HK1059782A1 - Indole derivatives useful for the treatment of cnsdisorders - Google Patents

Indole derivatives useful for the treatment of cnsdisorders

Info

Publication number
HK1059782A1
HK1059782A1 HK04102653A HK04102653A HK1059782A1 HK 1059782 A1 HK1059782 A1 HK 1059782A1 HK 04102653 A HK04102653 A HK 04102653A HK 04102653 A HK04102653 A HK 04102653A HK 1059782 A1 HK1059782 A1 HK 1059782A1
Authority
HK
Hong Kong
Prior art keywords
cnsdisorders
treatment
indole derivatives
derivatives useful
useful
Prior art date
Application number
HK04102653A
Other languages
English (en)
Inventor
Jakob Felding
Benny Bang-Andersen
Garrick Paul Smith
Kim Andersen
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Publication of HK1059782A1 publication Critical patent/HK1059782A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
HK04102653A 2000-07-21 2004-04-15 Indole derivatives useful for the treatment of cnsdisorders HK1059782A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200001123 2000-07-21
PCT/DK2001/000507 WO2002008223A1 (en) 2000-07-21 2001-07-17 Indole derivatives useful for the treatment of cns disorders

Publications (1)

Publication Number Publication Date
HK1059782A1 true HK1059782A1 (en) 2004-07-16

Family

ID=8159625

Family Applications (1)

Application Number Title Priority Date Filing Date
HK04102653A HK1059782A1 (en) 2000-07-21 2004-04-15 Indole derivatives useful for the treatment of cnsdisorders

Country Status (29)

Country Link
US (1) US6743809B2 (xx)
EP (1) EP1305307B1 (xx)
JP (1) JP2004504396A (xx)
KR (1) KR100851793B1 (xx)
CN (1) CN1264838C (xx)
AR (1) AR029858A1 (xx)
AT (1) ATE266024T1 (xx)
AU (2) AU2001281738B2 (xx)
BG (1) BG107528A (xx)
BR (1) BR0112998A (xx)
CA (1) CA2416212C (xx)
CZ (1) CZ301114B6 (xx)
DE (1) DE60103162T2 (xx)
EA (1) EA004749B1 (xx)
ES (1) ES2219554T3 (xx)
HK (1) HK1059782A1 (xx)
HR (1) HRP20030015A2 (xx)
HU (1) HUP0302820A3 (xx)
IL (2) IL153605A0 (xx)
IS (1) IS2172B (xx)
MX (1) MXPA02012927A (xx)
NO (1) NO323799B1 (xx)
NZ (1) NZ523436A (xx)
PT (1) PT1305307E (xx)
SK (1) SK286701B6 (xx)
TR (1) TR200401488T4 (xx)
UA (1) UA73995C2 (xx)
WO (1) WO2002008223A1 (xx)
ZA (1) ZA200300287B (xx)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1687294B1 (en) 2003-11-17 2014-05-21 Boehringer Ingelheim International GmbH Novel piperidine-substituted indoles-or hetero-derivatives thereof and their use as modulators of chemokine receptor (ccr-3)
TWI391387B (zh) * 2004-05-12 2013-04-01 Eisai R&D Man Co Ltd 具有哌啶環之吲哚衍生物
US7759365B2 (en) 2005-04-30 2010-07-20 Boehringer Ingelheim International Gmbh Piperidine-substituted indoles
US8153660B2 (en) 2006-10-27 2012-04-10 Boehringer Ingelheim International Gmbh Piperidyl-propane-thiol CCR3 modulators
CN101486654B (zh) * 2009-03-04 2012-10-10 西安近代化学研究所 2-甲基-3-硝基苯乙酸合成方法
CN110041318B (zh) * 2018-01-17 2022-07-29 中国科学院上海药物研究所 一类多巴胺d5受体激动剂及其制备和应用
CN110498789B (zh) * 2018-05-17 2022-04-05 上海医药工业研究院 芳烷哌啶类衍生物及其在多靶点抗抑郁症中的应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2322470A1 (de) * 1973-05-04 1974-11-21 Boehringer Sohn Ingelheim Neue indolyl-piperidino-(bzw. 1,2,5,6tetrahydro-pyridyl-)butyrophenone und verfahren zu ihrer herstellung
AT332401B (de) * 1973-11-26 1976-09-27 Roussel Uclaf Verfahren zur herstellung von neuen (4'-(3''-indolyl)-piperidino)-alkylarylketonderivaten
GB8719167D0 (en) * 1987-08-13 1987-09-23 Glaxo Group Ltd Chemical compounds
PT88255B (pt) * 1987-08-13 1995-03-01 Glaxo Group Ltd Processo para a preparacao de derivados do indole
AU675964B2 (en) * 1992-08-05 1997-02-27 John Wyeth & Brother Limited Amide derivatives
WO1994024127A1 (en) * 1993-04-22 1994-10-27 Pfizer Limited Indole derivatives as 5-h1-like agonists for use in migraine
ES2063700B1 (es) * 1993-04-28 1995-07-16 Vita Invest Sa Agente activo sobre el sistema nervioso central, proceso para su preparacion y composiciones farmaceuticas que lo contengan.
US5576321A (en) * 1995-01-17 1996-11-19 Eli Lilly And Company Compounds having effects on serotonin-related systems
GB9718712D0 (en) * 1997-09-03 1997-11-12 Merck Sharp & Dohme Theraputic Agents

Also Published As

Publication number Publication date
BR0112998A (pt) 2003-06-24
HUP0302820A3 (en) 2006-04-28
PT1305307E (pt) 2004-09-30
NO323799B1 (no) 2007-07-09
DE60103162T2 (de) 2005-05-04
TR200401488T4 (tr) 2004-08-23
EA004749B1 (ru) 2004-08-26
WO2002008223A1 (en) 2002-01-31
IL153605A (en) 2008-07-08
MXPA02012927A (es) 2003-05-15
EP1305307A1 (en) 2003-05-02
UA73995C2 (en) 2005-10-17
HUP0302820A2 (hu) 2003-12-29
AU8173801A (en) 2002-02-05
EP1305307B1 (en) 2004-05-06
AR029858A1 (es) 2003-07-16
US6743809B2 (en) 2004-06-01
SK2032003A3 (en) 2003-06-03
NO20030127L (no) 2003-01-10
SK286701B6 (sk) 2009-03-05
KR100851793B1 (ko) 2008-08-13
HRP20030015A2 (en) 2005-02-28
ZA200300287B (en) 2004-03-02
PL359157A1 (en) 2004-08-23
CA2416212C (en) 2007-10-30
ES2219554T3 (es) 2004-12-01
CZ301114B6 (cs) 2009-11-11
NZ523436A (en) 2004-07-30
ATE266024T1 (de) 2004-05-15
DE60103162D1 (de) 2004-06-09
NO20030127D0 (no) 2003-01-10
BG107528A (bg) 2003-10-31
EA200300179A1 (ru) 2003-06-26
IL153605A0 (en) 2003-07-06
IS2172B (is) 2006-11-15
CA2416212A1 (en) 2002-01-31
JP2004504396A (ja) 2004-02-12
IS6663A (is) 2002-12-23
CZ2003196A3 (cs) 2003-05-14
AU2001281738B2 (en) 2006-12-21
CN1451002A (zh) 2003-10-22
CN1264838C (zh) 2006-07-19
US20030166664A1 (en) 2003-09-04
KR20030017643A (ko) 2003-03-03

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20100717