HRP20090146T3 - Camptothecins conjugated in position 7 to cyclic peptides as cytostatic agents - Google Patents

Camptothecins conjugated in position 7 to cyclic peptides as cytostatic agents

Info

Publication number
HRP20090146T3
HRP20090146T3 HR20090146T HRP20090146T HRP20090146T3 HR P20090146 T3 HRP20090146 T3 HR P20090146T3 HR 20090146 T HR20090146 T HR 20090146T HR P20090146 T HRP20090146 T HR P20090146T HR P20090146 T3 HRP20090146 T3 HR P20090146T3
Authority
HR
Croatia
Prior art keywords
group
branched
linear
alkylene
alkyl
Prior art date
Application number
HR20090146T
Other languages
English (en)
Croatian (hr)
Inventor
Del Pozzo Alma
Penco Sergio
Merlini Lucio
Giannini Giuseppe
Ornella Tinti Maria
Pisano Claudio
Zunino Franco
Alloatti Domenico
Vesci Loredana
Dallavalle Sabrina
Ming Hong Ni
Original Assignee
Sigma-Tau Industrie Farmaceutiche Riunite S.P.A.
Istituto Nazionale Per Lo Studio E La Cura Dei Tumori
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma-Tau Industrie Farmaceutiche Riunite S.P.A., Istituto Nazionale Per Lo Studio E La Cura Dei Tumori filed Critical Sigma-Tau Industrie Farmaceutiche Riunite S.P.A.
Publication of HRP20090146T3 publication Critical patent/HRP20090146T3/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50Cyclic peptides containing at least one abnormal peptide link
    • C07K7/52Cyclic peptides containing at least one abnormal peptide link with only normal peptide links in the ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64Cyclic peptides containing only normal peptide links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HR20090146T 2004-05-13 2009-03-11 Camptothecins conjugated in position 7 to cyclic peptides as cytostatic agents HRP20090146T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT000240A ITRM20040240A1 (it) 2004-05-13 2004-05-13 Camptotecine coniugate in posizione 7 con antagonisti delle integrine.
PCT/IT2005/000260 WO2005111063A1 (en) 2004-05-13 2005-05-04 Camptothecins conjugated in position 7 to cyclic peptides as cytostatic agents

Publications (1)

Publication Number Publication Date
HRP20090146T3 true HRP20090146T3 (en) 2009-05-31

Family

ID=34968014

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20090146T HRP20090146T3 (en) 2004-05-13 2009-03-11 Camptothecins conjugated in position 7 to cyclic peptides as cytostatic agents

Country Status (23)

Country Link
US (1) US7705012B2 (it)
EP (1) EP1753776B1 (it)
JP (1) JP4805917B2 (it)
KR (1) KR101145815B1 (it)
CN (1) CN1953989B (it)
AR (1) AR048949A1 (it)
AT (1) ATE420891T1 (it)
AU (1) AU2005243417B2 (it)
BR (1) BRPI0510983A (it)
CA (1) CA2563708A1 (it)
CY (1) CY1108985T1 (it)
DE (1) DE602005012390D1 (it)
DK (1) DK1753776T3 (it)
ES (1) ES2321114T3 (it)
HR (1) HRP20090146T3 (it)
IT (1) ITRM20040240A1 (it)
MX (1) MXPA06012884A (it)
PL (1) PL1753776T3 (it)
PT (1) PT1753776E (it)
RS (1) RS51169B (it)
SI (1) SI1753776T1 (it)
TW (1) TWI352703B (it)
WO (1) WO2005111063A1 (it)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITRM20040239A1 (it) * 2004-05-13 2004-08-13 Sigma Tau Ind Farmaceuti Derivati ciclopeptidici ad attivita' antintegrine.
US8853233B2 (en) * 2007-02-13 2014-10-07 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Broad-spectrum anti-cancer treatment based on iminocamptothecin derivatives
TW201004647A (en) * 2008-05-20 2010-02-01 Sigma Tau Ind Farmaceuti Novel dual targeting antitumoural conjugates
US8853151B2 (en) * 2009-06-30 2014-10-07 The Regents Of The University Of Michigan Pro-drug complexes and related methods of use
US9073974B2 (en) 2009-12-21 2015-07-07 The Regents Of The University Of California RGD-containing cyclic peptides
WO2011100688A1 (en) 2010-02-12 2011-08-18 Dana-Farber Cancer Institute, Inc. Improved antagonists of muc1
WO2013026015A1 (en) 2011-08-18 2013-02-21 Dana-Farber Cancer Institute, Inc. Muc1 ligand traps for use in treating cancers
CN102516258B (zh) * 2011-11-11 2014-06-25 正大天晴药业集团股份有限公司 水溶性维生素e衍生物修饰的脂溶性抗癌药物化合物和制剂、该化合物的制备方法及应用
US9044421B2 (en) 2012-03-28 2015-06-02 Genus Oncology, Llc Treating MUC1-expressing cancers with combination therapies
EP3310787B9 (en) 2015-06-18 2020-07-01 Ramot at Tel-Aviv University Ltd. Taggable heteroaromatic drugs and conjugates thereof
US10494403B2 (en) * 2018-03-06 2019-12-03 Ciphore Biomed Technology Limited Company Cyclopeptide, pharmaceutical or cosmetic composition comprising the same and method for preparing the same

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0540099T3 (da) * 1991-10-29 1996-06-17 Glaxo Wellcome Inc Vandopløselige camptothecinderivater
US5646159A (en) * 1994-07-20 1997-07-08 Research Triangle Institute Water-soluble esters of camptothecin compounds
CA2192725C (en) 1995-12-28 2004-04-20 Kenji Tsujihara Camptothecin derivatives
PT1017675E (pt) * 1997-02-14 2006-09-29 Bionumerik Pharmaceuticals Inc Derivados da camtotecina altamente lipofilos
DE19815812A1 (de) * 1998-04-08 1999-10-14 Bayer Ag Modifizierte Cytostatika
DE69901379T2 (de) 1999-03-09 2002-11-07 Sigma Tau Ind Farmaceuti Camptothecin-Derivate mit Antitumor-Wirkung
RU2002109215A (ru) * 1999-09-08 2003-12-10 Байер Акциенгезельшафт (De) Индуцированное интегрином влияние на место действия лекарственного средства
AU2002220593A1 (en) * 2000-10-06 2002-04-15 Novartis Ag Targeting molecules for adenoviral vectors
WO2002096367A2 (en) * 2001-05-30 2002-12-05 Targesome, Inc. Targeted multivalent macromolecules

Also Published As

Publication number Publication date
KR101145815B1 (ko) 2012-05-16
AR048949A1 (es) 2006-06-14
BRPI0510983A (pt) 2007-12-04
US20080033003A1 (en) 2008-02-07
CA2563708A1 (en) 2005-11-24
ES2321114T3 (es) 2009-06-02
CN1953989B (zh) 2012-10-10
CN1953989A (zh) 2007-04-25
EP1753776B1 (en) 2009-01-14
ITRM20040240A1 (it) 2004-08-13
TW200606165A (en) 2006-02-16
JP2008504235A (ja) 2008-02-14
WO2005111063A1 (en) 2005-11-24
AU2005243417B2 (en) 2011-07-07
CY1108985T1 (el) 2014-07-02
RS51169B (sr) 2010-10-31
TWI352703B (en) 2011-11-21
PT1753776E (pt) 2009-03-05
EP1753776A1 (en) 2007-02-21
PL1753776T3 (pl) 2009-06-30
SI1753776T1 (sl) 2009-06-30
DK1753776T3 (da) 2009-05-11
MXPA06012884A (es) 2007-02-15
US7705012B2 (en) 2010-04-27
ATE420891T1 (de) 2009-01-15
JP4805917B2 (ja) 2011-11-02
AU2005243417A2 (en) 2005-11-24
KR20070012530A (ko) 2007-01-25
AU2005243417A1 (en) 2005-11-24
DE602005012390D1 (de) 2009-03-05

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