HRP20010483B1 - Nesteroidne supstance, antiupalnog djelovanja - Google Patents
Nesteroidne supstance, antiupalnog djelovanjaInfo
- Publication number
- HRP20010483B1 HRP20010483B1 HR20010483A HRP20010483A HRP20010483B1 HR P20010483 B1 HRP20010483 B1 HR P20010483B1 HR 20010483 A HR20010483 A HR 20010483A HR P20010483 A HRP20010483 A HR P20010483A HR P20010483 B1 HRP20010483 B1 HR P20010483B1
- Authority
- HR
- Croatia
- Prior art keywords
- group
- alkyl group
- different
- atom
- unsubstituted
- Prior art date
Links
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 title 1
- 125000006527 (C1-C5) alkyl group Chemical group 0.000 abstract 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 abstract 1
- 125000001494 2-propynyl group Chemical group [H]C#CC([H])([H])* 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 125000004966 cyanoalkyl group Chemical group 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/02—1,2-Oxazines; Hydrogenated 1,2-oxazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/536—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with carbocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
- C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Anesthesiology (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Supstanca opće formule I: s tim da je rečena formula definirana slijedećim parametrima: R1 i R2 su jednaki ili različiti i predstavljaju atom vodika,C1-C5 alkilnu skupinu, ili pak zajedno s C-atomomlanca predstavljaju prsten s ukupno 3-7 članova, R3 predstavlja C1-C5alkilnu skupinu, ili pak djelomično ili sasvim fluoriniranu C1-C5 alkilnu skupinu, A predstavlja skupinu (isprekidana linija označava stranu povezivanja) u kojoj R4 predstavlja atom vodika, C1-C5 alkilnu skupinu, C1-C10 acilnu skupinu, C3-C10 karboalkoksialkilnu skupinu, C2-C5 cijanoalkilnu skupinu, C3-C10 nesupstituiranu ili supstituiranu alilnu skupinu, C3-C10 nesupstituiranuili supstituiranu propargilnu skupinu, C2-C5 alkoksialkilnu skupinu, C1-C5 alkilnu skupinu koja je djelomično ili sasvim supstituirana atomima fluora, s tim da su R5 i R8 međusobno jednaki ili različiti i odabrani su između atoma vodika ili halogena, ili pak C1-C5 alkoksi skupine, i R4 i R5 zajednooznačavaju heterociklički prsten, koji osim atomakisika opcionalno može sadržavati barem jedan različiti atom iz skupine kisik, dušik i sumpor, s ukupno 5-7 članova, B predstavlja karbonilnu skupinuili CH2 skupinu, iAr predstavlja prstenasti sustav, koji je odabran iz skupine s općim parcijalnim formulama 2-5naznačena time, da je izabrana iz: Patent sadrži još 2 patentna zahtjeva.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19856475A DE19856475A1 (de) | 1998-11-27 | 1998-11-27 | Nichtsteroidale Entzündungshemmer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HRP20010483A2 HRP20010483A2 (en) | 2003-12-31 |
| HRP20010483B1 true HRP20010483B1 (hr) | 2007-08-31 |
Family
ID=7890303
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20010483A HRP20010483B1 (hr) | 1998-11-27 | 2001-06-26 | Nesteroidne supstance, antiupalnog djelovanja |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US6323199B1 (hr) |
| EP (1) | EP1133486B1 (hr) |
| JP (1) | JP2002531446A (hr) |
| KR (1) | KR100762058B1 (hr) |
| CN (1) | CN1171883C (hr) |
| AR (1) | AR021419A1 (hr) |
| AT (1) | ATE285405T1 (hr) |
| AU (1) | AU762735B2 (hr) |
| BG (1) | BG65030B1 (hr) |
| BR (1) | BR9915755A (hr) |
| CA (1) | CA2352367A1 (hr) |
| CO (1) | CO5140109A1 (hr) |
| CZ (1) | CZ20011866A3 (hr) |
| DE (2) | DE19856475A1 (hr) |
| EA (1) | EA003299B1 (hr) |
| EE (1) | EE200100283A (hr) |
| ES (1) | ES2235543T3 (hr) |
| HK (1) | HK1043592B (hr) |
| HR (1) | HRP20010483B1 (hr) |
| HU (1) | HUP0104578A3 (hr) |
| IL (2) | IL143393A0 (hr) |
| MY (1) | MY136016A (hr) |
| NO (1) | NO20012562L (hr) |
| NZ (1) | NZ511950A (hr) |
| PE (1) | PE20001245A1 (hr) |
| PL (1) | PL348329A1 (hr) |
| PT (1) | PT1133486E (hr) |
| SK (1) | SK7212001A3 (hr) |
| UA (1) | UA73102C2 (hr) |
| WO (1) | WO2000032584A2 (hr) |
| ZA (1) | ZA200105280B (hr) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7238707B2 (en) * | 2000-07-28 | 2007-07-03 | Schering Ag | Substituted pentanols, a process for their production and their use as anti-inflammatory agents |
| DE10346940B3 (de) * | 2003-10-06 | 2005-06-16 | Schering Ag | Substituierte Pentanole, ihre Verwendung zur Herstellung von Arzneimitteln speziell Entzündungshemmer sowie diese enthaltende pharmazeutische Präparate |
| DE10038639A1 (de) * | 2000-07-28 | 2002-02-21 | Schering Ag | Nichtsteroidale Entzündungshemmer |
| CA2446136C (en) * | 2001-05-03 | 2011-07-05 | Galileo Pharmaceuticals, Inc. | Pyruvate derivatives |
| CA2472746A1 (en) * | 2002-01-14 | 2003-07-24 | Boehringer Ingelheim Pharmaceuticals, Inc. | Glucocorticoid mimetics, methods of making them, pharmaceutical formulations containing them and uses thereof |
| JP2005521717A (ja) * | 2002-03-26 | 2005-07-21 | ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド | グルココルチコイドミメチックス、その製造方法、その医薬組成物、及び使用 |
| CN1633296A (zh) * | 2002-03-26 | 2005-06-29 | 贝林格尔·英格海姆药物公司 | 糖皮质素模拟物、其制备方法、药物组合物及其用途 |
| US6897224B2 (en) * | 2002-04-02 | 2005-05-24 | Schering Ag | Quinoline and isoquinoline derivatives, a process for their production and their use as inflammation inhibitors |
| DE10215316C1 (de) * | 2002-04-02 | 2003-12-18 | Schering Ag | Chinolin- und Isochinolin-Derivate, ein pharmazeutisches Mittel und ihre Verwendung als Entzündungshemmer |
| US7186864B2 (en) | 2002-05-29 | 2007-03-06 | Boehringer Ingelheim Pharmaceuticals, Inc. | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof |
| US7074806B2 (en) * | 2002-06-06 | 2006-07-11 | Boehringer Ingelheim Pharmaceuticals, Inc. | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof |
| JP2006504678A (ja) * | 2002-08-21 | 2006-02-09 | ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド | グルココルチコイドミメチックス、その製造方法、その医薬組成物、及び使用 |
| EP1539141B1 (en) * | 2002-08-29 | 2010-07-14 | Boehringer Ingelheim Pharmaceuticals Inc. | 3-(sulfonamidoethyl)-indole derivatives for use as glucocorticoid mimetics in the treatment of inflammatory, allergic and proliferative diseases |
| US7112584B2 (en) * | 2002-12-20 | 2006-09-26 | Schering Ag | Nonsteroidal antiinflammatory agents |
| DE10261874A1 (de) * | 2002-12-20 | 2004-07-08 | Schering Ag | Nichtsteroidale Entzündungshemmer |
| MXPA05006872A (es) * | 2003-01-03 | 2005-08-16 | Boehringer Ingelheim Pharma | Derivados de 1-propanol y 1-propilamina y su uso como ligandos glucocorticoides. |
| WO2004071389A2 (en) * | 2003-02-15 | 2004-08-26 | Glaxo Group Limited | Non-steroidal infalmmation inhibitors |
| US20040224992A1 (en) * | 2003-02-27 | 2004-11-11 | Boehringer Ingelheim Pharmaceuticals, Inc. | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof |
| US20050090559A1 (en) * | 2003-07-01 | 2005-04-28 | Markus Berger | Heterocyclically-substituted pentanol derivatives, process for their production and their use as anti-inflammatory agents |
| JP2008529963A (ja) * | 2003-07-01 | 2008-08-07 | バイエル・シエーリング・ファーマ アクチエンゲゼルシャフト | 複素環式−置換されたペンタノール誘導体類、それらの生成方法及び抗炎症剤としてのそれらの使用 |
| UY28526A1 (es) | 2003-09-24 | 2005-04-29 | Boehringer Ingelheim Pharma | Miméticos de glucocorticoides, métodos de preparación composiciones farmacéuticas y usos de los mismos |
| DE10347385A1 (de) * | 2003-10-08 | 2005-05-12 | Schering Ag | Umgelagerte Pentanole, ein Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer |
| JP4468369B2 (ja) * | 2003-10-16 | 2010-05-26 | ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド | ある種のトリフルオロメチル置換アルコールの立体選択的合成 |
| US7795272B2 (en) * | 2004-03-13 | 2010-09-14 | Boehringer Ingelheim Pharmaceutical, Inc. | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions and uses thereof |
| GB0418045D0 (en) | 2004-08-12 | 2004-09-15 | Glaxo Group Ltd | Compounds |
| ES2326907T3 (es) * | 2004-12-27 | 2009-10-21 | Boehringer Ingelheim Pharmaceuticals Inc. | Mimeticos de glucocorticoides, metodos para su preparacion, composiciones farmaceuticas y su uso. |
| RU2007148225A (ru) | 2005-06-10 | 2009-07-20 | БЕРИНГЕР ИНГЕЛЬХАЙМ ИНТЕРНАЦИОНАЛЬ ГмбХ (DE) | Глюкокортикоидные миметики, способы их получения, фармацевтические композиции и их применение |
| DE102005030292A1 (de) * | 2005-06-24 | 2007-01-11 | Schering Ag | Nichtsteroidale Progesteronrezeptor-Modulatoren |
| GB0513297D0 (en) * | 2005-06-29 | 2005-08-03 | Glaxo Group Ltd | Novel compounds |
| CA2519010A1 (en) | 2005-09-13 | 2007-03-13 | Cognos Incorporated | Query framework system and method |
| TW200815361A (en) * | 2005-10-20 | 2008-04-01 | Astrazeneca Ab | Chemical compounds |
| GB0522880D0 (en) * | 2005-11-09 | 2005-12-21 | Glaxo Group Ltd | Novel compounds |
| CN101326169B (zh) * | 2005-12-09 | 2011-11-16 | 霍夫曼-拉罗奇有限公司 | 作为抗炎剂的糖皮质激素受体调节剂 |
| BRPI0619519A2 (pt) * | 2005-12-09 | 2011-10-04 | Hoffmann La Roche | compostos de propionamida como agentes antiinflamatórios |
| WO2007120083A1 (en) * | 2006-04-13 | 2007-10-25 | Astrazeneca Ab | The use of carboxamide derivatives in the manufacture of a medicament for the treatment of inflammatory, allergic and dermatological conditions |
| CA2649509A1 (en) * | 2006-04-20 | 2007-11-01 | Glaxo Group Limited | Novel compounds |
| GB0611587D0 (en) * | 2006-06-12 | 2006-07-19 | Glaxo Group Ltd | Novel compounds |
| WO2008000777A2 (en) * | 2006-06-29 | 2008-01-03 | Glaxo Group Limited | Phenyl- pyrazole derivatives, process for their preparation and their pharmaceutical use |
| TW200829578A (en) | 2006-11-23 | 2008-07-16 | Astrazeneca Ab | Chemical compounds 537 |
| WO2008070507A2 (en) * | 2006-12-06 | 2008-06-12 | Boehringer Ingelheim International Gmbh | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof |
| WO2008074814A1 (en) * | 2006-12-20 | 2008-06-26 | Glaxo Group Limited | Pyrazole derivatives as non-steroidal glucocorticoid receptor ligands |
| JO2754B1 (en) * | 2006-12-21 | 2014-03-15 | استرازينكا ايه بي | Amylendazoleil derivatives for the treatment of glucocorticoid-mediated disorders |
| UY30805A1 (es) * | 2006-12-21 | 2008-07-31 | Bayer Schering Pharma Ag | Moduladores no esteroides de receptores de progesterona |
| CL2008000474A1 (es) * | 2007-02-15 | 2008-08-22 | Argenta Discovery Ltd | Compuestos derivados de azonia-biciclo-[2.2.2]octano, moduladores del receptor m3; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como epoc, asma, sindrome del intestino irritable, entre otras. |
| SA109300309B1 (ar) | 2008-05-20 | 2013-01-22 | باير شيرنج فارما ايه جي | مشتقات فينيل وبنزو داي أوكسينيل إندازول بها استبدال |
| MX2010013095A (es) * | 2008-06-06 | 2010-12-21 | Boehringer Ingelheim Int | Mimeticos de glucocorticoides, metodos para su fabricacion, composiciones farmaceuticas y usos de los mismos. |
| GB0814729D0 (en) * | 2008-08-12 | 2008-09-17 | Argenta Discovery Ltd | New combination |
| AU2010280323A1 (en) | 2009-07-31 | 2012-03-08 | Cadila Healthcare Limited | Novel compounds as modulators of glucocorticoid receptors |
| WO2011061527A1 (en) | 2009-11-17 | 2011-05-26 | Astrazeneca Ab | Combinations comprising a glucocorticoid receptor modulator for the treatment of respiratory diseases |
| EP3569228A1 (en) * | 2018-05-17 | 2019-11-20 | Association pour la recherche à l'IGBMC (ARI) | Non-steroidal selective glucocorticoid receptor agonistic modulators (segrams) and uses thereof |
| US20190151283A1 (en) | 2017-10-27 | 2019-05-23 | Association Pour La Recherche À L'igbmc (Ari) | NON-STEROIDAL SELECTIVE GLUCOCORTICOID RECEPTOR AGONISTIC MODULATORS (SEGRAMs) AND USES THEREOF |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1261835A (en) | 1984-08-20 | 1989-09-26 | Masaaki Toda | (fused) benz(thio)amides |
| GB8617652D0 (en) * | 1986-07-18 | 1986-08-28 | Ici Plc | Acylanilide derivatives |
| GB8617653D0 (en) | 1986-07-18 | 1986-08-28 | Ici Plc | Amide derivatives |
| DE19723722A1 (de) * | 1997-05-30 | 1998-12-10 | Schering Ag | Nichtsteroidale Gestagene |
-
1998
- 1998-11-27 DE DE19856475A patent/DE19856475A1/de not_active Withdrawn
-
1999
- 1999-11-24 US US09/448,278 patent/US6323199B1/en not_active Expired - Fee Related
- 1999-11-26 AR ARP990106045A patent/AR021419A1/es unknown
- 1999-11-26 CO CO99074717A patent/CO5140109A1/es unknown
- 1999-11-26 PE PE1999001188A patent/PE20001245A1/es not_active Application Discontinuation
- 1999-11-26 MY MYPI99005172A patent/MY136016A/en unknown
- 1999-11-29 BR BR9915755-1A patent/BR9915755A/pt not_active Application Discontinuation
- 1999-11-29 EE EEP200100283A patent/EE200100283A/xx unknown
- 1999-11-29 AU AU19760/00A patent/AU762735B2/en not_active Ceased
- 1999-11-29 CZ CZ20011866A patent/CZ20011866A3/cs unknown
- 1999-11-29 EP EP99963476A patent/EP1133486B1/de not_active Expired - Lifetime
- 1999-11-29 SK SK721-2001A patent/SK7212001A3/sk unknown
- 1999-11-29 EA EA200100529A patent/EA003299B1/ru not_active IP Right Cessation
- 1999-11-29 NZ NZ511950A patent/NZ511950A/en unknown
- 1999-11-29 PL PL99348329A patent/PL348329A1/xx unknown
- 1999-11-29 JP JP2000585226A patent/JP2002531446A/ja not_active Withdrawn
- 1999-11-29 WO PCT/EP1999/009754 patent/WO2000032584A2/de not_active Application Discontinuation
- 1999-11-29 KR KR1020017006613A patent/KR100762058B1/ko not_active IP Right Cessation
- 1999-11-29 UA UA2001064447A patent/UA73102C2/uk unknown
- 1999-11-29 CN CN99815852.6A patent/CN1171883C/zh not_active Expired - Fee Related
- 1999-11-29 PT PT99963476T patent/PT1133486E/pt unknown
- 1999-11-29 DE DE59911340T patent/DE59911340D1/de not_active Expired - Fee Related
- 1999-11-29 AT AT99963476T patent/ATE285405T1/de not_active IP Right Cessation
- 1999-11-29 CA CA002352367A patent/CA2352367A1/en not_active Abandoned
- 1999-11-29 ES ES99963476T patent/ES2235543T3/es not_active Expired - Lifetime
- 1999-11-29 HU HU0104578A patent/HUP0104578A3/hu unknown
- 1999-11-29 IL IL14339399A patent/IL143393A0/xx active IP Right Grant
-
2001
- 2001-05-21 BG BG105527A patent/BG65030B1/bg unknown
- 2001-05-24 IL IL143393A patent/IL143393A/en not_active IP Right Cessation
- 2001-05-25 NO NO20012562A patent/NO20012562L/no not_active Application Discontinuation
- 2001-06-26 ZA ZA200105280A patent/ZA200105280B/en unknown
- 2001-06-26 HR HR20010483A patent/HRP20010483B1/hr not_active IP Right Cessation
-
2002
- 2002-07-16 HK HK02105244.1A patent/HK1043592B/zh not_active IP Right Cessation
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HRP20010483B1 (hr) | Nesteroidne supstance, antiupalnog djelovanja | |
| OA09311A (fr) | "Dérivés de 4-benzoylisoxazole, compositions les contenant et leur utilisation comme herbicides". | |
| DE602004032431D1 (de) | Pyrimidin-verbindungen und diese enthaltende zusammensetzungen zur schädlingsbekämpfung | |
| MA19706A1 (fr) | Nouveaux derives du cyano-2 benzimidazole, leur preparation et leur utilisation comme fongicides . | |
| DE69012515D1 (de) | Haarfärbemittel. | |
| EA200500862A1 (ru) | Синоменин и соединения синоменина, синтез и применение | |
| ES2037016T3 (es) | 1-arilpirazoles. | |
| BR9807279A (pt) | Composições aditivas de lavanderia acrescidas de enxaguante contendo agentes protetores de cor | |
| MY105950A (en) | 4-acyloxyquinoline derivatives and insecticidal or acaricidal compositions containing same. | |
| KR900002704A (ko) | 공업 자재용 살균 조성물 | |
| KR910019632A (ko) | 비스(알킬-치환-4-히드록시페닐티오)알칸 유사체를 유효성분으로 함유하는 백내장 발병 억제용 제약 조성물 | |
| EA200601092A1 (ru) | Фунгицидные смеси на основе производных карбаматов и инсектицидов | |
| EA200000101A1 (ru) | Производные бензотиофена, их применение и композиции | |
| KR900014311A (ko) | 치환 옥심 에테르 및 이것을 함유하는 살균제 | |
| DE69416683D1 (de) | Benzolactam-derivate | |
| YU43902A (sh) | Novi razgranati supstituisani amino derivati od 3-amino-1- -fenil-1h(1,2,4) triazola, postupak za njihovo dobijanje i farmaceutski preparati koji ih sadrže | |
| YU152091A (sh) | Fungicidni derivati 3,3-bistioalkil-2-piridilakrilne kiseline | |
| HUP9901137A2 (hu) | N-szulfonil- és N-szulfinil-aminosav-származékok, előállításuk, a vegyületeket hatóanyagként tartalmazó mikrobicid készítmények és alkalmazásuk | |
| DE68918832D1 (de) | Benzoxazepinderivate. | |
| CO4700285A1 (es) | Derivados de 1-oxo-2-(fenilsulfonilamino)pentilpiperidina, su preparacion y su aplciacion en la terapeutica | |
| KR930023031A (ko) | 아졸 유도체를 함유하는 항아로마타제제 | |
| DE69426106D1 (de) | Thienyl- und Furylpyrrol Derivate, deren Herstellung und deren Verwendung als Insektizide und Akarizide | |
| EA199901023A1 (ru) | Фунгицидная смесь | |
| MA21606A1 (fr) | Compses 1,2- ou 1,6 dihydropyridimiques substitues en positions 2,6 . | |
| KR960016720A (ko) | 안정화된 3-이소티아졸론 용액 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A1OB | Publication of a patent application | ||
| ARAI | Request for the grant of a patent on the basis of the submitted results of a substantive examination of a patent application | ||
| ODRP | Renewal fee for the maintenance of a patent |
Payment date: 20070724 Year of fee payment: 8 |
|
| B1PR | Patent granted | ||
| PBON | Lapse due to non-payment of renewal fee |
Effective date: 20071130 |