BRPI0609741A8 - composto, método de preparação e uso do mesmo, composição farmacêutica, e ,método para tratar distúrbios mentais em um mamífero. - Google Patents

composto, método de preparação e uso do mesmo, composição farmacêutica, e ,método para tratar distúrbios mentais em um mamífero.

Info

Publication number
BRPI0609741A8
BRPI0609741A8 BRPI0609741A BRPI0609741A BRPI0609741A8 BR PI0609741 A8 BRPI0609741 A8 BR PI0609741A8 BR PI0609741 A BRPI0609741 A BR PI0609741A BR PI0609741 A BRPI0609741 A BR PI0609741A BR PI0609741 A8 BRPI0609741 A8 BR PI0609741A8
Authority
BR
Brazil
Prior art keywords
compound
preparation
pharmaceutical composition
mammal
mental disorders
Prior art date
Application number
BRPI0609741A
Other languages
English (en)
Inventor
Johannes Heeres Gerhardus
Original Assignee
Merck Sharp & Dohme
Msd Oss Bv
N V Organon
Organon Biosciences Nederland B V
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36617328&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0609741(A8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Sharp & Dohme, Msd Oss Bv, N V Organon, Organon Biosciences Nederland B V filed Critical Merck Sharp & Dohme
Publication of BRPI0609741A2 publication Critical patent/BRPI0609741A2/pt
Publication of BRPI0609741A8 publication Critical patent/BRPI0609741A8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

composto, método de preparação e uso do mesmo, e, composição farmacêutica. a invenção refere-se a uma forma cristalina ortorrômbica de composto (z)-2-butenodioato de trans-5-cloro-2,3 ,3 a, 1 2b-tetraidro-2-metil- 1h-dibenz[2,3 :6,7]oxepino[4,5-c]pirrol, aos métodos para a preparação desta forma de cristal e às composições farmacêuticas compreendendo uma forma cristalina ortorrômbica.
BRPI0609741A 2005-04-07 2006-04-06 composto, método de preparação e uso do mesmo, composição farmacêutica, e ,método para tratar distúrbios mentais em um mamífero. BRPI0609741A8 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP05102742.3 2005-04-07
EP05102742 2005-04-07
EP05102969 2005-04-14
EP05102969.2 2005-04-14
PCT/EP2006/061408 WO2006106135A1 (en) 2005-04-07 2006-04-06 Crystal form of asenapine maleate

Publications (2)

Publication Number Publication Date
BRPI0609741A2 BRPI0609741A2 (pt) 2010-04-27
BRPI0609741A8 true BRPI0609741A8 (pt) 2018-03-13

Family

ID=36617328

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0609741A BRPI0609741A8 (pt) 2005-04-07 2006-04-06 composto, método de preparação e uso do mesmo, composição farmacêutica, e ,método para tratar distúrbios mentais em um mamífero.

Country Status (31)

Country Link
EP (2) EP1917267B1 (pt)
JP (1) JP5058151B2 (pt)
KR (1) KR101422843B1 (pt)
AR (1) AR056306A1 (pt)
AT (2) ATE418556T1 (pt)
AU (1) AU2006231617B2 (pt)
BR (1) BRPI0609741A8 (pt)
CA (1) CA2603509C (pt)
CY (2) CY1106902T1 (pt)
DE (2) DE602006000080T2 (pt)
DK (2) DK1710245T3 (pt)
DO (1) DOP2006000082A (pt)
ES (2) ES2318742T3 (pt)
GT (1) GT200600135A (pt)
HN (1) HN2006014095A (pt)
HR (1) HRP20070429T3 (pt)
IL (1) IL186355A (pt)
MX (1) MX2007012445A (pt)
MY (1) MY137969A (pt)
NO (1) NO340520B1 (pt)
NZ (1) NZ562124A (pt)
PE (1) PE20061311A1 (pt)
PL (2) PL1917267T3 (pt)
PT (2) PT1917267E (pt)
RS (1) RS50532B (pt)
RU (1) RU2405786C2 (pt)
SI (2) SI1917267T1 (pt)
SV (1) SV2006002473A (pt)
TW (1) TWI364423B (pt)
UY (1) UY29459A1 (pt)
WO (1) WO2006106135A1 (pt)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CL2007002891A1 (es) * 2006-10-06 2008-04-18 Organon Nv Trans-5-cloro-2-metil-2,3,3a,12b-tetrahidro-1h-dibenz-[2,3:6,7]oxepino[4,5-c]pirrol 50% amorfo en base al peso total del compuesto; procedimiento de preparacion; composicion farmaceutica; y uso para el tratamiento de un trastorno seleccionado entre e
TW201113018A (en) * 2009-06-24 2011-04-16 Organon Nv Injectable formulations containing asenapine and method of treatment using same
US8779161B2 (en) 2010-06-18 2014-07-15 Dr. Reddy's Laboratories Limited Asenapine maleate
WO2012066565A2 (en) * 2010-11-16 2012-05-24 Cadila Healthcare Limited Asenapine maleate amorphous and crystalline form and process for preparation thereof
EP2468750A1 (en) 2010-12-13 2012-06-27 Chemo Ibérica, S.A. Polymorphic forms of asenapine maleate and processes for their preparation
WO2012123325A1 (en) 2011-03-11 2012-09-20 Medichem S.A. NEW CRYSTAL FORMS OF THE SALT OF TRANS-5-CHLORO-2-METHYL-2,3,3A,12b-TETRAHYDRO-1H-DIBENZO[2,3:6,7]OXEPINO[4,5-c]PYRROLE WITH MALEIC ACID
ITMI20110734A1 (it) * 2011-05-02 2012-11-03 Olon Spa Sali cristallini di asenapina
EP2524920A1 (en) 2011-05-17 2012-11-21 Sandoz AG Novel Crystalline Asenapine Hydrochloride Salt Forms
EP2524919A1 (en) 2011-05-17 2012-11-21 Sandoz AG Novel crystalline salts of Asenapine with organic Di-acids and Tri-acids
EP2524921A1 (en) 2011-05-17 2012-11-21 Sandoz AG Novel Crystalline Salts of Asenapine
US9505771B2 (en) 2011-05-18 2016-11-29 Laboratories Lesvi S.L. Stable micronised monoclin form of asenapine maleate and its synthesis
WO2012156676A1 (en) 2011-05-18 2012-11-22 Laboratorios Lesvi S.L. Monoclinic crystalline form of asenapine maleate with a specific particle size distribution
WO2013041604A1 (en) 2011-09-21 2013-03-28 Sandoz Ag Crystal form of asenapine maleate
EP2572703A1 (en) 2011-09-21 2013-03-27 Hexal AG Compressed oral dosage form for asenapine maleate
KR102013476B1 (ko) * 2012-07-26 2019-08-22 히사미쓰 세이야꾸 가부시키가이샤 첩부제 및 그 제조 방법
ITMI20121810A1 (it) 2012-10-24 2014-04-25 Chemo Iberica Sa Poliformi di maleato di asenapina e processo per la loro preparazione
US9597291B2 (en) 2012-12-11 2017-03-21 Alfred E. Tiefenbacher (Gmbh & Co. Kg) Orally disintegrating tablet containing asenapine
WO2014127786A1 (en) 2013-02-22 2014-08-28 Zentiva, K.S. Orally disintegrating pharmaceutical composition comprising asenapine
US10786520B2 (en) 2015-09-02 2020-09-29 Eloxx Pharmaceuticals Ltd. Aminoglycoside derivatives and uses thereof in treating genetic disorders
MX2019007391A (es) 2016-12-20 2019-08-16 Lts Lohmann Therapie Systeme Ag Sistema terapeutico transdermico que contiene asenapina.
EP3558276A1 (en) 2016-12-20 2019-10-30 LTS Lohmann Therapie-Systeme AG Transdermal therapeutic system containing asenapine and polysiloxane or polyisobutylene
WO2019002204A1 (en) 2017-06-26 2019-01-03 Lts Lohmann Therapie-Systeme Ag TRANSDERMAL THERAPEUTIC SYSTEM CONTAINING ASENAPINE AND SILICONE-TYPE ACRYLIC HYBRID POLYMER
WO2019243452A1 (en) 2018-06-20 2019-12-26 Lts Lohmann Therapie-Systeme Ag Transdermal therapeutic system containing asenapine

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7605526A (nl) * 1976-05-24 1977-11-28 Akzo Nv Nieuwe tetracyclische derivaten.
HU225051B1 (en) * 1994-03-02 2006-05-29 Organon Ireland Ltd Sublingual or buccal pharmaceutical compositions containing trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1h-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole
WO1999032108A1 (en) * 1997-12-19 1999-07-01 Akzo Nobel N.V. Org-5222 in the treatment of depression
TWI327915B (en) * 2003-06-12 2010-08-01 Organon Nv Pharmaceutical composition comprising antipsychotic agent and use of the antipsychotic agent for treating patients with overweight

Also Published As

Publication number Publication date
IL186355A0 (en) 2008-01-20
PT1917267E (pt) 2009-02-04
HRP20070429T3 (en) 2007-11-30
GT200600135A (es) 2006-11-07
CY1108742T1 (el) 2014-04-09
IL186355A (en) 2016-05-31
EP1917267A1 (en) 2008-05-07
AU2006231617A1 (en) 2006-10-12
DK1710245T3 (da) 2007-12-03
DE602006004463D1 (de) 2009-02-05
EP1710245A1 (en) 2006-10-11
EP1710245B1 (en) 2007-08-22
PL1917267T3 (pl) 2009-06-30
SI1917267T1 (sl) 2009-04-30
PL1710245T3 (pl) 2008-01-31
JP5058151B2 (ja) 2012-10-24
PT1710245E (pt) 2007-10-03
DE602006000080D1 (de) 2007-10-04
AU2006231617B2 (en) 2010-06-03
SV2006002473A (es) 2009-11-24
JP2008534656A (ja) 2008-08-28
DOP2006000082A (es) 2006-11-30
ES2293626T3 (es) 2008-03-16
CA2603509A1 (en) 2006-10-12
ES2318742T3 (es) 2009-05-01
BRPI0609741A2 (pt) 2010-04-27
PE20061311A1 (es) 2007-02-09
DE602006000080T2 (de) 2008-05-15
CA2603509C (en) 2013-12-03
RS50532B (sr) 2010-05-07
SI1710245T1 (sl) 2007-12-31
EP1917267B1 (en) 2008-12-24
KR20080005253A (ko) 2008-01-10
ATE370954T1 (de) 2007-09-15
MY137969A (en) 2009-04-30
RU2405786C2 (ru) 2010-12-10
NO20075142L (no) 2007-11-05
NZ562124A (en) 2010-07-30
WO2006106135A1 (en) 2006-10-12
TW200722428A (en) 2007-06-16
TWI364423B (en) 2012-05-21
DK1917267T3 (da) 2009-04-14
AR056306A1 (es) 2007-10-03
KR101422843B1 (ko) 2014-07-24
RU2007141198A (ru) 2009-05-20
NO340520B1 (no) 2017-05-02
UY29459A1 (es) 2006-11-30
ATE418556T1 (de) 2009-01-15
HN2006014095A (es) 2010-08-19
CY1106902T1 (el) 2012-09-26
MX2007012445A (es) 2007-11-07

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Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: MSD OSS B.V. (NL)

B25A Requested transfer of rights approved

Owner name: ORGANON BIOSCIENCES NEDERLAND B.V. (NL)

B25A Requested transfer of rights approved

Owner name: MERCK SHARP AND DOHME B.V. (NL)

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 14A ANUIDADE.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.11 PUBLICADO NA RPI 2561, DE 04/02/2020.