MXPA05012113A - Procedimiento para sintetizar intermediarios inhibidores de beta-lactamasa. - Google Patents

Procedimiento para sintetizar intermediarios inhibidores de beta-lactamasa.

Info

Publication number
MXPA05012113A
MXPA05012113A MXPA05012113A MXPA05012113A MXPA05012113A MX PA05012113 A MXPA05012113 A MX PA05012113A MX PA05012113 A MXPA05012113 A MX PA05012113A MX PA05012113 A MXPA05012113 A MX PA05012113A MX PA05012113 A MXPA05012113 A MX PA05012113A
Authority
MX
Mexico
Prior art keywords
lactamase inhibitor
synthesizing beta
inhibitor intermediates
beta
formula
Prior art date
Application number
MXPA05012113A
Other languages
English (en)
Inventor
Ramesh Venkat Matur
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of MXPA05012113A publication Critical patent/MXPA05012113A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/182—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La invencion se refiere a un procedimiento enzimatico para la produccion de un intermediario, acido heteroaril-2-carboxilico biciclico, de la formula (I) (ver formula (I)) en donde X y Y se definen en la descripcion y los cuales son utiles en la preparacion de inhibidores de beta-lactamasa, mediante la hidrolisis enzimatica selectiva de una mezcla de esteres hidrolizables posicionales de la formula (II) y (III) (ver formulas (II) y (III)) en donde X, Y y R se definen en la descripcion.
MXPA05012113A 2003-05-16 2004-05-12 Procedimiento para sintetizar intermediarios inhibidores de beta-lactamasa. MXPA05012113A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US47146103P 2003-05-16 2003-05-16
PCT/US2004/014833 WO2004104008A1 (en) 2003-05-16 2004-05-12 PROCESS FOR SYNTHESIZING β-LACTAMASE INHIBITOR INTERMEDIATES

Publications (1)

Publication Number Publication Date
MXPA05012113A true MXPA05012113A (es) 2006-02-08

Family

ID=33476848

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA05012113A MXPA05012113A (es) 2003-05-16 2004-05-12 Procedimiento para sintetizar intermediarios inhibidores de beta-lactamasa.

Country Status (12)

Country Link
US (1) US7316917B2 (es)
EP (1) EP1626972A1 (es)
JP (1) JP2007501635A (es)
CN (1) CN1823069A (es)
AR (1) AR045681A1 (es)
AU (1) AU2004240924A1 (es)
BR (1) BRPI0410642A (es)
CA (1) CA2525507A1 (es)
CL (1) CL2004001037A1 (es)
MX (1) MXPA05012113A (es)
TW (1) TW200505925A (es)
WO (1) WO2004104008A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1823074A (zh) * 2003-05-16 2006-08-23 惠氏控股公司 合成β－内酰胺酶抑制剂中间体的方法
ITRM20050345A1 (it) * 2005-06-30 2007-01-01 Sigma Tau Ind Farmaceuti Sintesi di deossi-biotinil esametilen diammina-dota.
MX2013003752A (es) 2010-10-07 2013-12-02 Basf Se Proceso para la preparación de cetonas, en particular cetonas macrociclicas.
CN105274174A (zh) * 2015-11-30 2016-01-27 精晶药业股份有限公司 一种生物酶转化制备丙谷二肽的方法
CN110923288A (zh) * 2019-12-19 2020-03-27 卓和药业集团有限公司 一种wxfl10203614中间体的生物学拆分方法
WO2023284775A1 (zh) * 2021-07-14 2023-01-19 上海海雁医药科技有限公司 吡唑衍生物及其中间体和制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4496739A (en) * 1982-01-27 1985-01-29 Sumitomo Chemical Company, Limited Intermediates to optically active cis-1,3-dibenzyl-hexahydro-1H-furo[3,4-d]imidazole-2,4-dione
GB9222700D0 (en) * 1992-10-29 1992-12-09 Smithkline Beecham Plc Chemical compounds
GB0106631D0 (en) * 2001-03-16 2001-05-09 Pfizer Ltd Pharmaceutically active compounds
AR039476A1 (es) * 2002-05-01 2005-02-23 Wyeth Corp Proceso para preparar derivados de 6-alquiliden penem
CN1823074A (zh) * 2003-05-16 2006-08-23 惠氏控股公司 合成β－内酰胺酶抑制剂中间体的方法

Also Published As

Publication number Publication date
BRPI0410642A (pt) 2006-07-04
AU2004240924A1 (en) 2004-12-02
CN1823069A (zh) 2006-08-23
WO2004104008A1 (en) 2004-12-02
US20040229324A1 (en) 2004-11-18
CL2004001037A1 (es) 2005-03-04
US7316917B2 (en) 2008-01-08
TW200505925A (en) 2005-02-16
EP1626972A1 (en) 2006-02-22
CA2525507A1 (en) 2004-12-02
JP2007501635A (ja) 2007-02-01
AR045681A1 (es) 2005-11-09

Similar Documents

Publication Publication Date Title
TW200726754A (en) Chemical process
WO2004052850A3 (en) Methods and compounds producing dipeptidyl peptidase iv inhibitors and intermediates thereof
WO2006004100A8 (ja) １，２－ジヒドロピリジン－２－オン化合物の製造方法
UA95600C2 (en) Synthesis scheme for lacosamide
TNSN08170A1 (en) 3-alkyl-5- (4-alkyl-5-oxo-tetrahydrofutran-2-yl) pyrrolidin-2-one derivatives as intermediates in the synthesis of renin inhibitors
TN2009000401A1 (en) New methods
SG170794A1 (en) Process for preparation of hiv protease inhibitors
TNSN07465A1 (en) Organic compounds
WO2006066044A3 (en) Processes for producing 4-aminoquinazolines
PL1670778T3 (pl) Przegrupowane pentanole, sposób ich wytwarzania i ich zastosowanie jako środków hamujących zapalenia
WO2007049295A3 (en) An improved one pot process for making key intermediate for gemcitabine hcl
WO2009052152A3 (en) Tigecycline and methods of preparing intermediates
MX2010013758A (es) Procedimiento para elaborar 2-amino-tiazolonas sustituidas.
MXPA05012113A (es) Procedimiento para sintetizar intermediarios inhibidores de beta-lactamasa.
TNSN08142A1 (en) Synthesis of renin inhibitors involving a cycloaddition reaction
WO2006122020A3 (en) Process for production of 4-biphenylyazetidin-2-ones
AU2003299300A1 (en) METHOD FOR THE PRODUCTION OF R-Alpha-LIPOIC ACID BY FERMENTATION
WO2006043175A3 (en) Process for preparing purine compounds
ATE486867T1 (de) Verfahren zur herstellung von hochreinem meloxicam und meloxicam-kaliumsalz
MEP1708A (xx) Postupak proizvodnje thip-a
MXPA05012110A (es) Procedimiento para sintetizar intermediarios inhibidores de beta-lactamasa.
TW200728267A (en) Processes and intermediates for the preparation of prostaglandins
DE602004030091D1 (de) Verfahren zur reduktiven deshalogenierung
GB0320738D0 (en) Novel process
TW200730524A (en) Process for making heteroaryl amine intermediate compounds