MX2010007404A - Procedimiento para la preparacion de asenapina y productos intermediarios utilizados en dicho procedimiento. - Google Patents
Procedimiento para la preparacion de asenapina y productos intermediarios utilizados en dicho procedimiento.Info
- Publication number
- MX2010007404A MX2010007404A MX2010007404A MX2010007404A MX2010007404A MX 2010007404 A MX2010007404 A MX 2010007404A MX 2010007404 A MX2010007404 A MX 2010007404A MX 2010007404 A MX2010007404 A MX 2010007404A MX 2010007404 A MX2010007404 A MX 2010007404A
- Authority
- MX
- Mexico
- Prior art keywords
- asenapine
- preparation
- intermediate products
- products used
- novel
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
Abstract
La invención se refiere a un procedimiento novedoso para la preparación de asenapina, es decir, trans-5-cloro-2-metil-2,3,3a,1 2b-tetrahidro-1H-dibenz[2,3:6,7]oxepino[4,5-c]pirrol, asi como a productos intermediarios novedosos para usarse en dicho procedimiento.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08150058 | 2008-01-04 | ||
PCT/EP2008/068187 WO2009087058A1 (en) | 2008-01-04 | 2008-12-22 | Process for the preparation of asenapine and intermediate products used in said process |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2010007404A true MX2010007404A (es) | 2010-10-05 |
Family
ID=39186767
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2010007404A MX2010007404A (es) | 2008-01-04 | 2008-12-22 | Procedimiento para la preparacion de asenapina y productos intermediarios utilizados en dicho procedimiento. |
Country Status (8)
Country | Link |
---|---|
US (2) | US7964739B2 (es) |
EP (1) | EP2240492B1 (es) |
JP (1) | JP2011508751A (es) |
CN (1) | CN101918411A (es) |
AT (1) | ATE527266T1 (es) |
CA (1) | CA2710800A1 (es) |
MX (1) | MX2010007404A (es) |
WO (1) | WO2009087058A1 (es) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5245428B2 (ja) * | 2007-07-06 | 2013-07-24 | 住友化学株式会社 | トランス−ジベンゾオキセノピロール化合物の製造方法およびその中間体 |
JP2011508751A (ja) * | 2008-01-04 | 2011-03-17 | ナームローゼ・フエンノートチヤツプ・オルガノン | アセナピンの調製方法および前記方法において使用される中間生成物 |
AU2010264670A1 (en) | 2009-06-24 | 2012-01-19 | Merck Sharp & Dohme B.V. | Injectable formulations containing asenapine and method of treatment using same |
WO2012040845A1 (en) * | 2010-09-27 | 2012-04-05 | Alphora Research Inc. | Process for the preparation of tetracyclic derivatives and intermediate products used in the process |
ES2575544T3 (es) | 2010-12-24 | 2016-06-29 | Medichem, S.A. | Procedimientos para la preparación de 5-cloro-2-metil-2,3,3a,12b-tetrahidro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pirrol |
ITMI20110734A1 (it) | 2011-05-02 | 2012-11-03 | Olon Spa | Sali cristallini di asenapina |
BR112014008588A2 (pt) | 2011-10-11 | 2017-04-18 | Ucb Pharma Sa | derivados de 2-oxo-piperidinila |
WO2013080069A1 (en) | 2011-11-28 | 2013-06-06 | Ranbaxy Laboratories Limited | Process for the preparation of asenapine intermediate |
US9447036B2 (en) | 2012-09-27 | 2016-09-20 | Bayer Cropscience Ag | Process for the preparation of optionally substituted phenyl and pyridyl pyrrolidines |
CN103113379A (zh) * | 2013-03-12 | 2013-05-22 | 盛世泰科生物医药技术(苏州)有限公司 | 阿塞那平马来酸盐的合成工艺 |
KR20180022795A (ko) * | 2015-06-30 | 2018-03-06 | 메르크 파텐트 게엠베하 | 중합가능 액정 물질 및 중합가능 액정 필름 |
CN105566336A (zh) * | 2016-01-08 | 2016-05-11 | 万特制药(海南)有限公司 | 一种制备阿塞那平去甲基杂质的新方法 |
CN110087641B (zh) | 2016-12-20 | 2024-03-12 | 罗曼治疗系统股份公司 | 含有阿塞那平和聚硅氧烷或聚异丁烯的透皮治疗系统 |
MX2019007391A (es) | 2016-12-20 | 2019-08-16 | Lts Lohmann Therapie Systeme Ag | Sistema terapeutico transdermico que contiene asenapina. |
CN110799180A (zh) | 2017-06-26 | 2020-02-14 | 罗曼治疗系统股份公司 | 含阿塞那平和硅氧烷丙烯酸杂化聚合物的经皮治疗系统 |
WO2019243452A1 (en) | 2018-06-20 | 2019-12-26 | Lts Lohmann Therapie-Systeme Ag | Transdermal therapeutic system containing asenapine |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL7605526A (nl) * | 1976-05-24 | 1977-11-28 | Akzo Nv | Nieuwe tetracyclische derivaten. |
RS51341B (en) | 2005-04-07 | 2011-02-28 | N.V. Organon | INTERMEDIATE COMPOUNDS FOR THE TRANS-5-CHLOR-2-METHYL-2,3A, 12B-TETRAHYDRO-1H-DIBENZE [2,3; 6,7] OXEPINO [4,5-C] Pyrrole |
US7872147B2 (en) * | 2005-04-07 | 2011-01-18 | N. V. Organon | Intermediate compounds for the preparation of trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole |
WO2007046554A1 (ja) * | 2005-10-21 | 2007-04-26 | Sumitomo Chemical Company, Limited | ジベンゾオキセピノピロール化合物の製造方法、その中間体及び該中間体の製造方法 |
US7750167B2 (en) * | 2006-07-05 | 2010-07-06 | N.V. Organon | Process for the preparation of asenapine and intermediate products used in said process |
TW200817414A (en) * | 2006-07-05 | 2008-04-16 | Organon Nv | Process for the preparation of asenapine and intermediate products used in said process |
US7875729B2 (en) * | 2007-01-05 | 2011-01-25 | Synthon Bv | Process for making asenapine |
JP2011508751A (ja) * | 2008-01-04 | 2011-03-17 | ナームローゼ・フエンノートチヤツプ・オルガノン | アセナピンの調製方法および前記方法において使用される中間生成物 |
-
2008
- 2008-12-22 JP JP2010541050A patent/JP2011508751A/ja not_active Withdrawn
- 2008-12-22 MX MX2010007404A patent/MX2010007404A/es not_active Application Discontinuation
- 2008-12-22 CN CN2008801239012A patent/CN101918411A/zh active Pending
- 2008-12-22 WO PCT/EP2008/068187 patent/WO2009087058A1/en active Application Filing
- 2008-12-22 US US12/341,281 patent/US7964739B2/en active Active
- 2008-12-22 CA CA2710800A patent/CA2710800A1/en not_active Abandoned
- 2008-12-22 AT AT08870123T patent/ATE527266T1/de not_active IP Right Cessation
- 2008-12-22 EP EP08870123A patent/EP2240492B1/en active Active
-
2011
- 2011-03-16 US US13/049,139 patent/US20110166363A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
ATE527266T1 (de) | 2011-10-15 |
US7964739B2 (en) | 2011-06-21 |
US20110166363A1 (en) | 2011-07-07 |
WO2009087058A1 (en) | 2009-07-16 |
US20090227803A1 (en) | 2009-09-10 |
EP2240492B1 (en) | 2011-10-05 |
CA2710800A1 (en) | 2009-07-16 |
JP2011508751A (ja) | 2011-03-17 |
EP2240492A1 (en) | 2010-10-20 |
CN101918411A (zh) | 2010-12-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
GB | Transfer or rights |
Owner name: MSD OSS B.V. |
|
FA | Abandonment or withdrawal |