IT1297034B1 - Acido 1,4,7,10-tetraazaciclododecan-1,4-diacetico - Google Patents

Acido 1,4,7,10-tetraazaciclododecan-1,4-diacetico

Info

Publication number
IT1297034B1
IT1297034B1 IT97MI002895A ITMI972895A IT1297034B1 IT 1297034 B1 IT1297034 B1 IT 1297034B1 IT 97MI002895 A IT97MI002895 A IT 97MI002895A IT MI972895 A ITMI972895 A IT MI972895A IT 1297034 B1 IT1297034 B1 IT 1297034B1
Authority
IT
Italy
Prior art keywords
diacetic acid
anions
well
tetraazaciclododecan
salts
Prior art date
Application number
IT97MI002895A
Other languages
English (en)
Inventor
Renato Geremia
Marcella Murru
Giorgio Ripa
Vittorio Valle
Original Assignee
Bracco Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco Spa filed Critical Bracco Spa
Priority to IT97MI002895A priority Critical patent/IT1297034B1/it
Priority to AT98966652T priority patent/ATE355281T1/de
Priority to US09/582,578 priority patent/US6417354B1/en
Priority to JP2000527535A priority patent/JP4460766B2/ja
Priority to DE69837219T priority patent/DE69837219T2/de
Priority to AU24156/99A priority patent/AU2415699A/en
Priority to EP98966652A priority patent/EP1045838B1/en
Priority to PCT/EP1998/008364 priority patent/WO1999035134A1/en
Publication of ITMI972895A1 publication Critical patent/ITMI972895A1/it
Application granted granted Critical
Publication of IT1297034B1 publication Critical patent/IT1297034B1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
    • A61K49/108—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA the metal complex being Gd-DOTA
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
IT97MI002895A 1997-12-30 1997-12-30 Acido 1,4,7,10-tetraazaciclododecan-1,4-diacetico IT1297034B1 (it)

Priority Applications (8)

Application Number Priority Date Filing Date Title
IT97MI002895A IT1297034B1 (it) 1997-12-30 1997-12-30 Acido 1,4,7,10-tetraazaciclododecan-1,4-diacetico
AT98966652T ATE355281T1 (de) 1997-12-30 1998-12-21 1,4,7,10-tetraazacyclododecan-1,4-diessigsäure
US09/582,578 US6417354B1 (en) 1997-12-30 1998-12-21 1,4,7,10-tetraazacyclododecane-1,4-diacetic acid
JP2000527535A JP4460766B2 (ja) 1997-12-30 1998-12-21 １，４，７，１０−テトラアザシクロドデカン−１，４−二酢酸
DE69837219T DE69837219T2 (de) 1997-12-30 1998-12-21 1,4,7,10-tetraazacyclododecan-1,4-diessigsäure
AU24156/99A AU2415699A (en) 1997-12-30 1998-12-21 1,4,7,10-tetraazacyclododecane-1,4-diacetic acid
EP98966652A EP1045838B1 (en) 1997-12-30 1998-12-21 1,4,7,10-tetraazacyclododecane-1,4-diacetic acid
PCT/EP1998/008364 WO1999035134A1 (en) 1997-12-30 1998-12-21 1,4,7,10-tetraazacyclododecane-1,4-diacetic acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT97MI002895A IT1297034B1 (it) 1997-12-30 1997-12-30 Acido 1,4,7,10-tetraazaciclododecan-1,4-diacetico

Publications (2)

Publication Number Publication Date
ITMI972895A1 ITMI972895A1 (it) 1999-06-30
IT1297034B1 true IT1297034B1 (it) 1999-08-03

Family

ID=11378473

Family Applications (1)

Application Number Title Priority Date Filing Date
IT97MI002895A IT1297034B1 (it) 1997-12-30 1997-12-30 Acido 1,4,7,10-tetraazaciclododecan-1,4-diacetico

Country Status (8)

Country Link
US (1) US6417354B1 (it)
EP (1) EP1045838B1 (it)
JP (1) JP4460766B2 (it)
AT (1) ATE355281T1 (it)
AU (1) AU2415699A (it)
DE (1) DE69837219T2 (it)
IT (1) IT1297034B1 (it)
WO (1) WO1999035134A1 (it)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2242996T3 (es) * 1997-03-07 2005-11-16 THE PROCTER & GAMBLE COMPANY Composiciones de blanqueo.
US20030017941A1 (en) * 1997-03-07 2003-01-23 The Procter & Gamble Company Catalysts and methods for catalytic oxidation
ZA981883B (en) * 1997-03-07 1998-09-01 Univ Kansas Catalysts and methods for catalytic oxidation
US20080125344A1 (en) * 2006-11-28 2008-05-29 Daryle Hadley Busch Bleach compositions
IT1297035B1 (it) * 1997-12-30 1999-08-03 Bracco Spa Derivati dell'acido 1,4,7,10-tetraazaciclododecan-1,4-diacetico
US20050192195A1 (en) * 2002-08-27 2005-09-01 Busch Daryle H. Catalysts and methods for catalytic oxidation
US20040048763A1 (en) * 2002-08-27 2004-03-11 The Procter & Gamble Co. Bleach compositions

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5132409A (en) * 1987-01-12 1992-07-21 Bracco Industria Chimica S.P.A. Macrocyclic chelating agents and chelates thereof
IT1224416B (it) * 1987-12-24 1990-10-04 Bracco Ind Chimica Spa Chelanti macrociclici e loro chelati
US5410043A (en) * 1991-12-06 1995-04-25 Schering Aktiengesellschaft Process for the production of mono-N-substituted tetraaza macrocycles
JPH09507837A (ja) 1993-11-26 1997-08-12 ザ・ダウ・ケミカル・カンパニー ポリアザ大環状化合物の製造法
US5833948A (en) * 1995-06-15 1998-11-10 Bracco Research S.A. Blood-pool imaging composition comprising micelles containing a lipophilic chelating agent and a non-ionic surfactant
IL125895A (en) * 1996-04-01 2001-09-13 Epix Medical Inc Use of an image-enhancing moiety in the preparation of a bioactivated nmr or optical imaging contrast agent from a prodrug

Also Published As

Publication number Publication date
EP1045838B1 (en) 2007-02-28
ITMI972895A1 (it) 1999-06-30
JP2002500219A (ja) 2002-01-08
WO1999035134A1 (en) 1999-07-15
JP4460766B2 (ja) 2010-05-12
AU2415699A (en) 1999-07-26
EP1045838A1 (en) 2000-10-25
ATE355281T1 (de) 2006-03-15
US6417354B1 (en) 2002-07-09
DE69837219D1 (de) 2007-04-12
DE69837219T2 (de) 2007-07-05

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Legal Events

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0001 Granted