KR840003648A - 위장장애를 일으키지 않는 생체에 유효한 철 유도체의 제조방법 - Google Patents

위장장애를 일으키지 않는 생체에 유효한 철 유도체의 제조방법 Download PDF

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KR840003648A
KR840003648A KR1019830000820A KR830000820A KR840003648A KR 840003648 A KR840003648 A KR 840003648A KR 1019830000820 A KR1019830000820 A KR 1019830000820A KR 830000820 A KR830000820 A KR 830000820A KR 840003648 A KR840003648 A KR 840003648A
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gastrointestinal disorders
living bodies
preparing iron
cause gastrointestinal
derivatives effective
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KR1019830000820A
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KR860001571B1 (ko
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스포톨레티 기안카를로 (외 2)
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가스톤 드 샌티스
이탈파마코 에스. 피. 에이.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/30—Extraction; Separation; Purification by precipitation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • C07K14/77—Ovalbumin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/832—Milk; colostrum
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/843—Digestive system
    • Y10S530/846—Liver

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Analytical Chemistry (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Botany (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

내용 없음

Description

위장장애를 일으키지 않는 생체에 유효한 철 유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제 1 도는 석시닐 훼로프로테인 유도체에 대한 UV-가스 스펙트럼도.
제 2 도는 형광방사 스펙트럼도.

Claims (4)

  1. 석시날화된 단백질을 pH 약 2내지 10의 수용성 매질내에서 철염과 반응시키고, 수득된 생성물을 pH 2 내지 4에서 침전에 의해 분리시키며 이때, 후자의 pH범위는 저절로 형성되거나 산성화시켜 형성시킴을 특징으로 하는, 철을 함유하는 석시닐화된 단백질의 제조방법.
  2. 제 1 항에 있어서, 중성에 가까운 pH에서 석시닐화된 단백질 및 철염을 반응시킴을 특징으로하는 방법.
  3. 석시날화된 단백질을 pH 약 2내지 약 10의 수용성 매질내에서 철염과 반응시키고, 반응생성물을 pH를 중성에 가깝게 조정한후 용매를 제거함으로써 분리시킴을 특징으로 하는, 철을 함유하는 석시닐화된 단백질의 제조방법.
  4. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019830000820A 1982-03-02 1983-02-28 석시닐화된 단백질-철 유도체의 제조방법 KR860001571B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT19908 1982-03-02
IT19908/82A IT1150213B (it) 1982-03-02 1982-03-02 Derivati di ferro biodisponibile esenti da gastrolesivita',procentimento di preparazione e relative composizioni farmaceutiche
IT19908A/82 1982-03-02

Publications (2)

Publication Number Publication Date
KR840003648A true KR840003648A (ko) 1984-09-15
KR860001571B1 KR860001571B1 (ko) 1986-10-08

Family

ID=11162241

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019830000820A KR860001571B1 (ko) 1982-03-02 1983-02-28 석시닐화된 단백질-철 유도체의 제조방법

Country Status (30)

Country Link
US (1) US4493829A (ko)
JP (1) JPS58159421A (ko)
KR (1) KR860001571B1 (ko)
AR (1) AR229805A1 (ko)
AT (1) AT390067B (ko)
AU (1) AU548034B2 (ko)
BE (1) BE896051A (ko)
BR (1) BR8301005A (ko)
CA (1) CA1222508A (ko)
CH (1) CH653893A5 (ko)
DE (1) DE3306622A1 (ko)
DK (1) DK159824C (ko)
ES (1) ES8403493A1 (ko)
FI (1) FI77574C (ko)
FR (1) FR2522664B1 (ko)
GB (1) GB2115821B (ko)
GR (1) GR78470B (ko)
HK (1) HK56086A (ko)
IE (1) IE54572B1 (ko)
IN (1) IN156079B (ko)
IT (1) IT1150213B (ko)
LU (1) LU84672A1 (ko)
MX (1) MX9203631A (ko)
MY (1) MY8600588A (ko)
NL (1) NL190399C (ko)
NO (1) NO163859C (ko)
PH (1) PH18538A (ko)
PT (1) PT76318B (ko)
SE (1) SE462716B (ko)
ZA (1) ZA831350B (ko)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1186787B (it) * 1985-11-06 1987-12-16 Mediolanum Farmaceutici Srl Ferro-derivati della globina e dell'acetilglobina dotati di elevata biodisponibilita',processo di preparazione e composizioni farmaceutiche
IT1207996B (it) * 1986-03-18 1989-06-01 Magis Farmaceutici Composti contenenti ferro biodisponibile, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono.
JP2520262B2 (ja) * 1987-08-21 1996-07-31 春幸 川原 パツチテスト材料
IT1222912B (it) * 1987-10-14 1990-09-12 Italfarmaco Spa Derivati polipeptidici a elevato tenore di ferro e altamente solubili atti alla terapia marziale procedimenti di preparazione e loro forme farmaceutiche
IT1223122B (it) * 1987-11-13 1990-09-12 Unibios Spa Derivati proteici del ferro altamente biodisponibile e tollerabili, loro preparazione e composizioni farmaceutiche che li contengono
US5322678A (en) * 1988-02-17 1994-06-21 Neorx Corporation Alteration of pharmacokinetics of proteins by charge modification
IT1237783B (it) * 1989-11-16 1993-06-17 Italfarmaco Spa Derivati di ferro-albumina biodisponibile, loro procedimento di preparazione e relative composizioni farmaceutiche.
IT1251702B (it) * 1991-10-16 1995-05-19 Mediolanum Farmaceutici Srl Complessi del ferro con la conalbumina e i suoi derivati
IT1251725B (it) * 1991-11-04 1995-05-23 Italfarmaco Spa Composti di ferro biodisponibile con ovotransferrina acilata o suoi derivati di idrolisi acilati
IT1291289B1 (it) * 1997-04-30 1999-01-07 Derivati Organici Lab Complessi costituiti da fe(iii) un composto poliidrossilato e ovalbumina
ITMO20040200A1 (it) * 2004-07-29 2004-10-29 Biofer Spa Processo per la produzione di complessi ferro succinilcaseina e ferro casein acetil aspartilato e loro utilizzato nelle relative composizioni farmaceutiche.
CN101321776A (zh) * 2005-12-06 2008-12-10 维福（国际）股份公司 用于制备铁-琥珀酰酪蛋白的方法
WO2009149553A1 (en) * 2008-06-12 2009-12-17 Universite Laval Modified protein excipient for delayed-release tablet
MA34319B1 (fr) 2010-06-30 2013-06-01 Italfarmaco Spa Caséinesuccinylate de fer (iii) et son procédé de préparation
CN102838667B (zh) * 2012-09-25 2014-06-25 济川药业集团有限公司 一种蛋白琥珀酸铁的制备方法
EP3091974B1 (en) * 2014-01-06 2020-04-01 Shield TX (UK) Limited Dosage regimen of ferric trimaltol
GB201416293D0 (en) 2014-09-15 2014-10-29 Solvotrin Therapeutics Ltd Methods and preparations
GB201418710D0 (en) 2014-10-21 2014-12-03 Iron Therapeutics Holdings Ag Dosage regimen
NO3034512T3 (ko) 2014-12-19 2018-05-05
CR20180488A (es) 2016-03-15 2019-03-12 Solvotrin Therapeutics Ltd Composiciones y metodos para aumentar la ingesta de hierro en un mamifero

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2932589A (en) * 1956-03-12 1960-04-12 Glidden Co Paper coating compositions and process
IL26551A (en) * 1965-10-08 1970-06-17 Diagnostic Data Inc Injectable protein and method of isolation and use
US3756682A (en) * 1967-02-13 1973-09-04 Schlumberger Technology Corp Method for outgassing permanent magnets
US3873296A (en) * 1968-06-24 1975-03-25 Ashmead H H Increasing metals in biological tissue
GB1284409A (en) * 1968-12-31 1972-08-09 Unilever Ltd Oil emulsions containing acylated protein emulsifiers
US3764711A (en) * 1971-03-29 1973-10-09 Carnation Co Acylated protein for coffee whitener formulations
US4017605A (en) * 1974-09-20 1977-04-12 Diagnostic Data, Inc. Acylated orgotein
US4020158A (en) * 1975-08-08 1977-04-26 Ashmead H H Increasing metals in biological tissue
NZ183858A (en) * 1976-12-17 1979-10-25 Ashmead Hh Polyvalent metal proteinates as food additives
US4208405A (en) * 1977-01-24 1980-06-17 Kelatron Pharmaceutical Division of Intermountain Laboratories Inc. Trace element composition for iron deficiency anemia
US4216144A (en) * 1977-10-20 1980-08-05 Ashmead H H Soluble iron proteinates
US4172072A (en) * 1977-10-20 1979-10-23 Ashmead H H Buffered enzymatically produced metal proteinates
SE451539B (sv) * 1979-11-16 1987-10-19 Sik Svenska Livsmedelsinst Hemjernanrikat aminosyrapreparat framstellt av hemproteiner och forfarande for dess framstellning

Also Published As

Publication number Publication date
IE830428L (en) 1983-09-02
PT76318A (en) 1983-04-01
IT1150213B (it) 1986-12-10
SE8301129D0 (sv) 1983-03-01
MX9203631A (es) 1992-07-01
NL190399C (nl) 1994-02-16
AR229805A1 (es) 1983-11-30
NL8300757A (nl) 1983-10-03
FI77574B (fi) 1988-12-30
NO830707L (no) 1983-09-05
US4493829A (en) 1985-01-15
KR860001571B1 (ko) 1986-10-08
GB8305691D0 (en) 1983-04-07
DK84883A (da) 1983-09-03
FR2522664B1 (fr) 1986-08-14
ES519944A0 (es) 1984-04-01
HK56086A (en) 1986-08-01
CH653893A5 (it) 1986-01-31
PT76318B (en) 1986-02-12
AU548034B2 (en) 1985-11-21
DK84883D0 (da) 1983-02-24
NO163859B (no) 1990-04-23
ES8403493A1 (es) 1984-04-01
FR2522664A1 (fr) 1983-09-09
IE54572B1 (en) 1989-11-22
GR78470B (ko) 1984-09-27
CA1222508A (en) 1987-06-02
MY8600588A (en) 1986-12-31
NO163859C (no) 1990-08-01
AU1185883A (en) 1983-09-08
IT8219908A0 (it) 1982-03-02
IN156079B (ko) 1985-05-11
GB2115821B (en) 1985-07-17
BR8301005A (pt) 1983-11-22
JPH0470317B2 (ko) 1992-11-10
FI830678A0 (fi) 1983-03-01
LU84672A1 (fr) 1983-09-08
NL190399B (nl) 1993-09-16
DK159824C (da) 1991-04-29
BE896051A (nl) 1983-07-01
SE462716B (sv) 1990-08-20
GB2115821A (en) 1983-09-14
DK159824B (da) 1990-12-10
FI830678L (fi) 1983-09-03
PH18538A (en) 1985-08-09
FI77574C (fi) 1989-04-10
ZA831350B (en) 1983-11-30
DE3306622A1 (de) 1983-09-15
AT390067B (de) 1990-03-12
JPS58159421A (ja) 1983-09-21
DE3306622C2 (ko) 1990-02-22
ATA70983A (de) 1989-08-15
SE8301129L (sv) 1983-09-03

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