HRP20080274T3 - 2-(1h-indolilsulfanil)-benzil amin derivati kao ssri - Google Patents

2-(1h-indolilsulfanil)-benzil amin derivati kao ssri

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Publication number
HRP20080274T3
HRP20080274T3 HR20080274T HRP20080274T HRP20080274T3 HR P20080274 T3 HRP20080274 T3 HR P20080274T3 HR 20080274 T HR20080274 T HR 20080274T HR P20080274 T HRP20080274 T HR P20080274T HR P20080274 T3 HRP20080274 T3 HR P20080274T3
Authority
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Croatia
Prior art keywords
indolylsulfanyl
ssri
amine derivatives
benzyl amine
benzyl
Prior art date
Application number
HR20080274T
Other languages
English (en)
Inventor
Kehler Jan
Juhl Karsten
Sejberg Jimmy
Bang Norgaard Morten
Original Assignee
H. Lundbeck A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H. Lundbeck A/S filed Critical H. Lundbeck A/S
Publication of HRP20080274T3 publication Critical patent/HRP20080274T3/hr

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/06—Anti-spasmodics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Anesthesiology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Spoj opće formule 1 : u kojem je atom sumpora pričvršćen na indol preko ugljikovog prstena indola iu kojem- R1-R2 se nezavisno biraju iz vodika, C1-6-alk(en/in)il, C3-8-cikloalk(en)il i C3-8-cikloalk(en), ili R1 i R2 zajedno s dušikom tvore 4-7-člani prsten koji sadrži nula ili jednu dvostruku svezu a, opcionalno, rečeni prsten, uz rečeni dušik, sadrži i još jedan heteroatom izabran iz dušika, kisika i sumpora; - R3-R12 se nezavisno biraju iz vodika, halogena, cijana, nitro, C1-6-alk(en/in)il,C3-8-cikloalk(en)il, C3-8-cikloalk(en)il-C1-6-alk(en/in)il, amino, C1-6-alk(en/in)ilamino, di-(C1-6-alk(en/in)il)amino, C1-6-alk(en/in)ilkarbonil, aminokarbonil, C1-6-alk(en/in)ililaminokarbonil, di-(C1-6-alk(en/in)il)aminokarbonil, hidroksi, C1-6-alk(en/in)iloksi, C1-6-alk(en/in)iltio, halo-C1-6-alk(en/in)il, halo-C1-6-alk(en/in)ilsulfonil, halo-C1-6-alk(en/in)ilsulfanil i C1-6-alk(en/in)ilsulfonil i- R13 se bira iz vodika i C1-6-alkil- pod uvjetom da se R10 bira iz vodika, halogena, cijana, C1-6-alk(en/in)il, hidroksil, i halo-C1-6-alk(en/in)il kao slobodna baza ili njezina sol, pod uvjetomda- ako je atom sumpora pričvršćen preko atoma br. 2 indola, tada R7 ne postoji; - ako je atom sumpora pričvršćen preko atoma br. 3 indola, tada R12 ne postoji; - ako je atom sumpora pričvršćen prekoatoma br. 4 indola, tada R8 ne postoji; - ako je atom sumpora pričvršćen preko atoma br. 5 indola, tada R9 ne postojiako je atom sumpora pričvršćen preko atoma br. 7 indola, tada R11 ne postoji. Patent sadrži još 16 patentnih zahtjeva.
HR20080274T 2003-12-23 2008-06-19 2-(1h-indolilsulfanil)-benzil amin derivati kao ssri HRP20080274T3 (hr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US53259303P 2003-12-23 2003-12-23
DKPA200301923 2003-12-23
PCT/DK2004/000894 WO2005061455A1 (en) 2003-12-23 2004-12-21 2-(1h-indolylsulfanyl)-benzyl amine derivatives as ssri

Publications (1)

Publication Number Publication Date
HRP20080274T3 true HRP20080274T3 (hr) 2008-12-31

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HR20080274T HRP20080274T3 (hr) 2003-12-23 2008-06-19 2-(1h-indolilsulfanil)-benzil amin derivati kao ssri
HR20110400T HRP20110400T1 (hr) 2003-12-23 2011-05-27 Derivati 2-(1h-indolilsulfanil)-benzil amina kao ssri

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HR20110400T HRP20110400T1 (hr) 2003-12-23 2011-05-27 Derivati 2-(1h-indolilsulfanil)-benzil amina kao ssri

Country Status (18)

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US (4) US7563908B2 (hr)
EP (1) EP1701940B1 (hr)
JP (3) JP4090491B2 (hr)
AT (1) ATE396970T1 (hr)
AU (1) AU2004303461B2 (hr)
BR (1) BRPI0417858B1 (hr)
CY (2) CY1108230T1 (hr)
DE (1) DE602004014190D1 (hr)
DK (1) DK1701940T3 (hr)
ES (1) ES2303960T3 (hr)
HR (2) HRP20080274T3 (hr)
IL (1) IL176111A (hr)
MX (1) MXPA06007172A (hr)
PL (1) PL1701940T3 (hr)
PT (1) PT1701940E (hr)
RS (1) RS50589B (hr)
SI (1) SI1701940T1 (hr)
WO (1) WO2005061455A1 (hr)

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US7737171B2 (en) 2010-06-15
US20080214644A1 (en) 2008-09-04
IL176111A (en) 2011-10-31
DE602004014190D1 (de) 2008-07-10
US20060160880A1 (en) 2006-07-20
WO2005061455A1 (en) 2005-07-07
AU2004303461A1 (en) 2005-07-07
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PT1701940E (pt) 2008-07-30
MXPA06007172A (es) 2006-08-23
CY1108230T1 (el) 2014-02-12
BRPI0417858A (pt) 2007-04-27
ATE396970T1 (de) 2008-06-15
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PL1701940T3 (pl) 2008-11-28
US7652150B2 (en) 2010-01-26
DK1701940T3 (da) 2008-09-08
IL176111A0 (en) 2006-10-05
US20080176922A1 (en) 2008-07-24
RS50589B (sr) 2010-05-07
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US20080214645A1 (en) 2008-09-04
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BRPI0417858B1 (pt) 2017-10-10
US7563908B2 (en) 2009-07-21

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