HRP20010215A2 - Genes of the 1-desoxy-d-xylulose biosynthetic pathway - Google Patents
Genes of the 1-desoxy-d-xylulose biosynthetic pathway Download PDFInfo
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- HRP20010215A2 HRP20010215A2 HR20010215A HRP20010215A HRP20010215A2 HR P20010215 A2 HRP20010215 A2 HR P20010215A2 HR 20010215 A HR20010215 A HR 20010215A HR P20010215 A HRP20010215 A HR P20010215A HR P20010215 A2 HRP20010215 A2 HR P20010215A2
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- 108090000623 proteins and genes Proteins 0.000 title claims description 23
- 230000006696 biosynthetic metabolic pathway Effects 0.000 title description 4
- IGUZJYCAXLYZEE-RFZPGFLSSA-N 1-deoxy-D-xylulose Chemical compound CC(=O)[C@@H](O)[C@H](O)CO IGUZJYCAXLYZEE-RFZPGFLSSA-N 0.000 title description 3
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 40
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 34
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 29
- 229920001184 polypeptide Polymers 0.000 claims description 26
- 238000000034 method Methods 0.000 claims description 25
- 210000004027 cell Anatomy 0.000 claims description 24
- 150000001413 amino acids Chemical class 0.000 claims description 18
- 241000894006 Bacteria Species 0.000 claims description 16
- 241000700605 Viruses Species 0.000 claims description 14
- 150000003505 terpenes Chemical class 0.000 claims description 14
- 241000206602 Eukaryota Species 0.000 claims description 13
- 102000004169 proteins and genes Human genes 0.000 claims description 13
- 230000015572 biosynthetic process Effects 0.000 claims description 12
- 150000001875 compounds Chemical class 0.000 claims description 12
- AJPADPZSRRUGHI-RFZPGFLSSA-N 1-deoxy-D-xylulose 5-phosphate Chemical compound CC(=O)[C@@H](O)[C@H](O)COP(O)(O)=O AJPADPZSRRUGHI-RFZPGFLSSA-N 0.000 claims description 10
- 108020004414 DNA Proteins 0.000 claims description 10
- 230000008569 process Effects 0.000 claims description 10
- 229910019142 PO4 Inorganic materials 0.000 claims description 9
- 230000000840 anti-viral effect Effects 0.000 claims description 8
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- 239000013604 expression vector Substances 0.000 claims description 8
- SNVLJLYUUXKWOJ-UHFFFAOYSA-N methylidenecarbene Chemical compound C=[C] SNVLJLYUUXKWOJ-UHFFFAOYSA-N 0.000 claims description 8
- 244000045947 parasite Species 0.000 claims description 8
- 239000010452 phosphate Substances 0.000 claims description 8
- 230000026731 phosphorylation Effects 0.000 claims description 8
- 238000006366 phosphorylation reaction Methods 0.000 claims description 8
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- 101100126492 Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) ispG1 gene Proteins 0.000 claims description 7
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- ZKDSJDSEVDWBAC-UHNVWZDZSA-N (2r,3r)-2,3,4-trihydroxy-2-methylbutanal Chemical compound O=C[C@@](O)(C)[C@H](O)CO ZKDSJDSEVDWBAC-UHNVWZDZSA-N 0.000 claims description 4
- HGVJFBSSLICXEM-UHNVWZDZSA-N (2s,3r)-2-methylbutane-1,2,3,4-tetrol Chemical compound OC[C@@](O)(C)[C@H](O)CO HGVJFBSSLICXEM-UHNVWZDZSA-N 0.000 claims description 4
- HGVJFBSSLICXEM-UHFFFAOYSA-N L-2-methyl-erythritol Natural products OCC(O)(C)C(O)CO HGVJFBSSLICXEM-UHFFFAOYSA-N 0.000 claims description 4
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- 108091034117 Oligonucleotide Proteins 0.000 claims description 3
- FPJRZKFBYYRPKI-UHNVWZDZSA-N [(2r,3r)-2,3-dihydroxy-3-methyl-4-oxobutyl] dihydrogen phosphate Chemical compound O=C[C@@](O)(C)[C@H](O)COP(O)(O)=O FPJRZKFBYYRPKI-UHNVWZDZSA-N 0.000 claims description 3
- XMWHRVNVKDKBRG-CRCLSJGQSA-N [(2s,3r)-2,3,4-trihydroxy-3-methylbutyl] dihydrogen phosphate Chemical compound OC[C@](O)(C)[C@@H](O)COP(O)(O)=O XMWHRVNVKDKBRG-CRCLSJGQSA-N 0.000 claims description 3
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- LXJXRIRHZLFYRP-VKHMYHEASA-L (R)-2-Hydroxy-3-(phosphonooxy)-propanal Natural products O=C[C@H](O)COP([O-])([O-])=O LXJXRIRHZLFYRP-VKHMYHEASA-L 0.000 claims description 2
- XMWHRVNVKDKBRG-UHNVWZDZSA-N 2-C-methyl-D-erythritol 4-(dihydrogen phosphate) Chemical compound OC[C@@](O)(C)[C@H](O)COP(O)(O)=O XMWHRVNVKDKBRG-UHNVWZDZSA-N 0.000 claims description 2
- LXJXRIRHZLFYRP-VKHMYHEASA-N D-glyceraldehyde 3-phosphate Chemical compound O=C[C@H](O)COP(O)(O)=O LXJXRIRHZLFYRP-VKHMYHEASA-N 0.000 claims description 2
- JDTGGHKXRGIEGA-JBUOLDKXSA-N P(=O)(O)(O)O.C[C@@](CO)(O)[C@H](O)CO Chemical compound P(=O)(O)(O)O.C[C@@](CO)(O)[C@H](O)CO JDTGGHKXRGIEGA-JBUOLDKXSA-N 0.000 claims description 2
- 230000003197 catalytic effect Effects 0.000 claims description 2
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- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 2
- KPAAYTACXWHADP-JBUOLDKXSA-N phosphoric acid (2R,3R)-2,3,4-trihydroxy-2-methylbutanal Chemical compound P(=O)(O)(O)O.C[C@@](C=O)(O)[C@H](O)CO KPAAYTACXWHADP-JBUOLDKXSA-N 0.000 claims description 2
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- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 2
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
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- IGUZJYCAXLYZEE-MGVUJODPSA-N (3S,4R)-1-deuterio-3,4,5-trihydroxypentan-2-one Chemical compound C(C(=O)[C@@H](O)[C@H](O)CO)[2H] IGUZJYCAXLYZEE-MGVUJODPSA-N 0.000 description 3
- 108020004705 Codon Proteins 0.000 description 3
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- KJTLQQUUPVSXIM-ZCFIWIBFSA-M (R)-mevalonate Chemical compound OCC[C@](O)(C)CC([O-])=O KJTLQQUUPVSXIM-ZCFIWIBFSA-M 0.000 description 2
- 241000203069 Archaea Species 0.000 description 2
- KJTLQQUUPVSXIM-UHFFFAOYSA-N DL-mevalonic acid Natural products OCCC(O)(C)CC(O)=O KJTLQQUUPVSXIM-UHFFFAOYSA-N 0.000 description 2
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
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- A61P33/00—Antiparasitic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
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- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
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- C12N9/0004—Oxidoreductases (1.)
- C12N9/0093—Oxidoreductases (1.) acting on CH or CH2 groups (1.17)
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
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- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/01267—1-Deoxy-D-xylulose-5-phosphate reductoisomerase (1.1.1.267)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y117/00—Oxidoreductases acting on CH or CH2 groups (1.17)
- C12Y117/07—Oxidoreductases acting on CH or CH2 groups (1.17) with an iron-sulfur protein as acceptor (1.17.7)
- C12Y117/07001—(E)-4-Hydroxy-3-methylbut-2-enyl-diphosphate synthase (1.17.7.1)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y202/00—Transferases transferring aldehyde or ketonic groups (2.2)
- C12Y202/01—Transketolases and transaldolases (2.2.1)
- C12Y202/01007—1-Deoxy-D-xylulose-5-phosphate synthase (2.2.1.7)
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- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
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- Animal Behavior & Ethology (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19843279 | 1998-09-22 | ||
| DE19923567A DE19923567A1 (de) | 1998-09-22 | 1999-05-21 | Gene des 1-Desoxy-D-xylulose-Biosynthesewegs |
| PCT/EP1999/007055 WO2000017233A2 (de) | 1998-09-22 | 1999-09-22 | Gene des 1-desoxy-d-xylulose-biosynthesewegs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20010215A2 true HRP20010215A2 (en) | 2002-06-30 |
Family
ID=26048996
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20010215A HRP20010215A2 (en) | 1998-09-22 | 2001-03-21 | Genes of the 1-desoxy-d-xylulose biosynthetic pathway |
Country Status (23)
| Country | Link |
|---|---|
| EP (1) | EP1115849B1 (xx) |
| JP (1) | JP2002526061A (xx) |
| CN (1) | CN1319134A (xx) |
| AP (1) | AP2001002104A0 (xx) |
| AT (1) | ATE317007T1 (xx) |
| AU (1) | AU767213B2 (xx) |
| BG (1) | BG105361A (xx) |
| BR (1) | BR9914028A (xx) |
| CA (1) | CA2343919A1 (xx) |
| CZ (1) | CZ2001990A3 (xx) |
| DE (1) | DE59913101D1 (xx) |
| EE (1) | EE200100174A (xx) |
| HR (1) | HRP20010215A2 (xx) |
| HU (1) | HUP0203649A2 (xx) |
| ID (1) | ID29772A (xx) |
| IL (1) | IL141888A0 (xx) |
| IS (1) | IS5872A (xx) |
| NO (1) | NO20011459L (xx) |
| OA (1) | OA11656A (xx) |
| PL (1) | PL348428A1 (xx) |
| SK (1) | SK3922001A3 (xx) |
| TR (1) | TR200100836T2 (xx) |
| WO (1) | WO2000017233A2 (xx) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999053071A1 (fr) | 1998-04-14 | 1999-10-21 | Kyowa Hakko Kogyo Co., Ltd. | Procede de production de composes isoprenoides au moyen de micro-organismes et procede de detection de composes ayant une action antibacterienne ou herbicide |
| JP2002541851A (ja) | 1999-04-15 | 2002-12-10 | カルジーン エルエルシー | イソプレノイド合成に関与するタンパク質の核酸配列 |
| DE19918949A1 (de) * | 1999-04-27 | 2000-11-23 | Basf Ag | Überexpression einer DNA-Sequenz codierend für eine 1-Desoxy-D-Xylulose-5-Phosphat Reduktoisomerase in Pflanzen |
| IL146347A0 (en) * | 1999-05-21 | 2002-07-25 | Jomaa Pharmaka Gmbh | Use of genes of the deoxy-d-xylulose phosphate biosynthetic pathway for altering the concentration of isoprenoid |
| US7122331B1 (en) | 1999-08-04 | 2006-10-17 | Wolfgang Eisenreich | Isoprenoid biosynthesis |
| US6872815B1 (en) | 2000-10-14 | 2005-03-29 | Calgene Llc | Nucleic acid sequences to proteins involved in tocopherol synthesis |
| DE10021688A1 (de) * | 2000-05-05 | 2001-11-15 | Hassan Jomaa | Gene des 1-Desoxy-D-xylulose-Biosynthesewegs |
| DE10027821A1 (de) * | 2000-06-05 | 2001-12-06 | Adelbert Bacher | Der Mevalonat-unabhängige Isoprenoidbiosyntheseweg |
| CA2418436C (en) | 2000-08-07 | 2017-07-11 | Monsanto Technology, Llc | Methyl-d-erythritol phosphate pathway genes |
| DE10201458A1 (de) | 2001-04-11 | 2002-10-17 | Adelbert Bacher | Intermediate und Enzyme des Mevalonat-unabhängigen Isoprenoidbiosyntheseweg |
| ATE419366T1 (de) | 2001-05-09 | 2009-01-15 | Monsanto Technology Llc | Tyra-gene und ihre verwendung |
| US7161061B2 (en) | 2001-05-09 | 2007-01-09 | Monsanto Technology Llc | Metabolite transporters |
| KR100906018B1 (ko) * | 2001-07-20 | 2009-07-06 | 바이오에이전시 아게 | 감마/델타 ｔ세포 활성화를 위한 유기-인 화합물 |
| US7244877B2 (en) | 2001-08-17 | 2007-07-17 | Monsanto Technology Llc | Methyltransferase from cotton and uses thereof |
| AR036962A1 (es) | 2001-10-25 | 2004-10-13 | Monsanto Technology Llc | Metiltransferasas aromaticas y usos de las mismas |
| BRPI0308740B1 (pt) | 2002-03-19 | 2018-11-21 | Monsanto Technology Llc | molécula de ácido nucléico codificando uma homogentisato prenil transferase (“hpt”) e método de produzir planta tendo semente com nível de tocoferol aumentado |
| EP1546334A4 (en) | 2002-08-05 | 2007-01-03 | Monsanto Technology Llc | GENES ASSOCIATED WITH TOCOPHEROL BIOSYNTHESIS AND USES THEREOF |
| CN106978425B (zh) * | 2017-02-17 | 2019-10-18 | 华中农业大学 | 东方巴贝斯虫1-脱氧-d-木酮糖-5-磷酸还原异构酶基因及其编码的蛋白 |
| JP2021505154A (ja) | 2017-12-07 | 2021-02-18 | ザイマージェン インコーポレイテッド | 発酵によって（６ｅ）−８−ヒドロキシゲラニオールを生産するための設計された生合成経路 |
| CN111868047A (zh) | 2017-12-21 | 2020-10-30 | 齐默尔根公司 | 荆芥内半缩醛氧化还原酶、荆芥内半缩醛合酶和能够产生荆芥内酯的微生物 |
| CN109342634A (zh) * | 2018-12-07 | 2019-02-15 | 西北大学 | 一种柱前衍生-hplc测定dxs酶催化活性的方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19752700A1 (de) * | 1997-11-28 | 1999-06-02 | Hoechst Schering Agrevo Gmbh | 1-Desoxy-D-xylulose-5-phosphat Synthase, Verfahren zur Identifizierung von Effektoren der 1-Desoxy-D-xylulose-5-phosphat Synthase und Effektoren der 1-Desoxy-D-xylulose-5-phosphat Synthase |
| SK15232000A3 (sk) * | 1998-04-14 | 2001-05-10 | Hassan Jomaa | Spôsob identifikácie chemických účinných látok a prostriedkov inhibície biosyntetickej cesty 1-deoxy-d-xylulóza-5-fosfátu |
-
1999
- 1999-09-22 IL IL14188899A patent/IL141888A0/xx unknown
- 1999-09-22 TR TR2001/00836T patent/TR200100836T2/xx unknown
- 1999-09-22 HU HU0203649A patent/HUP0203649A2/hu unknown
- 1999-09-22 OA OA1200100074A patent/OA11656A/en unknown
- 1999-09-22 AP APAP/P/2001/002104A patent/AP2001002104A0/en unknown
- 1999-09-22 PL PL99348428A patent/PL348428A1/xx not_active Application Discontinuation
- 1999-09-22 AU AU61947/99A patent/AU767213B2/en not_active Ceased
- 1999-09-22 CZ CZ2001990A patent/CZ2001990A3/cs unknown
- 1999-09-22 EE EEP200100174A patent/EE200100174A/xx unknown
- 1999-09-22 DE DE59913101T patent/DE59913101D1/de not_active Expired - Lifetime
- 1999-09-22 CN CN99811200A patent/CN1319134A/zh active Pending
- 1999-09-22 BR BR9914028-4A patent/BR9914028A/pt not_active IP Right Cessation
- 1999-09-22 AT AT99948831T patent/ATE317007T1/de not_active IP Right Cessation
- 1999-09-22 EP EP99948831A patent/EP1115849B1/de not_active Expired - Lifetime
- 1999-09-22 ID IDW20010573A patent/ID29772A/id unknown
- 1999-09-22 CA CA002343919A patent/CA2343919A1/en not_active Abandoned
- 1999-09-22 SK SK392-2001A patent/SK3922001A3/sk unknown
- 1999-09-22 JP JP2000574141A patent/JP2002526061A/ja active Pending
- 1999-09-22 WO PCT/EP1999/007055 patent/WO2000017233A2/de active IP Right Grant
-
2001
- 2001-02-28 IS IS5872A patent/IS5872A/is unknown
- 2001-03-19 BG BG105361A patent/BG105361A/xx unknown
- 2001-03-21 HR HR20010215A patent/HRP20010215A2/hr not_active Application Discontinuation
- 2001-03-22 NO NO20011459A patent/NO20011459L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| IS5872A (is) | 2001-02-28 |
| SK3922001A3 (en) | 2001-09-11 |
| DE59913101D1 (de) | 2006-04-13 |
| AU767213B2 (en) | 2003-11-06 |
| WO2000017233A3 (de) | 2000-05-25 |
| WO2000017233A2 (de) | 2000-03-30 |
| EP1115849B1 (de) | 2006-02-01 |
| BG105361A (en) | 2001-10-31 |
| NO20011459L (no) | 2001-05-22 |
| OA11656A (en) | 2004-12-08 |
| PL348428A1 (en) | 2002-05-20 |
| TR200100836T2 (tr) | 2001-10-22 |
| AP2001002104A0 (en) | 2001-03-31 |
| ID29772A (id) | 2001-10-11 |
| JP2002526061A (ja) | 2002-08-20 |
| CA2343919A1 (en) | 2000-03-30 |
| HUP0203649A2 (hu) | 2003-02-28 |
| IL141888A0 (en) | 2002-03-10 |
| CZ2001990A3 (cs) | 2002-01-16 |
| NO20011459D0 (no) | 2001-03-22 |
| CN1319134A (zh) | 2001-10-24 |
| BR9914028A (pt) | 2001-07-03 |
| EE200100174A (et) | 2002-08-15 |
| AU6194799A (en) | 2000-04-10 |
| EP1115849A2 (de) | 2001-07-18 |
| ATE317007T1 (de) | 2006-02-15 |
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