HRP20040929B1 - Proces za pripremu kiselih soli gemifloxacina - Google Patents

Proces za pripremu kiselih soli gemifloxacina

Info

Publication number
HRP20040929B1
HRP20040929B1 HRP20040929AA HRP20040929A HRP20040929B1 HR P20040929 B1 HRP20040929 B1 HR P20040929B1 HR P20040929A A HRP20040929A A HR P20040929AA HR P20040929 A HRP20040929 A HR P20040929A HR P20040929 B1 HRP20040929 B1 HR P20040929B1
Authority
HR
Croatia
Prior art keywords
gemifloxacin
acid salts
preparing acid
present
step process
Prior art date
Application number
HRP20040929AA
Other languages
English (en)
Inventor
Hoon Choi
Sang-Chul Choi
Do-Hyun Nam
Bo-Seung Choi
Original Assignee
Lg Life Sciences Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lg Life Sciences Ltd. filed Critical Lg Life Sciences Ltd.
Publication of HRP20040929A2 publication Critical patent/HRP20040929A2/hr
Publication of HRP20040929B1 publication Critical patent/HRP20040929B1/hr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)

Abstract

Predstavljeni izum se odnosi na proces pripremanja kiselih soli Gemifloxacina, kinolinskog tipa antibiotskog sredstva koje ima jak antimikropski učinak. Postupak, sukladno predstavljenom izumu može osigurati koristi kao što su jednostavnost postupka, poboljšanje produktivnosti i iskoristivosti i slično smanjivanjem uobičajenog procesa od tri koraka na proces od dva koraka.
HRP20040929AA 2002-04-08 2004-10-07 Proces za pripremu kiselih soli gemifloxacina HRP20040929B1 (hr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2002-0018847A KR100517638B1 (ko) 2002-04-08 2002-04-08 게미플록사신 산염의 새로운 제조방법
PCT/KR2003/000683 WO2003087100A1 (en) 2002-04-08 2003-04-04 Process for preparing acid salts of gemifloxacin

Publications (2)

Publication Number Publication Date
HRP20040929A2 HRP20040929A2 (en) 2005-02-28
HRP20040929B1 true HRP20040929B1 (hr) 2013-12-06

Family

ID=36241771

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20040929AA HRP20040929B1 (hr) 2002-04-08 2004-10-07 Proces za pripremu kiselih soli gemifloxacina

Country Status (32)

Country Link
US (1) US7361762B2 (hr)
EP (1) EP1497290B1 (hr)
JP (1) JP4315815B2 (hr)
KR (1) KR100517638B1 (hr)
CN (1) CN1291987C (hr)
AP (1) AP1786A (hr)
AT (1) ATE404559T1 (hr)
AU (1) AU2003219581B2 (hr)
BR (1) BRPI0309037B8 (hr)
CA (1) CA2481217C (hr)
CO (1) CO5611198A2 (hr)
CY (1) CY1108469T1 (hr)
DE (1) DE60322872D1 (hr)
DK (1) DK1497290T3 (hr)
EA (1) EA007222B1 (hr)
ES (1) ES2311694T3 (hr)
GE (1) GEP20074025B (hr)
HK (1) HK1074440A1 (hr)
HR (1) HRP20040929B1 (hr)
IL (1) IL164328A (hr)
IS (1) IS2731B (hr)
MA (1) MA26408A1 (hr)
MX (1) MXPA04009777A (hr)
NO (1) NO330042B1 (hr)
NZ (1) NZ536174A (hr)
OA (1) OA12801A (hr)
PL (1) PL372815A1 (hr)
PT (1) PT1497290E (hr)
SI (1) SI1497290T1 (hr)
UA (1) UA77070C2 (hr)
WO (1) WO2003087100A1 (hr)
ZA (1) ZA200408088B (hr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1412078B1 (en) * 2001-08-02 2008-10-08 LG Life Sciences Limited Processes for the production of amino-protected derivatives of 4-aminomethylene-pyrrolidin-3-one, gemifloxacin or a salt thereof
WO2006134431A1 (en) * 2005-05-03 2006-12-21 Ranbaxy Laboratories Limited Formate salt of gemifloxacin
EP2161270A1 (en) * 2005-06-15 2010-03-10 Hetero Drugs Limited Gemifloxacin hydrates
BRPI0708606A2 (pt) * 2006-03-07 2011-06-14 Wockhardt Ltd prà-fÁrmacos de Ácido benzoquinolizina-2-carboxÍlico
WO2008053324A1 (en) * 2006-10-31 2008-05-08 Orchid Chemicals & Pharmaceuticals Limited An improved process for the preparation of gemifloxacin mesylate

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998042705A1 (en) * 1997-03-21 1998-10-01 Lg Chemical Ltd. Salt of naphthyridine carboxylic acid derivative
US5869670A (en) * 1994-06-16 1999-02-09 Lg Chemical Ltd. 7-(4-aminomethyl-3-methyloxyiminopyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid and the process for the preparation thereof
WO1999044991A1 (en) * 1998-03-04 1999-09-10 Lg Chemical Ltd. Process for preparing a protected 4-aminomethyl-pyrrolidin-3-one
WO2001018002A1 (en) * 1999-09-03 2001-03-15 Sb Pharmco Puerto Rico Inc Process for production of naphthyridine-3-carboxylic acid derivatives

Family Cites Families (23)

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Publication number Priority date Publication date Assignee Title
JPS57134482A (en) 1981-02-13 1982-08-19 Dainippon Pharmaceut Co Ltd 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-1,8- naphthyridine-3-carboxylic acid-3/2 hydrate and its preparation
IN162769B (hr) 1984-11-13 1988-07-09 Kyorin Seiyaku Kk
NZ222047A (en) 1986-10-08 1991-01-29 Bristol Myers Co Quinoline - or naphthyridine - carboxylic acid anti-bacterial agents
JPH01100165A (ja) 1987-10-13 1989-04-18 Shionogi & Co Ltd オキシムまたはヒドロキシアミン誘導体系抗菌剤
US4920120A (en) 1988-01-25 1990-04-24 Warner-Lambert Company Antibacterial agents
JPH0356479A (ja) 1989-07-24 1991-03-12 Takeshi Yokota 水溶性キノロン誘導体のｐ‐トルエンスルホン酸塩
WO1991002526A1 (en) 1989-08-16 1991-03-07 Pfizer Inc. Azabicyclo quinolone carboxylic acids
US5137892A (en) 1990-12-12 1992-08-11 Abbott Laboratories Quinoline, naphthyridine and pyridobenzoxazine derivatives
US5276041A (en) 1991-11-08 1994-01-04 Kaken Pharmaceutical Co., Ltd. Oxime derivatives
JPH0673056A (ja) 1992-08-26 1994-03-15 Kaken Pharmaceut Co Ltd キノリンカルボン酸誘導体およびその塩
US5776944A (en) * 1994-06-16 1998-07-07 Lg Chemical Ltd. 7-(4-aminomethyl-3-methyloxyiminopyrroplidin-1-yl)-1-cyclopropyl-6-flu oro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid and the process for the preparation thereof
JP3449658B2 (ja) 1994-12-21 2003-09-22 杏林製薬株式会社 安定性に優れた８−アルコキシキノロンカルボン酸水和物並びにその製造方法
DK0789697T3 (da) 1995-06-06 1998-10-19 Pfizer Krystalform af vandfrit 7-([1alfa, 5alfa, 6alfa,]-6-amino-3-azabicyclo[3.1.0]hex-3-yl)-6-fluor-1-(2,4-difluorphenyl)-1,4-d
UA59341C2 (uk) 1995-08-11 2003-09-15 Пфайзер, Інк. (1s,2s)-1-(4-гідроксифеніл)-2-(4-гідрокси-4-фенілпіперидин-1-іл)-1-пропанолметансульфонат тригідрат
UA49880C2 (uk) 1996-03-29 2002-10-15 Смітклайн Бічам Корпорейшн Дигідрат ерпоcартану, фармацевтична композиція, спосіб отримання твердої дозованої форми, спосіб блокування рецепторів ангіотензину іі
US6127400A (en) 1998-05-29 2000-10-03 Pharmacia & Upjohn Company Salts of diamine pyrrolidine
GB9820405D0 (en) 1998-09-18 1998-11-11 Smithkline Beecham Plc Process
PT1223935E (pt) 1999-06-29 2008-04-03 Lg Life Sciences Ltd Utilização de compostos de gemifloxacina contra bactérias
AU6947900A (en) 1999-09-01 2001-03-26 Smithkline Beecham Corporation Methods of use of fluoroquinolone compounds against bacteria
GB9920919D0 (en) 1999-09-03 1999-11-10 Sb Pharmco Inc Novel compound
AU7709400A (en) 1999-09-22 2001-04-24 Smithkline Beecham Corporation Methods of use of fluoroquinolone compounds against bacteria
KR20010091379A (ko) 2000-03-15 2001-10-23 성재갑 7-(4-아미노메틸-3-옥심)피롤리딘 치환체를 갖는 퀴놀린카르복실산 유도체의 신규 제조방법
KR20020018560A (ko) 2000-09-01 2002-03-08 성재갑 3-아미노메틸-4-ｚ-메톡시이미노피롤리딘의 신규 제조방법

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5869670A (en) * 1994-06-16 1999-02-09 Lg Chemical Ltd. 7-(4-aminomethyl-3-methyloxyiminopyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid and the process for the preparation thereof
WO1998042705A1 (en) * 1997-03-21 1998-10-01 Lg Chemical Ltd. Salt of naphthyridine carboxylic acid derivative
WO1999044991A1 (en) * 1998-03-04 1999-09-10 Lg Chemical Ltd. Process for preparing a protected 4-aminomethyl-pyrrolidin-3-one
WO2001018002A1 (en) * 1999-09-03 2001-03-15 Sb Pharmco Puerto Rico Inc Process for production of naphthyridine-3-carboxylic acid derivatives

Also Published As

Publication number Publication date
BRPI0309037B8 (pt) 2021-05-25
CY1108469T1 (el) 2014-04-09
IL164328A0 (en) 2005-12-18
MA26408A1 (fr) 2004-12-01
ES2311694T3 (es) 2009-02-16
GEP20074025B (en) 2007-01-25
EA007222B1 (ru) 2006-08-25
CN1649868A (zh) 2005-08-03
NO330042B1 (no) 2011-02-07
DE60322872D1 (de) 2008-09-25
MXPA04009777A (es) 2004-12-13
EP1497290A1 (en) 2005-01-19
HRP20040929A2 (en) 2005-02-28
CO5611198A2 (es) 2006-02-28
NO20044629L (no) 2004-10-27
IL164328A (en) 2009-08-03
US20050148622A1 (en) 2005-07-07
CA2481217C (en) 2010-06-01
PL372815A1 (en) 2005-08-08
IS7477A (is) 2004-09-30
BRPI0309037B1 (pt) 2018-07-31
AP1786A (en) 2007-10-04
CN1291987C (zh) 2006-12-27
KR20030080292A (ko) 2003-10-17
BR0309037A (pt) 2005-02-01
SI1497290T1 (sl) 2008-12-31
DK1497290T3 (da) 2008-12-15
WO2003087100A1 (en) 2003-10-23
JP4315815B2 (ja) 2009-08-19
EA200401328A1 (ru) 2005-06-30
HK1074440A1 (en) 2005-11-11
AU2003219581A1 (en) 2003-10-27
IS2731B (is) 2011-04-15
EP1497290B1 (en) 2008-08-13
UA77070C2 (uk) 2006-10-16
US7361762B2 (en) 2008-04-22
PT1497290E (pt) 2008-11-14
EP1497290A4 (en) 2006-05-10
NZ536174A (en) 2006-09-29
ATE404559T1 (de) 2008-08-15
CA2481217A1 (en) 2003-10-23
AP2004003148A0 (en) 2004-12-31
ZA200408088B (en) 2006-05-31
OA12801A (en) 2006-07-11
AU2003219581B2 (en) 2006-08-24
JP2005529112A (ja) 2005-09-29
KR100517638B1 (ko) 2005-09-28

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