HRP20010845B1 - Cinnamoylaminoalkyl-substituted benzenesulfonamide derivatives - Google Patents
Cinnamoylaminoalkyl-substituted benzenesulfonamide derivativesInfo
- Publication number
- HRP20010845B1 HRP20010845B1 HR20010845A HRP20010845A HRP20010845B1 HR P20010845 B1 HRP20010845 B1 HR P20010845B1 HR 20010845 A HR20010845 A HR 20010845A HR P20010845 A HRP20010845 A HR P20010845A HR P20010845 B1 HRP20010845 B1 HR P20010845B1
- Authority
- HR
- Croatia
- Prior art keywords
- alkyl
- phenyl
- group
- substituted
- halogen
- Prior art date
Links
- 150000008331 benzenesulfonamides Chemical class 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 14
- 229910052736 halogen Inorganic materials 0.000 abstract 8
- 150000002367 halogens Chemical class 0.000 abstract 8
- 229910052739 hydrogen Inorganic materials 0.000 abstract 7
- 239000001257 hydrogen Substances 0.000 abstract 7
- 125000001424 substituent group Chemical group 0.000 abstract 7
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 6
- 229910052760 oxygen Inorganic materials 0.000 abstract 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 6
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 5
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 5
- -1 cyanoimino Chemical group 0.000 abstract 5
- 239000001301 oxygen Substances 0.000 abstract 5
- 229910052717 sulfur Inorganic materials 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 2
- 125000005842 heteroatom Chemical group 0.000 abstract 2
- 239000011593 sulfur Substances 0.000 abstract 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 125000006729 (C2-C5) alkenyl group Chemical group 0.000 abstract 1
- 125000006730 (C2-C5) alkynyl group Chemical group 0.000 abstract 1
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 229910052757 nitrogen Chemical group 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
- C07C311/52—Y being a hetero atom
- C07C311/53—X and Y not being nitrogen atoms, e.g. N-sulfonylcarbamic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
- C07C311/52—Y being a hetero atom
- C07C311/54—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea
- C07C311/57—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings
- C07C311/58—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings having nitrogen atoms of the sulfonylurea groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/40—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of thiourea or isothiourea groups further bound to other hetero atoms
- C07C335/42—Sulfonylthioureas; Sulfonylisothioureas
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19923086A DE19923086A1 (de) | 1999-05-20 | 1999-05-20 | Cinnamoylaminoalkyl-substituierte Benzolsulfonamidderivate, Verfahren zu ihrer Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
| PCT/EP2000/004091 WO2000071513A1 (en) | 1999-05-20 | 2000-05-06 | Cinnamoylaminoalkyl-substituted benzenesulfonamide derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| HRP20010845A2 HRP20010845A2 (en) | 2003-04-30 |
| HRP20010845A9 HRP20010845A9 (en) | 2010-06-30 |
| HRP20010845B1 true HRP20010845B1 (en) | 2010-08-31 |
Family
ID=7908577
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20010845A HRP20010845B1 (en) | 1999-05-20 | 2001-11-16 | Cinnamoylaminoalkyl-substituted benzenesulfonamide derivatives |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US6350778B1 (da) |
| EP (1) | EP1183236B1 (da) |
| JP (1) | JP4559640B2 (da) |
| KR (1) | KR100968729B1 (da) |
| CN (1) | CN1243730C (da) |
| AR (1) | AR035625A1 (da) |
| AT (1) | ATE252554T1 (da) |
| AU (1) | AU771675B2 (da) |
| BR (1) | BR0010821B1 (da) |
| CA (1) | CA2374226C (da) |
| CZ (1) | CZ302943B6 (da) |
| DE (2) | DE19923086A1 (da) |
| DK (1) | DK1183236T3 (da) |
| EE (1) | EE04611B1 (da) |
| ES (1) | ES2208342T3 (da) |
| HK (1) | HK1047574B (da) |
| HR (1) | HRP20010845B1 (da) |
| HU (1) | HU229041B1 (da) |
| IL (2) | IL146372A0 (da) |
| ME (1) | MEP41508A (da) |
| MX (1) | MXPA01011725A (da) |
| NO (1) | NO321558B1 (da) |
| PL (1) | PL201560B1 (da) |
| PT (1) | PT1183236E (da) |
| RS (1) | RS50172B (da) |
| RU (1) | RU2242462C2 (da) |
| SK (1) | SK287237B6 (da) |
| TR (1) | TR200103312T2 (da) |
| WO (1) | WO2000071513A1 (da) |
| ZA (1) | ZA200109481B (da) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10054482A1 (de) | 2000-11-03 | 2002-05-08 | Aventis Pharma Gmbh | Heteroarylacryloylaminoalkyl-substituierte Benzolsulfonamidderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
| DE10054481A1 (de) | 2000-11-03 | 2002-05-08 | Aventis Pharma Gmbh | Acylaminoalkyl-substituierte Benzolsulfonamidderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
| CN1237185C (zh) * | 2003-06-04 | 2006-01-18 | 中国科学院上海药物研究所 | Sars冠状病毒3cl蛋白酶三维结构模型与抗sars药物 |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1443878A1 (de) * | 1963-10-19 | 1968-12-12 | Hoechst Ag | Verfahren zur Herstellung von Benzolsulfonylharnstoffen |
| DE1518877A1 (de) * | 1964-10-07 | 1969-01-30 | Hoechst Ag | Benzolsulfonylharnstoffe und Verfahren zu ihrer Herstellung |
| DE1545810A1 (de) * | 1965-05-06 | 1969-12-11 | Hoechst Ag | Verfahren zur Herstellung von Benzolsulfonylsemicarbaziden |
| EP0612724A1 (de) * | 1993-02-23 | 1994-08-31 | Hoechst Aktiengesellschaft | Substituierte Benzolsulfonylharnstoffe und -thioharnstoffe- Verfahren zu ihrer Herstellung und ihre Verwendung als Pharmazeutika |
| EP0727416A1 (de) * | 1995-02-17 | 1996-08-21 | Hoechst Aktiengesellschaft | Substituierte Benzolsulfonylharnstoffe und -thioharnstoffe, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1518816C3 (de) | 1965-03-24 | 1975-05-22 | Farbwerke Hoechst Ag, Vormals Meister Lucius & Bruening, 6000 Frankfurt | Benzolsulfonylharnstoffe, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Präparate |
| US4066639A (en) | 1965-05-06 | 1978-01-03 | Hoechst Aktiengesellschaft | Benzene-sulfonyl semicarbazides and process for preparing them |
| DE2413514C3 (de) * | 1974-03-21 | 1982-03-04 | Hoechst Ag, 6000 Frankfurt | N-Acylaminoathylbenzolsulfonyl-N'-methylharnstoffe, Verfahren zu ihrer Herstellung und deren Verwendung |
| DE4341655A1 (de) | 1993-12-07 | 1995-06-08 | Hoechst Ag | Aminosubstituierte Benzolsulfonylharnstoffe und -thioharnstoffe, Verfahren zu ihrer Herstellung und ihre Verwendung als Pharmazeutika |
| JPH0826995A (ja) * | 1994-07-22 | 1996-01-30 | Nisshin Flour Milling Co Ltd | ベンズイミダゾール誘導体を含有する抗不整脈剤 |
| DE19832009A1 (de) | 1998-07-16 | 2000-01-20 | Hoechst Marion Roussel De Gmbh | 2,5-Substituierte Benzolsulfonylharnstoffe und -thioharnstoffe, Verfahren zu ihrer Herstellung, ihre Verwendung und sie enthaltende pharamazeutische Präparate |
| KR100981592B1 (ko) | 1998-09-10 | 2010-09-13 | 사노피-아벤티스 도이칠란트 게엠베하 | 벤젠설포닐(티오)우레아 또는 베타-수용체 차단제와 배합된 벤젠설포닐(티오)우레아를 포함하는 자율신경계 기능부전의 치료 또는 예방을 위한 약제학적 조성물 |
| US6303637B1 (en) * | 1998-10-30 | 2001-10-16 | Merck & Co., Inc. | Heterocyclic potassium channel inhibitors |
| US6194458B1 (en) * | 1998-10-30 | 2001-02-27 | Merck & Co., Inc. | Benzamide potassium channel inhibitors |
| US6632836B1 (en) * | 1998-10-30 | 2003-10-14 | Merck & Co., Inc. | Carbocyclic potassium channel inhibitors |
-
1999
- 1999-05-20 DE DE19923086A patent/DE19923086A1/de not_active Withdrawn
-
2000
- 2000-05-06 AT AT00938626T patent/ATE252554T1/de active
- 2000-05-06 EE EEP200100609A patent/EE04611B1/xx not_active IP Right Cessation
- 2000-05-06 JP JP2000619770A patent/JP4559640B2/ja not_active Expired - Fee Related
- 2000-05-06 WO PCT/EP2000/004091 patent/WO2000071513A1/en active IP Right Grant
- 2000-05-06 PT PT00938626T patent/PT1183236E/pt unknown
- 2000-05-06 PL PL351751A patent/PL201560B1/pl unknown
- 2000-05-06 EP EP00938626A patent/EP1183236B1/en not_active Expired - Lifetime
- 2000-05-06 CA CA2374226A patent/CA2374226C/en not_active Expired - Fee Related
- 2000-05-06 CN CNB008078203A patent/CN1243730C/zh not_active Expired - Fee Related
- 2000-05-06 ME MEP-415/08A patent/MEP41508A/xx unknown
- 2000-05-06 SK SK1669-2001A patent/SK287237B6/sk not_active IP Right Cessation
- 2000-05-06 CZ CZ20014149A patent/CZ302943B6/cs not_active IP Right Cessation
- 2000-05-06 MX MXPA01011725A patent/MXPA01011725A/es active IP Right Grant
- 2000-05-06 RU RU2001134291/04A patent/RU2242462C2/ru not_active IP Right Cessation
- 2000-05-06 IL IL14637200A patent/IL146372A0/xx active IP Right Grant
- 2000-05-06 BR BRPI0010821-9A patent/BR0010821B1/pt not_active IP Right Cessation
- 2000-05-06 AU AU53933/00A patent/AU771675B2/en not_active Ceased
- 2000-05-06 DE DE60006104T patent/DE60006104T2/de not_active Expired - Lifetime
- 2000-05-06 ES ES00938626T patent/ES2208342T3/es not_active Expired - Lifetime
- 2000-05-06 DK DK00938626T patent/DK1183236T3/da active
- 2000-05-06 TR TR2001/03312T patent/TR200103312T2/xx unknown
- 2000-05-06 KR KR1020017014819A patent/KR100968729B1/ko not_active IP Right Cessation
- 2000-05-06 HU HU0201906A patent/HU229041B1/hu not_active IP Right Cessation
- 2000-05-06 RS YUP-817/01A patent/RS50172B/sr unknown
- 2000-05-19 AR ARP000102388A patent/AR035625A1/es active IP Right Grant
- 2000-05-19 US US09/573,166 patent/US6350778B1/en not_active Expired - Lifetime
-
2001
- 2001-11-06 IL IL146372A patent/IL146372A/en not_active IP Right Cessation
- 2001-11-16 ZA ZA200109481A patent/ZA200109481B/xx unknown
- 2001-11-16 HR HR20010845A patent/HRP20010845B1/xx not_active IP Right Cessation
- 2001-11-19 NO NO20015636A patent/NO321558B1/no not_active IP Right Cessation
-
2002
- 2002-11-29 HK HK02108646.9A patent/HK1047574B/zh not_active IP Right Cessation
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1443878A1 (de) * | 1963-10-19 | 1968-12-12 | Hoechst Ag | Verfahren zur Herstellung von Benzolsulfonylharnstoffen |
| DE1518877A1 (de) * | 1964-10-07 | 1969-01-30 | Hoechst Ag | Benzolsulfonylharnstoffe und Verfahren zu ihrer Herstellung |
| DE1545810A1 (de) * | 1965-05-06 | 1969-12-11 | Hoechst Ag | Verfahren zur Herstellung von Benzolsulfonylsemicarbaziden |
| EP0612724A1 (de) * | 1993-02-23 | 1994-08-31 | Hoechst Aktiengesellschaft | Substituierte Benzolsulfonylharnstoffe und -thioharnstoffe- Verfahren zu ihrer Herstellung und ihre Verwendung als Pharmazeutika |
| EP0727416A1 (de) * | 1995-02-17 | 1996-08-21 | Hoechst Aktiengesellschaft | Substituierte Benzolsulfonylharnstoffe und -thioharnstoffe, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
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