HRP20070429T3 - Crystal form of asenapine maleate - Google Patents
Crystal form of asenapine maleateInfo
- Publication number
- HRP20070429T3 HRP20070429T3 HR20070429T HRP20070429T HRP20070429T3 HR P20070429 T3 HRP20070429 T3 HR P20070429T3 HR 20070429 T HR20070429 T HR 20070429T HR P20070429 T HRP20070429 T HR P20070429T HR P20070429 T3 HRP20070429 T3 HR P20070429T3
- Authority
- HR
- Croatia
- Prior art keywords
- crystal form
- asenapine maleate
- asenapine
- maleate
- oxepino
- Prior art date
Links
- GMDCDXMAFMEDAG-CHHFXETESA-N (S,S)-asenapine maleate Chemical compound OC(=O)\C=C/C(O)=O.O1C2=CC=CC=C2[C@H]2CN(C)C[C@@H]2C2=CC(Cl)=CC=C21 GMDCDXMAFMEDAG-CHHFXETESA-N 0.000 title 1
- 229960001615 asenapine maleate Drugs 0.000 title 1
- 239000013078 crystal Substances 0.000 title 1
- VSWBSWWIRNCQIJ-HUUCEWRRSA-N (S,S)-asenapine Chemical compound O1C2=CC=CC=C2[C@H]2CN(C)C[C@@H]2C2=CC(Cl)=CC=C21 VSWBSWWIRNCQIJ-HUUCEWRRSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05102742 | 2005-04-07 | ||
| EP05102969 | 2005-04-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20070429T3 true HRP20070429T3 (en) | 2007-11-30 |
Family
ID=36617328
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20070429T HRP20070429T3 (en) | 2005-04-07 | 2007-09-19 | Crystal form of asenapine maleate |
Country Status (31)
| Country | Link |
|---|---|
| EP (2) | EP1917267B1 (ko) |
| JP (1) | JP5058151B2 (ko) |
| KR (1) | KR101422843B1 (ko) |
| AR (1) | AR056306A1 (ko) |
| AT (2) | ATE370954T1 (ko) |
| AU (1) | AU2006231617B2 (ko) |
| BR (1) | BRPI0609741A8 (ko) |
| CA (1) | CA2603509C (ko) |
| CY (2) | CY1106902T1 (ko) |
| DE (2) | DE602006004463D1 (ko) |
| DK (2) | DK1917267T3 (ko) |
| DO (1) | DOP2006000082A (ko) |
| ES (2) | ES2318742T3 (ko) |
| GT (1) | GT200600135A (ko) |
| HN (1) | HN2006014095A (ko) |
| HR (1) | HRP20070429T3 (ko) |
| IL (1) | IL186355A (ko) |
| MX (1) | MX2007012445A (ko) |
| MY (1) | MY137969A (ko) |
| NO (1) | NO340520B1 (ko) |
| NZ (1) | NZ562124A (ko) |
| PE (1) | PE20061311A1 (ko) |
| PL (2) | PL1917267T3 (ko) |
| PT (2) | PT1710245E (ko) |
| RS (1) | RS50532B (ko) |
| RU (1) | RU2405786C2 (ko) |
| SI (2) | SI1710245T1 (ko) |
| SV (1) | SV2006002473A (ko) |
| TW (1) | TWI364423B (ko) |
| UY (1) | UY29459A1 (ko) |
| WO (1) | WO2006106135A1 (ko) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20081457A1 (es) * | 2006-10-06 | 2008-10-18 | Organon Nv | Asenapina amorfa, procesos para prepararlas y su uso para tratar trastornos del sistema nervioso central |
| BRPI1011453A2 (pt) * | 2009-06-24 | 2016-03-15 | Msd Oss Bv | formulacao, forma de dosagem de um medicamento, e, sal de hemipamoato de asenapina |
| EP2582704A4 (en) * | 2010-06-18 | 2014-04-02 | Reddys Lab Ltd Dr | Asenapine MALEATE |
| WO2012066565A2 (en) * | 2010-11-16 | 2012-05-24 | Cadila Healthcare Limited | Asenapine maleate amorphous and crystalline form and process for preparation thereof |
| EP2468750A1 (en) | 2010-12-13 | 2012-06-27 | Chemo Ibérica, S.A. | Polymorphic forms of asenapine maleate and processes for their preparation |
| WO2012123325A1 (en) | 2011-03-11 | 2012-09-20 | Medichem S.A. | NEW CRYSTAL FORMS OF THE SALT OF TRANS-5-CHLORO-2-METHYL-2,3,3A,12b-TETRAHYDRO-1H-DIBENZO[2,3:6,7]OXEPINO[4,5-c]PYRROLE WITH MALEIC ACID |
| ITMI20110734A1 (it) * | 2011-05-02 | 2012-11-03 | Olon Spa | Sali cristallini di asenapina |
| EP2524921A1 (en) | 2011-05-17 | 2012-11-21 | Sandoz AG | Novel Crystalline Salts of Asenapine |
| EP2524919A1 (en) | 2011-05-17 | 2012-11-21 | Sandoz AG | Novel crystalline salts of Asenapine with organic Di-acids and Tri-acids |
| EP2524920A1 (en) | 2011-05-17 | 2012-11-21 | Sandoz AG | Novel Crystalline Asenapine Hydrochloride Salt Forms |
| WO2012156676A1 (en) * | 2011-05-18 | 2012-11-22 | Laboratorios Lesvi S.L. | Monoclinic crystalline form of asenapine maleate with a specific particle size distribution |
| ES2665843T3 (es) * | 2011-05-18 | 2018-04-27 | Laboratorios Lesvi, S.L. | Síntesis de una forma de maleato de asenapina monoclínica micronizada estable |
| EP2572703A1 (en) | 2011-09-21 | 2013-03-27 | Hexal AG | Compressed oral dosage form for asenapine maleate |
| WO2013041604A1 (en) | 2011-09-21 | 2013-03-28 | Sandoz Ag | Crystal form of asenapine maleate |
| KR102013477B1 (ko) * | 2012-07-26 | 2019-08-22 | 히사미쓰 세이야꾸 가부시키가이샤 | 첩부제 |
| ITMI20121810A1 (it) | 2012-10-24 | 2014-04-25 | Chemo Iberica Sa | Poliformi di maleato di asenapina e processo per la loro preparazione |
| WO2014090386A1 (en) | 2012-12-11 | 2014-06-19 | Alfred E. Tiefenbacher (Gmbh & Co. Kg) | Orally disintegrating tablet containing asenapine |
| WO2014127786A1 (en) | 2013-02-22 | 2014-08-28 | Zentiva, K.S. | Orally disintegrating pharmaceutical composition comprising asenapine |
| US10786520B2 (en) | 2015-09-02 | 2020-09-29 | Eloxx Pharmaceuticals Ltd. | Aminoglycoside derivatives and uses thereof in treating genetic disorders |
| US20180193283A1 (en) | 2016-12-20 | 2018-07-12 | Lts Lohmann Therapie-Systeme Ag | Transdermal therapeutic system containing asenapine |
| US11337932B2 (en) | 2016-12-20 | 2022-05-24 | Lts Lohmann Therapie-Systeme Ag | Transdermal therapeutic system containing asenapine and polysiloxane or polyisobutylene |
| EP3644973B1 (en) | 2017-06-26 | 2021-03-24 | LTS LOHMANN Therapie-Systeme AG | Transdermal therapeutic system containing asenapine and silicone acrylic hybrid polymer |
| JP2021529737A (ja) | 2018-06-20 | 2021-11-04 | エルテーエス ローマン テラピー−ジステーメ アーゲー | アセナピンを含有する経皮治療システム |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL7605526A (nl) * | 1976-05-24 | 1977-11-28 | Akzo Nv | Nieuwe tetracyclische derivaten. |
| NZ282394A (en) * | 1994-03-02 | 1997-12-19 | Akzo Nobel Nv | Dissolving tablets contain a dibenz[2,3:6,7] oxepino[4,5-c]pyrrole derivative for sublingual or buccal administration |
| WO1999032108A1 (en) * | 1997-12-19 | 1999-07-01 | Akzo Nobel N.V. | Org-5222 in the treatment of depression |
| TWI327915B (en) * | 2003-06-12 | 2010-08-01 | Organon Nv | Pharmaceutical composition comprising antipsychotic agent and use of the antipsychotic agent for treating patients with overweight |
-
2006
- 2006-04-06 PT PT06112332T patent/PT1710245E/pt unknown
- 2006-04-06 DO DO2006P000082A patent/DOP2006000082A/es unknown
- 2006-04-06 TW TW095112187A patent/TWI364423B/zh active
- 2006-04-06 ES ES06725622T patent/ES2318742T3/es active Active
- 2006-04-06 NZ NZ562124A patent/NZ562124A/en unknown
- 2006-04-06 UY UY29459A patent/UY29459A1/es not_active Application Discontinuation
- 2006-04-06 MY MYPI20061554A patent/MY137969A/en unknown
- 2006-04-06 SI SI200630006T patent/SI1710245T1/sl unknown
- 2006-04-06 ES ES06112332T patent/ES2293626T3/es active Active
- 2006-04-06 DE DE602006004463T patent/DE602006004463D1/de active Active
- 2006-04-06 GT GT200600135A patent/GT200600135A/es unknown
- 2006-04-06 BR BRPI0609741A patent/BRPI0609741A8/pt not_active IP Right Cessation
- 2006-04-06 WO PCT/EP2006/061408 patent/WO2006106135A1/en active Application Filing
- 2006-04-06 HN HN2006014095A patent/HN2006014095A/es unknown
- 2006-04-06 MX MX2007012445A patent/MX2007012445A/es active IP Right Grant
- 2006-04-06 AR ARP060101358A patent/AR056306A1/es not_active Application Discontinuation
- 2006-04-06 JP JP2008504776A patent/JP5058151B2/ja active Active
- 2006-04-06 CA CA2603509A patent/CA2603509C/en active Active
- 2006-04-06 AT AT06112332T patent/ATE370954T1/de active
- 2006-04-06 DE DE602006000080T patent/DE602006000080T2/de active Active
- 2006-04-06 RS RSP-2007/0436A patent/RS50532B/sr unknown
- 2006-04-06 PT PT06725622T patent/PT1917267E/pt unknown
- 2006-04-06 PE PE2006000377A patent/PE20061311A1/es active IP Right Grant
- 2006-04-06 KR KR1020077025428A patent/KR101422843B1/ko active IP Right Grant
- 2006-04-06 DK DK06725622T patent/DK1917267T3/da active
- 2006-04-06 EP EP06725622A patent/EP1917267B1/en active Active
- 2006-04-06 SV SV2006002473A patent/SV2006002473A/es unknown
- 2006-04-06 DK DK06112332T patent/DK1710245T3/da active
- 2006-04-06 AU AU2006231617A patent/AU2006231617B2/en active Active
- 2006-04-06 EP EP06112332A patent/EP1710245B1/en active Active
- 2006-04-06 SI SI200630190T patent/SI1917267T1/sl unknown
- 2006-04-06 AT AT06725622T patent/ATE418556T1/de active
- 2006-04-06 PL PL06725622T patent/PL1917267T3/pl unknown
- 2006-04-06 RU RU2007141198/04A patent/RU2405786C2/ru active Protection Beyond IP Right Term
- 2006-04-06 PL PL06112332T patent/PL1710245T3/pl unknown
-
2007
- 2007-09-19 HR HR20070429T patent/HRP20070429T3/xx unknown
- 2007-10-02 CY CY20071101258T patent/CY1106902T1/el unknown
- 2007-10-07 IL IL186355A patent/IL186355A/en active IP Right Grant
- 2007-10-10 NO NO20075142A patent/NO340520B1/no unknown
-
2009
- 2009-01-30 CY CY20091100111T patent/CY1108742T1/el unknown
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