AR021419A1 - El empleo de compuestos no esteroides para preparar medicamentos antiinflamatorios, los compuestos no esteroides que son apropiados para este empleo y lospreparados farmaceuticos que contienen estos ultimos compuestos - Google Patents
El empleo de compuestos no esteroides para preparar medicamentos antiinflamatorios, los compuestos no esteroides que son apropiados para este empleo y lospreparados farmaceuticos que contienen estos ultimos compuestosInfo
- Publication number
- AR021419A1 AR021419A1 ARP990106045A ARP990106045A AR021419A1 AR 021419 A1 AR021419 A1 AR 021419A1 AR P990106045 A ARP990106045 A AR P990106045A AR P990106045 A ARP990106045 A AR P990106045A AR 021419 A1 AR021419 A1 AR 021419A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- compounds
- substituted
- groups
- partial formulas
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/02—1,2-Oxazines; Hydrogenated 1,2-oxazines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/536—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with carbocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
- C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
Abstract
El empleo de compuestos no esteroides para la preparacion de medicamentos con efecto antiinflamatorio, compuestos que responden a la formula general (1),en donde: R1 y R2 son iguales o diferentes y representan un átomo de hidrogeno, un grupo alquiloC1-5 o, junto al átomo de C de la cadena, representan unanillo que en total tiene de 3 a 7 miembros; R3 representa un grupo alquilo C1-5 parcialmente o totalmente fluorado; A representa el grupo de formula (6) donde(la línea punteada significa una ligadura), en el cual R4 representa un átomo de hidrogeno, un grupo alquilo C1-5, un grupo acilo C1-10, un grupocarbalcoxialquilo C3-10, un grupo cianoalquilo C2-5, un grupo alilo C3-10 sustituido o sustituido, un grupo propargilo C3-10 sustituido o nosustituido, ungrupo alcoxialquilo C2-5, un grupo alquilo C1-5 parcialmente o totalmente sustituido con átomos de fluor; R5 a R8 son iguales o diferentes y se eligen delgrupo formado por los átomos de hidrogeno, los átomos de halogeno y los grupos alcoxi C1-5, y R4 y R5, juntos, también representan un anillo heterocíclico queen total tiene de 5 a 7 miembros y que, además del átomo de oxígeno, puede contener eventualmente al menos otro heteroátomo del grupo formado por el oxígeno,el nitrogeno y el azufre; B representa un grupo carbonilo o un grupo CH2; y Ar representa un sistema de anillos elegido del grupo de las formulas parciales (2)a (5), en donde los restos X3a, X3b, X4, X6, X7 (en las formulas parciales (2) y (3)) e Y4, Y5, Y7, Y8 (enlas formulas parciales (4) y (5)) son iguales odiferentes y se eligen entre los átomos de hidrogeno, los grupos aluilo C1-5, los grupos alquilo C1-5 parcialmente o totalmente fluorados, y además, los restosX4, X6, X7 (de las formulas parciales (2) y(3)) o los restos Y5, Y7, Y8 (en las formulas parciales (4) y (5)) se eligen entre los átomos de halogeno, losgrupos hidroxilo, los grupos alcoxi C1-5 o los grupos alcanoiloxi C1-5, y, para el caso en que B representa un grupo CH2, también se empleansales, aceptablesdesde el punto de vista fisiologico, de los compuestos de la formula general (1) que se forman por agregados de ácidos. Los preparados farmacéuticos que
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19856475A DE19856475A1 (de) | 1998-11-27 | 1998-11-27 | Nichtsteroidale Entzündungshemmer |
Publications (1)
Publication Number | Publication Date |
---|---|
AR021419A1 true AR021419A1 (es) | 2002-07-17 |
Family
ID=7890303
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP990106045A AR021419A1 (es) | 1998-11-27 | 1999-11-26 | El empleo de compuestos no esteroides para preparar medicamentos antiinflamatorios, los compuestos no esteroides que son apropiados para este empleo y lospreparados farmaceuticos que contienen estos ultimos compuestos |
Country Status (31)
Country | Link |
---|---|
US (1) | US6323199B1 (es) |
EP (1) | EP1133486B1 (es) |
JP (1) | JP2002531446A (es) |
KR (1) | KR100762058B1 (es) |
CN (1) | CN1171883C (es) |
AR (1) | AR021419A1 (es) |
AT (1) | ATE285405T1 (es) |
AU (1) | AU762735B2 (es) |
BG (1) | BG65030B1 (es) |
BR (1) | BR9915755A (es) |
CA (1) | CA2352367A1 (es) |
CO (1) | CO5140109A1 (es) |
CZ (1) | CZ20011866A3 (es) |
DE (2) | DE19856475A1 (es) |
EA (1) | EA003299B1 (es) |
EE (1) | EE200100283A (es) |
ES (1) | ES2235543T3 (es) |
HK (1) | HK1043592B (es) |
HR (1) | HRP20010483B1 (es) |
HU (1) | HUP0104578A3 (es) |
IL (2) | IL143393A0 (es) |
MY (1) | MY136016A (es) |
NO (1) | NO20012562L (es) |
NZ (1) | NZ511950A (es) |
PE (1) | PE20001245A1 (es) |
PL (1) | PL348329A1 (es) |
PT (1) | PT1133486E (es) |
SK (1) | SK7212001A3 (es) |
UA (1) | UA73102C2 (es) |
WO (1) | WO2000032584A2 (es) |
ZA (1) | ZA200105280B (es) |
Families Citing this family (51)
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DE10038639A1 (de) | 2000-07-28 | 2002-02-21 | Schering Ag | Nichtsteroidale Entzündungshemmer |
US7238707B2 (en) * | 2000-07-28 | 2007-07-03 | Schering Ag | Substituted pentanols, a process for their production and their use as anti-inflammatory agents |
DE10346940B3 (de) * | 2003-10-06 | 2005-06-16 | Schering Ag | Substituierte Pentanole, ihre Verwendung zur Herstellung von Arzneimitteln speziell Entzündungshemmer sowie diese enthaltende pharmazeutische Präparate |
DE60228954D1 (en) * | 2001-05-03 | 2008-10-30 | Galileo Lab Inc | Pyruvatderivate |
CA2472746A1 (en) * | 2002-01-14 | 2003-07-24 | Boehringer Ingelheim Pharmaceuticals, Inc. | Glucocorticoid mimetics, methods of making them, pharmaceutical formulations containing them and uses thereof |
ES2298508T3 (es) * | 2002-03-26 | 2008-05-16 | Boehringer Ingelheim Pharmaceuticals Inc. | Mimeticos de glucocorticoides, metodos para prepararlos, composiciones farmaceuticas y sus usos. |
CA2477764A1 (en) * | 2002-03-26 | 2003-10-09 | Boehringer Ingelheim Pharmaceuticals, Inc. | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof |
DE10215316C1 (de) * | 2002-04-02 | 2003-12-18 | Schering Ag | Chinolin- und Isochinolin-Derivate, ein pharmazeutisches Mittel und ihre Verwendung als Entzündungshemmer |
US6897224B2 (en) * | 2002-04-02 | 2005-05-24 | Schering Ag | Quinoline and isoquinoline derivatives, a process for their production and their use as inflammation inhibitors |
US7186864B2 (en) * | 2002-05-29 | 2007-03-06 | Boehringer Ingelheim Pharmaceuticals, Inc. | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof |
US7074806B2 (en) * | 2002-06-06 | 2006-07-11 | Boehringer Ingelheim Pharmaceuticals, Inc. | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof |
CA2496175A1 (en) * | 2002-08-21 | 2004-03-04 | Boehringer Ingelheim Pharmaceuticals, Inc. | Substituted hihydroquinolines as glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof |
BR0313923A (pt) * | 2002-08-29 | 2005-07-12 | Boehringer Ingelheim Pharma | Derivados de 3-(sulfonamidoetil)-indol para uso como miméticos de glicocorticóide no tratamento de doenças inflamatórias, alérgicas e proliferativas |
DE10261874A1 (de) * | 2002-12-20 | 2004-07-08 | Schering Ag | Nichtsteroidale Entzündungshemmer |
US7112584B2 (en) * | 2002-12-20 | 2006-09-26 | Schering Ag | Nonsteroidal antiinflammatory agents |
EP1583745A1 (en) * | 2003-01-03 | 2005-10-12 | Boehringer Ingelheim Pharmaceuticals Inc. | 1-propanol and 1-propylamine derivatives and their use as glucocorticoid ligands |
WO2004071389A2 (en) * | 2003-02-15 | 2004-08-26 | Glaxo Group Limited | Non-steroidal infalmmation inhibitors |
US20040224992A1 (en) * | 2003-02-27 | 2004-11-11 | Boehringer Ingelheim Pharmaceuticals, Inc. | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof |
MXPA06000169A (es) * | 2003-07-01 | 2006-04-27 | Schering Ag | Derivados de pentanol heterociclicamente sustituidos, procedimiento para su preparacion y su uso como anti-inflamatorios. |
US20050090559A1 (en) * | 2003-07-01 | 2005-04-28 | Markus Berger | Heterocyclically-substituted pentanol derivatives, process for their production and their use as anti-inflammatory agents |
UY28526A1 (es) | 2003-09-24 | 2005-04-29 | Boehringer Ingelheim Pharma | Miméticos de glucocorticoides, métodos de preparación composiciones farmacéuticas y usos de los mismos |
DE10347385A1 (de) * | 2003-10-08 | 2005-05-12 | Schering Ag | Umgelagerte Pentanole, ein Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer |
US7507843B2 (en) * | 2003-10-16 | 2009-03-24 | Boehringer Ingelheim Pharmaceuticals, Inc. | Stereoselective synthesis of certain trifluoromethyl-substituted alcohols |
US7795272B2 (en) * | 2004-03-13 | 2010-09-14 | Boehringer Ingelheim Pharmaceutical, Inc. | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions and uses thereof |
GB0418045D0 (en) | 2004-08-12 | 2004-09-15 | Glaxo Group Ltd | Compounds |
JP2008525525A (ja) * | 2004-12-27 | 2008-07-17 | ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド | グルココルチコイドミメティクス、その製法、医薬組成物及び使用 |
JP2008543780A (ja) * | 2005-06-10 | 2008-12-04 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | グルココルチコイド模倣薬、それらの製造方法、医薬組成物及びそれらの使用 |
DE102005030292A1 (de) * | 2005-06-24 | 2007-01-11 | Schering Ag | Nichtsteroidale Progesteronrezeptor-Modulatoren |
GB0513297D0 (en) * | 2005-06-29 | 2005-08-03 | Glaxo Group Ltd | Novel compounds |
CA2519010A1 (en) | 2005-09-13 | 2007-03-13 | Cognos Incorporated | Query framework system and method |
TW200815361A (en) * | 2005-10-20 | 2008-04-01 | Astrazeneca Ab | Chemical compounds |
GB0522880D0 (en) * | 2005-11-09 | 2005-12-21 | Glaxo Group Ltd | Novel compounds |
CN101326169B (zh) * | 2005-12-09 | 2011-11-16 | 霍夫曼-拉罗奇有限公司 | 作为抗炎剂的糖皮质激素受体调节剂 |
EP1960351B1 (en) * | 2005-12-09 | 2013-06-19 | F.Hoffmann-La Roche Ag | Propionamide compounds as antiinflammatory agents |
WO2007120083A1 (en) * | 2006-04-13 | 2007-10-25 | Astrazeneca Ab | The use of carboxamide derivatives in the manufacture of a medicament for the treatment of inflammatory, allergic and dermatological conditions |
EA200801997A1 (ru) | 2006-04-20 | 2009-04-28 | Глаксо Груп Лимитед | Новые соединения |
GB0611587D0 (en) * | 2006-06-12 | 2006-07-19 | Glaxo Group Ltd | Novel compounds |
WO2008000777A2 (en) * | 2006-06-29 | 2008-01-03 | Glaxo Group Limited | Phenyl- pyrazole derivatives, process for their preparation and their pharmaceutical use |
TW200829578A (en) | 2006-11-23 | 2008-07-16 | Astrazeneca Ab | Chemical compounds 537 |
KR20090097908A (ko) * | 2006-12-06 | 2009-09-16 | 베링거 인겔하임 인터내셔날 게엠베하 | 글루코코르티코이드 모사물, 이의 제조 방법, 이의 약제학적 조성물 및 용도 |
WO2008074814A1 (en) * | 2006-12-20 | 2008-06-26 | Glaxo Group Limited | Pyrazole derivatives as non-steroidal glucocorticoid receptor ligands |
UY30805A1 (es) * | 2006-12-21 | 2008-07-31 | Bayer Schering Pharma Ag | Moduladores no esteroides de receptores de progesterona |
JO2754B1 (en) * | 2006-12-21 | 2014-03-15 | استرازينكا ايه بي | Amylendazoleil derivatives for the treatment of glucocorticoid-mediated disorders |
MX2009008323A (es) * | 2007-02-15 | 2009-08-13 | Argenta Discovery Ltd | Derivados heterociclicos como receptores muscarinicos m3. |
US8211930B2 (en) * | 2008-05-20 | 2012-07-03 | Astrazeneca Ab | Phenyl and benzodioxinyl substituted indazoles derivatives |
SI2300472T1 (sl) * | 2008-06-06 | 2012-05-31 | Boehringer Ingelheim Int | Glukokortikoidni mimetiki postopki za njihovo pripravo farmacevtski sestavki in njihove uporabe |
GB0814729D0 (en) * | 2008-08-12 | 2008-09-17 | Argenta Discovery Ltd | New combination |
AU2010280323A1 (en) | 2009-07-31 | 2012-03-08 | Cadila Healthcare Limited | Novel compounds as modulators of glucocorticoid receptors |
WO2011061527A1 (en) | 2009-11-17 | 2011-05-26 | Astrazeneca Ab | Combinations comprising a glucocorticoid receptor modulator for the treatment of respiratory diseases |
EP3569228A1 (en) | 2018-05-17 | 2019-11-20 | Association pour la recherche à l'IGBMC (ARI) | Non-steroidal selective glucocorticoid receptor agonistic modulators (segrams) and uses thereof |
FI3700513T3 (fi) | 2017-10-27 | 2022-12-15 | Ei-steroidiset selektiiviset glukortikoidireseptorin agonistimodulaattorit (segramit) ja niiden käyttö |
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---|---|---|---|---|
CA1261835A (en) | 1984-08-20 | 1989-09-26 | Masaaki Toda | (fused) benz(thio)amides |
GB8617652D0 (en) * | 1986-07-18 | 1986-08-28 | Ici Plc | Acylanilide derivatives |
GB8617653D0 (en) | 1986-07-18 | 1986-08-28 | Ici Plc | Amide derivatives |
DE19723722A1 (de) | 1997-05-30 | 1998-12-10 | Schering Ag | Nichtsteroidale Gestagene |
-
1998
- 1998-11-27 DE DE19856475A patent/DE19856475A1/de not_active Withdrawn
-
1999
- 1999-11-24 US US09/448,278 patent/US6323199B1/en not_active Expired - Fee Related
- 1999-11-26 CO CO99074717A patent/CO5140109A1/es unknown
- 1999-11-26 MY MYPI99005172A patent/MY136016A/en unknown
- 1999-11-26 AR ARP990106045A patent/AR021419A1/es unknown
- 1999-11-26 PE PE1999001188A patent/PE20001245A1/es not_active Application Discontinuation
- 1999-11-29 EE EEP200100283A patent/EE200100283A/xx unknown
- 1999-11-29 PL PL99348329A patent/PL348329A1/xx unknown
- 1999-11-29 EP EP99963476A patent/EP1133486B1/de not_active Expired - Lifetime
- 1999-11-29 WO PCT/EP1999/009754 patent/WO2000032584A2/de not_active Application Discontinuation
- 1999-11-29 PT PT99963476T patent/PT1133486E/pt unknown
- 1999-11-29 JP JP2000585226A patent/JP2002531446A/ja not_active Withdrawn
- 1999-11-29 UA UA2001064447A patent/UA73102C2/uk unknown
- 1999-11-29 EA EA200100529A patent/EA003299B1/ru not_active IP Right Cessation
- 1999-11-29 CA CA002352367A patent/CA2352367A1/en not_active Abandoned
- 1999-11-29 CZ CZ20011866A patent/CZ20011866A3/cs unknown
- 1999-11-29 NZ NZ511950A patent/NZ511950A/en unknown
- 1999-11-29 DE DE59911340T patent/DE59911340D1/de not_active Expired - Fee Related
- 1999-11-29 BR BR9915755-1A patent/BR9915755A/pt not_active Application Discontinuation
- 1999-11-29 ES ES99963476T patent/ES2235543T3/es not_active Expired - Lifetime
- 1999-11-29 AT AT99963476T patent/ATE285405T1/de not_active IP Right Cessation
- 1999-11-29 SK SK721-2001A patent/SK7212001A3/sk unknown
- 1999-11-29 CN CN99815852.6A patent/CN1171883C/zh not_active Expired - Fee Related
- 1999-11-29 KR KR1020017006613A patent/KR100762058B1/ko not_active IP Right Cessation
- 1999-11-29 IL IL14339399A patent/IL143393A0/xx active IP Right Grant
- 1999-11-29 HU HU0104578A patent/HUP0104578A3/hu unknown
- 1999-11-29 AU AU19760/00A patent/AU762735B2/en not_active Ceased
-
2001
- 2001-05-21 BG BG105527A patent/BG65030B1/bg unknown
- 2001-05-24 IL IL143393A patent/IL143393A/en not_active IP Right Cessation
- 2001-05-25 NO NO20012562A patent/NO20012562L/no not_active Application Discontinuation
- 2001-06-26 ZA ZA200105280A patent/ZA200105280B/en unknown
- 2001-06-26 HR HR20010483A patent/HRP20010483B1/xx not_active IP Right Cessation
-
2002
- 2002-07-16 HK HK02105244.1A patent/HK1043592B/zh not_active IP Right Cessation
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