ATE527266T1 - Herstellungsverfahren für asenapin und in diesem verfahren verwendete zwischenprodukte - Google Patents
Herstellungsverfahren für asenapin und in diesem verfahren verwendete zwischenprodukteInfo
- Publication number
- ATE527266T1 ATE527266T1 AT08870123T AT08870123T ATE527266T1 AT E527266 T1 ATE527266 T1 AT E527266T1 AT 08870123 T AT08870123 T AT 08870123T AT 08870123 T AT08870123 T AT 08870123T AT E527266 T1 ATE527266 T1 AT E527266T1
- Authority
- AT
- Austria
- Prior art keywords
- asenapine
- intermediate products
- products used
- production process
- production
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08150058 | 2008-01-04 | ||
PCT/EP2008/068187 WO2009087058A1 (en) | 2008-01-04 | 2008-12-22 | Process for the preparation of asenapine and intermediate products used in said process |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE527266T1 true ATE527266T1 (de) | 2011-10-15 |
Family
ID=39186767
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT08870123T ATE527266T1 (de) | 2008-01-04 | 2008-12-22 | Herstellungsverfahren für asenapin und in diesem verfahren verwendete zwischenprodukte |
Country Status (8)
Country | Link |
---|---|
US (2) | US7964739B2 (de) |
EP (1) | EP2240492B1 (de) |
JP (1) | JP2011508751A (de) |
CN (1) | CN101918411A (de) |
AT (1) | ATE527266T1 (de) |
CA (1) | CA2710800A1 (de) |
MX (1) | MX2010007404A (de) |
WO (1) | WO2009087058A1 (de) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5245428B2 (ja) * | 2007-07-06 | 2013-07-24 | 住友化学株式会社 | トランス−ジベンゾオキセノピロール化合物の製造方法およびその中間体 |
ATE527266T1 (de) * | 2008-01-04 | 2011-10-15 | Organon Nv | Herstellungsverfahren für asenapin und in diesem verfahren verwendete zwischenprodukte |
CN102596172A (zh) | 2009-06-24 | 2012-07-18 | Msd欧斯股份有限公司 | 含有阿塞那平的注射剂和使用其的治疗方法 |
US20130274466A1 (en) * | 2010-09-27 | 2013-10-17 | Alphora Research Inc. | Process for the preparation of tetracyclic derivatives and intermediate products used in the process |
EP2468751B1 (de) | 2010-12-24 | 2016-03-16 | Medichem, S.A. | Verfahren zur Herstellung von 5-Chlor-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrol |
ITMI20110734A1 (it) | 2011-05-02 | 2012-11-03 | Olon Spa | Sali cristallini di asenapina |
EA025288B1 (ru) | 2011-10-11 | 2016-12-30 | Юсб Фарма, С.А. | Производные 2-оксопиперидинила |
EP2785718A1 (de) | 2011-11-28 | 2014-10-08 | Ranbaxy Laboratories Limited | Verfahren zur herstellung eines asenapin-zwischenproduktes |
CN104619683B (zh) | 2012-09-27 | 2017-05-10 | 拜耳农作物科学股份公司 | 用于制备任选地取代的苯基和吡啶基吡咯烷类的方法 |
CN103113379A (zh) * | 2013-03-12 | 2013-05-22 | 盛世泰科生物医药技术(苏州)有限公司 | 阿塞那平马来酸盐的合成工艺 |
WO2017001039A1 (en) * | 2015-06-30 | 2017-01-05 | Merck Patent Gmbh | Polymerisable liquid crystal material and polymerised liquid crystal film |
CN105566336A (zh) * | 2016-01-08 | 2016-05-11 | 万特制药(海南)有限公司 | 一种制备阿塞那平去甲基杂质的新方法 |
PL3338768T3 (pl) | 2016-12-20 | 2020-05-18 | Lts Lohmann Therapie-Systeme Ag | Transdermalny system terapeutyczny zawierający asenapinę |
KR102614709B1 (ko) | 2016-12-20 | 2023-12-18 | 에르테에스 로만 테라피-시스테메 아게 | 아세나핀 및 폴리실록산 또는 폴리이소부틸렌을 함유하는 경피흡수 치료 시스템 |
EP3644973B1 (de) | 2017-06-26 | 2021-03-24 | LTS LOHMANN Therapie-Systeme AG | Transdermales therapeutisches system mit hybridem asenapin- und silikonacrylpolymer |
CA3101420A1 (en) | 2018-06-20 | 2019-12-26 | Lts Lohmann Therapie-Systeme Ag | Transdermal therapeutic system containing asenapine |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL7605526A (nl) * | 1976-05-24 | 1977-11-28 | Akzo Nv | Nieuwe tetracyclische derivaten. |
UA93043C2 (ru) | 2005-04-07 | 2011-01-10 | Н.В. Органон | ПРОМЕЖУТОЧНЫЕ СОЕДИНЕНИЯ ДЛЯ ПОЛУЧЕНИЯ ТРАНС-5-ХЛОР-2-МЕТИЛ-2,3,3А,12В-ТЕТРАГИДРО-1Н-ДИБЕНЗ[2,3:6,7]ОКСЕПИНО[4,5-с]ПИРОЛА |
US7872147B2 (en) * | 2005-04-07 | 2011-01-18 | N. V. Organon | Intermediate compounds for the preparation of trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole |
WO2007046554A1 (ja) * | 2005-10-21 | 2007-04-26 | Sumitomo Chemical Company, Limited | ジベンゾオキセピノピロール化合物の製造方法、その中間体及び該中間体の製造方法 |
TW200817414A (en) * | 2006-07-05 | 2008-04-16 | Organon Nv | Process for the preparation of asenapine and intermediate products used in said process |
US7750167B2 (en) * | 2006-07-05 | 2010-07-06 | N.V. Organon | Process for the preparation of asenapine and intermediate products used in said process |
US7875729B2 (en) * | 2007-01-05 | 2011-01-25 | Synthon Bv | Process for making asenapine |
ATE527266T1 (de) * | 2008-01-04 | 2011-10-15 | Organon Nv | Herstellungsverfahren für asenapin und in diesem verfahren verwendete zwischenprodukte |
-
2008
- 2008-12-22 AT AT08870123T patent/ATE527266T1/de not_active IP Right Cessation
- 2008-12-22 MX MX2010007404A patent/MX2010007404A/es not_active Application Discontinuation
- 2008-12-22 CA CA2710800A patent/CA2710800A1/en not_active Abandoned
- 2008-12-22 WO PCT/EP2008/068187 patent/WO2009087058A1/en active Application Filing
- 2008-12-22 JP JP2010541050A patent/JP2011508751A/ja not_active Withdrawn
- 2008-12-22 US US12/341,281 patent/US7964739B2/en active Active
- 2008-12-22 CN CN2008801239012A patent/CN101918411A/zh active Pending
- 2008-12-22 EP EP08870123A patent/EP2240492B1/de active Active
-
2011
- 2011-03-16 US US13/049,139 patent/US20110166363A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20110166363A1 (en) | 2011-07-07 |
CA2710800A1 (en) | 2009-07-16 |
EP2240492B1 (de) | 2011-10-05 |
EP2240492A1 (de) | 2010-10-20 |
MX2010007404A (es) | 2010-10-05 |
WO2009087058A1 (en) | 2009-07-16 |
US20090227803A1 (en) | 2009-09-10 |
JP2011508751A (ja) | 2011-03-17 |
CN101918411A (zh) | 2010-12-15 |
US7964739B2 (en) | 2011-06-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE527266T1 (de) | Herstellungsverfahren für asenapin und in diesem verfahren verwendete zwischenprodukte | |
MX2007008790A (es) | Pirazolo piridinas sustituidas, composiciones que las contienen, metodo de produccion de las mismas, y su uso. | |
MY150542A (en) | Cmet inhibitors | |
TW200800968A (en) | Sulfoximine-substituted pyrimidines, processes for production thereof and use thereof as drugs | |
MX2009007436A (es) | Derivados espirociclicos de acido tetronico. | |
MX2010012298A (es) | Activadores de glucocinasa. | |
DE602006014558D1 (de) | Verbessertes verfahren für die herstellung von tee | |
EA200702329A1 (ru) | Замещенные пирролпиридины, содержащие их композиции, способ получения и применение | |
MX2011009369A (es) | 2-mercaptoquinolin-3-carboxamidas sustituidas como moduladores de kcnq2/3. | |
MY178926A (en) | Bispecific anti-vegf/anti-ang-2 antibodies | |
UY30931A1 (es) | Amidas de 4-aril-1,4-dihidro-1,6-naftiridina sustituidas y su uso | |
AU2010233994A8 (en) | Bispecific anti-ErbB-3/anti-c-Met antibodies | |
MX2012002434A (es) | Conjugados de dimeros de pirrolo[1,4] benzodiazepina como agentes anticacerosos. | |
ATE445620T1 (de) | Herstellungsverfahren für asenapin und in diesem verfahren verwendete zwischenprodukte | |
EA200701648A1 (ru) | Замещённые пирролы и имидазолы, содержащие их композиции, способ получения и применение | |
MY146084A (en) | Benzyl amines, a process for their production and their use as anti-inflammatory agents | |
MX2011008825A (es) | 3-aminoisoxazolopiridinas sustituidas como moduladores de kcnq2/3. | |
TW200806221A (en) | Method of relating different products by a common feature | |
NZ586187A (en) | Processes for the synthesis of sinomenine derivatives and their intermediate | |
WO2013170072A3 (en) | Compounds for the treatment of neurological disorders | |
WO2009115084A3 (de) | Pyrrolopyrimidin-derivate und deren verwendungen | |
MX2011009338A (es) | 3-amino-2-mercaptoquinolinas sustituidas como moduladores de kcnq2/3. | |
HK1154258A1 (en) | Ammonium polyurethane and or polycarbonate compounds | |
TW200621703A (en) | Alkylidene-tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents | |
WO2007115929A8 (de) | Thiazolyl-dihydro-quinazoline |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |