YU52302A - Novi derivati 1,3-dihidro-2h-indol-2-ona i njihova upotreba kao liganada za v1b i v1a receptore arginin-vazopresina - Google Patents

Novi derivati 1,3-dihidro-2h-indol-2-ona i njihova upotreba kao liganada za v1b i v1a receptore arginin-vazopresina

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Publication number
YU52302A
YU52302A YU52302A YUP52302A YU52302A YU 52302 A YU52302 A YU 52302A YU 52302 A YU52302 A YU 52302A YU P52302 A YUP52302 A YU P52302A YU 52302 A YU52302 A YU 52302A
Authority
YU
Yugoslavia
Prior art keywords
arginine
indol
dihydro
ligands
derivatives
Prior art date
Application number
YU52302A
Other languages
English (en)
Inventor
Richard Roux
Gal Claudine Serradeil-Le
Bernard Tonnerre
Jean Wagnon
Original Assignee
Sanofi-Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi-Aventis filed Critical Sanofi-Aventis
Priority to MEP-173/08A priority Critical patent/MEP17308A/xx
Publication of YU52302A publication Critical patent/YU52302A/sh
Publication of RS50290B publication Critical patent/RS50290B/sr

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    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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  • Health & Medical Sciences (AREA)
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  • Urology & Nephrology (AREA)
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  • Hematology (AREA)
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  • Ophthalmology & Optometry (AREA)
  • Obesity (AREA)
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Abstract

Ovaj pronalazak se odnosi na jedinjenja formule: kao i na nihove moguće soli sa mineralnim ili organskim kiselinama, njihove solvate i/ili hidrate, koji imaju afinitet i selektivnost prema V1b receptoru, ili prema oba receptora V1b i V1a arginin-vazopresina. Ovaj pronalazak se takodje odnosi na postupak njihovog dobijanja, intermedijarna jedinjenja formule (II) koja se koriste u njihovom dobijanju, na farmaceutske preparate koji ih sadrže i na njihovu upotrebu u dobijanju medikamenata.[The invention concerns compounds of formula (I) and their possible salts with mineral or organic acids, their solvates and/or hydrates, having affinity and selectivity for V1b receptor or for both V1b and V1a arginine-vasopressin receptors. The invention also concerns their preparation method, intermediate compounds of formula (II) used in their preparation, pharmaceutical compositions containing them for use in preparing medicines.
YUP-523/02A 2000-01-25 2001-01-24 Novi derivati 1,3-dihidro-2h-indol-2-ona i njihova upotreba kao liganada za v1b i v1a receptore arginin-vazopresina RS50290B (sr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
MEP-173/08A MEP17308A (en) 2000-01-25 2001-01-24 Novel 1,3-dihydro-2h-indol-2-one derivatives and their use as ligands for v 1b and v 1a arginine-vasopressin receptors

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0000957A FR2804114B1 (fr) 2000-01-25 2000-01-25 Nouveaux derives de 1,3-dihydro-2h-indol-2-one, un procede pour leur preparation et les compositions pharmaceutiques en contenant

Publications (2)

Publication Number Publication Date
YU52302A true YU52302A (sh) 2006-05-25
RS50290B RS50290B (sr) 2009-09-08

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KR (1) KR100689922B1 (sh)
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FR (1) FR2804114B1 (sh)
HK (1) HK1050900A1 (sh)
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HU (1) HU229081B1 (sh)
IL (2) IL150539A0 (sh)
IS (1) IS2313B (sh)
ME (1) MEP17308A (sh)
MX (1) MXPA02007259A (sh)
NO (1) NO323607B1 (sh)
PL (1) PL204160B1 (sh)
PT (1) PT1255751E (sh)
RS (1) RS50290B (sh)
SI (1) SI1255751T1 (sh)
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TR (1) TR200402344T4 (sh)
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UA (1) UA74354C2 (sh)
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ZA (1) ZA200205224B (sh)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2804114B1 (fr) * 2000-01-25 2002-03-08 Sanofi Synthelabo Nouveaux derives de 1,3-dihydro-2h-indol-2-one, un procede pour leur preparation et les compositions pharmaceutiques en contenant
FR2805536B1 (fr) * 2000-02-25 2002-08-23 Sanofi Synthelabo Nouveaux derives de 1,3-dihydro-2h-indol-2-one, un procede pour leur preparation et les compositions pharmaceutiques en contenant
FR2842527B1 (fr) * 2002-07-19 2005-01-28 Sanofi Synthelabo Derives d'acyloxypyrolidine, leur preparation et leur application en therapeutique
WO2005021534A1 (ja) * 2003-08-28 2005-03-10 Taisho Pharmaceutical Co., Ltd. １，３−ジヒドロ−２ｈ−インドール−２−オン誘導体
US8580842B2 (en) * 2003-09-30 2013-11-12 Abbott Gmbh & Co. Kg Heteroaryl-substituted 1,3-dihydroindol-2-one derivatives and medicaments containing them
US20050070718A1 (en) 2003-09-30 2005-03-31 Abbott Gmbh & Co. Kg Heteroaryl-substituted 1,3-dihydroindol-2-one derivatives and medicaments containing them
US20050165082A1 (en) * 2003-12-16 2005-07-28 Wyeth Methods of treating vasomotor symptoms
US7517899B2 (en) 2004-03-30 2009-04-14 Wyeth Phenylaminopropanol derivatives and methods of their use
US7414052B2 (en) 2004-03-30 2008-08-19 Wyeth Phenylaminopropanol derivatives and methods of their use
WO2006038119A1 (en) * 2004-10-08 2006-04-13 Warner-Lambert Company Llc Stereoselective synthesis of n-protected alkoxy prolines
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