IT1150213B - Derivati di ferro biodisponibile esenti da gastrolesivita',procentimento di preparazione e relative composizioni farmaceutiche - Google Patents

Derivati di ferro biodisponibile esenti da gastrolesivita',procentimento di preparazione e relative composizioni farmaceutiche

Info

Publication number
IT1150213B
IT1150213B IT19908/82A IT1990882A IT1150213B IT 1150213 B IT1150213 B IT 1150213B IT 19908/82 A IT19908/82 A IT 19908/82A IT 1990882 A IT1990882 A IT 1990882A IT 1150213 B IT1150213 B IT 1150213B
Authority
IT
Italy
Prior art keywords
gastrolesivity
pharmaceutical compositions
preparation procedure
related pharmaceutical
bioavailable iron
Prior art date
Application number
IT19908/82A
Other languages
English (en)
Other versions
IT8219908A0 (it
Inventor
Giancarlo Sportoletti
Pier Giuseppe Pagella
Pietro Cremonesi
Original Assignee
Italfarmaco Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Italfarmaco Spa filed Critical Italfarmaco Spa
Publication of IT8219908A0 publication Critical patent/IT8219908A0/it
Priority to IT19908/82A priority Critical patent/IT1150213B/it
Priority to CH922/83A priority patent/CH653893A5/it
Priority to ES519944A priority patent/ES519944A0/es
Priority to AR291195A priority patent/AR229805A1/es
Priority to DK084883A priority patent/DK159824C/da
Priority to US06/469,282 priority patent/US4493829A/en
Priority to PH28572A priority patent/PH18538A/en
Priority to DE19833306622 priority patent/DE3306622A1/de
Priority to AU11858/83A priority patent/AU548034B2/en
Priority to ZA831350A priority patent/ZA831350B/xx
Priority to FR8303268A priority patent/FR2522664B1/fr
Priority to KR1019830000820A priority patent/KR860001571B1/ko
Priority to CA000422538A priority patent/CA1222508A/en
Priority to GR70623A priority patent/GR78470B/el
Priority to AT0070983A priority patent/AT390067B/de
Priority to IE428/83A priority patent/IE54572B1/en
Priority to NO830707A priority patent/NO163859C/no
Priority to SE8301129A priority patent/SE462716B/sv
Priority to JP58033718A priority patent/JPS58159421A/ja
Priority to BE2/60041A priority patent/BE896051A/nl
Priority to NLAANVRAGE8300757,A priority patent/NL190399C/xx
Priority to FI830678A priority patent/FI77574C/fi
Priority to PT76318A priority patent/PT76318B/pt
Priority to MX594483A priority patent/MX154554A/es
Priority to IN263/CAL/83A priority patent/IN156079B/en
Priority to LU84672A priority patent/LU84672A1/fr
Priority to GB08305691A priority patent/GB2115821B/en
Priority to BR8301005A priority patent/BR8301005A/pt
Priority to HK560/86A priority patent/HK56086A/xx
Application granted granted Critical
Publication of IT1150213B publication Critical patent/IT1150213B/it
Priority to MY588/86A priority patent/MY8600588A/xx
Priority to MX9203631A priority patent/MX9203631A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/30—Extraction; Separation; Purification by precipitation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • C07K14/77—Ovalbumin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/832—Milk; colostrum
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/843—Digestive system
    • Y10S530/846—Liver
IT19908/82A 1982-03-02 1982-03-02 Derivati di ferro biodisponibile esenti da gastrolesivita',procentimento di preparazione e relative composizioni farmaceutiche IT1150213B (it)

Priority Applications (31)

Application Number Priority Date Filing Date Title
IT19908/82A IT1150213B (it) 1982-03-02 1982-03-02 Derivati di ferro biodisponibile esenti da gastrolesivita',procentimento di preparazione e relative composizioni farmaceutiche
CH922/83A CH653893A5 (it) 1982-03-02 1983-02-18 Derivati di ferro biodisponibile esenti da gastrolesivita, procedimento di preparazione e relative composizioni farmaceutiche.
ES519944A ES519944A0 (es) 1982-03-02 1983-02-21 Procedimiento para la preparacion de proteinas succiniladas que contienen hierro.
AR291195A AR229805A1 (es) 1982-03-02 1983-02-22 Procedimiento para la preparacion de proteinas succiniladas que contienen hierro
DK084883A DK159824C (da) 1982-03-02 1983-02-24 Analogifremgangsmaade til fremstilling af succinylferroproteiner
US06/469,282 US4493829A (en) 1982-03-02 1983-02-24 Bio-available succinylated protein-iron derivatives which do not cause gastric lesions, method of preparation and related pharmaceutical compounds
PH28572A PH18538A (en) 1982-03-02 1983-02-25 Bio-available derivatives from succinylated proteins,method of their preparation and pharmaceutical compositions thereof
DE19833306622 DE3306622A1 (de) 1982-03-02 1983-02-25 Bio-verfuegbare eisenderivate, die keine gastrischen schaeden verursachen, verfahren zu ihrer herstellung und diese derivate enthaltende arzneimittel
AU11858/83A AU548034B2 (en) 1982-03-02 1983-02-25 Bio available iron derivatives which do not cause gastric lesions
ZA831350A ZA831350B (en) 1982-03-02 1983-02-28 Bio-available iron derivatives which do not cause gastric lesions,method of preparation and related pharmaceutical compounds
FR8303268A FR2522664B1 (fr) 1982-03-02 1983-02-28 Derives de fer biodisponible non dommageables au systeme gastrique, leur procede de preparation et leur application en therapeutique
KR1019830000820A KR860001571B1 (ko) 1982-03-02 1983-02-28 석시닐화된 단백질-철 유도체의 제조방법
CA000422538A CA1222508A (en) 1982-03-02 1983-02-28 Bio-available iron derivatives which do not cause gastric lesions, method of preparation and related pharmaceutical compounds
GR70623A GR78470B (it) 1982-03-02 1983-02-28
AT0070983A AT390067B (de) 1982-03-02 1983-03-01 Verfahren zur herstellung von succinylierten proteinen
MX594483A MX154554A (es) 1982-03-02 1983-03-01 Procedimiento para la preparacion de proteinas succiniladas que contienen hierro
NO830707A NO163859C (no) 1982-03-02 1983-03-01 Fremgangsmaate ved fremstilling av terapeutisk aktive succinylerte jernholdige proteiner.
SE8301129A SE462716B (sv) 1982-03-02 1983-03-01 Biotillgaengliga foereningar innehaallande protein och jaern och som icke foerorsakar foeraendringar paa magens slemhinna, deras framstaellning och farmaceutiska beredningar innehaallande desamma
JP58033718A JPS58159421A (ja) 1982-03-02 1983-03-01 胃損傷をおこさない生物学的に利用できる鉄誘導体、その製造法およびそれを有効成分とする医薬
BE2/60041A BE896051A (nl) 1982-03-02 1983-03-01 Resorbeerbaar ijzerderivaat dat de maagwand niet aantast, werkwijze voor zijn bereiding en geneesmiddelen met dit derivaat daarin
NLAANVRAGE8300757,A NL190399C (nl) 1982-03-02 1983-03-01 IJzer-bevattend eiwitmateriaal, bereiding daarvan, en farmaceutisch preparaat voor de behandeling van sideropene anaemie.
FI830678A FI77574C (fi) 1982-03-02 1983-03-01 Foerfarande foer framstaellning av derivat av succinyl-ferroprotein.
PT76318A PT76318B (en) 1982-03-02 1983-03-01 Process for preparing biodisposable iron derivatives without gastric prejudical activity and of pharmaceutical compositions containing the same
IE428/83A IE54572B1 (en) 1982-03-02 1983-03-01 Pharmaceutically active succinylated proteins comprising iron
IN263/CAL/83A IN156079B (it) 1982-03-02 1983-03-02
LU84672A LU84672A1 (fr) 1982-03-02 1983-03-02 Derives de fer biodisponible non dommageables au systeme gastrique,leur procede de preparation et leur application en therapeutique
GB08305691A GB2115821B (en) 1982-03-02 1983-03-02 Bio-available iron derivatives which do no cause gastric lesions, method of preparation and related pharmaceutical compounds
BR8301005A BR8301005A (pt) 1982-03-02 1983-03-03 Proteina,processo para preparacao das mesmas,e composicoes farmaceuticas
HK560/86A HK56086A (en) 1982-03-02 1986-07-24 Pharmaceutically active succinylated proteins comprising iron
MY588/86A MY8600588A (en) 1982-03-02 1986-12-30 Pharmaceutically active succinylated proteins comprising iron
MX9203631A MX9203631A (es) 1982-03-02 1992-06-26 Proteinas succiniladas que contienen hierro.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT19908/82A IT1150213B (it) 1982-03-02 1982-03-02 Derivati di ferro biodisponibile esenti da gastrolesivita',procentimento di preparazione e relative composizioni farmaceutiche

Publications (2)

Publication Number Publication Date
IT8219908A0 IT8219908A0 (it) 1982-03-02
IT1150213B true IT1150213B (it) 1986-12-10

Family

ID=11162241

Family Applications (1)

Application Number Title Priority Date Filing Date
IT19908/82A IT1150213B (it) 1982-03-02 1982-03-02 Derivati di ferro biodisponibile esenti da gastrolesivita',procentimento di preparazione e relative composizioni farmaceutiche

Country Status (30)

Country Link
US (1) US4493829A (it)
JP (1) JPS58159421A (it)
KR (1) KR860001571B1 (it)
AR (1) AR229805A1 (it)
AT (1) AT390067B (it)
AU (1) AU548034B2 (it)
BE (1) BE896051A (it)
BR (1) BR8301005A (it)
CA (1) CA1222508A (it)
CH (1) CH653893A5 (it)
DE (1) DE3306622A1 (it)
DK (1) DK159824C (it)
ES (1) ES519944A0 (it)
FI (1) FI77574C (it)
FR (1) FR2522664B1 (it)
GB (1) GB2115821B (it)
GR (1) GR78470B (it)
HK (1) HK56086A (it)
IE (1) IE54572B1 (it)
IN (1) IN156079B (it)
IT (1) IT1150213B (it)
LU (1) LU84672A1 (it)
MX (1) MX9203631A (it)
MY (1) MY8600588A (it)
NL (1) NL190399C (it)
NO (1) NO163859C (it)
PH (1) PH18538A (it)
PT (1) PT76318B (it)
SE (1) SE462716B (it)
ZA (1) ZA831350B (it)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012001712A1 (en) 2010-06-30 2012-01-05 Italfarmaco S.P.A. Iron (iii) caseinsuccinylate and method for the preparation thereof

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1186787B (it) * 1985-11-06 1987-12-16 Mediolanum Farmaceutici Srl Ferro-derivati della globina e dell'acetilglobina dotati di elevata biodisponibilita',processo di preparazione e composizioni farmaceutiche
IT1207996B (it) * 1986-03-18 1989-06-01 Magis Farmaceutici Composti contenenti ferro biodisponibile, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono.
JP2520262B2 (ja) * 1987-08-21 1996-07-31 春幸 川原 パツチテスト材料
IT1222912B (it) * 1987-10-14 1990-09-12 Italfarmaco Spa Derivati polipeptidici a elevato tenore di ferro e altamente solubili atti alla terapia marziale procedimenti di preparazione e loro forme farmaceutiche
IT1223122B (it) * 1987-11-13 1990-09-12 Unibios Spa Derivati proteici del ferro altamente biodisponibile e tollerabili, loro preparazione e composizioni farmaceutiche che li contengono
US5322678A (en) * 1988-02-17 1994-06-21 Neorx Corporation Alteration of pharmacokinetics of proteins by charge modification
IT1237783B (it) * 1989-11-16 1993-06-17 Italfarmaco Spa Derivati di ferro-albumina biodisponibile, loro procedimento di preparazione e relative composizioni farmaceutiche.
IT1251702B (it) * 1991-10-16 1995-05-19 Mediolanum Farmaceutici Srl Complessi del ferro con la conalbumina e i suoi derivati
IT1251725B (it) * 1991-11-04 1995-05-23 Italfarmaco Spa Composti di ferro biodisponibile con ovotransferrina acilata o suoi derivati di idrolisi acilati
IT1291289B1 (it) * 1997-04-30 1999-01-07 Derivati Organici Lab Complessi costituiti da fe(iii) un composto poliidrossilato e ovalbumina
ITMO20040200A1 (it) * 2004-07-29 2004-10-29 Biofer Spa Processo per la produzione di complessi ferro succinilcaseina e ferro casein acetil aspartilato e loro utilizzato nelle relative composizioni farmaceutiche.
ATE444303T1 (de) * 2005-12-06 2009-10-15 Vifor Int Ag Verfahren zur herstellung von ferrisuccinylcasein
CA2726700C (en) * 2008-06-12 2018-05-22 Universite Laval Modified protein excipient for delayed-release tablet
CN102838667B (zh) * 2012-09-25 2014-06-25 济川药业集团有限公司 一种蛋白琥珀酸铁的制备方法
AU2015204192B2 (en) 2014-01-06 2020-03-26 Shield TX (UK) Limited Dosage regimen of ferric trimaltol
GB201416293D0 (en) 2014-09-15 2014-10-29 Solvotrin Therapeutics Ltd Methods and preparations
GB201418710D0 (en) 2014-10-21 2014-12-03 Iron Therapeutics Holdings Ag Dosage regimen
PL3034512T3 (pl) 2014-12-19 2018-03-30 Ioulia Tseti Sposób wytwarzania kompleksów żelaza (III) z N-acetyloaspartylowaną kazeiną i ich zastosowanie w kompozycjach farmaceutycznych
EP3429560A1 (en) 2016-03-15 2019-01-23 Solvotrin Therapeutics Ltd. Compositions and methods for increasing iron intake in a mammal

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US2932589A (en) * 1956-03-12 1960-04-12 Glidden Co Paper coating compositions and process
IL26551A (en) * 1965-10-08 1970-06-17 Diagnostic Data Inc Injectable protein and method of isolation and use
US3756682A (en) * 1967-02-13 1973-09-04 Schlumberger Technology Corp Method for outgassing permanent magnets
US3873296A (en) * 1968-06-24 1975-03-25 Ashmead H H Increasing metals in biological tissue
GB1284409A (en) * 1968-12-31 1972-08-09 Unilever Ltd Oil emulsions containing acylated protein emulsifiers
US3764711A (en) * 1971-03-29 1973-10-09 Carnation Co Acylated protein for coffee whitener formulations
US4017605A (en) * 1974-09-20 1977-04-12 Diagnostic Data, Inc. Acylated orgotein
US4020158A (en) * 1975-08-08 1977-04-26 Ashmead H H Increasing metals in biological tissue
NZ183858A (en) * 1976-12-17 1979-10-25 Ashmead Hh Polyvalent metal proteinates as food additives
US4208405A (en) * 1977-01-24 1980-06-17 Kelatron Pharmaceutical Division of Intermountain Laboratories Inc. Trace element composition for iron deficiency anemia
US4172072A (en) * 1977-10-20 1979-10-23 Ashmead H H Buffered enzymatically produced metal proteinates
US4216144A (en) * 1977-10-20 1980-08-05 Ashmead H H Soluble iron proteinates
SE451539B (sv) * 1979-11-16 1987-10-19 Sik Svenska Livsmedelsinst Hemjernanrikat aminosyrapreparat framstellt av hemproteiner och forfarande for dess framstellning

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012001712A1 (en) 2010-06-30 2012-01-05 Italfarmaco S.P.A. Iron (iii) caseinsuccinylate and method for the preparation thereof

Also Published As

Publication number Publication date
DK84883A (da) 1983-09-03
US4493829A (en) 1985-01-15
FI830678L (fi) 1983-09-03
FR2522664B1 (fr) 1986-08-14
PT76318A (en) 1983-04-01
SE8301129D0 (sv) 1983-03-01
BE896051A (nl) 1983-07-01
KR840003648A (ko) 1984-09-15
IE830428L (en) 1983-09-02
GB2115821B (en) 1985-07-17
GB2115821A (en) 1983-09-14
KR860001571B1 (ko) 1986-10-08
BR8301005A (pt) 1983-11-22
AT390067B (de) 1990-03-12
DK84883D0 (da) 1983-02-24
GR78470B (it) 1984-09-27
DK159824C (da) 1991-04-29
AU548034B2 (en) 1985-11-21
CA1222508A (en) 1987-06-02
JPS58159421A (ja) 1983-09-21
ES8403493A1 (es) 1984-04-01
FI77574C (fi) 1989-04-10
NL190399C (nl) 1994-02-16
NL8300757A (nl) 1983-10-03
AU1185883A (en) 1983-09-08
CH653893A5 (it) 1986-01-31
JPH0470317B2 (it) 1992-11-10
DE3306622A1 (de) 1983-09-15
IN156079B (it) 1985-05-11
SE462716B (sv) 1990-08-20
SE8301129L (sv) 1983-09-03
ZA831350B (en) 1983-11-30
AR229805A1 (es) 1983-11-30
GB8305691D0 (en) 1983-04-07
PH18538A (en) 1985-08-09
DE3306622C2 (it) 1990-02-22
NL190399B (nl) 1993-09-16
IT8219908A0 (it) 1982-03-02
NO163859B (no) 1990-04-23
ATA70983A (de) 1989-08-15
PT76318B (en) 1986-02-12
MX9203631A (es) 1992-07-01
FI830678A0 (fi) 1983-03-01
DK159824B (da) 1990-12-10
LU84672A1 (fr) 1983-09-08
IE54572B1 (en) 1989-11-22
FR2522664A1 (fr) 1983-09-09
FI77574B (fi) 1988-12-30
ES519944A0 (es) 1984-04-01
HK56086A (en) 1986-08-01
NO830707L (no) 1983-09-05
MY8600588A (en) 1986-12-31
NO163859C (no) 1990-08-01

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