HRP20031026B1 - Amino benzoksazol sulfonamidni inhibitori hiv proteaze širokog spektra - Google Patents

Amino benzoksazol sulfonamidni inhibitori hiv proteaze širokog spektra

Info

Publication number
HRP20031026B1
HRP20031026B1 HRP20031026AA HRP20031026A HRP20031026B1 HR P20031026 B1 HRP20031026 B1 HR P20031026B1 HR P20031026A A HRP20031026A A HR P20031026AA HR P20031026 A HRP20031026 A HR P20031026A HR P20031026 B1 HRP20031026 B1 HR P20031026B1
Authority
HR
Croatia
Prior art keywords
het
alkyl
cycloalkyl
aryl
group
Prior art date
Application number
HRP20031026AA
Other languages
English (en)
Croatian (hr)
Inventor
Dominique@Louis@Nestor@Ghislai@Surleraux
Sandrine@Marie@Helene@Vendeville
Wim@Gaston@Verschueren
Marie@Pierre@T@M@M@G@De@Bethune
Herman@Augustinus@De@Kock
Abdellah@Tahri
Original Assignee
Tibotec@Pharmaceuticals@Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tibotec@Pharmaceuticals@Ltd filed Critical Tibotec@Pharmaceuticals@Ltd
Publication of HRP20031026A2 publication Critical patent/HRP20031026A2/hr
Publication of HRP20031026B1 publication Critical patent/HRP20031026B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
HRP20031026AA 2001-05-11 2002-05-10 Amino benzoksazol sulfonamidni inhibitori hiv proteaze širokog spektra HRP20031026B1 (hr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01201732 2001-05-11
PCT/EP2002/005212 WO2002092595A1 (en) 2001-05-11 2002-05-10 Broadspectrum 2-amino-benzoxazole sulfonamide hiv protease inhibitors

Publications (2)

Publication Number Publication Date
HRP20031026A2 HRP20031026A2 (en) 2005-10-31
HRP20031026B1 true HRP20031026B1 (hr) 2012-07-31

Family

ID=8180286

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20031026AA HRP20031026B1 (hr) 2001-05-11 2002-05-10 Amino benzoksazol sulfonamidni inhibitori hiv proteaze širokog spektra

Country Status (31)

Country Link
US (2) US7622490B2 (cs)
EP (1) EP1387842B1 (cs)
JP (1) JP4467889B2 (cs)
KR (1) KR100878853B1 (cs)
CN (1) CN100549007C (cs)
AP (1) AP1652A (cs)
AR (1) AR035970A1 (cs)
AT (1) ATE429431T1 (cs)
AU (1) AU2002310818B2 (cs)
BG (1) BG66350B1 (cs)
BR (1) BR0209594A (cs)
CA (1) CA2444895C (cs)
CY (1) CY1109247T1 (cs)
CZ (1) CZ304524B6 (cs)
DE (1) DE60232067D1 (cs)
DK (1) DK1387842T3 (cs)
EA (1) EA009590B1 (cs)
EE (1) EE05307B1 (cs)
ES (1) ES2325809T3 (cs)
HR (1) HRP20031026B1 (cs)
HU (1) HUP0400438A3 (cs)
IL (1) IL158093A0 (cs)
MX (1) MXPA03010258A (cs)
NO (1) NO326883B1 (cs)
NZ (1) NZ529250A (cs)
OA (1) OA13134A (cs)
PL (1) PL209029B1 (cs)
PT (1) PT1387842E (cs)
SK (1) SK287952B6 (cs)
WO (1) WO2002092595A1 (cs)
ZA (1) ZA200307799B (cs)

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Publication number Priority date Publication date Assignee Title
ATE329579T1 (de) 1999-11-12 2006-07-15 Abbott Lab Feste dispersion mit ritonavir, fenofibrat oder griseofulvin
US7364752B1 (en) 1999-11-12 2008-04-29 Abbott Laboratories Solid dispersion pharamaceutical formulations
DE10026698A1 (de) 2000-05-30 2001-12-06 Basf Ag Selbstemulgierende Wirkstoffformulierung und Verwendung dieser Formulierung
AU2003202914A1 (en) 2002-01-07 2003-07-24 Sequoia Pharmaceuticals Broad spectrum inhibitors
US7157489B2 (en) 2002-03-12 2007-01-02 The Board Of Trustees Of The University Of Illinois HIV protease inhibitors
US8025899B2 (en) 2003-08-28 2011-09-27 Abbott Laboratories Solid pharmaceutical dosage form
PT1670773E (pt) * 2003-09-30 2007-05-31 Tibotec Pharm Ltd Métodos para a preparação de compostos de sulfonamida de benzoxazole e os seus intermediários.
US20050131042A1 (en) * 2003-12-11 2005-06-16 Flentge Charles A. HIV protease inhibiting compounds
US8193227B2 (en) 2003-12-11 2012-06-05 Abbott Laboratories HIV protease inhibiting compounds
AU2004309122B2 (en) 2003-12-23 2011-07-21 Janssen Sciences Ireland Unlimited Company Process for the preparation of (3R,3aS,6AR)-hexahydrofuro [2,3-b] furan-3-yl (1S,2R)-3-[[(4-aminophenyl) sulfonyl] (isobutyl) amino]-1-benzyl-2-hydroxypropylcarbamate
UA85567C2 (en) 2003-12-23 2009-02-10 Тиботек Фармасьютикелз Лтд. Process for the preparation of (3r,3as,6ar)-hexahydrofuro [2,3-b] furan-3-yl (1s,2r)-3-[[(4-aminophenyl) sulfonyl] (isobutyl) amino]-1-benzyl-2-hydroxypropylcarbamate
WO2005110428A2 (en) * 2004-05-07 2005-11-24 Sequoia Pharmaceuticals, Inc. Resistance-repellent retroviral protease inhibitors
CN101128469B (zh) 2005-02-25 2012-11-14 泰博特克药品有限公司 蛋白酶抑制剂前体的合成
AR053845A1 (es) * 2005-04-15 2007-05-23 Tibotec Pharm Ltd 5-tiazolilmetil[(1s,2r)-3-[[(2-amino-6-benzoxazolil)sulfonil)](2-metilpropil)amino]-2-hidroxi-1-(fenilmetil)propil]carbamato como mejorador de farmacos metabolizados por el citocromo p450
US20120220520A1 (en) * 2006-10-17 2012-08-30 Van T Klooster Gerben Albert Eleutherius Bioavailable combinations for hcv treatment
WO2014194519A1 (en) 2013-06-07 2014-12-11 Merck Sharp & Dohme Corp. Imidazole derivatives and methods of use thereof for improving pharmacokinetics of drug

Citations (5)

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Publication number Priority date Publication date Assignee Title
WO1995006030A1 (en) * 1993-08-24 1995-03-02 G.D. Searle & Co. Hydroxyethylamino sulphonamides useful as retroviral protease inhibitors
WO1996028418A1 (en) * 1995-03-10 1996-09-19 G.D. Searle & Co. Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
WO1996028464A1 (en) * 1995-03-10 1996-09-19 G.D. Searle & Co. Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
WO1996028463A1 (en) * 1995-03-10 1996-09-19 G.D. Searle & Co. Amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
WO1997018205A1 (en) * 1995-11-15 1997-05-22 G.D. Searle & Co. Substituted sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors

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SE8204879D0 (sv) 1982-08-26 1982-08-26 Haessle Ab Novel chemical intermediates
ATE141635T1 (de) 1990-03-09 1996-09-15 Milliken Res Corp Organische materialien, die sulfonamidogebundene poly(oxyalkylen)gruppen tragen und ihre herstellung
US5145684A (en) 1991-01-25 1992-09-08 Sterling Drug Inc. Surface modified drug nanoparticles
EP0656886B1 (en) * 1992-08-25 1997-06-25 G.D. Searle & Co. N-(alkanoylamino-2-hydroxypropyl)-sulfonamides useful as retroviral protease inhibitors
PH30929A (en) 1992-09-03 1997-12-23 Janssen Pharmaceutica Nv Beads having a core coated with an antifungal and a polymer.
CZ289214B6 (cs) 1993-10-01 2001-12-12 Astra Aktiebolag Způsob zpracování jemně děleného práąkového léčiva, zařízení k provádění tohoto způsobu a aglomeráty vyrobené tímto způsobem
EP1586558A3 (en) 1995-01-20 2005-10-26 G.D. Searle LLC. Bis-sulfonamide hydroxyethylamino retroviral protease inhinitors
RU2174519C2 (ru) 1995-03-10 2001-10-10 Джи. Ди. Сирл Энд Ко. Гидроксиэтиламино сульфонамиды гетероциклокарбонил аминокислоты, ингибирующие ретровирусную протеазу
ATE255883T1 (de) 1996-05-20 2003-12-15 Janssen Pharmaceutica Nv Fungizide mittel mit verbesserter bioverfügbarkeit
AU734248B2 (en) 1997-03-26 2001-06-07 Janssen Pharmaceutica N.V. Pellets having a core coated with an antifungal and a polymer
GB9717849D0 (en) 1997-08-23 1997-10-29 Seal Sands Chemicals Limited Preparation of pyridene derivatives
AU2012199A (en) 1997-12-24 1999-07-19 Vertex Pharmaceuticals Incorporated Prodrugs of aspartyl protease inhibitors
ID25551A (id) 1997-12-24 2000-10-12 Vertex Pharma Bahan baku obat penghambat protease aspartil
US6436989B1 (en) 1997-12-24 2002-08-20 Vertex Pharmaceuticals, Incorporated Prodrugs of aspartyl protease inhibitors
AU2010299A (en) 1997-12-24 1999-07-19 Vertex Pharmaceuticals Incorporated Prodrugs os aspartyl protease inhibitors
PT1088098E (pt) 1998-06-23 2011-05-25 Univ Illinois Medicamento para tratar mam?feros infectados com hiv
AU4828199A (en) 1998-06-23 2000-01-10 Board Of Trustees Of The University Of Illinois, The Multi-drug resistant retroviral protease inhibitors and associated methods
JP4417010B2 (ja) * 2001-04-09 2010-02-17 テイボテク・フアーマシユーチカルズ・リミテツド 広範囲２−（置換−アミノ）−ベンズオキサゾールスルホンアミドｈｉｖプロテアーゼ阻害剤

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995006030A1 (en) * 1993-08-24 1995-03-02 G.D. Searle & Co. Hydroxyethylamino sulphonamides useful as retroviral protease inhibitors
WO1996028418A1 (en) * 1995-03-10 1996-09-19 G.D. Searle & Co. Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
WO1996028464A1 (en) * 1995-03-10 1996-09-19 G.D. Searle & Co. Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
WO1996028463A1 (en) * 1995-03-10 1996-09-19 G.D. Searle & Co. Amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
WO1997018205A1 (en) * 1995-11-15 1997-05-22 G.D. Searle & Co. Substituted sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors

Also Published As

Publication number Publication date
ZA200307799B (en) 2005-03-30
PL366780A1 (en) 2005-02-07
WO2002092595A1 (en) 2002-11-21
SK14902003A3 (sk) 2004-07-07
US7863306B2 (en) 2011-01-04
EP1387842B1 (en) 2009-04-22
EE05307B1 (et) 2010-06-15
BG108309A (bg) 2004-12-30
US20040106661A1 (en) 2004-06-03
NO20034988D0 (no) 2003-11-10
MXPA03010258A (es) 2005-03-07
HUP0400438A2 (hu) 2004-08-30
OA13134A (en) 2006-12-13
CZ304524B6 (cs) 2014-06-18
EA200301234A1 (ru) 2004-04-29
CA2444895C (en) 2011-02-15
JP2004534757A (ja) 2004-11-18
CY1109247T1 (el) 2014-07-02
EE200300547A (et) 2004-02-16
AR035970A1 (es) 2004-07-28
PT1387842E (pt) 2009-07-20
HUP0400438A3 (en) 2007-08-28
CA2444895A1 (en) 2002-11-21
PL209029B1 (pl) 2011-07-29
KR20040022417A (ko) 2004-03-12
DE60232067D1 (de) 2009-06-04
ATE429431T1 (de) 2009-05-15
NO326883B1 (no) 2009-03-09
BG66350B1 (bg) 2013-08-30
CN100549007C (zh) 2009-10-14
HK1062912A1 (en) 2004-12-03
ES2325809T3 (es) 2009-09-18
EP1387842A1 (en) 2004-02-11
AU2002310818B2 (en) 2007-12-13
EA009590B1 (ru) 2008-02-28
NZ529250A (en) 2005-05-27
BR0209594A (pt) 2004-03-30
HRP20031026A2 (en) 2005-10-31
KR100878853B1 (ko) 2009-01-15
AP1652A (en) 2006-08-11
US20100029632A1 (en) 2010-02-04
CN1507446A (zh) 2004-06-23
SK287952B6 (sk) 2012-06-04
AP2003002904A0 (en) 2003-12-31
JP4467889B2 (ja) 2010-05-26
IL158093A0 (en) 2004-03-28
US7622490B2 (en) 2009-11-24
CZ20033290A3 (cs) 2004-05-12
DK1387842T3 (da) 2009-08-10

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