HRP20010256B1 - Derivati izosorbidnog mononitrata i njihova upotreba kao vazodilatornih sredstava sa smanjenom tolerancijom - Google Patents

Derivati izosorbidnog mononitrata i njihova upotreba kao vazodilatornih sredstava sa smanjenom tolerancijom

Info

Publication number
HRP20010256B1
HRP20010256B1 HR20010256A HRP20010256A HRP20010256B1 HR P20010256 B1 HRP20010256 B1 HR P20010256B1 HR 20010256 A HR20010256 A HR 20010256A HR P20010256 A HRP20010256 A HR P20010256A HR P20010256 B1 HRP20010256 B1 HR P20010256B1
Authority
HR
Croatia
Prior art keywords
group
vasodilators
alkyl
reduced tolerance
derivatives
Prior art date
Application number
HR20010256A
Other languages
English (en)
Croatian (hr)
Inventor
Repolles Moliner Jose
Pubill Coy Francisco
Cabeza Llorente Lydia
Banus Marcelili Carbo
Negrie Rofes Cristina
Antonio Cerda Riudavets Juan
Ferrer Siso Alicia
W. Radomski Marek
Salas Perez-Rasilla Eduardo
Martinez Bonnin Juan
Original Assignee
Lacer S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lacer S.A. filed Critical Lacer S.A.
Publication of HRP20010256A2 publication Critical patent/HRP20010256A2/hr
Publication of HRP20010256B1 publication Critical patent/HRP20010256B1/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D493/00Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
HR20010256A 1998-10-07 1999-10-04 Derivati izosorbidnog mononitrata i njihova upotreba kao vazodilatornih sredstava sa smanjenom tolerancijom HRP20010256B1 (hr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES009802076A ES2142773B1 (es) 1998-10-07 1998-10-07 Derivados de mononitrato de isosorbida y su empleo como agentes vasodilatadores con tolerancia desminuida.
PCT/ES1999/000316 WO2000020420A1 (es) 1998-10-07 1999-10-04 Derivados de mononitrato de isosorbida y su empleo como agentes vasodilatadores con tolerancia disminuida

Publications (2)

Publication Number Publication Date
HRP20010256A2 HRP20010256A2 (en) 2002-04-30
HRP20010256B1 true HRP20010256B1 (hr) 2009-08-31

Family

ID=8305360

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20010256A HRP20010256B1 (hr) 1998-10-07 1999-10-04 Derivati izosorbidnog mononitrata i njihova upotreba kao vazodilatornih sredstava sa smanjenom tolerancijom

Country Status (40)

Country Link
US (2) US20010051735A1 (cs)
EP (1) EP1120419B1 (cs)
JP (1) JP4659214B2 (cs)
KR (1) KR100641801B1 (cs)
CN (1) CN1096465C (cs)
AP (1) AP1555A (cs)
AR (1) AR020538A1 (cs)
AT (1) ATE323707T1 (cs)
AU (1) AU762724B2 (cs)
BG (1) BG65135B1 (cs)
BR (1) BR9914355B1 (cs)
CA (1) CA2346010C (cs)
CO (1) CO5180544A1 (cs)
CU (1) CU23162A3 (cs)
CZ (1) CZ294551B6 (cs)
DE (2) DE69930949T2 (cs)
DK (1) DK1120419T3 (cs)
EA (1) EA003360B1 (cs)
EE (1) EE04374B1 (cs)
ES (2) ES2142773B1 (cs)
GB (1) GB2359810B (cs)
GE (1) GEP20043162B (cs)
GT (1) GT199900173A (cs)
HR (1) HRP20010256B1 (cs)
HU (1) HUP0103937A3 (cs)
ID (1) ID29946A (cs)
IL (2) IL142391A0 (cs)
IS (1) IS2312B (cs)
NO (1) NO328584B1 (cs)
NZ (1) NZ510855A (cs)
OA (1) OA11661A (cs)
PA (1) PA8483901A1 (cs)
PE (1) PE20001083A1 (cs)
PL (1) PL200028B1 (cs)
PT (1) PT1120419E (cs)
RS (1) RS50112B (cs)
TR (1) TR200100961T2 (cs)
WO (1) WO2000020420A1 (cs)
YU (1) YU25201A (cs)
ZA (1) ZA200102836B (cs)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2258365B1 (es) * 2003-10-03 2007-12-01 Lacer, S.A. Derivados de disulfuro, sulfuro, sulfoxido y sulfona de azucares ciclicos y sus usos.
EP1941876A1 (en) * 2006-12-28 2008-07-09 Lacer, S.A. Isosorbide mononitrate derivatives for the treatment of Inflammation and ocular hypertension
ES2332565B1 (es) * 2007-01-23 2010-10-21 Lacer, S.A. Uso de derivados de mononitrato de dianhidrohexita como agentes antiinflamatorios.
IE20070934A1 (en) 2007-12-21 2009-06-24 Trinity College Dublin Efficient aspirin prodrugs
EP2240491B1 (en) 2008-01-09 2015-07-15 Amura Therapeutics Limited TETRAHYDROFURO(2,3-b)PYRROL-3-ONE DERIVATIVES AS INHIBITORS OF CYSTEINE PROTEINASES
CA2706082C (en) * 2008-02-07 2017-10-03 Nicox S.A. Nitric oxide donor compounds
EP2149576A1 (en) 2008-07-22 2010-02-03 Lacer, S.A. Isosorbide Nitrates having vasodilating activity
EP2149577B1 (en) * 2008-07-22 2011-04-27 Lacer, S.A. New stereospecific method for the preparation of dioxa-bicyclooctane compounds
EP2177216A1 (en) 2008-10-13 2010-04-21 Lacer, S.A. Use of dianhydrohexite mononitrate derivatives as healing agents
WO2010055138A1 (en) * 2008-11-14 2010-05-20 Lacer, S.A. New stereospecific method for the preparation of dioxa-bicyclooctane compounds
EP2199294A1 (en) 2008-12-19 2010-06-23 Lacer, S.A. New stereospecific method for the preparation of dioxa bicyclooctane nitrate compounds
EP2301941B1 (en) * 2009-09-10 2013-06-19 Cognis IP Management GmbH Isosorbide glyceryl ether derivatives and their use in household applications
ES2587191T3 (es) 2009-12-23 2016-10-21 Arca Biopharma, Inc. Métodos y composiciones para enfermedades y afecciones cardiovasculares
CN102241687A (zh) * 2011-05-23 2011-11-16 中国人民解放军第四军医大学 抗缺血/再灌注损伤的药物
US9061962B2 (en) 2011-10-24 2015-06-23 Nicox Science Ireland Quinone based nitric oxide donating compounds
AU2014226533A1 (en) * 2013-03-05 2015-08-13 Archer Daniels Midland Company Isohexide monotriflates and process for synthesis thereof
WO2014169976A1 (en) 2013-04-18 2014-10-23 Nicox Science Ireland Quinone based nitric oxide donating compounds
CN104650108B (zh) * 2013-11-18 2017-05-24 富力 连翘脂素硫酸酯及其衍生物、制备方法及其应用
CN105461731B (zh) * 2014-08-07 2017-05-24 富力 连翘脂素布洛芬酯、其制备及其应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0290885A2 (en) * 1987-05-08 1988-11-17 CHIESI FARMACEUTICI S.p.A. 1,4:3,6-Dianhydrosorbitol 2-mono-nitrate and 5-mononitrate esters, a process for the preparation thereof and pharmaceutical compositions therefrom
US4891373A (en) * 1988-11-23 1990-01-02 Pfizer Inc. Aminopropanol derivatives of 1,4:3,6-dianhydrohexitol nitrates, processes for their preparation and their use as medicaments
WO1993003037A1 (fr) * 1991-08-07 1993-02-18 Laboratoires Hoechst, Société Anonyme Nitrates organiques, leurs procedes de preparation et leur utilisation dans le traitement de maladies cardiovasculaires
US5665766A (en) * 1992-07-30 1997-09-09 Cal International Limited Ester of an organic nitrate and a salicylate

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1356374A (fr) 1963-02-12 1964-03-27 Machine à fonctions multiples pour le travail du bois
GB1356374A (en) 1971-04-29 1974-06-12 American Home Prod Mononitrate esters of 1,3 3,6-dianhydro-d-glucitol
US3886196A (en) 1973-02-07 1975-05-27 Phillips Petroleum Co Magnesium-aluminum-silicate-phosphate catalysts for ammonialytic cleavage of lactams to form omega-aminonitriles
DE3028289C2 (de) 1980-07-25 1986-11-27 Dr. Willmar Schwabe GmbH & Co, 7500 Karlsruhe 2-O- und 5-O-substituierte 1.4;3.6-Dianhydro-hexit-mononitrate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zubereitungen
DE3248548A1 (de) * 1982-12-29 1984-07-05 Heinrich Mack Nachf., 7918 Illertissen Acylderivate von 1,4:3,6-dianhydro-hexiten, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3421072A1 (de) 1984-06-06 1985-12-12 Heinrich Mack Nachf., 7918 Illertissen 1,4:3,6-dianhydro-hexit-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3602067A1 (de) 1986-01-24 1987-07-30 Mack Chem Pharm 2,6-dioxabicyclo(3.3.0)octan-derivate, ihre herstellung und verwendung als arzneimittel
DE3606634A1 (de) 1986-02-28 1987-09-03 Mack Chem Pharm Isohexid-nucleoside, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3741005A1 (de) 1987-12-03 1989-06-15 Mack Chem Pharm Aminopropanol-derivate von 1,4:3,6-dianhydro-hexit-nitraten, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
JP2628756B2 (ja) * 1988-09-15 1997-07-09 シュバルツファルマ アクチェンゲゼルシャフト 新規有機ニトレート及びそれらの製造方法
US5428061A (en) 1988-09-15 1995-06-27 Schwarz Pharma Ag Organic nitrates and method for their preparation
CA2014520C (en) 1989-04-17 1996-07-16 Fumio Suzuki Hexitol derivatives
NL9001955A (nl) * 1990-09-05 1992-04-01 Cedona Pharm Bv Nieuwe thiazolidinederivaten.
IL120531A (en) 1997-03-26 2006-12-31 Yissum Res Dev Co Nitric oxide donors and pharmaceutical compositions containing them

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0290885A2 (en) * 1987-05-08 1988-11-17 CHIESI FARMACEUTICI S.p.A. 1,4:3,6-Dianhydrosorbitol 2-mono-nitrate and 5-mononitrate esters, a process for the preparation thereof and pharmaceutical compositions therefrom
US4891373A (en) * 1988-11-23 1990-01-02 Pfizer Inc. Aminopropanol derivatives of 1,4:3,6-dianhydrohexitol nitrates, processes for their preparation and their use as medicaments
WO1993003037A1 (fr) * 1991-08-07 1993-02-18 Laboratoires Hoechst, Société Anonyme Nitrates organiques, leurs procedes de preparation et leur utilisation dans le traitement de maladies cardiovasculaires
US5665766A (en) * 1992-07-30 1997-09-09 Cal International Limited Ester of an organic nitrate and a salicylate

Also Published As

Publication number Publication date
AU762724B2 (en) 2003-07-03
GB2359810B (en) 2003-12-03
BR9914355B1 (pt) 2014-10-21
GB0111172D0 (en) 2001-06-27
IS5910A (is) 2001-03-29
DE69930949D1 (de) 2006-05-24
EP1120419B1 (en) 2006-04-19
GT199900173A (es) 2001-03-30
CO5180544A1 (es) 2002-07-30
KR100641801B1 (ko) 2006-11-02
GB2359810A (en) 2001-09-05
CU23162A3 (es) 2006-07-18
HUP0103937A2 (hu) 2002-02-28
AR020538A1 (es) 2002-05-15
NO20011778D0 (no) 2001-04-06
EP1120419A1 (en) 2001-08-01
ID29946A (id) 2001-10-25
RS50112B (sr) 2009-03-25
ZA200102836B (en) 2002-09-25
NO328584B1 (no) 2010-03-22
HUP0103937A3 (en) 2003-11-28
DE69930949T2 (de) 2006-12-28
IS2312B (is) 2007-11-15
US20030225134A1 (en) 2003-12-04
CZ20011257A3 (cs) 2001-08-15
PE20001083A1 (es) 2000-11-28
AP2001002128A0 (en) 2001-06-30
DK1120419T3 (da) 2006-07-03
PL200028B1 (pl) 2008-11-28
ES2142773A1 (es) 2000-04-16
WO2000020420A1 (es) 2000-04-13
BG65135B1 (bg) 2007-03-30
ATE323707T1 (de) 2006-05-15
AP1555A (en) 2006-01-18
PL347030A1 (en) 2002-03-11
EA003360B1 (ru) 2003-04-24
JP2002526544A (ja) 2002-08-20
BR9914355A (pt) 2001-06-26
KR20010088848A (ko) 2001-09-28
CA2346010C (en) 2010-01-12
PA8483901A1 (es) 2000-09-29
TR200100961T2 (tr) 2003-02-21
EE200100207A (et) 2002-06-17
OA11661A (en) 2004-12-08
HRP20010256A2 (en) 2002-04-30
US20010051735A1 (en) 2001-12-13
EE04374B1 (et) 2004-10-15
US6858632B2 (en) 2005-02-22
EA200100422A1 (ru) 2001-10-22
ES2257871T3 (es) 2006-08-01
NZ510855A (en) 2004-02-27
PT1120419E (pt) 2006-07-31
CN1096465C (zh) 2002-12-18
GEP20043162B (en) 2004-01-26
AU6204199A (en) 2000-04-26
BG105417A (en) 2001-12-29
NO20011778L (no) 2001-04-06
CA2346010A1 (en) 2000-04-13
IL142391A0 (en) 2002-03-10
IL142391A (en) 2007-07-24
DE19983612T1 (de) 2001-09-27
CZ294551B6 (cs) 2005-01-12
YU25201A (sh) 2003-04-30
ES2142773B1 (es) 2001-01-01
JP4659214B2 (ja) 2011-03-30
CN1322205A (zh) 2001-11-14

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