HRP20080186T3 - Use of tricyclic compounds as glycine transport inhibitors - Google Patents

Use of tricyclic compounds as glycine transport inhibitors

Info

Publication number
HRP20080186T3
HRP20080186T3 HR20080186T HRP20080186T HRP20080186T3 HR P20080186 T3 HRP20080186 T3 HR P20080186T3 HR 20080186 T HR20080186 T HR 20080186T HR P20080186 T HRP20080186 T HR P20080186T HR P20080186 T3 HRP20080186 T3 HR P20080186T3
Authority
HR
Croatia
Prior art keywords
group
alkyl
phenyl
groups
optionally substituted
Prior art date
Application number
HR20080186T
Other languages
English (en)
Croatian (hr)
Inventor
Dargazanli Gihad
Estenne-Bouhtou Geneviève
Magat Pascale
Marabout Beno�t
Roger Pierre
Original Assignee
Sanofi-Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi-Aventis filed Critical Sanofi-Aventis
Publication of HRP20080186T3 publication Critical patent/HRP20080186T3/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Rheumatology (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HR20080186T 2003-10-17 2004-10-15 Use of tricyclic compounds as glycine transport inhibitors HRP20080186T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0312165A FR2861076B1 (fr) 2003-10-17 2003-10-17 Derives de n-heterocyclymethylbenzamide, leur preparation et leur application en therapeutique
PCT/FR2004/002643 WO2005037783A2 (fr) 2003-10-17 2004-10-15 Composes tricycliques comme inhibiteurs de transport de glycine

Publications (1)

Publication Number Publication Date
HRP20080186T3 true HRP20080186T3 (en) 2008-05-31

Family

ID=34385252

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20080186T HRP20080186T3 (en) 2003-10-17 2004-10-15 Use of tricyclic compounds as glycine transport inhibitors

Country Status (32)

Country Link
US (3) US7288656B2 (OSRAM)
EP (1) EP1680421B1 (OSRAM)
JP (1) JP4853918B2 (OSRAM)
KR (1) KR101125305B1 (OSRAM)
CN (2) CN1882587B (OSRAM)
AT (1) ATE386036T1 (OSRAM)
AU (1) AU2004281217B2 (OSRAM)
BR (1) BRPI0415489A (OSRAM)
CA (1) CA2542647C (OSRAM)
CR (1) CR8342A (OSRAM)
CY (1) CY1108925T1 (OSRAM)
DE (1) DE602004011806T2 (OSRAM)
DK (1) DK1680421T3 (OSRAM)
EC (1) ECSP066511A (OSRAM)
ES (1) ES2300837T3 (OSRAM)
FR (1) FR2861076B1 (OSRAM)
HR (1) HRP20080186T3 (OSRAM)
IL (1) IL174940A (OSRAM)
MA (1) MA28099A1 (OSRAM)
ME (1) ME00111B (OSRAM)
NO (1) NO335462B1 (OSRAM)
NZ (1) NZ547163A (OSRAM)
OA (1) OA13317A (OSRAM)
PL (1) PL1680421T3 (OSRAM)
PT (1) PT1680421E (OSRAM)
RS (2) RS51587B (OSRAM)
RU (1) RU2346945C2 (OSRAM)
SG (1) SG147435A1 (OSRAM)
TN (1) TNSN06110A1 (OSRAM)
UA (1) UA81186C2 (OSRAM)
WO (1) WO2005037783A2 (OSRAM)
ZA (1) ZA200603861B (OSRAM)

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FR2842804B1 (fr) 2002-07-29 2004-09-03 Sanofi Synthelabo Derives de n-[phenyl(piperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique
FR2861071B1 (fr) * 2003-10-17 2006-01-06 Sanofi Synthelabo Derives de n-[phenyl(alkylpiperidin-2-yl) methyl]benzamide, leur prepartation et leur application en therapeutique
FR2861074B1 (fr) * 2003-10-17 2006-04-07 Sanofi Synthelabo Derives de n-[phenyl(piperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique
FR2861076B1 (fr) * 2003-10-17 2006-01-06 Sanofi Synthelabo Derives de n-heterocyclymethylbenzamide, leur preparation et leur application en therapeutique
WO2006038070A2 (en) * 2004-03-30 2006-04-13 Painceptor Pharma Corporation Compositions and methods for modulating gated ion channels
FR2906251B1 (fr) * 2006-09-22 2008-11-07 Sanofi Aventis Sa Derives de pyrrolizine, indolizine et quinolizine, leur preparation et leur application en therapeutique
US11817637B2 (en) 2006-11-18 2023-11-14 Rfmicron, Inc. Radio frequency identification (RFID) moisture tag(s) and sensors with extended sensing via capillaries
WO2009013535A1 (en) * 2007-07-23 2009-01-29 Astrazeneca Ab 2-azabicyclo(2.2.2)octane derivatives as modulators of the glycine transporter i receptor
CN101784533B (zh) 2007-08-22 2013-08-21 艾博特股份有限两合公司 4-苄基氨基喹啉、含有它们的药物组合物和它们在治疗中的用途
ES2397764T3 (es) 2008-04-01 2013-03-11 Abbott Gmbh & Co. Kg Tetrahidroisoquinolinas, composiciones farmacéuticas que las contienen, y su uso en terapia
JP2012511006A (ja) * 2008-12-04 2012-05-17 サノフイ アザビシクロ−トリフルオロメチルベンズアミド誘導体の新規な結晶多形
WO2010087761A1 (en) * 2009-01-28 2010-08-05 Astrazeneca Ab 2-aza-bicyclo[2.2.2]octane compounds and uses thereof
UY32397A (es) * 2009-01-28 2010-08-31 Astrazeneca Ab Compuestos de 2-aza-biciclo [2,2,1] heptano y sus usos
FR2941954B1 (fr) * 2009-02-10 2011-04-08 Sanofi Aventis Derives de n-°(6-aza-bicyclo°3.2.1!oct-1-yl)-aryl-methyl! benzamide, leur preparation et leur application en therapeutique
FR2941953B1 (fr) * 2009-02-10 2011-04-08 Sanofi Aventis Derives de n-°(2-aza-bicyclo°2.1.1!hex-1-yl)-benzamide, leur preparation et leur application en therapeutique
TW201038569A (en) 2009-02-16 2010-11-01 Abbott Gmbh & Co Kg Heterocyclic compounds, pharmaceutical compositions containing them, and their use in therapy
AR075442A1 (es) 2009-02-16 2011-03-30 Abbott Gmbh & Co Kg Derivados de aminotetralina, composiciones farmaceuticas que las contienen y sus usos en terapia
RU2011141778A (ru) * 2009-03-16 2013-04-27 Санофи Производные n-[(2-азабицикло[2.1.1]гекс-1-ил)арилметил]гетеробензамида, их получение и их применение в терапии
FR2943059A1 (fr) * 2009-03-16 2010-09-17 Sanofi Aventis Derives de n-°6-aza-bicyclo°3.2.1!oct-5-yl)-aryl-methyl!- heterobenzamide,leur preparation et leur application en therapeutique
FR2943056A1 (fr) * 2009-03-16 2010-09-17 Sanofi Aventis Derives de n-°2-aza-bicyclo°2.1.1!hex-1-yl)-aryl-methyl!- heterobenzamide, leur preparation et leur application en therapeutique
FR2944284A1 (fr) * 2009-04-14 2010-10-15 Sanofi Aventis Derives de n-°7-aza-bicyclo°2.2.1!hept-1-yl)-aryl-methyl! -benzamide, leur preparation et leur application en therapeutique
US8153653B2 (en) * 2010-06-22 2012-04-10 Hoffmann-La Roche Inc. Amido-tropane derivatives
US8846743B2 (en) 2010-08-13 2014-09-30 Abbott Laboratories Aminoindane derivatives, pharmaceutical compositions containing them, and their use in therapy
US8877794B2 (en) 2010-08-13 2014-11-04 Abbott Laboratories Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy
US9051280B2 (en) 2010-08-13 2015-06-09 AbbVie Deutschland GmbH & Co. KG Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy
US9045459B2 (en) * 2010-08-13 2015-06-02 AbbVie Deutschland GmbH & Co. KG Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy
US8883839B2 (en) 2010-08-13 2014-11-11 Abbott Laboratories Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy
US9309200B2 (en) 2011-05-12 2016-04-12 AbbVie Deutschland GmbH & Co. KG Benzazepine derivatives, pharmaceutical compositions containing them, and their use in therapy
US8853196B2 (en) 2011-08-05 2014-10-07 AbbVie Deutschland GmbH & Co. KG Aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives, pharmaceutical compositions containing them, and their use in therapy
CA2853254A1 (en) 2011-11-18 2013-05-23 Abbvie Inc. N-substituted aminobenzocycloheptene, aminotetraline, aminoindane and phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy
EP2786986B1 (en) * 2011-11-29 2018-02-28 Vivozon, Inc. Novel benzamide derivative and use thereof
US9365512B2 (en) 2012-02-13 2016-06-14 AbbVie Deutschland GmbH & Co. KG Isoindoline derivatives, pharmaceutical compositions containing them, and their use in therapy
US9656955B2 (en) 2013-03-15 2017-05-23 Abbvie Inc. Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy
US9650334B2 (en) 2013-03-15 2017-05-16 Abbvie Inc. Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy
MX2016004936A (es) 2013-10-17 2016-12-20 Abbvie Deutschland Derivados de aminocromano, aminotiocromano y amino-1,2,3,4-tetrahi droquinilina, composiciones farmaceuticas que los contienen, y su uso en terapia.
CA2924699A1 (en) 2013-10-17 2015-04-23 AbbVie Deutschland GmbH & Co. KG Aminotetraline and aminoindane derivatives, pharmaceutical compositions containing them, and their use in therapy
US9550754B2 (en) 2014-09-11 2017-01-24 AbbVie Deutschland GmbH & Co. KG 4,5-dihydropyrazole derivatives, pharmaceutical compositions containing them, and their use in therapy
WO2016060938A2 (en) 2014-10-08 2016-04-21 RF Micron, Inc. Radio frequency identification (rfid) moisture tag(s) and sensors with extended sensing via capillaries
JP6906227B2 (ja) * 2017-08-18 2021-07-21 国立大学法人千葉大学 ハロゲン結合ドナー／有機塩基複合型化合物及び酸塩基複合触媒

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Also Published As

Publication number Publication date
ES2300837T3 (es) 2008-06-16
JP4853918B2 (ja) 2012-01-11
FR2861076A1 (fr) 2005-04-22
US8513246B2 (en) 2013-08-20
ME00111B (me) 2010-10-10
MA28099A1 (fr) 2006-08-01
WO2005037783A2 (fr) 2005-04-28
HK1098465A1 (en) 2007-07-20
US20080070941A1 (en) 2008-03-20
US20060264441A1 (en) 2006-11-23
KR20060109432A (ko) 2006-10-20
ATE386036T1 (de) 2008-03-15
RS20060314A (sr) 2008-08-07
RU2006116889A (ru) 2007-11-27
UA81186C2 (en) 2007-12-10
NZ547163A (en) 2010-01-29
CA2542647C (fr) 2012-07-10
EP1680421B1 (fr) 2008-02-13
JP2007508361A (ja) 2007-04-05
ZA200603861B (en) 2007-12-27
NO20062030L (no) 2006-07-07
PT1680421E (pt) 2008-05-13
DK1680421T3 (da) 2008-06-09
NO335462B1 (no) 2014-12-15
IL174940A (en) 2010-11-30
OA13317A (fr) 2007-04-13
PL1680421T3 (pl) 2008-07-31
CN101684118B (zh) 2013-04-10
TNSN06110A1 (fr) 2007-11-15
CN1882587B (zh) 2012-06-27
MEP12208A (en) 2010-06-10
CR8342A (es) 2006-10-04
DE602004011806D1 (de) 2008-03-27
WO2005037783A3 (fr) 2005-07-07
HK1142887A1 (en) 2010-12-17
AU2004281217B2 (en) 2010-07-22
US7288656B2 (en) 2007-10-30
CA2542647A1 (fr) 2005-04-28
CN101684118A (zh) 2010-03-31
CY1108925T1 (el) 2014-07-02
RU2346945C2 (ru) 2009-02-20
IL174940A0 (en) 2006-08-20
FR2861076B1 (fr) 2006-01-06
SG147435A1 (en) 2008-11-28
RS51587B (sr) 2011-08-31
ECSP066511A (es) 2006-10-10
DE602004011806T2 (de) 2009-02-05
KR101125305B1 (ko) 2012-03-27
CN1882587A (zh) 2006-12-20
EP1680421A2 (fr) 2006-07-19
AU2004281217A1 (en) 2005-04-28
BRPI0415489A (pt) 2006-12-26
US20100022548A1 (en) 2010-01-28
US7619089B2 (en) 2009-11-17

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