HRP20030015A2 - Indole derivatives useful for the treatment of cns disorders - Google Patents
Indole derivatives useful for the treatment of cns disorders Download PDFInfo
- Publication number
- HRP20030015A2 HRP20030015A2 HR20030015A HRP20030015A HRP20030015A2 HR P20030015 A2 HRP20030015 A2 HR P20030015A2 HR 20030015 A HR20030015 A HR 20030015A HR P20030015 A HRP20030015 A HR P20030015A HR P20030015 A2 HRP20030015 A2 HR P20030015A2
- Authority
- HR
- Croatia
- Prior art keywords
- indole
- ethyl
- piperidin
- chloro
- methylphenyl
- Prior art date
Links
- 238000011282 treatment Methods 0.000 title claims description 24
- 150000002475 indoles Chemical class 0.000 title claims description 3
- 229940054051 antipsychotic indole derivative Drugs 0.000 title 1
- -1 cyano, nitro, amino, hydroxy Chemical group 0.000 claims description 121
- 150000001875 compounds Chemical class 0.000 claims description 92
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 34
- 238000000034 method Methods 0.000 claims description 21
- 230000000694 effects Effects 0.000 claims description 19
- 229910052739 hydrogen Inorganic materials 0.000 claims description 18
- 239000001257 hydrogen Substances 0.000 claims description 18
- 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 claims description 17
- 229910052736 halogen Inorganic materials 0.000 claims description 15
- 150000002367 halogens Chemical class 0.000 claims description 15
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 15
- 125000001889 triflyl group Chemical group FC(F)(F)S(*)(=O)=O 0.000 claims description 14
- 125000004482 piperidin-4-yl group Chemical group N1CCC(CC1)* 0.000 claims description 13
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 claims description 12
- 201000000980 schizophrenia Diseases 0.000 claims description 12
- 208000024891 symptom Diseases 0.000 claims description 12
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 11
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 11
- 150000003839 salts Chemical class 0.000 claims description 11
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 11
- 208000019901 Anxiety disease Diseases 0.000 claims description 10
- 230000036506 anxiety Effects 0.000 claims description 10
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 10
- 229910052760 oxygen Inorganic materials 0.000 claims description 10
- 125000001424 substituent group Chemical group 0.000 claims description 10
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims description 9
- 229910052717 sulfur Inorganic materials 0.000 claims description 9
- 125000006621 (C3-C8) cycloalkyl-(C1-C6) alkyl group Chemical group 0.000 claims description 8
- 208000028017 Psychotic disease Diseases 0.000 claims description 8
- 239000002253 acid Substances 0.000 claims description 8
- 125000003118 aryl group Chemical group 0.000 claims description 8
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 8
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims description 7
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims description 7
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 7
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 claims description 7
- 229920006395 saturated elastomer Polymers 0.000 claims description 7
- WRMNZCZEMHIOCP-UHFFFAOYSA-N 2-phenylethanol Chemical compound OCCC1=CC=CC=C1 WRMNZCZEMHIOCP-UHFFFAOYSA-N 0.000 claims description 6
- 229940079593 drug Drugs 0.000 claims description 6
- 239000003814 drug Substances 0.000 claims description 6
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 claims description 5
- 208000019695 Migraine disease Diseases 0.000 claims description 5
- 125000001072 heteroaryl group Chemical group 0.000 claims description 5
- 206010027599 migraine Diseases 0.000 claims description 5
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims description 4
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 claims description 4
- 208000021384 Obsessive-Compulsive disease Diseases 0.000 claims description 4
- 125000002252 acyl group Chemical group 0.000 claims description 4
- 230000016571 aggressive behavior Effects 0.000 claims description 4
- 239000000164 antipsychotic agent Substances 0.000 claims description 4
- 229910002091 carbon monoxide Inorganic materials 0.000 claims description 4
- 239000003085 diluting agent Substances 0.000 claims description 4
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 claims description 4
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 claims description 4
- 208000019906 panic disease Diseases 0.000 claims description 4
- 239000008194 pharmaceutical composition Substances 0.000 claims description 4
- 230000007958 sleep Effects 0.000 claims description 4
- COKJNEXXCRXHKU-UHFFFAOYSA-N 1-[3-[2-[4-(5-fluoro-1h-indol-3-yl)piperidin-1-yl]ethyl]-4-methylphenyl]-3-(4-fluorophenyl)urea Chemical compound C1=C(CCN2CCC(CC2)C=2C3=CC(F)=CC=C3NC=2)C(C)=CC=C1NC(=O)NC1=CC=C(F)C=C1 COKJNEXXCRXHKU-UHFFFAOYSA-N 0.000 claims description 3
- SZCVKMOVEPYVAY-UHFFFAOYSA-N 3-[3-[2-[4-(6-chloro-1h-indol-3-yl)piperidin-1-yl]ethyl]-4-methylphenyl]-1-methyl-1-phenylurea Chemical compound C=1C=C(C)C(CCN2CCC(CC2)C=2C3=CC=C(Cl)C=C3NC=2)=CC=1NC(=O)N(C)C1=CC=CC=C1 SZCVKMOVEPYVAY-UHFFFAOYSA-N 0.000 claims description 3
- OZMNONYSCNSFPO-UHFFFAOYSA-N 3-cyclohexyl-n-[3-[2-[4-(5-fluoro-1h-indol-3-yl)piperidin-1-yl]ethyl]-4-methylphenyl]propanamide Chemical compound C1=C(CCN2CCC(CC2)C=2C3=CC(F)=CC=C3NC=2)C(C)=CC=C1NC(=O)CCC1CCCCC1 OZMNONYSCNSFPO-UHFFFAOYSA-N 0.000 claims description 3
- DSKIXYWEEZMPKP-UHFFFAOYSA-N 4-chloro-n-[3-[2-[4-(7-chloro-1h-indol-3-yl)piperidin-1-yl]ethyl]-4-methylphenyl]benzamide Chemical compound C1=C(CCN2CCC(CC2)C=2C3=CC=CC(Cl)=C3NC=2)C(C)=CC=C1NC(=O)C1=CC=C(Cl)C=C1 DSKIXYWEEZMPKP-UHFFFAOYSA-N 0.000 claims description 3
- UPWHNYKFYLPTLY-UHFFFAOYSA-N 4-fluoro-n-[3-[2-[4-(5-fluoro-1h-indol-3-yl)piperidin-1-yl]ethyl]-4-methylphenyl]benzamide Chemical compound C1=C(CCN2CCC(CC2)C=2C3=CC(F)=CC=C3NC=2)C(C)=CC=C1NC(=O)C1=CC=C(F)C=C1 UPWHNYKFYLPTLY-UHFFFAOYSA-N 0.000 claims description 3
- 208000010877 cognitive disease Diseases 0.000 claims description 3
- 239000003937 drug carrier Substances 0.000 claims description 3
- 125000002541 furyl group Chemical group 0.000 claims description 3
- 125000005842 heteroatom Chemical group 0.000 claims description 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 3
- SYBVOKCVTYSRPG-UHFFFAOYSA-N n-[3-[2-[4-(5-chloro-1h-indol-3-yl)piperidin-1-yl]ethyl]-4-methylphenyl]-3-methoxybenzamide Chemical compound COC1=CC=CC(C(=O)NC=2C=C(CCN3CCC(CC3)C=3C4=CC(Cl)=CC=C4NC=3)C(C)=CC=2)=C1 SYBVOKCVTYSRPG-UHFFFAOYSA-N 0.000 claims description 3
- XDPFARVEOFULEU-UHFFFAOYSA-N n-[3-[2-[4-(5-fluoro-1h-indol-3-yl)piperidin-1-yl]ethyl]-4-methylphenyl]-2-methylpropanamide Chemical compound CC(C)C(=O)NC1=CC=C(C)C(CCN2CCC(CC2)C=2C3=CC(F)=CC=C3NC=2)=C1 XDPFARVEOFULEU-UHFFFAOYSA-N 0.000 claims description 3
- NIFCQXBHZRSABD-UHFFFAOYSA-N n-[3-[2-[4-(5-fluoro-1h-indol-3-yl)piperidin-1-yl]ethyl]-4-methylphenyl]-3-methoxybenzamide Chemical compound COC1=CC=CC(C(=O)NC=2C=C(CCN3CCC(CC3)C=3C4=CC(F)=CC=C4NC=3)C(C)=CC=2)=C1 NIFCQXBHZRSABD-UHFFFAOYSA-N 0.000 claims description 3
- PHNBIPAXSGYUAL-UHFFFAOYSA-N n-[3-[2-[4-(5-fluoro-1h-indol-3-yl)piperidin-1-yl]ethyl]-4-methylphenyl]-3-phenylpropanamide Chemical compound C1=C(CCN2CCC(CC2)C=2C3=CC(F)=CC=C3NC=2)C(C)=CC=C1NC(=O)CCC1=CC=CC=C1 PHNBIPAXSGYUAL-UHFFFAOYSA-N 0.000 claims description 3
- NUTRIFZDVOBUDS-UHFFFAOYSA-N n-[3-[2-[4-(5-fluoro-1h-indol-3-yl)piperidin-1-yl]ethyl]-4-methylphenyl]-4-methylbenzamide Chemical compound C1=CC(C)=CC=C1C(=O)NC1=CC=C(C)C(CCN2CCC(CC2)C=2C3=CC(F)=CC=C3NC=2)=C1 NUTRIFZDVOBUDS-UHFFFAOYSA-N 0.000 claims description 3
- PXWRAGRXMNGNBJ-UHFFFAOYSA-N n-[3-[2-[4-(5-fluoro-1h-indol-3-yl)piperidin-1-yl]ethyl]-4-methylphenyl]cyclopropanecarboxamide Chemical compound C1=C(CCN2CCC(CC2)C=2C3=CC(F)=CC=C3NC=2)C(C)=CC=C1NC(=O)C1CC1 PXWRAGRXMNGNBJ-UHFFFAOYSA-N 0.000 claims description 3
- YFLQNIXJLUAWHP-UHFFFAOYSA-N n-[3-[2-[4-(5-fluoro-1h-indol-3-yl)piperidin-1-yl]ethyl]-4-methylphenyl]morpholine-4-carboxamide Chemical compound C1=C(CCN2CCC(CC2)C=2C3=CC(F)=CC=C3NC=2)C(C)=CC=C1NC(=O)N1CCOCC1 YFLQNIXJLUAWHP-UHFFFAOYSA-N 0.000 claims description 3
- HIMBSTFPSOTMBD-UHFFFAOYSA-N n-[3-[2-[4-(5-fluoro-1h-indol-3-yl)piperidin-1-yl]ethyl]-4-methylphenyl]pyridine-3-carboxamide Chemical compound C1=C(CCN2CCC(CC2)C=2C3=CC(F)=CC=C3NC=2)C(C)=CC=C1NC(=O)C1=CC=CN=C1 HIMBSTFPSOTMBD-UHFFFAOYSA-N 0.000 claims description 3
- ROYKPHBDQQUOPT-UHFFFAOYSA-N n-[3-[2-[4-(6-chloro-1h-indol-3-yl)piperidin-1-yl]ethyl]-4-methylphenyl]-4-methylbenzamide Chemical compound C1=CC(C)=CC=C1C(=O)NC1=CC=C(C)C(CCN2CCC(CC2)C=2C3=CC=C(Cl)C=C3NC=2)=C1 ROYKPHBDQQUOPT-UHFFFAOYSA-N 0.000 claims description 3
- GHKVCRWGSMPFBT-UHFFFAOYSA-N n-[3-[2-[4-(6-chloro-1h-indol-3-yl)piperidin-1-yl]ethyl]-4-methylphenyl]acetamide Chemical group CC(=O)NC1=CC=C(C)C(CCN2CCC(CC2)C=2C3=CC=C(Cl)C=C3NC=2)=C1 GHKVCRWGSMPFBT-UHFFFAOYSA-N 0.000 claims description 3
- BJQIJWIVRSICQY-UHFFFAOYSA-N n-[3-[2-[4-(6-chloro-1h-indol-3-yl)piperidin-1-yl]ethyl]-4-methylphenyl]cyclopentanecarboxamide Chemical compound C1=C(CCN2CCC(CC2)C=2C3=CC=C(Cl)C=C3NC=2)C(C)=CC=C1NC(=O)C1CCCC1 BJQIJWIVRSICQY-UHFFFAOYSA-N 0.000 claims description 3
- GDWYHPJDBGGMAY-UHFFFAOYSA-N n-[3-[2-[4-(6-chloro-1h-indol-3-yl)piperidin-1-yl]ethyl]-4-methylphenyl]pyridine-3-carboxamide Chemical compound C1=C(CCN2CCC(CC2)C=2C3=CC=C(Cl)C=C3NC=2)C(C)=CC=C1NC(=O)C1=CC=CN=C1 GDWYHPJDBGGMAY-UHFFFAOYSA-N 0.000 claims description 3
- BWBNZVJTOUWTRO-UHFFFAOYSA-N n-[3-[2-[4-(6-chloro-1h-indol-3-yl)piperidin-1-yl]ethyl]-4-methylphenyl]thiophene-2-carboxamide Chemical compound C1=C(CCN2CCC(CC2)C=2C3=CC=C(Cl)C=C3NC=2)C(C)=CC=C1NC(=O)C1=CC=CS1 BWBNZVJTOUWTRO-UHFFFAOYSA-N 0.000 claims description 3
- XHNCUDFWPYXDNO-UHFFFAOYSA-N n-[3-[2-[4-(7-chloro-1h-indol-3-yl)piperidin-1-yl]ethyl]-4-methylphenyl]-3-phenylpropanamide Chemical compound C1=C(CCN2CCC(CC2)C=2C3=CC=CC(Cl)=C3NC=2)C(C)=CC=C1NC(=O)CCC1=CC=CC=C1 XHNCUDFWPYXDNO-UHFFFAOYSA-N 0.000 claims description 3
- KFKUIMDCNNLHTM-UHFFFAOYSA-N n-[3-[2-[4-(7-chloro-1h-indol-3-yl)piperidin-1-yl]ethyl]-4-methylphenyl]-4-fluorobenzamide Chemical compound C1=C(CCN2CCC(CC2)C=2C3=CC=CC(Cl)=C3NC=2)C(C)=CC=C1NC(=O)C1=CC=C(F)C=C1 KFKUIMDCNNLHTM-UHFFFAOYSA-N 0.000 claims description 3
- GDDHTDLBSUZWCA-UHFFFAOYSA-N n-[3-[2-[4-(7-chloro-1h-indol-3-yl)piperidin-1-yl]ethyl]-4-methylphenyl]-4-methylbenzamide Chemical compound C1=CC(C)=CC=C1C(=O)NC1=CC=C(C)C(CCN2CCC(CC2)C=2C3=CC=CC(Cl)=C3NC=2)=C1 GDDHTDLBSUZWCA-UHFFFAOYSA-N 0.000 claims description 3
- FMOBAHNKNCLUHS-UHFFFAOYSA-N n-[3-[2-[4-(7-chloro-1h-indol-3-yl)piperidin-1-yl]ethyl]-4-methylphenyl]benzamide Chemical compound C1=C(CCN2CCC(CC2)C=2C3=CC=CC(Cl)=C3NC=2)C(C)=CC=C1NC(=O)C1=CC=CC=C1 FMOBAHNKNCLUHS-UHFFFAOYSA-N 0.000 claims description 3
- ICOKBOHVIJCZKC-UHFFFAOYSA-N n-[3-[2-[4-(7-chloro-1h-indol-3-yl)piperidin-1-yl]ethyl]-4-methylphenyl]cyclopropanecarboxamide Chemical compound C1=C(CCN2CCC(CC2)C=2C3=CC=CC(Cl)=C3NC=2)C(C)=CC=C1NC(=O)C1CC1 ICOKBOHVIJCZKC-UHFFFAOYSA-N 0.000 claims description 3
- NNRXNDWFUPQDHU-UHFFFAOYSA-N n-[3-[2-[4-(7-chloro-1h-indol-3-yl)piperidin-1-yl]ethyl]-4-methylphenyl]hexanamide Chemical compound CCCCCC(=O)NC1=CC=C(C)C(CCN2CCC(CC2)C=2C3=CC=CC(Cl)=C3NC=2)=C1 NNRXNDWFUPQDHU-UHFFFAOYSA-N 0.000 claims description 3
- YIJBZDYVCNJSES-UHFFFAOYSA-N n-[3-[2-[4-(7-chloro-1h-indol-3-yl)piperidin-1-yl]ethyl]-4-methylphenyl]pyridine-3-carboxamide Chemical compound C1=C(CCN2CCC(CC2)C=2C3=CC=CC(Cl)=C3NC=2)C(C)=CC=C1NC(=O)C1=CC=CN=C1 YIJBZDYVCNJSES-UHFFFAOYSA-N 0.000 claims description 3
- VKOBFZFQQXPWBP-UHFFFAOYSA-N n-[3-[2-[4-(7-chloro-1h-indol-3-yl)piperidin-1-yl]ethyl]-4-methylphenyl]pyridine-4-carboxamide Chemical compound C1=C(CCN2CCC(CC2)C=2C3=CC=CC(Cl)=C3NC=2)C(C)=CC=C1NC(=O)C1=CC=NC=C1 VKOBFZFQQXPWBP-UHFFFAOYSA-N 0.000 claims description 3
- WJQQWWVNJCNWMS-UHFFFAOYSA-N n-[3-[2-[4-(7-chloro-1h-indol-3-yl)piperidin-1-yl]ethyl]-4-methylphenyl]thiophene-2-carboxamide Chemical compound C1=C(CCN2CCC(CC2)C=2C3=CC=CC(Cl)=C3NC=2)C(C)=CC=C1NC(=O)C1=CC=CS1 WJQQWWVNJCNWMS-UHFFFAOYSA-N 0.000 claims description 3
- PLQMWLUVQABXSI-UHFFFAOYSA-N n-[3-[2-[4-(7-chloro-1h-indol-3-yl)piperidin-1-yl]ethyl]-4-methylphenyl]thiophene-3-carboxamide Chemical compound C1=C(CCN2CCC(CC2)C=2C3=CC=CC(Cl)=C3NC=2)C(C)=CC=C1NC(=O)C=1C=CSC=1 PLQMWLUVQABXSI-UHFFFAOYSA-N 0.000 claims description 3
- 125000004076 pyridyl group Chemical group 0.000 claims description 3
- 125000001412 tetrahydropyranyl group Chemical group 0.000 claims description 3
- 125000001544 thienyl group Chemical group 0.000 claims description 3
- 125000003441 thioacyl group Chemical group 0.000 claims description 3
- GEZMEIHVFSWOCA-UHFFFAOYSA-N (4-fluorophenyl)methanol Chemical compound OCC1=CC=C(F)C=C1 GEZMEIHVFSWOCA-UHFFFAOYSA-N 0.000 claims description 2
- 125000004391 aryl sulfonyl group Chemical group 0.000 claims description 2
- 229910052799 carbon Inorganic materials 0.000 claims description 2
- WPOPOPFNZYPKAV-UHFFFAOYSA-N cyclobutylmethanol Chemical compound OCC1CCC1 WPOPOPFNZYPKAV-UHFFFAOYSA-N 0.000 claims description 2
- 230000006872 improvement Effects 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- CSRGGHAQRBPQBW-UHFFFAOYSA-N n-[3-[2-[4-(5-fluoro-1h-indol-3-yl)-3,6-dihydro-2h-pyridin-1-yl]ethyl]-4-methylphenyl]acetamide Chemical compound CC(=O)NC1=CC=C(C)C(CCN2CC=C(CC2)C=2C3=CC(F)=CC=C3NC=2)=C1 CSRGGHAQRBPQBW-UHFFFAOYSA-N 0.000 claims description 2
- SRAQFFXJBJEVGN-UHFFFAOYSA-N n-[3-[2-[4-(5-fluoro-1h-indol-3-yl)-3,6-dihydro-2h-pyridin-1-yl]ethyl]-4-methylphenyl]pyridine-3-carboxamide Chemical compound C1=C(CCN2CC=C(CC2)C=2C3=CC(F)=CC=C3NC=2)C(C)=CC=C1NC(=O)C1=CC=CN=C1 SRAQFFXJBJEVGN-UHFFFAOYSA-N 0.000 claims description 2
- JIRPRUOEKMRRCC-UHFFFAOYSA-N n-[3-[2-[4-(5-fluoro-1h-indol-3-yl)piperidin-1-yl]ethyl]-4-methylphenyl]acetamide Chemical compound CC(=O)NC1=CC=C(C)C(CCN2CCC(CC2)C=2C3=CC(F)=CC=C3NC=2)=C1 JIRPRUOEKMRRCC-UHFFFAOYSA-N 0.000 claims description 2
- SIJAQKZIQFOKIC-UHFFFAOYSA-N n-[3-[2-[4-(5-fluoro-1h-indol-3-yl)piperidin-1-yl]ethyl]-4-methylphenyl]cyclobutanecarboxamide Chemical compound C1=C(CCN2CCC(CC2)C=2C3=CC(F)=CC=C3NC=2)C(C)=CC=C1NC(=O)C1CCC1 SIJAQKZIQFOKIC-UHFFFAOYSA-N 0.000 claims description 2
- XQICOXCELYJLLR-UHFFFAOYSA-N n-[3-[2-[4-(6-chloro-1h-indol-3-yl)piperidin-1-yl]ethyl]-4-methylphenyl]-3-methoxybenzamide Chemical compound COC1=CC=CC(C(=O)NC=2C=C(CCN3CCC(CC3)C=3C4=CC=C(Cl)C=C4NC=3)C(C)=CC=2)=C1 XQICOXCELYJLLR-UHFFFAOYSA-N 0.000 claims description 2
- KJWRXPGADNQRCA-UHFFFAOYSA-N n-[3-[2-[4-(6-chloro-1h-indol-3-yl)piperidin-1-yl]ethyl]-4-methylphenyl]cyclopropanecarboxamide Chemical compound C1=C(CCN2CCC(CC2)C=2C3=CC=C(Cl)C=C3NC=2)C(C)=CC=C1NC(=O)C1CC1 KJWRXPGADNQRCA-UHFFFAOYSA-N 0.000 claims description 2
- KIXJKVGKALVEBC-UHFFFAOYSA-N n-[3-[2-[4-(7-chloro-1h-indol-3-yl)-3,6-dihydro-2h-pyridin-1-yl]ethyl]-4-methylphenyl]acetamide Chemical compound CC(=O)NC1=CC=C(C)C(CCN2CC=C(CC2)C=2C3=CC=CC(Cl)=C3NC=2)=C1 KIXJKVGKALVEBC-UHFFFAOYSA-N 0.000 claims description 2
- HCHMGLZVWPQNSZ-UHFFFAOYSA-N n-[3-[2-[4-(7-chloro-1h-indol-3-yl)-3,6-dihydro-2h-pyridin-1-yl]ethyl]-4-methylphenyl]pyridine-3-carboxamide Chemical compound C1=C(CCN2CC=C(CC2)C=2C3=CC=CC(Cl)=C3NC=2)C(C)=CC=C1NC(=O)C1=CC=CN=C1 HCHMGLZVWPQNSZ-UHFFFAOYSA-N 0.000 claims description 2
- IULCHZDFEFRUFG-UHFFFAOYSA-N n-[3-[2-[4-(7-chloro-1h-indol-3-yl)piperidin-1-yl]ethyl]-4-methylphenyl]-2-(4-methoxyphenyl)acetamide Chemical compound C1=CC(OC)=CC=C1CC(=O)NC1=CC=C(C)C(CCN2CCC(CC2)C=2C3=CC=CC(Cl)=C3NC=2)=C1 IULCHZDFEFRUFG-UHFFFAOYSA-N 0.000 claims description 2
- SPOFUJQNHLVFOS-UHFFFAOYSA-N n-[3-[2-[4-(7-chloro-1h-indol-3-yl)piperidin-1-yl]ethyl]-4-methylphenyl]-4-methoxybenzamide Chemical compound C1=CC(OC)=CC=C1C(=O)NC1=CC=C(C)C(CCN2CCC(CC2)C=2C3=CC=CC(Cl)=C3NC=2)=C1 SPOFUJQNHLVFOS-UHFFFAOYSA-N 0.000 claims description 2
- 125000004193 piperazinyl group Chemical group 0.000 claims description 2
- 125000000714 pyrimidinyl group Chemical group 0.000 claims description 2
- 125000000168 pyrrolyl group Chemical group 0.000 claims description 2
- 125000003396 thiol group Chemical class [H]S* 0.000 claims 5
- CTWLIHIEDTYNRM-UHFFFAOYSA-N 4-fluoro-n-[3-[2-[4-(5-fluoro-1h-indol-3-yl)-3,6-dihydro-2h-pyridin-1-yl]ethyl]-4-methylphenyl]benzamide Chemical compound C1=C(CCN2CC=C(CC2)C=2C3=CC(F)=CC=C3NC=2)C(C)=CC=C1NC(=O)C1=CC=C(F)C=C1 CTWLIHIEDTYNRM-UHFFFAOYSA-N 0.000 claims 1
- MKEMFDINUGGRIP-UHFFFAOYSA-N n-[3-[2-[4-(5-chloro-1h-indol-3-yl)piperidin-1-yl]ethyl]-4-methylphenyl]thiophene-2-carboxamide Chemical compound C1=C(CCN2CCC(CC2)C=2C3=CC(Cl)=CC=C3NC=2)C(C)=CC=C1NC(=O)C1=CC=CS1 MKEMFDINUGGRIP-UHFFFAOYSA-N 0.000 claims 1
- HKHYNBPXKNILOH-UHFFFAOYSA-N n-[3-[2-[4-(5-fluoro-1h-indol-3-yl)piperidin-1-yl]ethyl]-4-methylphenyl]-2,2-dimethylpropanamide Chemical compound CC1=CC=C(NC(=O)C(C)(C)C)C=C1CCN1CCC(C=2C3=CC(F)=CC=C3NC=2)CC1 HKHYNBPXKNILOH-UHFFFAOYSA-N 0.000 claims 1
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- 125000002757 morpholinyl group Chemical group 0.000 description 1
- HSJDRNJAYXUCGQ-UHFFFAOYSA-N n-[3-[2-[4-(7-chloro-1h-indol-3-yl)piperidin-1-yl]ethyl]-4-methylphenyl]cyclobutanecarboxamide Chemical compound C1=C(CCN2CCC(CC2)C=2C3=CC=CC(Cl)=C3NC=2)C(C)=CC=C1NC(=O)C1CCC1 HSJDRNJAYXUCGQ-UHFFFAOYSA-N 0.000 description 1
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- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
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- 150000003891 oxalate salts Chemical class 0.000 description 1
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- 125000004430 oxygen atom Chemical group O* 0.000 description 1
- WUHLVXDDBHWHLQ-UHFFFAOYSA-N pentazole Chemical group N=1N=NNN=1 WUHLVXDDBHWHLQ-UHFFFAOYSA-N 0.000 description 1
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- 125000004592 phthalazinyl group Chemical group C1(=NN=CC2=CC=CC=C12)* 0.000 description 1
- 125000003386 piperidinyl group Chemical group 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920005990 polystyrene resin Polymers 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 229910000027 potassium carbonate Inorganic materials 0.000 description 1
- 229920001592 potato starch Polymers 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 229940069328 povidone Drugs 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
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- 125000004368 propenyl group Chemical group C(=CC)* 0.000 description 1
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- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
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- 208000020016 psychiatric disease Diseases 0.000 description 1
- 125000003373 pyrazinyl group Chemical group 0.000 description 1
- 125000002098 pyridazinyl group Chemical group 0.000 description 1
- ATBIAJXSKNPHEI-UHFFFAOYSA-N pyridine-3-carbonyl chloride Chemical compound ClC(=O)C1=CC=CN=C1 ATBIAJXSKNPHEI-UHFFFAOYSA-N 0.000 description 1
- RVQZKNOMKUSGCI-UHFFFAOYSA-N pyridine-4-carbonyl chloride Chemical compound ClC(=O)C1=CC=NC=C1 RVQZKNOMKUSGCI-UHFFFAOYSA-N 0.000 description 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 description 1
- 125000002294 quinazolinyl group Chemical group N1=C(N=CC2=CC=CC=C12)* 0.000 description 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
- 125000005493 quinolyl group Chemical group 0.000 description 1
- 125000001567 quinoxalinyl group Chemical group N1=C(C=NC2=CC=CC=C12)* 0.000 description 1
- 229940044551 receptor antagonist Drugs 0.000 description 1
- 239000002464 receptor antagonist Substances 0.000 description 1
- 238000006268 reductive amination reaction Methods 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000003215 serotonin 5-HT2 receptor antagonist Substances 0.000 description 1
- 230000013275 serotonin uptake Effects 0.000 description 1
- 230000003860 sleep quality Effects 0.000 description 1
- 239000012279 sodium borohydride Substances 0.000 description 1
- 229910000033 sodium borohydride Inorganic materials 0.000 description 1
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000010532 solid phase synthesis reaction Methods 0.000 description 1
- 108010092215 spiroperidol receptor Proteins 0.000 description 1
- 239000001119 stannous chloride Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008223 sterile water Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 125000004434 sulfur atom Chemical group 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- QYTJFOBUAJLXAR-UHFFFAOYSA-N tert-butyl 4-(5-fluoro-1h-indol-3-yl)piperidine-1-carboxylate Chemical compound C1CN(C(=O)OC(C)(C)C)CCC1C1=CNC2=CC=C(F)C=C12 QYTJFOBUAJLXAR-UHFFFAOYSA-N 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 description 1
- 125000004853 tetrahydropyridinyl group Chemical group N1(CCCC=C1)* 0.000 description 1
- 125000005942 tetrahydropyridyl group Chemical group 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 125000000335 thiazolyl group Chemical group 0.000 description 1
- 125000002813 thiocarbonyl group Chemical group *C(*)=S 0.000 description 1
- 125000004568 thiomorpholinyl group Chemical group 0.000 description 1
- HFRXJVQOXRXOPP-UHFFFAOYSA-N thionyl bromide Chemical compound BrS(Br)=O HFRXJVQOXRXOPP-UHFFFAOYSA-N 0.000 description 1
- ZPHGMBGIFODUMF-UHFFFAOYSA-N thiophen-2-ylmethanol Chemical compound OCC1=CC=CS1 ZPHGMBGIFODUMF-UHFFFAOYSA-N 0.000 description 1
- QIQITDHWZYEEPA-UHFFFAOYSA-N thiophene-2-carbonyl chloride Chemical compound ClC(=O)C1=CC=CS1 QIQITDHWZYEEPA-UHFFFAOYSA-N 0.000 description 1
- QTWBEVAYYDZLQL-UHFFFAOYSA-N thiophene-3-carbonyl chloride Chemical compound ClC(=O)C=1C=CSC=1 QTWBEVAYYDZLQL-UHFFFAOYSA-N 0.000 description 1
- GZNAASVAJNXPPW-UHFFFAOYSA-M tin(4+) chloride dihydrate Chemical compound O.O.[Cl-].[Sn+4] GZNAASVAJNXPPW-UHFFFAOYSA-M 0.000 description 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
- 125000004044 trifluoroacetyl group Chemical group FC(C(=O)*)(F)F 0.000 description 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 description 1
- 238000001665 trituration Methods 0.000 description 1
- 150000003672 ureas Chemical class 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA200001123 | 2000-07-21 | ||
PCT/DK2001/000507 WO2002008223A1 (en) | 2000-07-21 | 2001-07-17 | Indole derivatives useful for the treatment of cns disorders |
Publications (1)
Publication Number | Publication Date |
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HRP20030015A2 true HRP20030015A2 (en) | 2005-02-28 |
Family
ID=8159625
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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HR20030015A HRP20030015A2 (en) | 2000-07-21 | 2003-01-09 | Indole derivatives useful for the treatment of cns disorders |
Country Status (29)
Country | Link |
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US (1) | US6743809B2 (pt) |
EP (1) | EP1305307B1 (pt) |
JP (1) | JP2004504396A (pt) |
KR (1) | KR100851793B1 (pt) |
CN (1) | CN1264838C (pt) |
AR (1) | AR029858A1 (pt) |
AT (1) | ATE266024T1 (pt) |
AU (2) | AU2001281738B2 (pt) |
BG (1) | BG107528A (pt) |
BR (1) | BR0112998A (pt) |
CA (1) | CA2416212C (pt) |
CZ (1) | CZ301114B6 (pt) |
DE (1) | DE60103162T2 (pt) |
EA (1) | EA004749B1 (pt) |
ES (1) | ES2219554T3 (pt) |
HK (1) | HK1059782A1 (pt) |
HR (1) | HRP20030015A2 (pt) |
HU (1) | HUP0302820A3 (pt) |
IL (2) | IL153605A0 (pt) |
IS (1) | IS2172B (pt) |
MX (1) | MXPA02012927A (pt) |
NO (1) | NO323799B1 (pt) |
NZ (1) | NZ523436A (pt) |
PT (1) | PT1305307E (pt) |
SK (1) | SK286701B6 (pt) |
TR (1) | TR200401488T4 (pt) |
UA (1) | UA73995C2 (pt) |
WO (1) | WO2002008223A1 (pt) |
ZA (1) | ZA200300287B (pt) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2004291297B2 (en) | 2003-11-17 | 2011-06-23 | Boehringer Ingelheim International Gmbh | Novel piperidine-substituted indoles- or heteroderivatives thereof |
TWI391387B (zh) * | 2004-05-12 | 2013-04-01 | Eisai R&D Man Co Ltd | 具有哌啶環之吲哚衍生物 |
WO2006117314A2 (en) | 2005-04-30 | 2006-11-09 | Boehringer Ingelheim International Gmbh | Novel piperidin- substituted indoles and their use as ccr-3 modulators |
CA2667547C (en) | 2006-10-27 | 2014-07-29 | Boehringer Ingelheim International Gmbh | Piperidyl-propane-thiol ccr3 modulators |
CN101486654B (zh) * | 2009-03-04 | 2012-10-10 | 西安近代化学研究所 | 2-甲基-3-硝基苯乙酸合成方法 |
CN110041318B (zh) * | 2018-01-17 | 2022-07-29 | 中国科学院上海药物研究所 | 一类多巴胺d5受体激动剂及其制备和应用 |
CN110498789B (zh) * | 2018-05-17 | 2022-04-05 | 上海医药工业研究院 | 芳烷哌啶类衍生物及其在多靶点抗抑郁症中的应用 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2322470A1 (de) * | 1973-05-04 | 1974-11-21 | Boehringer Sohn Ingelheim | Neue indolyl-piperidino-(bzw. 1,2,5,6tetrahydro-pyridyl-)butyrophenone und verfahren zu ihrer herstellung |
AT332401B (de) * | 1973-11-26 | 1976-09-27 | Roussel Uclaf | Verfahren zur herstellung von neuen (4'-(3''-indolyl)-piperidino)-alkylarylketonderivaten |
US4997841A (en) * | 1987-08-13 | 1991-03-05 | Glaxo Group Limited | Indole derivatives |
GB8719167D0 (en) * | 1987-08-13 | 1987-09-23 | Glaxo Group Ltd | Chemical compounds |
CA2141810A1 (en) * | 1992-08-05 | 1994-02-17 | Ian A. Cliffe | Amide derivatives |
DK0695301T3 (da) * | 1993-04-22 | 1996-12-09 | Pfizer Ltd | Indolderivater som 5-HT1-lignende agonister til anvendelse ved migræne |
ES2063700B1 (es) * | 1993-04-28 | 1995-07-16 | Vita Invest Sa | Agente activo sobre el sistema nervioso central, proceso para su preparacion y composiciones farmaceuticas que lo contengan. |
US5576321A (en) * | 1995-01-17 | 1996-11-19 | Eli Lilly And Company | Compounds having effects on serotonin-related systems |
GB9718712D0 (en) * | 1997-09-03 | 1997-11-12 | Merck Sharp & Dohme | Theraputic Agents |
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2001
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- 2001-07-17 DE DE60103162T patent/DE60103162T2/de not_active Expired - Fee Related
- 2001-07-17 IL IL15360501A patent/IL153605A0/xx unknown
- 2001-07-17 CZ CZ20030196A patent/CZ301114B6/cs not_active IP Right Cessation
- 2001-07-17 PT PT01960182T patent/PT1305307E/pt unknown
- 2001-07-17 NZ NZ523436A patent/NZ523436A/en unknown
- 2001-07-17 AT AT01960182T patent/ATE266024T1/de not_active IP Right Cessation
- 2001-07-17 KR KR1020037000850A patent/KR100851793B1/ko not_active IP Right Cessation
- 2001-07-17 HU HU0302820A patent/HUP0302820A3/hu unknown
- 2001-07-17 AU AU2001281738A patent/AU2001281738B2/en not_active Ceased
- 2001-07-17 EA EA200300179A patent/EA004749B1/ru not_active IP Right Cessation
- 2001-07-17 WO PCT/DK2001/000507 patent/WO2002008223A1/en active IP Right Grant
- 2001-07-17 EP EP01960182A patent/EP1305307B1/en not_active Expired - Lifetime
- 2001-07-17 BR BR0112998-8A patent/BR0112998A/pt not_active IP Right Cessation
- 2001-07-17 SK SK203-2003A patent/SK286701B6/sk not_active IP Right Cessation
- 2001-07-17 TR TR2004/01488T patent/TR200401488T4/xx unknown
- 2001-07-17 AU AU8173801A patent/AU8173801A/xx active Pending
- 2001-07-17 CA CA002416212A patent/CA2416212C/en not_active Expired - Fee Related
- 2001-07-17 CN CNB018151078A patent/CN1264838C/zh not_active Expired - Fee Related
- 2001-07-17 ES ES01960182T patent/ES2219554T3/es not_active Expired - Lifetime
- 2001-07-17 JP JP2002514129A patent/JP2004504396A/ja active Pending
- 2001-07-17 UA UA2003010167A patent/UA73995C2/uk unknown
- 2001-07-20 AR ARP010103457A patent/AR029858A1/es unknown
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2002
- 2002-12-23 IS IS6663A patent/IS2172B/is unknown
- 2002-12-24 IL IL153605A patent/IL153605A/en not_active IP Right Cessation
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2003
- 2003-01-09 HR HR20030015A patent/HRP20030015A2/hr not_active Application Discontinuation
- 2003-01-10 ZA ZA200300287A patent/ZA200300287B/en unknown
- 2003-01-10 NO NO20030127A patent/NO323799B1/no not_active IP Right Cessation
- 2003-01-17 US US10/347,574 patent/US6743809B2/en not_active Expired - Fee Related
- 2003-02-05 BG BG107528A patent/BG107528A/bg unknown
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