HRP20020626B1 - Novi 1,3-dihidro-2h-indol-2-on derivati i njihova uporaba kao liganada za v<sub>1b</sub> i v<sub>1a</sub> arginin-vazopresinske receptore - Google Patents
Novi 1,3-dihidro-2h-indol-2-on derivati i njihova uporaba kao liganada za v<sub>1b</sub> i v<sub>1a</sub> arginin-vazopresinske receptoreInfo
- Publication number
- HRP20020626B1 HRP20020626B1 HR20020626A HRP20020626A HRP20020626B1 HR P20020626 B1 HRP20020626 B1 HR P20020626B1 HR 20020626 A HR20020626 A HR 20020626A HR P20020626 A HRP20020626 A HR P20020626A HR P20020626 B1 HRP20020626 B1 HR P20020626B1
- Authority
- HR
- Croatia
- Prior art keywords
- radical
- methoxy
- phenyl
- atom
- indol
- Prior art date
Links
- 102000004136 Vasopressin Receptors Human genes 0.000 title 1
- 108090000643 Vasopressin Receptors Proteins 0.000 title 1
- JYGFTBXVXVMTGB-UHFFFAOYSA-N indolin-2-one Chemical class C1=CC=C2NC(=O)CC2=C1 JYGFTBXVXVMTGB-UHFFFAOYSA-N 0.000 title 1
- 239000003446 ligand Substances 0.000 title 1
- -1 trifluoromethoxy radical Chemical class 0.000 abstract 9
- GRVDJDISBSALJP-UHFFFAOYSA-N methyloxidanyl Chemical compound [O]C GRVDJDISBSALJP-UHFFFAOYSA-N 0.000 abstract 5
- 229910052801 chlorine Inorganic materials 0.000 abstract 3
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 229910052731 fluorine Inorganic materials 0.000 abstract 2
- 125000001153 fluoro group Chemical group F* 0.000 abstract 2
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical compound [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 2
- VOLGAXAGEUPBDM-UHFFFAOYSA-N $l^{1}-oxidanylethane Chemical compound CC[O] VOLGAXAGEUPBDM-UHFFFAOYSA-N 0.000 abstract 1
- WZKSXHQDXQKIQJ-UHFFFAOYSA-N F[C](F)F Chemical compound F[C](F)F WZKSXHQDXQKIQJ-UHFFFAOYSA-N 0.000 abstract 1
- BQIKRTGTPBOIMK-UHFFFAOYSA-N [O]C[O] Chemical group [O]C[O] BQIKRTGTPBOIMK-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- QUPDWYMUPZLYJZ-UHFFFAOYSA-N ethyl Chemical compound C[CH2] QUPDWYMUPZLYJZ-UHFFFAOYSA-N 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- QNLOWBMKUIXCOW-UHFFFAOYSA-N indol-2-one Chemical group C1=CC=CC2=NC(=O)C=C21 QNLOWBMKUIXCOW-UHFFFAOYSA-N 0.000 abstract 1
- 239000002184 metal Chemical group 0.000 abstract 1
- 150000007522 mineralic acids Chemical class 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- 235000005985 organic acids Nutrition 0.000 abstract 1
- 150000003254 radicals Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/541—Non-condensed thiazines containing further heterocyclic rings
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Abstract
Spoj prikazan formulom (Ia) u obliku lijevo-zakrećućeg izomera: naznačen time da: R1 predstavlja atom klora; metilni radikal; trifluorometoksi radikal; R2 predstavlja atom vodika ili je na poziciji 6 indol-2-ona i predstavlja atom klora, metilni radikal ili metoksi radikal ili trifluorometil radikal; R3 predstavlja atom klora; atom fluora, metoksi radikal ili etoksi radikal; R4 predstavlja atom vodika ili je na poziciji 3 ili 4 fenila i predstavlja atom fluora ili metoksi radikal; ili je alternativno R4 na poziciji 3 fenila i zajedno s R3 predstavlja metilendioksi radikal; R5 predstavlja dimetilamino radikal ili metoksi radikal; R6 predstavlja atom vodika; metal radikal, etil radikal; terc-butiloksikarbonilmetil radikal; karboksimetil radikal; [[2-hidroksi-1-(hidroksimetil)-1-metiletil]amino]karbonilmetil radikal; (1-piperazinil)karbonil metil radikal; (4-morfonilinil)karbonilmetil radikal; 3-(4-morfolinil)propanoil radikal; R7 je na poziciji 2 fenila i predstavlja metoksi radikalR8 predstavlja metoksi radikali njegove soli s anorganskim ili organskim kiselinama, njegovi solvati i/ili hidrati. Patent sadrži još 7 patentnih zahtjeva.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0000957A FR2804114B1 (fr) | 2000-01-25 | 2000-01-25 | Nouveaux derives de 1,3-dihydro-2h-indol-2-one, un procede pour leur preparation et les compositions pharmaceutiques en contenant |
PCT/FR2001/000226 WO2001055130A2 (fr) | 2000-01-25 | 2001-01-24 | Derives de 1,3-dihydro-2h-indol-2-one et leur utilisation en tant que ligands des recepteurs v1b ou v1b et v1a de l'arginine-vasopressine |
Publications (2)
Publication Number | Publication Date |
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HRP20020626A2 HRP20020626A2 (en) | 2003-10-31 |
HRP20020626B1 true HRP20020626B1 (hr) | 2009-04-30 |
Family
ID=8846307
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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HR20020626A HRP20020626B1 (hr) | 2000-01-25 | 2002-07-24 | Novi 1,3-dihidro-2h-indol-2-on derivati i njihova uporaba kao liganada za v<sub>1b</sub> i v<sub>1a</sub> arginin-vazopresinske receptore |
Country Status (36)
Country | Link |
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US (3) | US6730695B2 (hr) |
EP (1) | EP1255751B1 (hr) |
JP (1) | JP3992498B2 (hr) |
KR (1) | KR100689922B1 (hr) |
CN (1) | CN1193025C (hr) |
AR (1) | AR027263A1 (hr) |
AT (1) | ATE269326T1 (hr) |
AU (1) | AU778196B2 (hr) |
BG (1) | BG65796B1 (hr) |
BR (1) | BR0107807B1 (hr) |
CA (1) | CA2396814C (hr) |
CZ (1) | CZ300917B6 (hr) |
DE (1) | DE60103853T2 (hr) |
DK (1) | DK1255751T3 (hr) |
EA (1) | EA004628B1 (hr) |
EE (1) | EE04779B1 (hr) |
ES (1) | ES2222342T3 (hr) |
FR (1) | FR2804114B1 (hr) |
HK (1) | HK1050900A1 (hr) |
HR (1) | HRP20020626B1 (hr) |
HU (1) | HU229081B1 (hr) |
IL (2) | IL150539A0 (hr) |
IS (1) | IS2313B (hr) |
ME (1) | MEP17308A (hr) |
MX (1) | MXPA02007259A (hr) |
NO (1) | NO323607B1 (hr) |
PL (1) | PL204160B1 (hr) |
PT (1) | PT1255751E (hr) |
RS (1) | RS50290B (hr) |
SI (1) | SI1255751T1 (hr) |
SK (1) | SK286976B6 (hr) |
TR (1) | TR200402344T4 (hr) |
TW (1) | TWI283672B (hr) |
UA (1) | UA74354C2 (hr) |
WO (1) | WO2001055130A2 (hr) |
ZA (1) | ZA200205224B (hr) |
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CA2593044A1 (en) * | 2004-12-31 | 2006-07-13 | Abbott Gmbh & Co. Kg | Substituted oxindole derivatives, medicaments containing said derivatives and use thereof |
JP5125501B2 (ja) * | 2005-01-28 | 2013-01-23 | 大正製薬株式会社 | 1,3−ジヒドロ−2h−インドール−2−オン化合物、及び芳香族複素環が縮合したピロリジン−2−オン化合物 |
CN101258134B (zh) * | 2005-03-11 | 2011-10-12 | 欧加农股份有限公司 | 2-(4-氧代-4h-喹唑啉-3-基)乙酰胺衍生物及其作为加压素v3拮抗剂的用途 |
TW200643015A (en) * | 2005-03-11 | 2006-12-16 | Akzo Nobel Nv | 2-(4-oxo-4H-quinazolin-3-yl)acetamide derivatives |
EP1861392A2 (de) | 2005-03-24 | 2007-12-05 | Abbott GmbH & Co. KG | Substituierte oxindol-derivate, diese enthaltende arzneimittel und deren verwendung |
DE102005014936A1 (de) | 2005-03-24 | 2006-12-14 | Abbott Gmbh & Co. Kg | Substituierte Oxindol-Derivate, diese enthaltende Arzneimittel und deren Verwendung |
DE102005014904A1 (de) * | 2005-03-26 | 2007-02-01 | Abbott Gmbh & Co. Kg | Substituierte Oxindol-Derivate, diese enthaltende Arzneimittel und deren Verwendung |
EP1890697B1 (en) | 2005-06-07 | 2015-03-04 | Pharmacopeia, LLC | Azinone and diazinone v3 inhibitors for depression and stress disorders |
US7576082B2 (en) | 2005-06-24 | 2009-08-18 | Hoffman-La Roche Inc. | Oxindole derivatives |
KR101523776B1 (ko) * | 2005-07-19 | 2015-05-28 | 아제반 파마슈티칼스, 인코퍼레이티드 | 베타-락타민 페닐알라닌, 시스테인 그리고 세린 바소프레신길항물질 |
WO2007063123A1 (de) | 2005-12-02 | 2007-06-07 | Abbott Gmbh & Co. Kg | Substituierte oxindol-derivate, diese enthaltende arzneimittel und deren verwendung |
CN101033209B (zh) * | 2006-03-09 | 2014-08-27 | 上海医药工业研究院 | 药物中间体(2s,4r)-4-羟基-n,n-二甲基-2-吡咯烷甲酰胺的制备方法 |
DE102006040915A1 (de) | 2006-08-26 | 2008-03-20 | Abbott Gmbh & Co. Kg | Substituierte Oxindol-Derivate, diese enthaltende Arzneimittel und deren Verwendung |
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KR20090107994A (ko) | 2006-09-11 | 2009-10-14 | 엔.브이.오가논 | 퀴나졸리논 및 이소퀴놀리논 아세트아미드 유도체 |
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US20080167286A1 (en) | 2006-12-12 | 2008-07-10 | Abbott Laboratories | Pharmaceutical compositions and their methods of use |
WO2008071779A1 (en) | 2006-12-13 | 2008-06-19 | N.V. Organon | V3 antagonists for the treatment or prevention of chronic pain |
UY30846A1 (es) | 2006-12-30 | 2008-07-31 | Abbott Gmbh & Amp | Derivados de oxindol sustituidos, medicamentos que los comprenden y uso de los mismos |
WO2010009775A1 (de) | 2007-12-07 | 2010-01-28 | Abbott Gmbh & Co. Kg | Carbamat-substituierte oxindol-derivate und ihre verwendung zur behandlung von vasopressin-abhängigen erkrankungen |
BRPI0820668A2 (pt) * | 2007-12-07 | 2017-08-22 | Abbott Gmbh & Co Kg | Derivados de oxindol substituídos por 5-halogênio e seu uso para tratar doenças dependentes de vasopressina |
EP2231643B1 (de) | 2007-12-07 | 2012-10-31 | Abbott GmbH & Co. KG | Amidomethyl-substitutierte Oxindol-Derivate und ihre Verwendung zur Herstellung eines Medikaments zur Behandlung von Vasopressin-abhängigen Erkrankungen |
ES2455197T3 (es) | 2007-12-07 | 2014-04-14 | Abbvie Deutschland Gmbh & Co Kg | Derivados de oxindol 5,6-disustituidos y el uso de los mismos para la preparación de un medicamento para el tratamiento de enfermedades dependientes de vasopresina |
CA2710946C (en) * | 2007-12-27 | 2016-05-31 | Abbott Gmbh & Co. Kg | Substituted oxindole-derivatives and the use thereof for the treatment of vasopressin-dependent illnesses |
FR2927625B1 (fr) * | 2008-02-19 | 2010-03-12 | Sanofi Aventis | Nouveaux derives de 3-aminoalkyl-1,3-dihydro-2h-indol-2-one, leur preparation et leur application en therapeutique |
FR2930249B1 (fr) | 2008-04-21 | 2010-05-14 | Sanofi Aventis | Nouveaux derives de 3-aminoalkyl-1,3-dihydro-2h-indol-2-one, leur preparation et leur application en therapeutique. |
WO2009140484A1 (en) * | 2008-05-15 | 2009-11-19 | Sanofi-Aventis | Processes for preparing amorphous drug substance |
WO2009140479A1 (en) * | 2008-05-15 | 2009-11-19 | Sanofi-Aventis | Amorphous solid dispersions |
US9040568B2 (en) | 2009-05-29 | 2015-05-26 | Abbvie Inc. | Pharmaceutical compositions for the treatment of pain |
KR101820185B1 (ko) | 2010-10-01 | 2018-01-18 | 다이쇼 세이야꾸 가부시끼가이샤 | 1,2,4-트리아졸론 유도체 |
CA2853227C (en) | 2011-10-27 | 2019-05-14 | Taisho Pharmaceutical Co., Ltd. | Azole derivative |
AU2013241076A1 (en) | 2012-03-30 | 2014-10-09 | Taisho Pharmaceutical Co., Ltd. | Fused azole derivative |
CN103342672B (zh) * | 2013-07-02 | 2015-12-23 | 扬州大学 | 取代吡咯烷-2-酮的新合成方法 |
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WO1995018105A1 (fr) * | 1993-12-24 | 1995-07-06 | Sanofi | Derives de 1,3-dihydroindol-2-one substitues en 3 par un groupe azote comme agonistes et/ou antagonistes de la vasopressine et/ou de l'ocytocine |
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FR2804114B1 (fr) * | 2000-01-25 | 2002-03-08 | Sanofi Synthelabo | Nouveaux derives de 1,3-dihydro-2h-indol-2-one, un procede pour leur preparation et les compositions pharmaceutiques en contenant |
FR2810320B1 (fr) * | 2000-06-19 | 2002-08-23 | Sanofi Synthelabo | Nouveaux derives de 1,3-dihydro-2h-indol-2-one, un procede pour leur preparation et les compositions pharmaceutiques en contenant |
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US5338755A (en) * | 1990-07-31 | 1994-08-16 | Elf Sanofi | N-sulfonylindoline derivatives, their preparation and the pharmaceutical compositions in which they are present |
WO1995018105A1 (fr) * | 1993-12-24 | 1995-07-06 | Sanofi | Derives de 1,3-dihydroindol-2-one substitues en 3 par un groupe azote comme agonistes et/ou antagonistes de la vasopressine et/ou de l'ocytocine |
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