ATE527266T1 - Herstellungsverfahren für asenapin und in diesem verfahren verwendete zwischenprodukte - Google Patents

Herstellungsverfahren für asenapin und in diesem verfahren verwendete zwischenprodukte

Info

Publication number
ATE527266T1
ATE527266T1 AT08870123T AT08870123T ATE527266T1 AT E527266 T1 ATE527266 T1 AT E527266T1 AT 08870123 T AT08870123 T AT 08870123T AT 08870123 T AT08870123 T AT 08870123T AT E527266 T1 ATE527266 T1 AT E527266T1
Authority
AT
Austria
Prior art keywords
asenapine
intermediate products
products used
production process
production
Prior art date
Application number
AT08870123T
Other languages
English (en)
Inventor
Gerardus Johannes Kemperman
Original Assignee
Organon Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Organon Nv filed Critical Organon Nv
Application granted granted Critical
Publication of ATE527266T1 publication Critical patent/ATE527266T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
AT08870123T 2008-01-04 2008-12-22 Herstellungsverfahren für asenapin und in diesem verfahren verwendete zwischenprodukte ATE527266T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08150058 2008-01-04
PCT/EP2008/068187 WO2009087058A1 (en) 2008-01-04 2008-12-22 Process for the preparation of asenapine and intermediate products used in said process

Publications (1)

Publication Number Publication Date
ATE527266T1 true ATE527266T1 (de) 2011-10-15

Family

ID=39186767

Family Applications (1)

Application Number Title Priority Date Filing Date
AT08870123T ATE527266T1 (de) 2008-01-04 2008-12-22 Herstellungsverfahren für asenapin und in diesem verfahren verwendete zwischenprodukte

Country Status (8)

Country Link
US (2) US7964739B2 (de)
EP (1) EP2240492B1 (de)
JP (1) JP2011508751A (de)
CN (1) CN101918411A (de)
AT (1) ATE527266T1 (de)
CA (1) CA2710800A1 (de)
MX (1) MX2010007404A (de)
WO (1) WO2009087058A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5245428B2 (ja) * 2007-07-06 2013-07-24 住友化学株式会社 トランス−ジベンゾオキセノピロール化合物の製造方法およびその中間体
WO2009087058A1 (en) * 2008-01-04 2009-07-16 N.V. Organon Process for the preparation of asenapine and intermediate products used in said process
BRPI1011453A2 (pt) 2009-06-24 2016-03-15 Msd Oss Bv formulacao, forma de dosagem de um medicamento, e, sal de hemipamoato de asenapina
WO2012040845A1 (en) * 2010-09-27 2012-04-05 Alphora Research Inc. Process for the preparation of tetracyclic derivatives and intermediate products used in the process
EP2468751B1 (de) 2010-12-24 2016-03-16 Medichem, S.A. Verfahren zur Herstellung von 5-Chlor-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrol
ITMI20110734A1 (it) 2011-05-02 2012-11-03 Olon Spa Sali cristallini di asenapina
ES2546317T3 (es) 2011-10-11 2015-09-22 Ucb Biopharma Sprl Derivados de 2-oxo-piperidinilo
WO2013080069A1 (en) 2011-11-28 2013-06-06 Ranbaxy Laboratories Limited Process for the preparation of asenapine intermediate
CN104619683B (zh) 2012-09-27 2017-05-10 拜耳农作物科学股份公司 用于制备任选地取代的苯基和吡啶基吡咯烷类的方法
CN103113379A (zh) * 2013-03-12 2013-05-22 盛世泰科生物医药技术(苏州)有限公司 阿塞那平马来酸盐的合成工艺
US11118112B2 (en) * 2015-06-30 2021-09-14 Merck Patent Gmbh Polymerisable liquid crystal material and polymerised liquid crystal film
CN105566336A (zh) * 2016-01-08 2016-05-11 万特制药(海南)有限公司 一种制备阿塞那平去甲基杂质的新方法
RU2762896C2 (ru) 2016-12-20 2021-12-23 Лтс Ломанн Терапи-Систем Аг Трансдермальная терапевтическая система, содержащая азенапин
CA3047354A1 (en) 2016-12-20 2018-06-28 Lts Lohmann Therapie-Systeme Ag Transdermal therapeutic system containing asenapine and polysiloxane or polyisobutylene
EP3644973B1 (de) 2017-06-26 2021-03-24 LTS LOHMANN Therapie-Systeme AG Transdermales therapeutisches system mit hybridem asenapin- und silikonacrylpolymer
CN110958876B (zh) 2018-06-20 2020-12-18 罗曼治疗系统股份公司 含有阿塞那平的透皮治疗系统
CN112533593A (zh) 2018-06-20 2021-03-19 罗曼治疗系统股份公司 含有阿塞那平的透皮治疗系统

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7605526A (nl) * 1976-05-24 1977-11-28 Akzo Nv Nieuwe tetracyclische derivaten.
US7872147B2 (en) * 2005-04-07 2011-01-18 N. V. Organon Intermediate compounds for the preparation of trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole
WO2006106136A1 (en) * 2005-04-07 2006-10-12 N.V. Organon Intermediate compounds for the preparation of trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1h-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole
WO2007046554A1 (ja) * 2005-10-21 2007-04-26 Sumitomo Chemical Company, Limited ジベンゾオキセピノピロール化合物の製造方法、その中間体及び該中間体の製造方法
TW200817414A (en) * 2006-07-05 2008-04-16 Organon Nv Process for the preparation of asenapine and intermediate products used in said process
US7750167B2 (en) * 2006-07-05 2010-07-06 N.V. Organon Process for the preparation of asenapine and intermediate products used in said process
US7875729B2 (en) * 2007-01-05 2011-01-25 Synthon Bv Process for making asenapine
WO2009087058A1 (en) * 2008-01-04 2009-07-16 N.V. Organon Process for the preparation of asenapine and intermediate products used in said process

Also Published As

Publication number Publication date
US20110166363A1 (en) 2011-07-07
JP2011508751A (ja) 2011-03-17
CN101918411A (zh) 2010-12-15
MX2010007404A (es) 2010-10-05
EP2240492A1 (de) 2010-10-20
EP2240492B1 (de) 2011-10-05
WO2009087058A1 (en) 2009-07-16
US20090227803A1 (en) 2009-09-10
CA2710800A1 (en) 2009-07-16
US7964739B2 (en) 2011-06-21

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