HRP20031026B1 - Amino benzoksazol sulfonamidni inhibitori hiv proteaze širokog spektra - Google Patents

Amino benzoksazol sulfonamidni inhibitori hiv proteaze širokog spektra

Info

Publication number
HRP20031026B1
HRP20031026B1 HRP20031026AA HRP20031026A HRP20031026B1 HR P20031026 B1 HRP20031026 B1 HR P20031026B1 HR P20031026A A HRP20031026A A HR P20031026AA HR P20031026 A HRP20031026 A HR P20031026A HR P20031026 B1 HRP20031026 B1 HR P20031026B1
Authority
HR
Croatia
Prior art keywords
het
alkyl
cycloalkyl
aryl
group
Prior art date
Application number
HRP20031026AA
Other languages
English (en)
Croatian (hr)
Inventor
Dominique@Louis@Nestor@Ghislai@Surleraux
Sandrine@Marie@Helene@Vendeville
Wim@Gaston@Verschueren
Marie@Pierre@T@M@M@G@De@Bethune
Herman@Augustinus@De@Kock
Abdellah@Tahri
Original Assignee
Tibotec@Pharmaceuticals@Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tibotec@Pharmaceuticals@Ltd filed Critical Tibotec@Pharmaceuticals@Ltd
Publication of HRP20031026A2 publication Critical patent/HRP20031026A2/hr
Publication of HRP20031026B1 publication Critical patent/HRP20031026B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
HRP20031026AA 2001-05-11 2002-05-10 Amino benzoksazol sulfonamidni inhibitori hiv proteaze širokog spektra HRP20031026B1 (hr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01201732 2001-05-11
PCT/EP2002/005212 WO2002092595A1 (en) 2001-05-11 2002-05-10 Broadspectrum 2-amino-benzoxazole sulfonamide hiv protease inhibitors

Publications (2)

Publication Number Publication Date
HRP20031026A2 HRP20031026A2 (en) 2005-10-31
HRP20031026B1 true HRP20031026B1 (hr) 2012-07-31

Family

ID=8180286

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20031026AA HRP20031026B1 (hr) 2001-05-11 2002-05-10 Amino benzoksazol sulfonamidni inhibitori hiv proteaze širokog spektra

Country Status (31)

Country Link
US (2) US7622490B2 (cs)
EP (1) EP1387842B1 (cs)
JP (1) JP4467889B2 (cs)
KR (1) KR100878853B1 (cs)
CN (1) CN100549007C (cs)
AP (1) AP1652A (cs)
AR (1) AR035970A1 (cs)
AT (1) ATE429431T1 (cs)
AU (1) AU2002310818B2 (cs)
BG (1) BG66350B1 (cs)
BR (1) BR0209594A (cs)
CA (1) CA2444895C (cs)
CY (1) CY1109247T1 (cs)
CZ (1) CZ304524B6 (cs)
DE (1) DE60232067D1 (cs)
DK (1) DK1387842T3 (cs)
EA (1) EA009590B1 (cs)
EE (1) EE05307B1 (cs)
ES (1) ES2325809T3 (cs)
HR (1) HRP20031026B1 (cs)
HU (1) HUP0400438A3 (cs)
IL (1) IL158093A0 (cs)
MX (1) MXPA03010258A (cs)
NO (1) NO326883B1 (cs)
NZ (1) NZ529250A (cs)
OA (1) OA13134A (cs)
PL (1) PL209029B1 (cs)
PT (1) PT1387842E (cs)
SK (1) SK287952B6 (cs)
WO (1) WO2002092595A1 (cs)
ZA (1) ZA200307799B (cs)

Families Citing this family (16)

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Publication number Priority date Publication date Assignee Title
CA2359945C (en) 1999-11-12 2011-04-26 Abbott Laboratories Inhibitors of crystallization in a solid dispersion
US7364752B1 (en) 1999-11-12 2008-04-29 Abbott Laboratories Solid dispersion pharamaceutical formulations
DE10026698A1 (de) 2000-05-30 2001-12-06 Basf Ag Selbstemulgierende Wirkstoffformulierung und Verwendung dieser Formulierung
US7109230B2 (en) 2002-01-07 2006-09-19 Sequoia Pharmaceuticals, Inc. Resistance-repellent retroviral protease inhibitors
US7157489B2 (en) 2002-03-12 2007-01-02 The Board Of Trustees Of The University Of Illinois HIV protease inhibitors
US8025899B2 (en) 2003-08-28 2011-09-27 Abbott Laboratories Solid pharmaceutical dosage form
ATE353323T1 (de) * 2003-09-30 2007-02-15 Tibotec Pharm Ltd Verfahren zur herstellung von benzoxazolsulfonamidverbindungen und zwischenprodukten davon
US8193227B2 (en) 2003-12-11 2012-06-05 Abbott Laboratories HIV protease inhibiting compounds
US20050131042A1 (en) * 2003-12-11 2005-06-16 Flentge Charles A. HIV protease inhibiting compounds
UA85567C2 (en) 2003-12-23 2009-02-10 Тиботек Фармасьютикелз Лтд. Process for the preparation of (3r,3as,6ar)-hexahydrofuro [2,3-b] furan-3-yl (1s,2r)-3-[[(4-aminophenyl) sulfonyl] (isobutyl) amino]-1-benzyl-2-hydroxypropylcarbamate
EP1725566B1 (en) 2003-12-23 2009-06-17 Tibotec Pharmaceuticals Ltd. Process for the preparation of (3r,3as,6ar)-hexahydrofuro [2,3-b] furan-3-yl (1s,2r)-3-[[(4-aminophenyl) sulfonyl] (isobutyl) amino]-1-benzyl-2-hydroxypropylcarbamate
JP5073480B2 (ja) * 2004-05-07 2012-11-14 セコイア、ファーマシューティカルズ、インコーポレイテッド 耐性防止レトロウイルスプロテアーゼ阻害薬
ATE440848T1 (de) 2005-02-25 2009-09-15 Tibotec Pharm Ltd Synthese von proteaseinhibitorvorstufen
AR053845A1 (es) * 2005-04-15 2007-05-23 Tibotec Pharm Ltd 5-tiazolilmetil[(1s,2r)-3-[[(2-amino-6-benzoxazolil)sulfonil)](2-metilpropil)amino]-2-hidroxi-1-(fenilmetil)propil]carbamato como mejorador de farmacos metabolizados por el citocromo p450
US20120220520A1 (en) * 2006-10-17 2012-08-30 Van T Klooster Gerben Albert Eleutherius Bioavailable combinations for hcv treatment
WO2014194519A1 (en) 2013-06-07 2014-12-11 Merck Sharp & Dohme Corp. Imidazole derivatives and methods of use thereof for improving pharmacokinetics of drug

Citations (5)

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Publication number Priority date Publication date Assignee Title
WO1995006030A1 (en) * 1993-08-24 1995-03-02 G.D. Searle & Co. Hydroxyethylamino sulphonamides useful as retroviral protease inhibitors
WO1996028464A1 (en) * 1995-03-10 1996-09-19 G.D. Searle & Co. Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
WO1996028463A1 (en) * 1995-03-10 1996-09-19 G.D. Searle & Co. Amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
WO1996028418A1 (en) * 1995-03-10 1996-09-19 G.D. Searle & Co. Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
WO1997018205A1 (en) * 1995-11-15 1997-05-22 G.D. Searle & Co. Substituted sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors

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SE8204879D0 (sv) 1982-08-26 1982-08-26 Haessle Ab Novel chemical intermediates
DE69121436T2 (de) 1990-03-09 1997-01-09 Milliken Res Corp Organische Materialien, die sulfonamidogebundene Poly(oxyalkylen)gruppen tragen und ihre Herstellung
US5145684A (en) 1991-01-25 1992-09-08 Sterling Drug Inc. Surface modified drug nanoparticles
WO1994004491A1 (en) * 1992-08-25 1994-03-03 G.D. Searle & Co. N-(alkanoylamino-2-hydroxypropyl)-sulfonamides useful as retroviral protease inhibitors
PH30929A (en) 1992-09-03 1997-12-23 Janssen Pharmaceutica Nv Beads having a core coated with an antifungal and a polymer.
EP0721331B1 (en) 1993-10-01 2001-12-05 AstraZeneca AB Process i
JP4014220B2 (ja) 1995-01-20 2007-11-28 ジー．ディー．サール アンド カンパニー ビス−スルホンアミドヒドロキシエチルアミノ レトロ ウイルスプロテアーゼインヒビター
ATE229033T1 (de) 1995-03-10 2002-12-15 Searle & Co Heterocyclocarbonyl-aminosäure-hydroxyethylamin - sulfonamid inhibitoren retroviraler proteasen
AU722101B2 (en) 1996-05-20 2000-07-20 Janssen Pharmaceutica N.V. Antifungal compositions with improved bioavailability
JP3608800B2 (ja) 1997-03-26 2005-01-12 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 抗真菌剤およびポリマーでコートされたコアを有するペレット剤
GB9717849D0 (en) 1997-08-23 1997-10-29 Seal Sands Chemicals Limited Preparation of pyridene derivatives
US6436989B1 (en) 1997-12-24 2002-08-20 Vertex Pharmaceuticals, Incorporated Prodrugs of aspartyl protease inhibitors
AU2010299A (en) 1997-12-24 1999-07-19 Vertex Pharmaceuticals Incorporated Prodrugs os aspartyl protease inhibitors
PL341762A1 (en) 1997-12-24 2001-05-07 Vertex Pharma Precursors of aspartil protease inhibitors
AU2012199A (en) 1997-12-24 1999-07-19 Vertex Pharmaceuticals Incorporated Prodrugs of aspartyl protease inhibitors
DE69943266D1 (de) 1998-06-23 2011-04-21 Trustees For The University Of Illinois Board Of Arzneimittel zur behandlung von hiv-infizierten säugetieren
AU4828199A (en) * 1998-06-23 2000-01-10 Board Of Trustees Of The University Of Illinois, The Multi-drug resistant retroviral protease inhibitors and associated methods
KR100872029B1 (ko) * 2001-04-09 2008-12-05 티보텍 파마슈티칼즈 리미티드 광범위 2-(치환된-아미노)-벤즈옥사졸 설폰아미드 ｈｉｖ프로테아제 저해제

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995006030A1 (en) * 1993-08-24 1995-03-02 G.D. Searle & Co. Hydroxyethylamino sulphonamides useful as retroviral protease inhibitors
WO1996028464A1 (en) * 1995-03-10 1996-09-19 G.D. Searle & Co. Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
WO1996028463A1 (en) * 1995-03-10 1996-09-19 G.D. Searle & Co. Amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
WO1996028418A1 (en) * 1995-03-10 1996-09-19 G.D. Searle & Co. Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
WO1997018205A1 (en) * 1995-11-15 1997-05-22 G.D. Searle & Co. Substituted sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors

Also Published As

Publication number Publication date
NZ529250A (en) 2005-05-27
BR0209594A (pt) 2004-03-30
CZ304524B6 (cs) 2014-06-18
JP4467889B2 (ja) 2010-05-26
EP1387842A1 (en) 2004-02-11
PL366780A1 (en) 2005-02-07
US20100029632A1 (en) 2010-02-04
AR035970A1 (es) 2004-07-28
CA2444895A1 (en) 2002-11-21
CY1109247T1 (el) 2014-07-02
ZA200307799B (en) 2005-03-30
OA13134A (en) 2006-12-13
US7622490B2 (en) 2009-11-24
HUP0400438A3 (en) 2007-08-28
PL209029B1 (pl) 2011-07-29
IL158093A0 (en) 2004-03-28
EA200301234A1 (ru) 2004-04-29
US20040106661A1 (en) 2004-06-03
SK287952B6 (sk) 2012-06-04
CN100549007C (zh) 2009-10-14
EE05307B1 (et) 2010-06-15
DE60232067D1 (de) 2009-06-04
MXPA03010258A (es) 2005-03-07
ES2325809T3 (es) 2009-09-18
DK1387842T3 (da) 2009-08-10
HK1062912A1 (en) 2004-12-03
HRP20031026A2 (en) 2005-10-31
EP1387842B1 (en) 2009-04-22
NO326883B1 (no) 2009-03-09
WO2002092595A1 (en) 2002-11-21
CA2444895C (en) 2011-02-15
EE200300547A (et) 2004-02-16
AP1652A (en) 2006-08-11
AU2002310818B2 (en) 2007-12-13
BG108309A (bg) 2004-12-30
JP2004534757A (ja) 2004-11-18
KR20040022417A (ko) 2004-03-12
KR100878853B1 (ko) 2009-01-15
ATE429431T1 (de) 2009-05-15
SK14902003A3 (sk) 2004-07-07
HUP0400438A2 (hu) 2004-08-30
CZ20033290A3 (cs) 2004-05-12
BG66350B1 (bg) 2013-08-30
CN1507446A (zh) 2004-06-23
NO20034988D0 (no) 2003-11-10
AP2003002904A0 (en) 2003-12-31
PT1387842E (pt) 2009-07-20
EA009590B1 (ru) 2008-02-28
US7863306B2 (en) 2011-01-04

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