HRP20090580T1 - Postupak dobivanja feri-sukcinilkazeina - Google Patents
Postupak dobivanja feri-sukcinilkazeina Download PDFInfo
- Publication number
- HRP20090580T1 HRP20090580T1 HR20090580T HRP20090580T HRP20090580T1 HR P20090580 T1 HRP20090580 T1 HR P20090580T1 HR 20090580 T HR20090580 T HR 20090580T HR P20090580 T HRP20090580 T HR P20090580T HR P20090580 T1 HRP20090580 T1 HR P20090580T1
- Authority
- HR
- Croatia
- Prior art keywords
- ferro
- casein
- succinyl casein
- succinyl
- aqueous suspension
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract 15
- 238000002360 preparation method Methods 0.000 title claims abstract 5
- 239000005018 casein Substances 0.000 claims abstract 32
- 235000021240 caseins Nutrition 0.000 claims abstract 32
- 239000007900 aqueous suspension Substances 0.000 claims abstract 11
- PMVSDNDAUGGCCE-TYYBGVCCSA-L Ferrous fumarate Chemical class [Fe+2].[O-]C(=O)\C=C\C([O-])=O PMVSDNDAUGGCCE-TYYBGVCCSA-L 0.000 claims abstract 6
- 239000003795 chemical substances by application Substances 0.000 claims abstract 6
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 claims abstract 5
- -1 succinyl casein Chemical compound 0.000 claims 8
- 239000007864 aqueous solution Substances 0.000 claims 4
- 238000001556 precipitation Methods 0.000 claims 3
- 239000002253 acid Substances 0.000 claims 2
- 239000002552 dosage form Substances 0.000 claims 2
- 238000001035 drying Methods 0.000 claims 2
- 239000002198 insoluble material Substances 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 230000035622 drinking Effects 0.000 claims 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims 1
- 239000011521 glass Substances 0.000 claims 1
- 239000012669 liquid formulation Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 239000006188 syrup Substances 0.000 claims 1
- 235000020357 syrup Nutrition 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4732—Casein
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
- A23J3/00—Working-up of proteins for foodstuffs
- A23J3/04—Animal proteins
- A23J3/08—Dairy proteins
- A23J3/10—Casein
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
- A23L33/165—Complexes or chelates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
Postupak dobivanja fero-sukcinilkazeina, koji se sastoji u sljedećim koracima: (a) reakcije kazeina s najmanje jednim sukcinilacijskim sredstvom, kako bi se dobilo vodenu suspenziju sukcinilkazeina, te (b) reakcije vodene suspenzije sukcinilkazeina, dobivene u koraku (a), s najmanje jednom željeznom solju, kako bi se dobilo fero-sukcinilkazein. Patent sadrži još 12 patentnih zahtjeva.
Claims (13)
1. Postupak dobivanja fero-sukcinilkazeina, koji se sastoji u sljedećim koracima:
(a) reakcije kazeina s najmanje jednim sukcinilacijskim sredstvom, kako bi se dobilo vodenu suspenziju sukcinilkazeina, te
(b) reakcije vodene suspenzije sukcinilkazeina, dobivene u koraku (a), s najmanje jednom željeznom solju, kako bi se dobilo fero-sukcinilkazein.
2. Postupak u skladu s patentnim zahtjevom 1, gdje se korak (a) sastoji u koracima:
(a1) suspendiranja kazeina u vodi,
(a2) ako je to potrebno, podešavanja pH vrijednosti vodene suspenzije na 6,
(a3) dodavanja najmanje jednog sukcinilacijskog sredstva, uz održavanje pH vrijednosti od najmanje 6 dodavanjem najmanje jedne baze.
3. Postupak u skladu s patentnim zahtjevima 1 ili 2, gdje se korak (a) dodatno sastoji u koraku:
(a4) nakon dovršenja dodavanja sukcinilacijskog sredstva, taloženja sukcinilkazeina dobivenog podešavanjem pH vrijednosti na otprilike 2 do 7,0, kako bi se dobilo vodenu suspenziju sukcinilkazeina čija je pH vrijednosti otprilike 2 do 7,0.
4. Postupak u skladu s bilo kojim od patentnih zahtjeva 1 do 3, gdje se korak (b) sastoji u:
(b1) dodavanju najmanje jedne željezne soli u vodenu suspenziju sukcinilkazeina.
5. Postupak u skladu s bilo kojim od patentnih zahtjeva 1 do 4, gdje se korak (b) sastoji u koraku:
(b2) dodavanja najmanje jedne željezne soli u vodenu suspenziju sukcinilkazeina, uz održavanje pH vrijednosti vodene suspenzije od najmanje 2 dodavanjem najmanje jedne baze, kako bi se dobilo fero-sukcinilkazein.
6. Postupak u skladu s bilo kojim od patentnih zahtjeva 1 do 5, koji se sastoji u koraku:
(c) otapanja fero-sukcinilkazeina, dobivenog dodavanjem najmanje jedne baze, kako bi se dobilo vodeni pripravak, koji sadrži otopljeni fero-sukcinilkazein.
7. Postupak u skladu s bilo kojim od patentnih zahtjeva 1 do 6, koji se dodatno sastoji u koracima:
(d) izdvajanja netopljivog materijala iz vodenog pripravka koji sadrži otopljeni fero-sukcinilkazein, kako bi se dobilo vodenu otopinu fero-sukcinilkazeina,
(e) taloženja fero-sukcinilkazeina iz navedene vodene otopine, dodavanjem najmanje jedne kiseline, te prikupljanja dobivenog fero-sukcinilkazeina, te
(f) sušenja navedenog dobivenog fero-sukcinilkazeina, ili daljnje obrade vlažnog dobivenog fero-sukcinilkazeina izravno u farmaceutsku formulaciju.
8. Postupak u skladu s bilo kojim od patentnih zahtjeva 1 do 7, koji se sastoji u sljedećim koracima:
(a) reakcije kazeina s najmanje jednim sukcinilacijskim sredstvom, kako bi se dobilo vodenu suspenziju sukcinilkazeina,
(b) reakcije navedene vodene suspenzije sukcinilkazeina, dobivene u koraku (a), s najmanje jednom željeznom solju, kako bi se dobilo fero-sukcinilkazein,
(c) otapanja fero-sukcinilkazeina uz dodavanje najmanje jedne baze, kako bi se dobilo vodeni pripravak, koji sadrži otopljeni fero-sukcinilkazein,
(d) izdvajanja netopljivog materijala iz navedenog vodenog pripravka koji sadrži otopljeni fero-sukcinilkazein, kako bi se dobilo vodenu otopinu fero-sukcinilkazeina,
(e) taloženja fero-sukcinilkazeina iz navedene vodene otopine, dodavanjem najmanje jedne kiseline, te prikupljanja dobivenog fero-sukcinilkazeina, te
(f) sušenja navedenog dobivenog fero-sukcinilkazeina, ili daljnje obrade vlažnog dobivenog fero-sukcinilkazeina izravno u farmaceutsku formulaciju.
9. Postupak u skladu s bilo kojim od patentnih zahtjeva 1 do 8, gdje se u koraku (a) sukcinilacijsko sredstvo dodaje kazeinu u najmanje dva, vremenski odvojena, koraka.
10. Postupak u skladu s bilo kojim od patentnih zahtjeva 1 do 9, gdje se u koraku (b) dodaje najmanje jednu željeznu sol.
11. Postupak u skladu s bilo kojim od patentnih zahtjeva 1 do 10, koji se dodatno sastoji u koraku proizvodnje farmaceutskog doziranja dobivenog fero-sukcinilkazeina.
12. Postupak u skladu s patentnim zahtjevom 11, gdje oblik doziranja je namijenjen oralnoj primjeni.
13. Postupak u skladu s patentnim zahtjevom 11, gdje oblik doziranja je tekuća formulacija, uključujući čaše za piće, sirupe, ljekovite napitke, otopine, suspenzije, sokove.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05111733 | 2005-12-06 | ||
| PCT/EP2006/068994 WO2007065812A1 (en) | 2005-12-06 | 2006-11-28 | Process for the preparation of ferri-succinylcasein |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20090580T1 true HRP20090580T1 (hr) | 2009-12-31 |
Family
ID=36218246
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20090580T HRP20090580T1 (hr) | 2005-12-06 | 2009-10-30 | Postupak dobivanja feri-sukcinilkazeina |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US20080299285A1 (hr) |
| EP (1) | EP1968996B1 (hr) |
| JP (1) | JP2009518350A (hr) |
| KR (1) | KR20080086446A (hr) |
| CN (1) | CN101321776A (hr) |
| AR (1) | AR058253A1 (hr) |
| AT (1) | ATE444303T1 (hr) |
| AU (1) | AU2006324080B2 (hr) |
| BR (1) | BRPI0619617A2 (hr) |
| CA (1) | CA2628614A1 (hr) |
| DE (1) | DE602006009562D1 (hr) |
| DK (1) | DK1968996T3 (hr) |
| ES (1) | ES2330478T3 (hr) |
| GT (1) | GT200800088A (hr) |
| HR (1) | HRP20090580T1 (hr) |
| MA (1) | MA30079B1 (hr) |
| NO (1) | NO20082749L (hr) |
| NZ (1) | NZ568332A (hr) |
| PE (1) | PE20071038A1 (hr) |
| PL (1) | PL1968996T3 (hr) |
| PT (1) | PT1968996E (hr) |
| RU (1) | RU2408601C2 (hr) |
| TN (1) | TNSN08244A1 (hr) |
| TW (1) | TW200728310A (hr) |
| WO (1) | WO2007065812A1 (hr) |
| ZA (1) | ZA200804264B (hr) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7981450B2 (en) * | 2008-06-20 | 2011-07-19 | Burcon Nutrascience (Mb) Corp. | Canola protein isolate |
| KR20110107228A (ko) * | 2010-03-24 | 2011-09-30 | 씨제이제일제당 (주) | 단백질 또는 단백질 가수분해물의 물성을 개선하는 방법 |
| PT2588488T (pt) | 2010-06-30 | 2017-06-26 | Italfarmaco Spa | Caseína-succinilato de ferro (iii) e método para a sua preparação |
| AU2013202190A1 (en) * | 2012-06-20 | 2014-01-16 | Massey University | Micronutrient Fortification Process and its Uses |
| CN102838667B (zh) * | 2012-09-25 | 2014-06-25 | 济川药业集团有限公司 | 一种蛋白琥珀酸铁的制备方法 |
| CN103059121B (zh) * | 2013-01-28 | 2014-08-06 | 甘肃农业大学 | 一种以牦牛乳酪蛋白为原料制备酰化酪蛋白的方法 |
| CN104402984B (zh) * | 2014-11-11 | 2018-09-07 | 武汉科福新药有限责任公司 | 一种高载铁量的蛋白琥珀酸铁的制备方法 |
| CN109982586A (zh) * | 2016-12-15 | 2019-07-05 | 雀巢产品技术援助有限公司 | 包含铁-酪蛋白络合物和对氧化敏感的化合物的呈粉末形式的组合物 |
| CN108264546A (zh) * | 2016-12-30 | 2018-07-10 | 河北凯盛医药科技有限公司 | 琥珀酰酪蛋白-亚铁及其制备方法和用途 |
| CN111000977A (zh) * | 2019-03-22 | 2020-04-14 | 江苏中天药业有限公司 | 一种蛋白琥珀酸铁固体新剂型及其制备方法 |
| CN113875991A (zh) * | 2021-09-26 | 2022-01-04 | 沈阳农业大学 | 一步自组装法制备琥珀酰化酪蛋白-磷脂-花色苷纳米粒及用途 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1150213B (it) * | 1982-03-02 | 1986-12-10 | Italfarmaco Spa | Derivati di ferro biodisponibile esenti da gastrolesivita',procentimento di preparazione e relative composizioni farmaceutiche |
| US6306201B1 (en) * | 1992-01-29 | 2001-10-23 | I.B.E. Company, Ltd. | Bivalent iron compounds |
| IT1297022B1 (it) * | 1997-12-24 | 1999-08-03 | Chemi Spa | Complesso di ferro-succinilcaseina, processo per la sua preparazione e composizioni farmaceutiche che lo contengono |
| ITMO20040200A1 (it) * | 2004-07-29 | 2004-10-29 | Biofer Spa | Processo per la produzione di complessi ferro succinilcaseina e ferro casein acetil aspartilato e loro utilizzato nelle relative composizioni farmaceutiche. |
-
2006
- 2006-11-28 AT AT06819816T patent/ATE444303T1/de active
- 2006-11-28 EP EP06819816A patent/EP1968996B1/en active Active
- 2006-11-28 CA CA002628614A patent/CA2628614A1/en not_active Abandoned
- 2006-11-28 BR BRPI0619617-9A patent/BRPI0619617A2/pt not_active IP Right Cessation
- 2006-11-28 DK DK06819816T patent/DK1968996T3/da active
- 2006-11-28 US US12/096,057 patent/US20080299285A1/en not_active Abandoned
- 2006-11-28 ES ES06819816T patent/ES2330478T3/es active Active
- 2006-11-28 PL PL06819816T patent/PL1968996T3/pl unknown
- 2006-11-28 NZ NZ568332A patent/NZ568332A/en not_active IP Right Cessation
- 2006-11-28 JP JP2008543769A patent/JP2009518350A/ja not_active Ceased
- 2006-11-28 AU AU2006324080A patent/AU2006324080B2/en not_active Ceased
- 2006-11-28 RU RU2008127373/04A patent/RU2408601C2/ru not_active IP Right Cessation
- 2006-11-28 KR KR1020087013878A patent/KR20080086446A/ko active IP Right Grant
- 2006-11-28 CN CNA2006800457129A patent/CN101321776A/zh active Pending
- 2006-11-28 WO PCT/EP2006/068994 patent/WO2007065812A1/en active Application Filing
- 2006-11-28 PT PT06819816T patent/PT1968996E/pt unknown
- 2006-11-28 DE DE602006009562T patent/DE602006009562D1/de active Active
- 2006-11-29 AR ARP060105267A patent/AR058253A1/es not_active Application Discontinuation
- 2006-12-05 TW TW095145135A patent/TW200728310A/zh unknown
- 2006-12-05 PE PE2006001547A patent/PE20071038A1/es not_active Application Discontinuation
-
2008
- 2008-05-16 ZA ZA200804264A patent/ZA200804264B/xx unknown
- 2008-06-05 GT GT200800088A patent/GT200800088A/es unknown
- 2008-06-05 TN TNP2008000244A patent/TNSN08244A1/en unknown
- 2008-06-13 NO NO20082749A patent/NO20082749L/no not_active Application Discontinuation
- 2008-06-20 MA MA31063A patent/MA30079B1/fr unknown
-
2009
- 2009-10-30 HR HR20090580T patent/HRP20090580T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL1968996T3 (pl) | 2010-03-31 |
| TW200728310A (en) | 2007-08-01 |
| NZ568332A (en) | 2010-11-26 |
| AU2006324080B2 (en) | 2012-04-12 |
| KR20080086446A (ko) | 2008-09-25 |
| DE602006009562D1 (de) | 2009-11-12 |
| WO2007065812A1 (en) | 2007-06-14 |
| ZA200804264B (en) | 2009-01-28 |
| US20080299285A1 (en) | 2008-12-04 |
| ES2330478T3 (es) | 2009-12-10 |
| AR058253A1 (es) | 2008-01-30 |
| MA30079B1 (fr) | 2008-12-01 |
| JP2009518350A (ja) | 2009-05-07 |
| RU2008127373A (ru) | 2010-01-20 |
| PE20071038A1 (es) | 2007-12-22 |
| PT1968996E (pt) | 2009-11-17 |
| RU2408601C2 (ru) | 2011-01-10 |
| EP1968996A1 (en) | 2008-09-17 |
| CA2628614A1 (en) | 2007-06-14 |
| DK1968996T3 (da) | 2009-12-21 |
| CN101321776A (zh) | 2008-12-10 |
| NO20082749L (no) | 2008-06-13 |
| ATE444303T1 (de) | 2009-10-15 |
| BRPI0619617A2 (pt) | 2011-10-04 |
| GT200800088A (es) | 2008-09-26 |
| EP1968996B1 (en) | 2009-09-30 |
| AU2006324080A1 (en) | 2007-06-14 |
| TNSN08244A1 (en) | 2009-10-30 |
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