HRP20020707B1 - Method for producing 6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1h-pyrrolizine-5-yl acetic acid - Google Patents

Method for producing 6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1h-pyrrolizine-5-yl acetic acid

Info

Publication number
HRP20020707B1
HRP20020707B1 HR20020707A HRP20020707A HRP20020707B1 HR P20020707 B1 HRP20020707 B1 HR P20020707B1 HR 20020707 A HR20020707 A HR 20020707A HR P20020707 A HRP20020707 A HR P20020707A HR P20020707 B1 HRP20020707 B1 HR P20020707B1
Authority
HR
Croatia
Prior art keywords
pyrrolizine
chlorophenyl
dihydro
dimethyl
phenyl
Prior art date
Application number
HR20020707A
Other languages
English (en)
Inventor
Kammermeier Thomas
Laufer Stefan
Merckle Philip
Striegel Hans-G�nter
Original Assignee
Merckle Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from MXPA/A/2000/001047A external-priority patent/MXPA00001047A/xx
Application filed by Merckle Gmbh filed Critical Merckle Gmbh
Publication of HRP20020707A2 publication Critical patent/HRP20020707A2/hr
Publication of HRP20020707B1 publication Critical patent/HRP20020707B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Postupci za dobivanje spojeva formule I, naznačeni time da se dobije spoj formule IIIkoji se pomiješa sa oksalilkloridom, a dobiveni produkt se tretira sa hidrazinom i jednim alkalmetalhidroksidom u vodenoj fazi na 120 do 180oC, u nazočnosti jednog alifatskog mono- ili di-alkohola, s točkom talištaod najmanje 140oC, a nakon završetka tretmana dodavanjem etera jednom 3-faznom-sistemu, dobije se gore navedeni spoj formule I, zakiseljivanjem srednje faze. Patent sadrži još 20 patentnih zahtjeva.
HR20020707A 2000-01-28 2002-08-28 Method for producing 6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1h-pyrrolizine-5-yl acetic acid HRP20020707B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
MXPA/A/2000/001047A MXPA00001047A (en) 2000-01-28 Method for producing 6-(4-chlorophenyl) -2,2-dimethyl-7- phenyl -2,3-dihydro- 1h-pyrrolizine- 5-yl acetic acid
PCT/EP2001/000852 WO2001055149A1 (de) 2000-01-28 2001-01-26 Verfahren zur herstellung von 6-(4-chlorphenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1h-pyrrolizin-5-yl-essigsäure

Publications (2)

Publication Number Publication Date
HRP20020707A2 HRP20020707A2 (en) 2004-12-31
HRP20020707B1 true HRP20020707B1 (en) 2006-05-31

Family

ID=32589023

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20020707A HRP20020707B1 (en) 2000-01-28 2002-08-28 Method for producing 6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1h-pyrrolizine-5-yl acetic acid

Country Status (31)

Country Link
US (1) US6417371B1 (hr)
EP (1) EP1252164B1 (hr)
JP (1) JP5143326B2 (hr)
KR (1) KR100749222B1 (hr)
CN (1) CN1160357C (hr)
AT (1) ATE262529T1 (hr)
AU (1) AU779616B2 (hr)
BG (1) BG65567B1 (hr)
BR (1) BR0107898A (hr)
CA (1) CA2397767C (hr)
CU (1) CU23193A3 (hr)
DE (1) DE50101761D1 (hr)
DK (1) DK1252164T3 (hr)
EA (1) EA004938B1 (hr)
EE (1) EE05125B1 (hr)
ES (1) ES2218382T3 (hr)
GE (1) GEP20043408B (hr)
HK (1) HK1047590A1 (hr)
HR (1) HRP20020707B1 (hr)
HU (1) HUP0300604A3 (hr)
IS (1) IS2404B (hr)
NZ (1) NZ520429A (hr)
PL (1) PL208027B1 (hr)
PT (1) PT1252164E (hr)
RS (1) RS50374B (hr)
SK (1) SK286608B6 (hr)
TR (1) TR200400691T4 (hr)
TW (1) TWI289561B (hr)
UA (1) UA72580C2 (hr)
WO (1) WO2001055149A1 (hr)
ZA (1) ZA200206832B (hr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10141285A1 (de) * 2001-08-23 2003-03-27 Merckle Gmbh Verfahren zur Herstellung von 6-(4-Chlorphenyl)-2,2-dimethyl-7-phnyl-2,3-dihydro-1H-pyrrolizin-5-yl-essigsäure
DE102005012971A1 (de) * 2005-03-21 2006-09-28 Merckle Gmbh Polymorphe Form von 6-(4-Chlorphenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl-essigsäure
WO2007108006A1 (en) * 2006-03-23 2007-09-27 Unichem Laboratories Limited Process for the preparation of 6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2, 3-dihydro-1h-pyrrolizin-5-yl acetic acid and its intermediates
DK2350082T3 (en) * 2008-10-31 2015-04-20 C A I R Biosciences Gmbh Choline and thromethamine salt of licofelone
EP3324959B1 (en) 2015-07-17 2023-07-12 The Board Of Regents Of The University Of Oklahoma Licofelone derivatives and methods of use

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3915450A1 (de) * 1989-05-11 1990-11-15 Gerd Prof Dr Dannhardt Substituierte pyrrolverbindungen und deren anwendung in der pharmazie
US5260451A (en) 1989-05-11 1993-11-09 Merckle Gmbh Substituted pyrrole compounds and use thereof in pharmaceutical compositions
DE4419247A1 (de) 1994-06-01 1995-12-07 Merckle Gmbh Sulfonylierte Pyrrolizincarbonsäureamide und deren Anwendung in der Pharmazie
DE4419246A1 (de) 1994-06-01 1995-12-07 Merckle Gmbh Heteroarylsubstituierte Pyrrolizinverbindungen und deren Anwendung in der Pharmazie
DE4419315A1 (de) 1994-06-01 1995-12-07 Merckle Gmbh Heteropyrrolizinverbindungen und deren Anwendung in der Pharmazie

Also Published As

Publication number Publication date
PL208027B1 (pl) 2011-03-31
CA2397767C (en) 2008-05-06
DE50101761D1 (de) 2004-04-29
IS2404B (is) 2008-09-15
HUP0300604A2 (hu) 2003-07-28
SK286608B6 (sk) 2009-02-05
HUP0300604A3 (en) 2003-10-28
CU23193A3 (es) 2007-03-23
EE200200417A (et) 2003-12-15
EP1252164A1 (de) 2002-10-30
WO2001055149A1 (de) 2001-08-02
DK1252164T3 (da) 2004-07-05
BG65567B1 (bg) 2008-12-30
EP1252164B1 (de) 2004-03-24
PL356774A1 (en) 2004-07-12
TR200400691T4 (tr) 2004-11-22
AU3371101A (en) 2001-08-07
US20020028953A1 (en) 2002-03-07
ATE262529T1 (de) 2004-04-15
SK10432002A3 (sk) 2003-02-04
RS50374B (sr) 2009-11-10
CA2397767A1 (en) 2001-08-02
JP2004517799A (ja) 2004-06-17
HRP20020707A2 (en) 2004-12-31
EE05125B1 (et) 2009-02-16
EA200200740A1 (ru) 2002-12-26
CN1160357C (zh) 2004-08-04
HK1047590A1 (en) 2003-02-28
ZA200206832B (en) 2003-10-07
BR0107898A (pt) 2002-11-05
JP5143326B2 (ja) 2013-02-13
EA004938B1 (ru) 2004-10-28
UA72580C2 (en) 2005-03-15
US6417371B1 (en) 2002-07-09
CN1396922A (zh) 2003-02-12
AU779616B2 (en) 2005-02-03
BG106951A (en) 2003-07-31
IS6475A (is) 2002-07-19
TWI289561B (en) 2007-11-11
YU56502A (sh) 2005-06-10
ES2218382T3 (es) 2004-11-16
NZ520429A (en) 2003-08-29
GEP20043408B (en) 2004-06-10
KR20020075895A (ko) 2002-10-07
KR100749222B1 (ko) 2007-08-13
PT1252164E (pt) 2004-08-31

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