EA200300179A1 - Производные индола для лечения заболеваний цнс - Google Patents
Производные индола для лечения заболеваний цнсInfo
- Publication number
- EA200300179A1 EA200300179A1 EA200300179A EA200300179A EA200300179A1 EA 200300179 A1 EA200300179 A1 EA 200300179A1 EA 200300179 A EA200300179 A EA 200300179A EA 200300179 A EA200300179 A EA 200300179A EA 200300179 A1 EA200300179 A1 EA 200300179A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- treatment
- cns diseases
- indol derivatives
- diseases
- psychoses
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Abstract
Настоящее изобретение относится к лигандам рецепторов допамина и серотонина, имеющим общую формулу (I), где значения R-R, W, n и X имеют значения приведенные в формуле изобретения и в описании. Соединения изобретения полезны при лечении некоторых психиатрических и неврологических заболеваний, например шизофрении, других психозов, заболеваний, связанных с тревожным состоянием, депрессии, мигрени, нарушений познавательной способности, ADHD и для улучшения сна.Международная заявка была опубликована вместе с отчетом о международном поиске.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA200001123 | 2000-07-21 | ||
PCT/DK2001/000507 WO2002008223A1 (en) | 2000-07-21 | 2001-07-17 | Indole derivatives useful for the treatment of cns disorders |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200300179A1 true EA200300179A1 (ru) | 2003-06-26 |
EA004749B1 EA004749B1 (ru) | 2004-08-26 |
Family
ID=8159625
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200300179A EA004749B1 (ru) | 2000-07-21 | 2001-07-17 | Производные индола для лечения заболеваний цнс |
Country Status (29)
Country | Link |
---|---|
US (1) | US6743809B2 (ru) |
EP (1) | EP1305307B1 (ru) |
JP (1) | JP2004504396A (ru) |
KR (1) | KR100851793B1 (ru) |
CN (1) | CN1264838C (ru) |
AR (1) | AR029858A1 (ru) |
AT (1) | ATE266024T1 (ru) |
AU (2) | AU2001281738B2 (ru) |
BG (1) | BG107528A (ru) |
BR (1) | BR0112998A (ru) |
CA (1) | CA2416212C (ru) |
CZ (1) | CZ301114B6 (ru) |
DE (1) | DE60103162T2 (ru) |
EA (1) | EA004749B1 (ru) |
ES (1) | ES2219554T3 (ru) |
HK (1) | HK1059782A1 (ru) |
HR (1) | HRP20030015A2 (ru) |
HU (1) | HUP0302820A3 (ru) |
IL (2) | IL153605A0 (ru) |
IS (1) | IS2172B (ru) |
MX (1) | MXPA02012927A (ru) |
NO (1) | NO323799B1 (ru) |
NZ (1) | NZ523436A (ru) |
PT (1) | PT1305307E (ru) |
SK (1) | SK286701B6 (ru) |
TR (1) | TR200401488T4 (ru) |
UA (1) | UA73995C2 (ru) |
WO (1) | WO2002008223A1 (ru) |
ZA (1) | ZA200300287B (ru) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2004291297B2 (en) | 2003-11-17 | 2011-06-23 | Boehringer Ingelheim International Gmbh | Novel piperidine-substituted indoles- or heteroderivatives thereof |
TWI391387B (zh) * | 2004-05-12 | 2013-04-01 | Eisai R&D Man Co Ltd | 具有哌啶環之吲哚衍生物 |
WO2006117314A2 (en) | 2005-04-30 | 2006-11-09 | Boehringer Ingelheim International Gmbh | Novel piperidin- substituted indoles and their use as ccr-3 modulators |
CA2667547C (en) | 2006-10-27 | 2014-07-29 | Boehringer Ingelheim International Gmbh | Piperidyl-propane-thiol ccr3 modulators |
CN101486654B (zh) * | 2009-03-04 | 2012-10-10 | 西安近代化学研究所 | 2-甲基-3-硝基苯乙酸合成方法 |
CN110041318B (zh) * | 2018-01-17 | 2022-07-29 | 中国科学院上海药物研究所 | 一类多巴胺d5受体激动剂及其制备和应用 |
CN110498789B (zh) * | 2018-05-17 | 2022-04-05 | 上海医药工业研究院 | 芳烷哌啶类衍生物及其在多靶点抗抑郁症中的应用 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2322470A1 (de) * | 1973-05-04 | 1974-11-21 | Boehringer Sohn Ingelheim | Neue indolyl-piperidino-(bzw. 1,2,5,6tetrahydro-pyridyl-)butyrophenone und verfahren zu ihrer herstellung |
AT332401B (de) * | 1973-11-26 | 1976-09-27 | Roussel Uclaf | Verfahren zur herstellung von neuen (4'-(3''-indolyl)-piperidino)-alkylarylketonderivaten |
US4997841A (en) * | 1987-08-13 | 1991-03-05 | Glaxo Group Limited | Indole derivatives |
GB8719167D0 (en) * | 1987-08-13 | 1987-09-23 | Glaxo Group Ltd | Chemical compounds |
CA2141810A1 (en) * | 1992-08-05 | 1994-02-17 | Ian A. Cliffe | Amide derivatives |
DK0695301T3 (da) * | 1993-04-22 | 1996-12-09 | Pfizer Ltd | Indolderivater som 5-HT1-lignende agonister til anvendelse ved migræne |
ES2063700B1 (es) * | 1993-04-28 | 1995-07-16 | Vita Invest Sa | Agente activo sobre el sistema nervioso central, proceso para su preparacion y composiciones farmaceuticas que lo contengan. |
US5576321A (en) * | 1995-01-17 | 1996-11-19 | Eli Lilly And Company | Compounds having effects on serotonin-related systems |
GB9718712D0 (en) * | 1997-09-03 | 1997-11-12 | Merck Sharp & Dohme | Theraputic Agents |
-
2001
- 2001-07-17 MX MXPA02012927A patent/MXPA02012927A/es active IP Right Grant
- 2001-07-17 DE DE60103162T patent/DE60103162T2/de not_active Expired - Fee Related
- 2001-07-17 IL IL15360501A patent/IL153605A0/xx unknown
- 2001-07-17 CZ CZ20030196A patent/CZ301114B6/cs not_active IP Right Cessation
- 2001-07-17 PT PT01960182T patent/PT1305307E/pt unknown
- 2001-07-17 NZ NZ523436A patent/NZ523436A/en unknown
- 2001-07-17 AT AT01960182T patent/ATE266024T1/de not_active IP Right Cessation
- 2001-07-17 KR KR1020037000850A patent/KR100851793B1/ko not_active IP Right Cessation
- 2001-07-17 HU HU0302820A patent/HUP0302820A3/hu unknown
- 2001-07-17 AU AU2001281738A patent/AU2001281738B2/en not_active Ceased
- 2001-07-17 EA EA200300179A patent/EA004749B1/ru not_active IP Right Cessation
- 2001-07-17 WO PCT/DK2001/000507 patent/WO2002008223A1/en active IP Right Grant
- 2001-07-17 EP EP01960182A patent/EP1305307B1/en not_active Expired - Lifetime
- 2001-07-17 BR BR0112998-8A patent/BR0112998A/pt not_active IP Right Cessation
- 2001-07-17 SK SK203-2003A patent/SK286701B6/sk not_active IP Right Cessation
- 2001-07-17 TR TR2004/01488T patent/TR200401488T4/xx unknown
- 2001-07-17 AU AU8173801A patent/AU8173801A/xx active Pending
- 2001-07-17 CA CA002416212A patent/CA2416212C/en not_active Expired - Fee Related
- 2001-07-17 CN CNB018151078A patent/CN1264838C/zh not_active Expired - Fee Related
- 2001-07-17 ES ES01960182T patent/ES2219554T3/es not_active Expired - Lifetime
- 2001-07-17 JP JP2002514129A patent/JP2004504396A/ja active Pending
- 2001-07-17 UA UA2003010167A patent/UA73995C2/uk unknown
- 2001-07-20 AR ARP010103457A patent/AR029858A1/es unknown
-
2002
- 2002-12-23 IS IS6663A patent/IS2172B/is unknown
- 2002-12-24 IL IL153605A patent/IL153605A/en not_active IP Right Cessation
-
2003
- 2003-01-09 HR HR20030015A patent/HRP20030015A2/hr not_active Application Discontinuation
- 2003-01-10 ZA ZA200300287A patent/ZA200300287B/en unknown
- 2003-01-10 NO NO20030127A patent/NO323799B1/no not_active IP Right Cessation
- 2003-01-17 US US10/347,574 patent/US6743809B2/en not_active Expired - Fee Related
- 2003-02-05 BG BG107528A patent/BG107528A/bg unknown
-
2004
- 2004-04-15 HK HK04102653A patent/HK1059782A1/xx not_active IP Right Cessation
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
SE0303180D0 (sv) | Novel compounds | |
SE0302232D0 (sv) | Novel Compounds | |
EA200500342A1 (ru) | Гетероциклические замещённые пиперазины для лечения шизофрении | |
EA200401282A1 (ru) | Пиридиноилпиперидины как агонисты 5-ht1f | |
SE0201635D0 (sv) | Novel compounds | |
MY135841A (en) | Novel benzodioxoles | |
EA200400006A1 (ru) | Бензоилсульфонамиды и сульфонилбензамидины для применения в качестве противоопухолевых агентов | |
BR0115436A (pt) | Compostos de piperazinilpirazina atuando como antagonistas do receptor 5ht-2 de serotonina | |
EA200301215A1 (ru) | Лиганды рецепторов 5-ht и их применение | |
EA200100203A1 (ru) | Производные 4,4-биарилпиперидина с активностью в отношении опиоидных рецепторов | |
MXPA05007115A (es) | Nuevos agonistas inversos del receptor cb 1. | |
EA200201119A1 (ru) | Лиганды меланокортиновых рецепторов | |
ATE449082T1 (de) | (3,4-dihydro-chinazolin-2-yl)-(2-aryloxy-ethyl) amine mit aktivität am 5-ht-rezeptor | |
EA200200731A1 (ru) | Производные фенилпиперазинила | |
ATE347555T1 (de) | 6-aminomorphinanderivate, herstellungsverfahren dafür und deren verwendung | |
MXPA05011198A (es) | Derivados de oxifenilo aromaticos y de sulfanilfenilo aromaticos. | |
EA200600860A1 (ru) | Производные n-тиазол-2-илбензамида | |
EA200300179A1 (ru) | Производные индола для лечения заболеваний цнс | |
DE60312029D1 (de) | Verfahren zur herstellung c-7 substituierter 5-androstene | |
AP2001002188A0 (en) | 5HT1 antagonists for antidepressant therapy. | |
BR0318521A (pt) | arilindenopiridinas e arilindenopirimidinas e métodos terapêuticos e profiláticos relacionados | |
EA200300084A1 (ru) | Производные индола, пригодные для лечения расстройств цнс | |
CY1108837T1 (el) | ΝΕΑ ΠΑΡΑΓΩΓΑ ΑΜΙΝΟΠΥΡΙΔΙΝΗΣ ΩΣ ΑΝΤΑΓΩΝΙΣΤΕΣ mGluR5 | |
ATE256678T1 (de) | 4-(2-pyridyl)piperazine als agonisten des 5ht7 rezeptors | |
CA2411412A1 (en) | Indole derivatives useful for the treatment of cns disorders |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ KZ KG MD TJ TM |
|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): BY RU |