DK1001930T3 (da) | 1997-07-31 | 2003-03-24 | Abbott Lab | N-hydroxyformamidderivater som inhibitorer af matrix-metalloproteinaser |
| TW514634B (en) | 1997-10-14 | 2002-12-21 | Lilly Co Eli | Process to make chiral compounds |
| DK1030836T3 (da) | 1997-11-12 | 2003-05-26 | Darwin Discovery Ltd | Hydroxam- og carboxylsyrederivater der har MMP- og TNF-inhiberende aktivitet |
| RU2208609C2 (ru) | 1998-02-04 | 2003-07-20 | Новартис Аг | Сульфониламинопроизводные, которые ингибируют разлагающие матрикс металлопротеиназы |
| US6329418B1 (en) | 1998-04-14 | 2001-12-11 | The Procter & Gamble Company | Substituted pyrrolidine hydroxamate metalloprotease inhibitors |
| AU4074799A (en) | 1998-05-14 | 1999-11-29 | Du Pont Pharmaceuticals Company | Substituted aryl hydroxamic acids as metalloproteinase inhibitors |
| JP2002516904A (ja) | 1998-06-03 | 2002-06-11 | ジーピーアイ ニル ホールディングス インコーポレイテッド | Ｎ−複素環式カルボン酸またはカルボン酸等配電子体のｎ−結合スルホンアミド |
| JP2002518368A (ja) | 1998-06-17 | 2002-06-25 | デュポン ファーマシューティカルズ カンパニー | メタロプロテイナーゼ阻害剤としての環式ヒドロキサム酸類 |
| FR2782082B3 (fr) | 1998-08-05 | 2000-09-22 | Sanofi Sa | Formes cristallines de (r)-(+)-n-[[3-[1-benzoyl-3-(3,4- dichlorophenyl)piperidin-3-yl]prop-1-yl]-4-phenylpiperidin-4 -yl]-n-methylacetamide (osanetant) et procede pour la preparation dudit compose |
| US6339101B1 (en) | 1998-08-14 | 2002-01-15 | Gpi Nil Holdings, Inc. | N-linked sulfonamides of N-heterocyclic carboxylic acids or isosteres for vision and memory disorders |
| EP1117616B1 (en) | 1998-10-07 | 2003-04-23 | Yazaki Corporation | Sol-gel process using porous mold |
| ATE260255T1 (de) | 1998-11-05 | 2004-03-15 | Pfizer Prod Inc | 5-oxo-pyrrolidine-2-carbonsäure- hydroxamidderivate |
| US6340691B1 (en) | 1999-01-27 | 2002-01-22 | American Cyanamid Company | Alkynyl containing hydroxamic acid compounds as matrix metalloproteinase and tace inhibitors |
| CN1343219A (zh) | 1999-01-28 | 2002-04-03 | 中外制药株式会社 | 取代的苯乙基胺衍生物 |
| US20020006920A1 (en) | 1999-07-22 | 2002-01-17 | Robinson Ralph Pelton | Arylsulfonylamino hydroxamic acid derivatives |
| ATE319702T1 (de) | 1999-08-02 | 2006-03-15 | Verfahren zur herstellung von benzothiophen- derivaten | |
| PL353455A1 (en) | 1999-08-12 | 2003-11-17 | Pharmacia Italia S.P.A. | 3(5)-amino-pyrazole derivatives, process for their preparation and their use as antitumor agents |
| US6283379B1 (en) * | 2000-02-14 | 2001-09-04 | Kic Thermal Profiling | Method for correlating processor and part temperatures using an air temperature sensor for a conveyorized thermal processor |
| US6525202B2 (en) | 2000-07-17 | 2003-02-25 | Wyeth | Cyclic amine phenyl beta-3 adrenergic receptor agonists |
| US20020065219A1 (en) | 2000-08-15 | 2002-05-30 | Naidu B. Narasimhulu | Water soluble thiazolyl peptide derivatives |
| US20020091107A1 (en) | 2000-09-08 | 2002-07-11 | Madar David J. | Oxazolidinone antibacterial agents |
| EP1191024A1 (en) | 2000-09-22 | 2002-03-27 | Harald Tschesche | Thiadiazines and their use as inhibitors of metalloproteinases |
| JP2004527511A (ja) * | 2001-03-15 | 2004-09-09 | アストラゼネカ・アクチエボラーグ | メタロプロテイナーゼ阻害剤 |
| SE0100903D0 (sv) | 2001-03-15 | 2001-03-15 | Astrazeneca Ab | Compounds |
| SE0100902D0 (sv) | 2001-03-15 | 2001-03-15 | Astrazeneca Ab | Compounds |
| US6890915B2 (en) | 2001-05-25 | 2005-05-10 | Bristol-Myers Squibb Pharma Company | Hydantoins and related heterocycles as inhibitors of matrix metalloproteinases and/or TNF-α converting enzyme (TACE) |
| GB0114004D0 (en) | 2001-06-08 | 2001-08-01 | Glaxo Group Ltd | Chemical compounds |
| SE0103710D0 (sv) | 2001-11-07 | 2001-11-07 | Astrazeneca Ab | Compounds |
| EP1550725A4 (en) | 2002-06-05 | 2010-08-25 | Kaneka Corp | PROCESS FOR PRODUCING OPTICALLY ACTIVE alpha-METHYLCYSTEINE DERIVATIVE |
| SE0202539D0 (sv) | 2002-08-27 | 2002-08-27 | Astrazeneca Ab | Compounds |
| GB0221250D0 (en) | 2002-09-13 | 2002-10-23 | Astrazeneca Ab | Compounds |
| GB0221246D0 (en) | 2002-09-13 | 2002-10-23 | Astrazeneca Ab | Compounds |
| US20040266832A1 (en) | 2003-06-26 | 2004-12-30 | Li Zheng J. | Crystal forms of 2-(3-difluoromethyl-5-phenyl-pyrazol-1-yl)-5-methanesulfonyl pyridine |
| TWI220073B (en) | 2003-07-24 | 2004-08-01 | Au Optronics Corp | Method for manufacturing polysilicon film |
| SE0401762D0 (sv) | 2004-07-05 | 2004-07-05 | Astrazeneca Ab | Novel compounds |
| SE0401763D0 (sv) | 2004-07-05 | 2004-07-05 | Astrazeneca Ab | Compounds |
| US7648992B2 (en) | 2004-07-05 | 2010-01-19 | Astrazeneca Ab | Hydantoin derivatives for the treatment of obstructive airway diseases |
| SE0403086D0 (sv) | 2004-12-17 | 2004-12-17 | Astrazeneca Ab | Compounds |
| SE0403085D0 (sv) | 2004-12-17 | 2004-12-17 | Astrazeneca Ab | Novel componds |
| TW200800954A (en) | 2006-03-16 | 2008-01-01 | Astrazeneca Ab | Novel crystal modifications |
| TW200740769A (en) | 2006-03-16 | 2007-11-01 | Astrazeneca Ab | Novel process |
| TW200831488A (en) | 2006-11-29 | 2008-08-01 | Astrazeneca Ab | Novel compounds |
-
2004
- 2004-07-05 SE SE0401762A patent/SE0401762D0/xx unknown
-
2005
- 2005-04-07 UA UAA200613009A patent/UA86977C2/ru unknown
- 2005-06-29 SA SA05260192A patent/SA05260192B1/ar unknown
- 2005-06-29 TW TW094121763A patent/TWI353985B/zh not_active IP Right Cessation
- 2005-07-01 MY MYPI20053029A patent/MY145613A/en unknown
- 2005-07-04 JP JP2007520267A patent/JP4390833B2/ja active Active
- 2005-07-04 ES ES05756403T patent/ES2335424T3/es active Active
- 2005-07-04 AT AT05756403T patent/ATE448219T1/de active
- 2005-07-04 CN CNB2005800228017A patent/CN100543024C/zh active Active
- 2005-07-04 AU AU2005260142A patent/AU2005260142B2/en not_active Ceased
- 2005-07-04 RS RSP-2010/0038A patent/RS51280B/sr unknown
- 2005-07-04 KR KR1020077000186A patent/KR101222736B1/ko not_active IP Right Cessation
- 2005-07-04 CA CA2569716A patent/CA2569716C/en not_active Expired - Fee Related
- 2005-07-04 EP EP05756403A patent/EP1778673B1/en active Active
- 2005-07-04 PL PL05756403T patent/PL1778673T3/pl unknown
- 2005-07-04 BR BRPI0512974-5A patent/BRPI0512974A/pt active Search and Examination
- 2005-07-04 RU RU2007101236/04A patent/RU2386629C2/ru not_active IP Right Cessation
- 2005-07-04 NZ NZ552101A patent/NZ552101A/en not_active IP Right Cessation
- 2005-07-04 PT PT05756403T patent/PT1778673E/pt unknown
- 2005-07-04 DE DE602005017636T patent/DE602005017636D1/de active Active
- 2005-07-04 WO PCT/SE2005/001092 patent/WO2006004532A1/en active Application Filing
- 2005-07-04 DK DK05756403.1T patent/DK1778673T3/da active
- 2005-07-04 SI SI200530892T patent/SI1778673T1/sl unknown
- 2005-07-04 MX MXPA06014661A patent/MXPA06014661A/es active IP Right Grant
- 2005-07-05 AR ARP050102793A patent/AR049578A1/es not_active Application Discontinuation
- 2005-07-05 UY UY29002A patent/UY29002A1/es not_active Application Discontinuation
-
2006
- 2006-12-07 IL IL179906A patent/IL179906A/en not_active IP Right Cessation
- 2006-12-19 ZA ZA200610698A patent/ZA200610698B/en unknown
-
2007
- 2007-01-30 NO NO20070576A patent/NO20070576L/no not_active Application Discontinuation
- 2007-10-17 HK HK07111163.1A patent/HK1102814A1/xx not_active IP Right Cessation
-
2009
- 2009-12-02 US US12/629,630 patent/US7989620B2/en active Active
-
2010
- 2010-01-11 CY CY20101100026T patent/CY1109728T1/el unknown
- 2010-01-11 HR HR20100020T patent/HRP20100020T1/hr unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HRP20100020T1 (hr) | Novi derivati hidantoina za liječenje opstruktivnih bolesti dišnih putova | |
| ES2292988T3 (es) | Derivados de nicotinamida utiles como inhibidores de pde4. | |
| JP2008505171A5 (ru) | ||
| JP2005505618A5 (ru) | ||
| AU2018342751A1 (en) | Selective P2X3 modulators | |
| JP2010536887A5 (ru) | ||
| JP2012500260A5 (ru) | ||
| TW200600086A (en) | Chemical compound | |
| RU2003105805A (ru) | Производные 4-фенилпиридина в качестве антагонистов рецепторов нейрокинина-1 | |
| MXPA03011629A (es) | Derivado de fenilpiridincarbonilpiperazina. | |
| JP2005509622A5 (ru) | ||
| TW200602028A (en) | Compounds | |
| JP2005511532A5 (ru) | ||
| RU2012153164A (ru) | Производные мочевины и их терапевтическое применение при лечении, среди прочего, заболеваний дыхательного пути | |
| JP2013520473A5 (ru) | ||
| JP2009534358A5 (ru) | ||
| JP2006512339A5 (ru) | ||
| EP1256576A1 (en) | Fused imidazolium derivatives | |
| JP2007518798A5 (ru) | ||
| JP2021501756A5 (ru) | ||
| JP2015502371A5 (ru) | ||
| JP2022507117A (ja) | 呼吸器疾患の処理のための新規な化合物 | |
| RU2008128566A (ru) | Органические соединения | |
| JP7223764B2 (ja) | Ｃｘｃｒ２アンタゴニスト | |
| ES2715394T3 (es) | Nuevo antifúngico derivado de oxodihidropiridinacarbohidrazida |