CL2004001037A1 - Procedimiento de prepwracion de acido heteroaril-2-carboxilico biciclico por hidrolisis enzimatica del correspondiente ester, utiles para sintetizar intermediarios del inhibidor de beta-lactamasa. - Google Patents

Procedimiento de prepwracion de acido heteroaril-2-carboxilico biciclico por hidrolisis enzimatica del correspondiente ester, utiles para sintetizar intermediarios del inhibidor de beta-lactamasa.

Info

Publication number
CL2004001037A1
CL2004001037A1 CL200401037A CL2004001037A CL2004001037A1 CL 2004001037 A1 CL2004001037 A1 CL 2004001037A1 CL 200401037 A CL200401037 A CL 200401037A CL 2004001037 A CL2004001037 A CL 2004001037A CL 2004001037 A1 CL2004001037 A1 CL 2004001037A1
Authority
CL
Chile
Prior art keywords
lactamasa
heteroaril
bicycle
beta
carboxylic acid
Prior art date
Application number
CL200401037A
Other languages
English (en)
Inventor
Ramesch Matur
Mark Edward Ruppen
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of CL2004001037A1 publication Critical patent/CL2004001037A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/182—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A UN PROCEDIMIENTO ENZIMATICO PARA LA PRODUCCION DE UN INTERMEDIARIO, EL ACIDO HETEROARIL-2-CARBOXILICO BICICLICO DE LA FORMULA, EN DONDE X e Y SE ENCUENTRAN DEFINIDOS EN LA MEMORIA DESCRIPTIVA Y EL CUAL ES UTIL EN LA PREPARACION DE INHIBIDORES DE BETA-LACTAMASA, POR MEDIO DE HIDROLISIS ENZIMATICAS SELECTIVA DE UNA MEZCLA DE ESTERES POSICIONALES HIDROLIZABLES DE LAS FORMULAS EN DONDE X,Y y R SE ENCUENTRAN EN LA MEMORIA DESCRIPTIVA.
CL200401037A 2003-05-16 2004-05-13 Procedimiento de prepwracion de acido heteroaril-2-carboxilico biciclico por hidrolisis enzimatica del correspondiente ester, utiles para sintetizar intermediarios del inhibidor de beta-lactamasa. CL2004001037A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US47146103P 2003-05-16 2003-05-16

Publications (1)

Publication Number Publication Date
CL2004001037A1 true CL2004001037A1 (es) 2005-03-04

Family

ID=33476848

Family Applications (1)

Application Number Title Priority Date Filing Date
CL200401037A CL2004001037A1 (es) 2003-05-16 2004-05-13 Procedimiento de prepwracion de acido heteroaril-2-carboxilico biciclico por hidrolisis enzimatica del correspondiente ester, utiles para sintetizar intermediarios del inhibidor de beta-lactamasa.

Country Status (12)

Country Link
US (1) US7316917B2 (es)
EP (1) EP1626972A1 (es)
JP (1) JP2007501635A (es)
CN (1) CN1823069A (es)
AR (1) AR045681A1 (es)
AU (1) AU2004240924A1 (es)
BR (1) BRPI0410642A (es)
CA (1) CA2525507A1 (es)
CL (1) CL2004001037A1 (es)
MX (1) MXPA05012113A (es)
TW (1) TW200505925A (es)
WO (1) WO2004104008A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1626975A2 (en) * 2003-05-16 2006-02-22 Wyeth Holdings Corporation PROCESS FOR SYNTHESIZING ß-LACTAMASE INHIBITOR IN INTERMEDIATES
ITRM20050345A1 (it) * 2005-06-30 2007-01-01 Sigma Tau Ind Farmaceuti Sintesi di deossi-biotinil esametilen diammina-dota.
MX2013003752A (es) 2010-10-07 2013-12-02 Basf Se Proceso para la preparación de cetonas, en particular cetonas macrociclicas.
CN105274174A (zh) * 2015-11-30 2016-01-27 精晶药业股份有限公司 一种生物酶转化制备丙谷二肽的方法
CN110923288A (zh) * 2019-12-19 2020-03-27 卓和药业集团有限公司 一种wxfl10203614中间体的生物学拆分方法
WO2023284775A1 (zh) * 2021-07-14 2023-01-19 上海海雁医药科技有限公司 吡唑衍生物及其中间体和制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4496739A (en) * 1982-01-27 1985-01-29 Sumitomo Chemical Company, Limited Intermediates to optically active cis-1,3-dibenzyl-hexahydro-1H-furo[3,4-d]imidazole-2,4-dione
GB9222700D0 (en) 1992-10-29 1992-12-09 Smithkline Beecham Plc Chemical compounds
GB0106631D0 (en) * 2001-03-16 2001-05-09 Pfizer Ltd Pharmaceutically active compounds
AR039476A1 (es) * 2002-05-01 2005-02-23 Wyeth Corp Proceso para preparar derivados de 6-alquiliden penem
EP1626975A2 (en) * 2003-05-16 2006-02-22 Wyeth Holdings Corporation PROCESS FOR SYNTHESIZING ß-LACTAMASE INHIBITOR IN INTERMEDIATES

Also Published As

Publication number Publication date
AU2004240924A1 (en) 2004-12-02
CA2525507A1 (en) 2004-12-02
EP1626972A1 (en) 2006-02-22
CN1823069A (zh) 2006-08-23
AR045681A1 (es) 2005-11-09
JP2007501635A (ja) 2007-02-01
US7316917B2 (en) 2008-01-08
BRPI0410642A (pt) 2006-07-04
US20040229324A1 (en) 2004-11-18
WO2004104008A1 (en) 2004-12-02
TW200505925A (en) 2005-02-16
MXPA05012113A (es) 2006-02-08

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