HK9182A - 1-(1,3-dioxolan-2-ylmethyl)-1h-imidazoles and 1h-1,2,4-triazoles - Google Patents

1-(1,3-dioxolan-2-ylmethyl)-1h-imidazoles and 1h-1,2,4-triazoles

Info

Publication number
HK9182A
HK9182A HK91/82A HK9182A HK9182A HK 9182 A HK9182 A HK 9182A HK 91/82 A HK91/82 A HK 91/82A HK 9182 A HK9182 A HK 9182A HK 9182 A HK9182 A HK 9182A
Authority
HK
Hong Kong
Prior art keywords
dioxolan
triazoles
imidazoles
ylmethyl
Prior art date
Application number
HK91/82A
Other languages
English (en)
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27117424&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK9182(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of HK9182A publication Critical patent/HK9182A/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
    • C07D295/03—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/26—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
HK91/82A 1977-01-31 1982-02-25 1-(1,3-dioxolan-2-ylmethyl)-1h-imidazoles and 1h-1,2,4-triazoles HK9182A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US76426377A 1977-01-31 1977-01-31
US05/853,728 US4144346A (en) 1977-01-31 1977-11-21 Novel 1-(1,3-dioxolan-2-ylmethyl)-1H-imidazoles

Publications (1)

Publication Number Publication Date
HK9182A true HK9182A (en) 1982-03-05

Family

ID=27117424

Family Applications (1)

Application Number Title Priority Date Filing Date
HK91/82A HK9182A (en) 1977-01-31 1982-02-25 1-(1,3-dioxolan-2-ylmethyl)-1h-imidazoles and 1h-1,2,4-triazoles

Country Status (36)

Country Link
US (4) US4144346A (de)
JP (1) JPS5395973A (de)
KR (1) KR810000675B1 (de)
AT (1) AT366683B (de)
AU (1) AU521329B2 (de)
BE (1) BE863382A (de)
CA (1) CA1094559A (de)
CH (1) CH644118A5 (de)
CS (1) CS194833B2 (de)
CY (1) CY1192A (de)
DE (1) DE2804096A1 (de)
DK (1) DK158042C (de)
ES (1) ES465981A1 (de)
FI (1) FI63398C (de)
FR (1) FR2378778A1 (de)
GB (1) GB1594859A (de)
GR (1) GR62553B (de)
HK (1) HK9182A (de)
HU (2) HU177646B (de)
IE (1) IE46035B1 (de)
IL (1) IL53923A (de)
IT (1) IT1155800B (de)
KE (1) KE3270A (de)
LU (1) LU78960A1 (de)
LV (1) LV5015A3 (de)
MY (1) MY8400209A (de)
NL (1) NL188578C (de)
NO (1) NO148643C (de)
NZ (1) NZ186275A (de)
PH (1) PH14635A (de)
PL (1) PL113973B1 (de)
PT (1) PT67600B (de)
SE (1) SE439773B (de)
SU (1) SU786899A3 (de)
YU (1) YU40319B (de)
ZA (1) ZA78548B (de)

Families Citing this family (106)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4232034A (en) * 1977-01-31 1980-11-04 Janssen Pharmaceutica, N.V. Heterocyclic derivatives of 1-(1,3-dioxolan-2-ylmethyl)-1H-imidazoles
US4229581A (en) * 1977-01-31 1980-10-21 Janssen Pharmaceutica N.V. Hydrazine carboxamide derivatives of 1-(1,3-dioxolan-2-ylmethyl)-1H-imidazoles and 1H-1,2,4-triazoles
US4144346A (en) * 1977-01-31 1979-03-13 Janssen Pharmaceutica N.V. Novel 1-(1,3-dioxolan-2-ylmethyl)-1H-imidazoles
US4229460A (en) * 1977-01-31 1980-10-21 Janssen Pharmaceutica N.V. Heterocyclic derivatives of 1-(1,3-dioxolan-2-ylmethyl)-1H-1,2,4-triazoles having antifungal and antibacterial properties
US4368200A (en) * 1978-06-23 1983-01-11 Janssen Pharmaceutica N.V. Heterocyclic derivatives of (4-phenyl-piperazine-1-yl-aryloxymethyl-1,3-dioxolan-2-yl)-methyl-1H-imidazoles and 1H-1,2,4-triazoles
US4218458A (en) * 1978-06-23 1980-08-19 Janssen Pharmaceutica, N.V. Heterocyclic derivatives of (4-aryloxy-methyl-1,3-dioxolan-2-yl)methyl-1H-imidazoles and 1H-1,2,4-triazoles
EP0006722B1 (de) * 1978-07-03 1984-09-05 Janssen Pharmaceutica N.V. (4-(Piperazin-1-yl-phenyloxymethyl)-1.3-dioxolan-2-ylmethyl)-1H-imidazol- und -1H-1.2.4-triazol-Derivate, ihre Herstellung und ihre Verwendung als Fungizide und Bacterizide
US4287195A (en) * 1978-07-14 1981-09-01 Janssen Pharmaceutica, N.V. Heterocyclic derivatives of [4-(piperazin-1-yl-phenyloxymethyl)-1,3-dioxolan-2-ylmethyl]-1H-imidazoles and 1H-1,2,4-triazoles
US4338327A (en) * 1978-10-06 1982-07-06 Janssen Pharmaceutica, N.V. Substituted 1-(2-aryl-1,3-dioxolan-2-ylmethyl)-1H-1,2,4-triazoles
US4503055A (en) * 1979-03-26 1985-03-05 Janssen Pharmaceutica, N.V. Derivatives of [4-(piperazin-1-yl-phenyloxymethyl)-1,3-dioxolan-2-ylmethyl]-1H-imidazoles and 1H-1,2,4-triazoles
DE3039087A1 (de) * 1980-10-16 1982-05-19 Hoechst Ag, 6000 Frankfurt 1-(1,3-dioxolan-2-ylmethyl)-azole, ihre salze, verfahren zu ihrer herstellung und ihre verwendung
US4490530A (en) * 1981-01-14 1984-12-25 Janssen Pharmaceutica N.V. Heterocyclic derivatives of (4-phenylpiperazin-1-yl-aryloxymethyl-1,3-dioxolan-2-yl)-methyl-1H-imidazoles and 1H-1,2,4-triazoles
DE3104311A1 (de) * 1981-02-07 1982-08-19 Bayer Ag, 5090 Leverkusen 2-azolylmethyl-1,3-dioxolan- und -dioxan-derivate, verfahren zu ihrer herstellung und ihre verwendung als fungizide
US4490540A (en) * 1981-09-14 1984-12-25 Janssen Pharmaceutica N.V. (2-Aryl-4-phenylthioalkyl-1,3-dioxolan-2-ylmethyl)azole derivatives
US4375474A (en) * 1982-02-11 1983-03-01 Syntex (U.S.A.) Inc. Dioxalane containing imidazole compounds, compositions and use
US4491588A (en) * 1982-03-31 1985-01-01 University Of Tennessee Research Corporation Treatment of psoriasis and seborrheic dermatitis with imidazole antibiotics
US4942162A (en) * 1982-03-31 1990-07-17 University Of Tennessee Research Corporation Topical treatment of seborrheic dermatitis with ketoconazole
EP0094052A3 (de) * 1982-05-12 1984-07-18 Hoechst Aktiengesellschaft 1-(1,3-Dioxolan-2-yl-methyl)-1H-imidazole und -1H-1,2,4-triazole und deren Salze, Verfahren zu ihrer Herstellung, sie enthaltende Mittel und ihre Verwendung
JPS59139380A (ja) * 1983-01-28 1984-08-10 Yoshiki Hamada １，３―ジオキソランアシラート誘導体及びその製造法
US4619931A (en) * 1983-02-28 1986-10-28 Janssen Pharmaceutica, N.V. [[4-[4-(4-phenyl-1-piperazinyl)phenoxymethyl]-1,3-dioxolan-2-yl]methyl]-1H-imidazoles and 1H-1,2,4-triazoles
US4735942A (en) * 1984-01-09 1988-04-05 Janssen Pharmaceutica, N.V. [[4-[4-(4-phenyl-1-piperazinyl)phenoxymethyl]-1,3-dioxolan-2-yl]-methyl]-1H-imidazoles and 1H-1,2,4-triazoles having antimicrobial properties
EP0121081B1 (de) * 1983-03-03 1991-01-30 BASF Aktiengesellschaft Azolylmethylcycloalkane, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE3308554A1 (de) * 1983-03-10 1984-09-13 Hoechst Ag, 6230 Frankfurt 1-/1,3-dioxolan-2-ylmethyl)-azole, ihre salze, verfahren zu ihrer herstellung und ihre verwendung
US4569935A (en) * 1983-03-17 1986-02-11 University Of Tennessee Research Corp. Topical treatment of psoriasis with imidazole antibiotics
DE3401694A1 (de) * 1984-01-19 1985-07-25 Basf Ag, 6700 Ludwigshafen Azolylmethylcycloacetale, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3404819A1 (de) * 1984-02-10 1985-08-14 Ludwig Heumann & Co GmbH, 8500 Nürnberg Neue 1,3-dioxolanylderivate, verfahren zu ihrer herstellung, ihre verwendung und diese verbindungen enthaltendes arzneimittel
EP0165781A1 (de) * 1984-06-18 1985-12-27 Eli Lilly And Company Aromatase inhibierende N-substituierte Imidazolderivate
DK354185A (da) * 1984-08-31 1986-03-01 Hoffmann La Roche 1,3-dioxolanderivater
US4661602A (en) * 1985-03-29 1987-04-28 G. D. Searle & Co. Substituted alkyl imidazole derivatives
US4628104A (en) * 1985-04-08 1986-12-09 G. D. Searle & Co. Imidazole ketone derivatives
US4761483A (en) * 1985-06-26 1988-08-02 G. D. Searle & Co. Chloro-substituted ketone imidazole derivatives
CA1292472C (en) * 1985-12-03 1991-11-26 Alfonsus Guilielmus Knaeps Derivatives of ¬¬4-¬4-(4-phenyl-1-piperazinyl)- phenoxymethyl|-1,3-dioxolan-2-yl|methyl|-1h-imidazoles and 1h-1,2,4-triazoles
US4791111A (en) * 1985-12-23 1988-12-13 Janssen Pharmaceutica, N.V. [[4-[4-(4-phenyl-1-piperazinyl)phenoxymethyl]-1,3-dioxolan-2-yl]methyl]-1H-imidazoles and 1H-1,2,4-triazoles having anti-microbial properties
FR2593816B1 (fr) * 1986-02-04 1989-02-10 Ire Celltarg Sa Derives d'imidazoles, procede de preparation et compositions fongicides les contenant
DE3609598A1 (de) * 1986-03-21 1987-10-01 Hoechst Ag 2-azolylmethyl-2-aryl-1,3-dioxolane und deren salze, verfahren zu ihrer herstellung, sie enthaltende mittel und ihre verwendung
DE3609597A1 (de) * 1986-03-21 1987-10-01 Hoechst Ag 2-azolylmethyl-2-aryl-1,3-dioxolane und deren salze, verfahren zu ihrer herstellung, sie enthaltende mittel und ihre verwendung
DE3609596A1 (de) * 1986-03-21 1987-10-01 Hoechst Ag 2-azolylmethyl-2-aryl-1,3-dioxolane und deren salze, verfahren zu ihrer herstellung, sie enthaltende mittel und ihre verwendung
DE3622791A1 (de) * 1986-07-07 1988-01-21 Heumann Pharma Gmbh & Co Neue 1,4-piperazinderivate, verfahren zu ihrer herstellung, ihre verwendung und diese verbindungen enthaltendes arzneimittel
US4788190A (en) * 1986-12-24 1988-11-29 Schering Corporation 2,4,4-tri- and 2,2,4,4-tetra substituted-1,3-dioxolane antifungal, antiallergy compounds
CA1331757C (en) * 1988-02-29 1994-08-30 Janssen Pharmaceutica Naamloze Vennootschap 5-lipoxygenase inhibiting 4-(4-phenyl-1-piperazinyl)phenols
AU614818B2 (en) * 1988-03-28 1991-09-12 Janssen Pharmaceutica N.V. 2-imidazolylmethyl-1,3-dioxolanyl methylthiophenyl carbamate derivatives and their use as antineoplastic agents
US4992421A (en) * 1988-04-19 1991-02-12 Abbott Laboratories Luteinizing hormone releasing hormone antagonist
GB8910069D0 (en) * 1989-05-03 1989-06-21 Janssen Pharmaceutica Nv Method of topically treating acne vulgaris
GB9014221D0 (en) * 1990-06-26 1990-08-15 Janssen Pharmaceutica Nv Method of treating alopecia
US5158949A (en) * 1990-12-20 1992-10-27 Syntex (U.S.A.) Inc. 1,3-dioxolane derivatives as cholesterol-lowering agents
JPH05255089A (ja) * 1991-12-18 1993-10-05 Sanwa Kagaku Kenkyusho Co Ltd 抗ウイルス剤
KR100239002B1 (ko) * 1992-03-20 2000-02-01 디르크 반테 피부의 그리스성 조절제
US5641494A (en) * 1992-03-20 1997-06-24 Janssen Pharmaceutica N.V. Agent for regulating the greasiness of the skin
US5274108A (en) * 1992-06-18 1993-12-28 Syntex (U.S.A.) Inc. Process for preparing 1,3-dioxolane derivatives
WO1994014446A1 (en) * 1992-12-22 1994-07-07 Sepracor, Inc. Methods and compositions of (+) ketoconazole for treating fungal, yeast and dermatophyte infections
AU5955094A (en) * 1992-12-22 1994-07-19 Sepracor, Inc. Methods and compositions of (-) ketoconazole for treating fungal yeast and dermatophyte infections
US6022532A (en) * 1993-03-12 2000-02-08 Janssen Pharmaceutica, N.V. Agent for regulating the greasiness of the skin
IL111584A0 (en) * 1993-11-18 1995-01-24 Merck & Co Inc Prodrugs of an inhibitor of hiv protease and pharmaceutical compositions containing them
CA2177683C (en) * 1993-12-23 1999-12-28 George Endel Deckner Tissue moisturizing and antimicrobial compositions
CA2177682C (en) * 1993-12-23 1999-12-28 Sekhar Mitra Antimicrobial wipe compositions
US5565478A (en) * 1994-03-14 1996-10-15 The United States Of America As Represented By The Department Of Health & Human Services Combination therapy using signal transduction inhibitors with paclitaxel and other taxane analogs
TW460296B (en) * 1994-09-01 2001-10-21 Janssen Pharmaceutica Nv Topical ketoconazole emulsion compositions without sodium sulfite
GB9509631D0 (en) * 1995-05-12 1995-07-05 Sandoz Ltd Antifungal combination
US5728834A (en) * 1996-11-14 1998-03-17 Wyckoff Chemical Company, Inc. Process for preparation of 4-aryl-1,2,4-triazol-3-ones
WO1998052518A1 (en) * 1997-07-02 1998-11-26 Neutrogena Corporation Methods for using compositions containing dichlorophenyl imidazoldioxolan to treat seborrheic dermatitis, dandruff, psoriasis, and acne, and compositions thereof
AUPO983897A0 (en) * 1997-10-17 1997-11-06 Soltec Research Pty Ltd Topical antifungal composition
ES2141667B1 (es) * 1997-11-04 2000-11-16 Sint Quimica Sa Procedimiento de preparacion del cis (+ -)-1-(4-(2-(2,4-diclorofenil)-2-(1h, 1,2,4-triazol-1-ilmetil)-1,3-dioxolan-4-il) metoxi) fenil)-4-(1-metiletil) piperazina.
US7767203B2 (en) 1998-08-07 2010-08-03 Ganeden Biotech, Inc. Methods for the dietary management of irritable bowel syndrome and carbohydrate malabsorption
US6461607B1 (en) 1998-08-24 2002-10-08 Ganeden Biotech, Inc. Probiotic, lactic acid-producing bacteria and uses thereof
KR20000051143A (ko) * 1999-01-19 2000-08-16 김충섭 불소화 비닐기가 치환된 신규의 아졸계 유도체 및 그의 제조방법
US6080744A (en) * 1999-02-10 2000-06-27 Ayon-Covarrubias; Blas Topical antifungal treatment
US6812238B1 (en) * 1999-11-02 2004-11-02 Basilea Pharmaceutica Ag N-substituted carbamoyloxyalkyl-azolium derivatives
US6673373B2 (en) 2001-02-01 2004-01-06 Carlsbad Technology Inc. Antifungal formulation and the methods for manufacturing and using the same
IL157771A0 (en) * 2001-03-27 2004-03-28 Galen Chemicals Ltd Intravaginal drug delivery devices for the administration of an antimicrobial agent
IL162859A0 (en) * 2002-02-05 2005-11-20 Novo Nordisk As Novel aryl-and heteroarylpiperazines
US20030236259A1 (en) * 2002-02-05 2003-12-25 Rolf Hohlweg Novel aryl- and heteroarylpiperazines
US8404751B2 (en) * 2002-09-27 2013-03-26 Hallux, Inc. Subunguicide, and method for treating onychomycosis
ATE461178T1 (de) 2003-07-29 2010-04-15 High Point Pharmaceuticals Llc Pyridazinyl-piperazine und deren verwendung als histamin-h3-rezeptorliganden
US20050074494A1 (en) * 2003-10-06 2005-04-07 Xiu-Xiu Cheng Itraconazole immediate release formulation
KR100517726B1 (ko) * 2003-10-30 2005-09-27 동부정밀화학 주식회사 3-클로로-4-[4-메틸-2-(1ｈ-1,2,4-트리아졸-1-일메틸)-1,3디옥솔란-2일]페닐4-클로로페닐에테르 화합물의 제조방법
AU2006264966B2 (en) 2005-07-04 2013-02-21 High Point Pharmaceuticals, Llc Histamine H3 receptor antagonists
EP2038256A1 (de) 2006-05-23 2009-03-25 TransTech Pharma, Inc 6-(4-cyclopropylpiperazin-1-yl)-2'-methyl-[3,4']-bipyridin und seine verwendung als arzneimittel
CA2659570C (en) 2006-05-29 2015-10-06 High Point Pharmaceuticals, Llc 3-(1,3-benzodioxol-5-yl)-6-(4-cyclopropylpiperazin-1-yl)-pyridazine, its salts and solvates and its use as histamine h3 receptor antagonist
US20080161324A1 (en) * 2006-09-14 2008-07-03 Johansen Lisa M Compositions and methods for treatment of viral diseases
ZA200902127B (en) 2006-10-02 2010-07-28 Cortendo Invest Ab Ketoconazole enantiomer in humans
TWI426918B (zh) * 2007-02-12 2014-02-21 Merck Sharp & Dohme Ｉｌ-２３拮抗劑於治療感染之用途
EP2014656A3 (de) 2007-06-11 2011-08-24 High Point Pharmaceuticals, LLC Neue heterocyclische H3-Antagonisten
JP5520223B2 (ja) 2007-08-29 2014-06-11 ガネーデン バイオテック インコーポレイテッド 焼き製品
EP2217083B1 (de) * 2007-10-16 2018-09-05 Ganeden Biotech, Inc. Getränkzusammensetzungen
WO2009129301A2 (en) * 2008-04-15 2009-10-22 Schering Corporation Oral pharmaceutical compositions in a molecular solid dispersion
MX2010011295A (es) * 2008-04-15 2010-11-12 Schering Corp Composiciones farmaceuticas orales en una dispersion solida que comprenden preferiblemente posaconazol y acetato-succinato de hidroxipropilmetilcelulosa.
US7788209B2 (en) * 2008-05-05 2010-08-31 United Technologies Corporation Hybrid fault reasoning and guided troubleshooting system that uses case-based reasoning and model-based reasoning
JP2009286756A (ja) 2008-05-30 2009-12-10 Fujifilm Finechemicals Co Ltd トリアゾール誘導体またはその塩
CN101302213B (zh) * 2008-06-30 2012-07-25 寿光富康制药有限公司 顺式-2-(2，4-二氯苯基)-2-([1，2，4]-三唑-1-甲基)-[1，3]二氧戊环-4-甲基甲磺酸酯的制备方法
CN101665490B (zh) * 2008-09-01 2012-01-04 浙江东亚药业有限公司 酮康唑衍生物的制备方法
BR122017003315B1 (pt) 2008-10-16 2018-01-16 Ganeden Biotech, Inc. Composições alimentícias compreendendo grãos e esporos isolados de bacillus coagulans, bem como seu método de preparação
EP2424550B1 (de) 2009-04-29 2017-06-07 Ganeden Biotech, Inc. Bakterienzellmembran formulierung
BRPI0904249B1 (pt) 2009-08-28 2018-03-06 Biolab Sanus Farmacêutica Ltda. Compostos éteres aralquil benzílicos, processo de preparação dos mesmos, uso dos referidos compostos, composição farmacêutica
CN101993436B (zh) * 2010-10-29 2012-06-27 杭州欧拓普生物技术有限公司 一种咪唑类抗真菌药物衍生物的制备方法
CN102070620B (zh) * 2011-01-25 2012-12-12 南京白敬宇制药有限责任公司 一种抑菌酯的制备方法
US11235008B2 (en) 2011-03-31 2022-02-01 Ganeden Biotech, Inc. Probiotic sports nutrition compositions
CN102627633A (zh) * 2012-03-21 2012-08-08 浙江丽晶化学有限公司 新康唑提纯新方法
US8530409B1 (en) * 2012-06-12 2013-09-10 Dipexium Pharmaceuticals LLC Stable pexiganan formulation
WO2014122530A1 (en) * 2013-02-06 2014-08-14 Cortendo Ab (Publ) Novel functionalized 4-(phenoxymethyl(-1,3-dioxolane analogs exhibiting cytochrome p450 inhibition and their method of use
JP2016514024A (ja) 2013-03-14 2016-05-19 ハラックス，インコーポレイテッド 爪部の感染症、疾患または障害の治療方法
CN104447711A (zh) * 2013-09-23 2015-03-25 南京白敬宇制药有限责任公司 合成酮康唑的方法
US20160244436A1 (en) * 2013-09-25 2016-08-25 Cortendo Ab (Publ) Novel functionalized 5-(phenoxymethyl)-1,3-dioxane analogs exhibiting cytochrome p450 inhibition and their method of use
US10149848B2 (en) 2015-12-09 2018-12-11 Cipla Limited Method for the treatment of bladder cancer
US11185548B2 (en) 2016-12-23 2021-11-30 Helmholtz Zentrum Munchen—Deutsches Forschungszentrum Für Gesundheit Und Umwelt (Gmbh) Inhibitors of cytochrome P450 family 7 subfamily B member 1 (CYP7B1) for use in treating diseases
CN117899079A (zh) 2017-06-22 2024-04-19 希普拉有限公司 癌症的治疗方法
WO2019246494A1 (en) 2018-06-21 2019-12-26 Yumanity Therapeutics, Inc. Compositions and methods for the treatment and prevention of neurological disorders

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3658797A (en) * 1968-08-06 1972-04-25 Lilly Co Eli Novel 5-nitroimidazole antiparasitic agents
US3575999A (en) * 1968-08-19 1971-04-20 Janssen Pharmaceutica Nv Ketal derivatives of imidazole
US4079062A (en) * 1974-11-18 1978-03-14 Janssen Pharmaceutica N.V. Triazole derivatives
CA1065873A (en) * 1975-01-27 1979-11-06 Janssen Pharmaceutica Naamloze Vennootschap Imidazole derivatives
US3936470A (en) * 1975-01-27 1976-02-03 Janssen Pharmaceutica N.V. 1,3-Dioxolan-2-ylmethylimidazoles
US4160841A (en) * 1977-01-31 1979-07-10 Janssen Pharmaceutica, N.V. Heterocyclic derivatives of 1-(1,3-dioxolan-2-ylmethyl)-1H-imidazoles
US4144346A (en) * 1977-01-31 1979-03-13 Janssen Pharmaceutica N.V. Novel 1-(1,3-dioxolan-2-ylmethyl)-1H-imidazoles
US4160838A (en) * 1977-06-02 1979-07-10 Janssen Pharmaceutica N.V. Antimicrobial and plant-growth-regulating triazole derivatives

Also Published As

Publication number Publication date
PH14635A (en) 1981-10-12
PL113973B1 (en) 1981-01-31
LU78960A1 (fr) 1978-06-21
GR62553B (en) 1979-05-09
CY1192A (en) 1983-10-07
CA1094559A (en) 1981-01-27
JPS5395973A (en) 1978-08-22
SE439773B (sv) 1985-07-01
DK42678A (da) 1978-08-01
FI63398B (fi) 1983-02-28
FR2378778B1 (de) 1981-07-24
IE780195L (en) 1978-07-31
AT366683B (de) 1982-04-26
NO780335L (no) 1978-08-01
FI63398C (fi) 1983-06-10
NO148643C (no) 1983-11-16
CH644118A5 (en) 1984-07-13
US4358449A (en) 1982-11-09
US4335125A (en) 1982-06-15
US4144346A (en) 1979-03-13
LV5015A3 (lv) 1993-06-10
SE7801088L (sv) 1978-08-01
AU3285078A (en) 1979-08-09
NO148643B (no) 1983-08-08
NL188578B (nl) 1992-03-02
BE863382A (nl) 1978-07-27
KE3270A (en) 1983-05-13
IT1155800B (it) 1987-01-28
PT67600B (en) 1980-01-14
KR810000675B1 (ko) 1981-06-20
ZA78548B (en) 1979-09-26
SU786899A3 (ru) 1980-12-07
US4223036A (en) 1980-09-16
YU22178A (en) 1983-01-21
IE46035B1 (en) 1983-01-26
NL7801048A (nl) 1978-08-02
PT67600A (en) 1978-02-01
DE2804096A1 (de) 1978-08-03
ES465981A1 (es) 1979-07-16
IT7847837A0 (it) 1978-01-30
HU184842B (en) 1984-10-29
DK158042C (da) 1990-08-13
FI780294A (fi) 1978-08-01
IL53923A0 (en) 1978-04-30
CS194833B2 (en) 1979-12-31
HU177646B (en) 1981-11-28
YU40319B (en) 1985-12-31
FR2378778A1 (fr) 1978-08-25
NZ186275A (en) 1980-08-26
GB1594859A (en) 1981-08-05
ATA63678A (de) 1981-09-15
MY8400209A (en) 1984-12-31
DK158042B (da) 1990-03-19
IL53923A (en) 1981-06-29
NL188578C (nl) 1992-08-03
JPS6257634B2 (de) 1987-12-02
AU521329B2 (en) 1982-03-25

Similar Documents

Publication Publication Date Title
KE3270A (en) 1-(1,3-dioxolan-2-ylmethyl)-1h-imidazoles and 1h-1,2,4-triazoles
AU515134B2 (en) 1-(2-aryl-2-r-ethyl)-1h-1,2,4-triazoles
GB2026486B (en) 1-(2-aryl-4,5-disubstituted-1,3-dioxolan-2-ylmethyl)-1h-imadazoles and 1h-1,2,4-triazoles
PT67599A (en) Novel heterocyclic derivatives of 1-(1,3-dioxolan-2-ylmethyl)-1h-imidazoles and 1h-1,2,4-triazoles
GB2027701B (en) 1-(2-aryl-1,3-dioxan-2-ylmethyl)-1h-imadazoles and 1h-1,2,4-triazoles
AU529866B2 (en) 1-(1,3-dioxolan-2-ylmethyl)-1h-1,2,4 triazole
GB1533706A (en) Fungicidal imidazoles and 1,2,4-triazoles
AU4213478A (en) Imidazole and triazole compounds
HK26281A (en) 3,5-disubstituted-1h-1,2,4-triazoles
JPS5714575A (en) Triazole and imidazole derivative,manufacture and use
GB2003466B (en) 1,2,4-triazoles
ZA793766B (en) 1-(2-aryl-1,3-dioxan-2-ylmethyl)-1h-imidazoles and 1h-1,2,4-triazoles
GB2034710B (en) 1h-1,2,4-triazoles
ZA774817B (en) Novel 1-(2-aryl-2-r-ethyl)-1h-1,2,4-triazoles
PH15061A (en) 1 and 4 phenylalkyl-1,2,4-triazoles
IE790789L (en) 1-(2-oximino-2-phenylethyl)-1,2,4-triazoles
ZA78547B (en) Novel heterocyclic derivatives of 1-(1,3-dioxolan-2-ylmethyl)-1h-imidazoles and 1h-1,2,4-triazoles

Legal Events

Date Code Title Description
PE Patent expired