SI1255751T1 - 1,3-dihydro-2h-indol-2-one derivatives and their use as ligands for v1b or v1b and v1a arginine-vasopressin receptors - Google Patents

1,3-dihydro-2h-indol-2-one derivatives and their use as ligands for v1b or v1b and v1a arginine-vasopressin receptors

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Publication number
SI1255751T1
SI1255751T1 SI200130155T SI200130155T SI1255751T1 SI 1255751 T1 SI1255751 T1 SI 1255751T1 SI 200130155 T SI200130155 T SI 200130155T SI 200130155 T SI200130155 T SI 200130155T SI 1255751 T1 SI1255751 T1 SI 1255751T1
Authority
SI
Slovenia
Prior art keywords
indol
dihydro
ligands
arginine
derivatives
Prior art date
Application number
SI200130155T
Other languages
English (en)
Slovenian (sl)
Inventor
Richard Roux
Gal Claudine Serradeil-Le
Bernard Tonnerre
Jean Wagnon
Original Assignee
Sanofi-Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi-Synthelabo filed Critical Sanofi-Synthelabo
Publication of SI1255751T1 publication Critical patent/SI1255751T1/xx

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
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    • C07D209/34—Oxygen atoms in position 2
SI200130155T 2000-01-25 2001-01-24 1,3-dihydro-2h-indol-2-one derivatives and their use as ligands for v1b or v1b and v1a arginine-vasopressin receptors SI1255751T1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0000957A FR2804114B1 (fr) 2000-01-25 2000-01-25 Nouveaux derives de 1,3-dihydro-2h-indol-2-one, un procede pour leur preparation et les compositions pharmaceutiques en contenant
PCT/FR2001/000226 WO2001055130A2 (fr) 2000-01-25 2001-01-24 Derives de 1,3-dihydro-2h-indol-2-one et leur utilisation en tant que ligands des recepteurs v1b ou v1b et v1a de l'arginine-vasopressine
EP01907685A EP1255751B1 (fr) 2000-01-25 2001-01-24 Derives de 1,3-dihydro-2h-indol-2-one et leur utilisation en tant que ligands des recepteurs v1b ou v1b et v1a de l'arginine-vasopressine

Publications (1)

Publication Number Publication Date
SI1255751T1 true SI1255751T1 (en) 2004-10-31

Family

ID=8846307

Family Applications (1)

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SI200130155T SI1255751T1 (en) 2000-01-25 2001-01-24 1,3-dihydro-2h-indol-2-one derivatives and their use as ligands for v1b or v1b and v1a arginine-vasopressin receptors

Country Status (36)

Country Link
US (3) US6730695B2 (xx)
EP (1) EP1255751B1 (xx)
JP (1) JP3992498B2 (xx)
KR (1) KR100689922B1 (xx)
CN (1) CN1193025C (xx)
AR (1) AR027263A1 (xx)
AT (1) ATE269326T1 (xx)
AU (1) AU778196B2 (xx)
BG (1) BG65796B1 (xx)
BR (1) BR0107807B1 (xx)
CA (1) CA2396814C (xx)
CZ (1) CZ300917B6 (xx)
DE (1) DE60103853T2 (xx)
DK (1) DK1255751T3 (xx)
EA (1) EA004628B1 (xx)
EE (1) EE04779B1 (xx)
ES (1) ES2222342T3 (xx)
FR (1) FR2804114B1 (xx)
HK (1) HK1050900A1 (xx)
HR (1) HRP20020626B1 (xx)
HU (1) HU229081B1 (xx)
IL (2) IL150539A0 (xx)
IS (1) IS2313B (xx)
ME (1) MEP17308A (xx)
MX (1) MXPA02007259A (xx)
NO (1) NO323607B1 (xx)
PL (1) PL204160B1 (xx)
PT (1) PT1255751E (xx)
RS (1) RS50290B (xx)
SI (1) SI1255751T1 (xx)
SK (1) SK286976B6 (xx)
TR (1) TR200402344T4 (xx)
TW (1) TWI283672B (xx)
UA (1) UA74354C2 (xx)
WO (1) WO2001055130A2 (xx)
ZA (1) ZA200205224B (xx)

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FR2805536B1 (fr) * 2000-02-25 2002-08-23 Sanofi Synthelabo Nouveaux derives de 1,3-dihydro-2h-indol-2-one, un procede pour leur preparation et les compositions pharmaceutiques en contenant
FR2842527B1 (fr) * 2002-07-19 2005-01-28 Sanofi Synthelabo Derives d'acyloxypyrolidine, leur preparation et leur application en therapeutique
WO2005021534A1 (ja) * 2003-08-28 2005-03-10 Taisho Pharmaceutical Co., Ltd. １，３−ジヒドロ−２ｈ−インドール−２−オン誘導体
US8580842B2 (en) * 2003-09-30 2013-11-12 Abbott Gmbh & Co. Kg Heteroaryl-substituted 1,3-dihydroindol-2-one derivatives and medicaments containing them
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US20050165082A1 (en) * 2003-12-16 2005-07-28 Wyeth Methods of treating vasomotor symptoms
US7517899B2 (en) 2004-03-30 2009-04-14 Wyeth Phenylaminopropanol derivatives and methods of their use
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JP5125501B2 (ja) * 2005-01-28 2013-01-23 大正製薬株式会社 １，３−ジヒドロ−２ｈ−インドール−２−オン化合物、及び芳香族複素環が縮合したピロリジン−２−オン化合物
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