HRP20000867B1 - Pharmaceutical formulations for aerosols with two or more active substances - Google Patents

Pharmaceutical formulations for aerosols with two or more active substances

Info

Publication number
HRP20000867B1
HRP20000867B1 HR20000867A HRP20000867A HRP20000867B1 HR P20000867 B1 HRP20000867 B1 HR P20000867B1 HR 20000867 A HR20000867 A HR 20000867A HR P20000867 A HRP20000867 A HR P20000867A HR P20000867 B1 HRP20000867 B1 HR P20000867B1
Authority
HR
Croatia
Prior art keywords
active substances
aerosols
pharmaceutical formulations
propellant
salts
Prior art date
Application number
HR20000867A
Other languages
English (en)
Croatian (hr)
Inventor
Patrick Mcnamara Daniel
A. De Stefano George
Original Assignee
Boehringer Ingelheim Pharmaceuticals Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26046888&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HRP20000867(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from DE1998127178 external-priority patent/DE19827178A1/de
Priority claimed from DE1998142963 external-priority patent/DE19842963A1/de
Application filed by Boehringer Ingelheim Pharmaceuticals Inc. filed Critical Boehringer Ingelheim Pharmaceuticals Inc.
Publication of HRP20000867A2 publication Critical patent/HRP20000867A2/hr
Publication of HRP20000867B1 publication Critical patent/HRP20000867B1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/12—Mucolytics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Otolaryngology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HR20000867A 1998-06-18 1999-06-08 Pharmaceutical formulations for aerosols with two or more active substances HRP20000867B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE1998127178 DE19827178A1 (de) 1998-06-18 1998-06-18 Pharmazeutische Formulierung für Aerosole mit zwei oder mehr Wirkstoffen
DE1998142963 DE19842963A1 (de) 1998-09-19 1998-09-19 Pharmazeutische Formulierung für Aerosole mit zwei oder mehr Wirkstoffen
PCT/US1999/012785 WO1999065464A1 (en) 1998-06-18 1999-06-08 Pharmaceutical formulations for aerosols with two or more active substances

Publications (2)

Publication Number Publication Date
HRP20000867A2 HRP20000867A2 (en) 2001-10-31
HRP20000867B1 true HRP20000867B1 (en) 2010-10-31

Family

ID=26046888

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20000867A HRP20000867B1 (en) 1998-06-18 1999-06-08 Pharmaceutical formulations for aerosols with two or more active substances

Country Status (32)

Country Link
EP (1) EP1087750B1 (cs)
JP (1) JP2003522102A (cs)
KR (1) KR100600423B1 (cs)
CN (1) CN1161104C (cs)
AR (1) AR019690A1 (cs)
AT (1) ATE253896T1 (cs)
AU (1) AU759222B2 (cs)
BG (1) BG65252B1 (cs)
BR (1) BR9911351A (cs)
CA (1) CA2335065C (cs)
CO (1) CO5070580A1 (cs)
CZ (1) CZ300910B6 (cs)
DE (1) DE69912781T2 (cs)
DK (1) DK1087750T3 (cs)
EE (1) EE04450B1 (cs)
ES (1) ES2211108T3 (cs)
HR (1) HRP20000867B1 (cs)
HU (1) HU229064B1 (cs)
ID (1) ID27554A (cs)
IL (2) IL140353A0 (cs)
ME (1) ME00838B (cs)
MY (1) MY121073A (cs)
NO (1) NO329416B1 (cs)
NZ (1) NZ509418A (cs)
PL (1) PL193695B1 (cs)
PT (1) PT1087750E (cs)
RS (1) RS49977B (cs)
RU (1) RU2218152C2 (cs)
SK (1) SK284756B6 (cs)
TR (1) TR200003721T2 (cs)
TW (1) TW528606B (cs)
WO (1) WO1999065464A1 (cs)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9616237D0 (en) 1996-08-01 1996-09-11 Norton Healthcare Ltd Aerosol formulations
US20010031244A1 (en) 1997-06-13 2001-10-18 Chiesi Farmaceutici S.P.A. Pharmaceutical aerosol composition
GB2332372B (en) * 1997-12-08 2002-08-14 Minnesota Mining & Mfg Pharmaceutical aerosol compositions
DZ2947A1 (fr) 1998-11-25 2004-03-15 Chiesi Farma Spa Inhalateur à compteur de dose sous pression.
ES2165768B1 (es) 1999-07-14 2003-04-01 Almirall Prodesfarma Sa Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen.
US7214687B2 (en) 1999-07-14 2007-05-08 Almirall Ag Quinuclidine derivatives and medicinal compositions containing the same
IT1313553B1 (it) 1999-07-23 2002-09-09 Chiesi Farma Spa Formulazioni ottimizzate costituite da soluzioni di steroidi dasomministrare per inalazione.
JP2003509359A (ja) 1999-09-11 2003-03-11 グラクソ グループ リミテッド プロピオン酸フルチカゾンの医薬製剤
AU1534501A (en) * 1999-11-23 2001-06-04 Glaxo Group Limited Pharmaceutical formulations of salmeterol
JP2003518484A (ja) * 1999-12-24 2003-06-10 グラクソ グループ リミテッド サルメテロールおよびプロピオン酸フルチカゾンの医薬用エアゾル製剤
IT1317846B1 (it) 2000-02-22 2003-07-15 Chiesi Farma Spa Formulazioni contenenti un farmaco anticolinergico per il trattamentodella broncopneumopatia cronica ostruttiva.
GB0008485D0 (en) * 2000-04-07 2000-05-24 Glaxo Group Ltd Pharmaceutical compositions
JP5392880B2 (ja) * 2000-05-22 2014-01-22 キエシ・フアルマチエウテイチ・ソチエタ・ペル・アチオニ 加圧式定量吸入器のための安定な製薬学的溶液製剤
DE10062712A1 (de) * 2000-12-15 2002-06-20 Boehringer Ingelheim Pharma Neue Arzneimittelkompositionen auf der Basis von Anticholinergika und Corticosteroiden
US20030055026A1 (en) 2001-04-17 2003-03-20 Dey L.P. Formoterol/steroid bronchodilating compositions and methods of use thereof
DE10130371A1 (de) * 2001-06-23 2003-01-02 Boehringer Ingelheim Pharma Neue Arzneimittelkompositionen auf der Basis von Anticholinergika, Corticosteroiden und Betamimetika
BRPI0212586B8 (pt) 2001-09-18 2021-05-25 Nycomed Danmark Aps composição na forma de uma solução aquosa, e, uso da mesma
JP2010184937A (ja) * 2001-10-26 2010-08-26 Dey Lp 慢性閉塞性肺疾患の症状を緩和するためのアルブテロールおよびイプラトロピウム吸入溶液、キット、吸入溶液を中に有する１容器を作成する方法、および、吸入溶液を作成する方法
GB0207899D0 (en) * 2002-04-05 2002-05-15 3M Innovative Properties Co Formoterol and cielesonide aerosol formulations
EP1915985A1 (en) * 2003-03-20 2008-04-30 Boehringer Ingelheim Pharmaceuticals Inc. Formulation for a Metered Dose Inhaler Using Hydro-Fluoro-Alkanes as Propellants
TWI359675B (en) 2003-07-10 2012-03-11 Dey L P Bronchodilating β-agonist compositions
US9308199B2 (en) * 2004-04-29 2016-04-12 Honeywell International Inc. Medicament formulations
EP1595531A1 (en) 2004-05-13 2005-11-16 CHIESI FARMACEUTICI S.p.A. Stable pharmaceutical solution formulations for pressurized metered dose inhalers
WO2006101882A2 (en) * 2005-03-16 2006-09-28 Honeywell International Inc. Medicament delivery formulations, devices and methods
DE102006053374A1 (de) * 2006-02-09 2007-08-16 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pharmazeutische Formulierung für Aerosole mit zwei oder mehr Wirkstoffen und mindestens einer oberflächenaktiven Substanz
DE102006017320A1 (de) 2006-04-11 2007-10-18 Boehringer Ingelheim Pharma Gmbh & Co. Kg Aerosolsuspensionsformulierungen mit TG 227 ea oder TG 134 a als Treibmittel
US8061350B2 (en) 2006-06-02 2011-11-22 Boehringer Ingelheim Pharma Gmbh & Co. Kg Process and device for dosing pharmaceutical agents
US20070286814A1 (en) * 2006-06-12 2007-12-13 Medispray Laboratories Pvt. Ltd. Stable aerosol pharmaceutical formulations
ES2298049B1 (es) 2006-07-21 2009-10-20 Laboratorios Almirall S.A. Procedimiento para fabricar bromuro de 3(r)-(2-hidroxi-2,2-ditien-2-ilacetoxi)-1-(3-fenoxipropil)-1-azoniabiciclo (2.2.2) octano.
RU2356537C2 (ru) * 2007-07-25 2009-05-27 Закрытое Акционерное Общество (ЗАО) "Пульмомед" Фармацевтический состав дозированных аэрозолей, содержащий противоастматические лекарственные средства в виде суспензий, растворов, эмульсий, растворов и эмульсий
EP2077132A1 (en) 2008-01-02 2009-07-08 Boehringer Ingelheim Pharma GmbH & Co. KG Dispensing device, storage device and method for dispensing a formulation
EP2100598A1 (en) 2008-03-13 2009-09-16 Laboratorios Almirall, S.A. Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease
EP2100599A1 (en) 2008-03-13 2009-09-16 Laboratorios Almirall, S.A. Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease
EP2408500B1 (en) 2009-03-17 2015-04-29 Boehringer Ingelheim International GmbH Dispensing device, and storage device for dispensing a formulation
JP5670421B2 (ja) 2009-03-31 2015-02-18 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング コンポーネント表面のコーティング方法
US9265910B2 (en) 2009-05-18 2016-02-23 Boehringer Ingelheim International Gmbh Adapter, inhalation device, and nebulizer
US10016568B2 (en) 2009-11-25 2018-07-10 Boehringer Ingelheim International Gmbh Nebulizer
JP5715640B2 (ja) 2009-11-25 2015-05-13 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ネブライザ
EP2504051B1 (en) 2009-11-25 2019-09-04 Boehringer Ingelheim International GmbH Nebulizer
EP2512438B1 (en) 2009-12-16 2017-01-25 3M Innovative Properties Company Formulations and methods for controlling mdi particle size delivery
US9943654B2 (en) 2010-06-24 2018-04-17 Boehringer Ingelheim International Gmbh Nebulizer
WO2012130757A1 (de) 2011-04-01 2012-10-04 Boehringer Ingelheim International Gmbh Medizinisches gerät mit behälter
EP2510928A1 (en) 2011-04-15 2012-10-17 Almirall, S.A. Aclidinium for use in improving the quality of sleep in respiratory patients
US9827384B2 (en) 2011-05-23 2017-11-28 Boehringer Ingelheim International Gmbh Nebulizer
WO2013152894A1 (de) 2012-04-13 2013-10-17 Boehringer Ingelheim International Gmbh Zerstäuber mit kodiermitteln
EP2835146B1 (en) 2013-08-09 2020-09-30 Boehringer Ingelheim International GmbH Nebulizer
JP6643231B2 (ja) 2013-08-09 2020-02-12 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ネブライザ
DK3139984T3 (da) 2014-05-07 2021-07-19 Boehringer Ingelheim Int Forstøver
PT3139982T (pt) 2014-05-07 2022-04-05 Boehringer Ingelheim Int Nebulizador
CN106255554B (zh) 2014-05-07 2021-05-04 勃林格殷格翰国际有限公司 容器、喷雾器及用途
WO2020152548A1 (en) * 2019-01-24 2020-07-30 Glenmark Pharmaceuticals Limited Stable aerosol inhalation compositions of formoterol

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0499344A2 (en) * 1988-12-06 1992-08-19 Riker Laboratories, Inc. Medicinal aerosol formulations
WO1994013262A1 (en) * 1992-12-09 1994-06-23 Boehringer Ingelheim Pharmaceuticals, Inc. Stabilized medicinal aerosol solution formulations
US5589156A (en) * 1994-05-02 1996-12-31 Henry; Richard A. Prilocaine and hydrofluourocarbon aerosol preparations
US5603918A (en) * 1995-06-09 1997-02-18 Boehringer Ingelheim Pharmaceuticals, Inc. Aerosol composition of a salt of ipratropium and a salt of albuterol
WO1998001147A1 (en) * 1996-07-08 1998-01-15 Rhone-Poulenc Rorer Limited Medicinal cyclosporin-a aerosol solution formulation

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0499344A2 (en) * 1988-12-06 1992-08-19 Riker Laboratories, Inc. Medicinal aerosol formulations
WO1994013262A1 (en) * 1992-12-09 1994-06-23 Boehringer Ingelheim Pharmaceuticals, Inc. Stabilized medicinal aerosol solution formulations
US5589156A (en) * 1994-05-02 1996-12-31 Henry; Richard A. Prilocaine and hydrofluourocarbon aerosol preparations
US5603918A (en) * 1995-06-09 1997-02-18 Boehringer Ingelheim Pharmaceuticals, Inc. Aerosol composition of a salt of ipratropium and a salt of albuterol
WO1998001147A1 (en) * 1996-07-08 1998-01-15 Rhone-Poulenc Rorer Limited Medicinal cyclosporin-a aerosol solution formulation

Also Published As

Publication number Publication date
NO20006318L (no) 2001-01-30
YU80000A (sh) 2003-04-30
HUP0104734A2 (hu) 2002-05-29
RS49977B (sr) 2008-09-29
TW528606B (en) 2003-04-21
CN1161104C (zh) 2004-08-11
PT1087750E (pt) 2004-02-27
CZ300910B6 (cs) 2009-09-09
EP1087750A1 (en) 2001-04-04
MY121073A (en) 2005-12-30
RU2218152C2 (ru) 2003-12-10
HK1037974A1 (en) 2002-03-01
KR20010072621A (ko) 2001-07-31
EP1087750B1 (en) 2003-11-12
DE69912781D1 (de) 2003-12-18
NZ509418A (en) 2003-06-30
ID27554A (id) 2001-04-12
IL140353A0 (en) 2002-02-10
NO20006318D0 (no) 2000-12-12
CA2335065C (en) 2008-06-03
EE200000759A (et) 2002-04-15
TR200003721T2 (tr) 2001-06-21
ATE253896T1 (de) 2003-11-15
BG105033A (bg) 2001-09-28
EE04450B1 (et) 2005-04-15
NO329416B1 (no) 2010-10-18
HRP20000867A2 (en) 2001-10-31
SK19392000A3 (sk) 2001-07-10
BG65252B1 (bg) 2007-10-31
AR019690A1 (es) 2002-03-13
HUP0104734A3 (en) 2003-05-28
ME00838B (me) 2008-09-29
DE69912781T2 (de) 2004-10-21
DK1087750T3 (da) 2004-01-26
BR9911351A (pt) 2001-03-13
IL140353A (en) 2006-09-05
JP2003522102A (ja) 2003-07-22
HU229064B1 (en) 2013-07-29
PL345685A1 (en) 2002-01-02
KR100600423B1 (ko) 2006-07-13
CZ20004750A3 (en) 2001-05-16
ES2211108T3 (es) 2004-07-01
AU4552199A (en) 2000-01-05
WO1999065464A1 (en) 1999-12-23
CA2335065A1 (en) 1999-12-23
AU759222B2 (en) 2003-04-10
CN1307470A (zh) 2001-08-08
PL193695B1 (pl) 2007-03-30
CO5070580A1 (es) 2001-08-28
SK284756B6 (sk) 2005-11-03

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