HK64089A - Medicinal compositions comprising as an active ingredient substituted 1,4-benzoquinones - Google Patents

Medicinal compositions comprising as an active ingredient substituted 1,4-benzoquinones Download PDF

Info

Publication number
HK64089A
HK64089A HK640/89A HK64089A HK64089A HK 64089 A HK64089 A HK 64089A HK 640/89 A HK640/89 A HK 640/89A HK 64089 A HK64089 A HK 64089A HK 64089 A HK64089 A HK 64089A
Authority
HK
Hong Kong
Prior art keywords
compound
dimethoxy
methyl
added
benzoquinone
Prior art date
Application number
HK640/89A
Other languages
German (de)
English (en)
French (fr)
Inventor
Isuke Imada
Akinobu Nagaoka
Minoru Hirata
Tetsuya Okutani
Giichi Goto
Original Assignee
Takeda Chemical Industries, Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries, Ltd. filed Critical Takeda Chemical Industries, Ltd.
Publication of HK64089A publication Critical patent/HK64089A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C46/00—Preparation of quinones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C46/00—Preparation of quinones
    • C07C46/02—Preparation of quinones by oxidation giving rise to quinoid structures
    • C07C46/06—Preparation of quinones by oxidation giving rise to quinoid structures of at least one hydroxy group on a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C46/00—Preparation of quinones
    • C07C46/02—Preparation of quinones by oxidation giving rise to quinoid structures
    • C07C46/06—Preparation of quinones by oxidation giving rise to quinoid structures of at least one hydroxy group on a six-membered aromatic ring
    • C07C46/08—Preparation of quinones by oxidation giving rise to quinoid structures of at least one hydroxy group on a six-membered aromatic ring with molecular oxygen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C50/00—Quinones
    • C07C50/26—Quinones containing groups having oxygen atoms singly bound to carbon atoms
    • C07C50/28—Quinones containing groups having oxygen atoms singly bound to carbon atoms with monocyclic quinoid structure

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
HK640/89A 1979-12-30 1989-08-10 Medicinal compositions comprising as an active ingredient substituted 1,4-benzoquinones HK64089A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP17112579A JPS5697223A (en) 1979-12-30 1979-12-30 Tissue metabolism activator

Publications (1)

Publication Number Publication Date
HK64089A true HK64089A (en) 1989-08-18

Family

ID=15917438

Family Applications (1)

Application Number Title Priority Date Filing Date
HK640/89A HK64089A (en) 1979-12-30 1989-08-10 Medicinal compositions comprising as an active ingredient substituted 1,4-benzoquinones

Country Status (9)

Country Link
US (1) US4436753A (enExample)
EP (1) EP0031727B1 (enExample)
JP (1) JPS5697223A (enExample)
AT (1) ATE21031T1 (enExample)
DE (2) DE3049039A1 (enExample)
HK (1) HK64089A (enExample)
IT (1) IT1144075B (enExample)
MY (1) MY8700652A (enExample)
SG (1) SG84688G (enExample)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3069496D1 (de) * 1979-06-28 1984-11-29 Takeda Chemical Industries Ltd 2,3-dialkoxy-1,4-quinone derivatives; method of producing 1,4-quinone derivatives
JPS58174313A (ja) * 1982-04-06 1983-10-13 Takeda Chem Ind Ltd 動物組織の線維化抑制剤
JPS58177934A (ja) * 1982-04-13 1983-10-18 Takeda Chem Ind Ltd ベンゾキノン誘導体
US4808339A (en) * 1982-04-13 1989-02-28 Takeda Chemical Industries, Ltd. Benzoquinone derivatives
JPS59204167A (ja) * 1983-05-02 1984-11-19 Takeda Chem Ind Ltd ヒドロキノン誘導体およびその製法
JPS60130515A (ja) * 1983-12-15 1985-07-12 Shiratori Seiyaku Kk 血中２，３−ジホスホグリセリン酸上昇剤
JPS60255749A (ja) * 1984-05-31 1985-12-17 Univ Nagoya キノン誘導体
MX9203040A (es) * 1984-08-01 1992-07-31 Takeda Chemical Industries Ltd Derivados de quinona y composicion farmaceutica que los contiene.
ATE64921T1 (de) * 1985-04-08 1991-07-15 Takeda Chemical Industries Ltd Benzochinonderivate, ihre herstellung und verwendung.
JP2503571B2 (ja) * 1988-02-26 1996-06-05 武田薬品工業株式会社 脳循環代謝改善剤
JPH08768B2 (ja) * 1989-08-24 1996-01-10 武田薬品工業株式会社 神経成長因子分泌誘導剤
RU1822549C (ru) * 1989-12-06 1996-08-20 Тихоокеанский институт биоорганической химии ДВО АН СССР Полигидрокси-1,4-нафтохиноны, обладающие свойством протектора миокарда при его ишемии и реперфузии
EP0560568A3 (en) * 1992-03-13 1994-06-29 Takeda Chemical Industries Ltd Hydroquinone derivatives and intermediates for production thereof
WO1993024650A1 (en) * 1992-05-28 1993-12-09 Monash University Therapeutic compositions
EP0788793A1 (en) 1996-02-01 1997-08-13 Takeda Chemical Industries, Ltd. Idebenone for the treatment of dementia
AU8562998A (en) * 1997-08-12 1999-03-01 Takeda Chemical Industries Ltd. Idebenone-containing preparation for percutaneous administration
DE19932197A1 (de) 1999-07-09 2001-01-18 Neudecker Birgit Topisch anzuwendendes Mittel mit schützender und regenerativer Wirkung
US20050152857A1 (en) * 2004-01-08 2005-07-14 Pcr Technology Holdings, Lc Method and preparation for reducing sunburn cell formation in skin
US20050175559A1 (en) * 2004-02-10 2005-08-11 Pcr Technology Holdings, Lc Method and preparation for reducing skin hyperpigmentation
WO2005079775A1 (en) * 2004-02-13 2005-09-01 Pcr Technology Holdings, Lc Method and preparation for reducing irritation and/or inflammatory reaction in human skin
CA2589252C (en) 2004-11-25 2012-12-04 Meiji Dairies Corporation Ameliorant for renal insufficiency
EA035619B1 (ru) 2005-06-01 2020-07-16 ПиТиСи ТЕРАПЬЮТИКС, ИНК. Композиции для использования в способе лечения митохондриальных нарушений
JP2009508867A (ja) * 2005-09-15 2009-03-05 エジソン ファーマシューティカルズ， インコーポレイテッド ミトコンドリア病および関連した様態の治療ならびにエネルギーバイオマーカーの調節のための酸化還元活性治療剤のテイル改変体
AR053665A1 (es) * 2006-01-23 2007-05-16 Creactivar S A Uso de la mimosina o un derivado de la misma, en el tratamiento de las manifestaciones cutaneas de la psoriasis y de los desordenes cutaneos relacionados con esta y una composicion cosmetica o farmaceutica que la comprende
EP1986636B1 (en) 2006-02-22 2013-04-24 Edison Pharmaceuticals, Inc. Phenol and 1,4-benzoquinone derivatives for use in the treatment of mitochondrial diseases
EP2344142B1 (en) 2008-09-10 2024-06-26 PTC Therapeutics, Inc. Treatment of pervasive developmental disorders with redox-active therapeutics
US20100129431A1 (en) * 2008-11-24 2010-05-27 Alpharx Inc. Idebenone composition for the treatment of neurological disorders
US20110159121A1 (en) * 2009-12-24 2011-06-30 LifeSpan Extension, LLC Methods and compositions for identifying, producing and using plant-derived products for modulating cell function and aging
CA2908929C (en) 2012-07-12 2021-01-26 Concert Pharmaceuticals, Inc. Deuterated idebenone
EP3389646A1 (en) 2015-12-17 2018-10-24 BioElectron Technology Corporation Flouroalkyl, flouroalkoxy, phenoxy, heteroaryloxy, alkoxy, and amine 1,4-benzoquinone derivatives for treatment of oxidative stress disorders

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5919930B2 (ja) 1974-05-02 1984-05-09 武田薬品工業株式会社 キノン酸誘導体の製造法
JPS51128932A (en) * 1975-04-30 1976-11-10 Takeda Chem Ind Ltd Organic compounds
DE3069496D1 (de) * 1979-06-28 1984-11-29 Takeda Chemical Industries Ltd 2,3-dialkoxy-1,4-quinone derivatives; method of producing 1,4-quinone derivatives

Also Published As

Publication number Publication date
DE3049039A1 (de) 1981-09-10
ATE21031T1 (de) 1986-08-15
JPS5697223A (en) 1981-08-05
IT1144075B (it) 1986-10-29
MY8700652A (en) 1987-12-31
EP0031727A2 (en) 1981-07-08
DE3071684D1 (en) 1986-09-04
IT8050468A0 (it) 1980-12-24
EP0031727B1 (en) 1986-07-30
JPH0112727B2 (enExample) 1989-03-02
EP0031727A3 (en) 1981-07-22
US4436753A (en) 1984-03-13
SG84688G (en) 1989-04-14

Similar Documents

Publication Publication Date Title
EP0031727B1 (en) Medicinal compositions comprising as an active ingredient substituted 1,4-benzoquinones
CA2259621C (en) Isocoumarin derivatives and their use in medicines
EP0202589B1 (en) Pharmaceutical compositions containing ascorbic acid derivatives
EP0038674B1 (en) Medicinal composition for treatment of allergic diseases
FR2543829A1 (fr) Preparations therapeutiques a base de nouveaux derives de la furo-(3,4-c)-pyridine
JPH04210683A (ja) チアゾリジン−２，４−ジオン誘導体およびこれを含有する糖尿病合併症治療薬
JP2889697B2 (ja) 新規なシクロプロピルスクアレン誘導体類と、コレステロール合成の抑制剤としてのそれらの用途
EP0388188B1 (en) Benzoxepin derivatives
US6127417A (en) Stable derivatives of ubiquinole, processes for their production and pharmaceutical use thereof
KR970002470B1 (ko) 아스코르빈산 유도체
JPH0755902B2 (ja) アルド−スリダクタ−ゼ阻害剤
US3870792A (en) Certain dihydrophthalizines for treating hemorrhage and thrombosis
JPS5943949B2 (ja) モラノリンのｎ−置換誘導体
EP0571267B1 (en) Use of azole derivatives for the preparation of drugs useful for inhibiting the aromatase and treating of estrogen-dependent diseases
JPWO1991003471A1 (ja) アスコルビン酸誘導体
JPS61275275A (ja) １，３−ジチオ−ル−２−イリデン誘導体
KR0171189B1 (ko) 당뇨병 치료용 제약 조성물
JP2718429B2 (ja) 肝庇護特性を有する医薬、その製造方法、１．２‐ジチオール‐３‐チオン‐ｓ‐オキシド化合物およびその製造方法
JP2754644B2 (ja) 新規リグナン類およびリグナン類を有効成分とする５―リポキシゲナーゼ阻害剤およびアルドースリダクターゼ阻害剤
US3947479A (en) Reduction of serum lipid levels, and agents and compositions useful therefor
JPS63101322A (ja) トロンボキサンａ↓２受容体拮抗剤
JP2756941B2 (ja) ２−クロロ−３−アリールアミノ−１，４−ナフトキノン誘導体の血小板凝集抑制剤としての用途
DK165115B (da) Bicycliske catechol-derivater, fremgangsmaade til fremstilling deraf og farmaceutiske praeparater indeholdende saadanne derivater
US4061772A (en) Derivatives of the 1,2-diarylethylene and pharmaceutical compositions thereof
US4001407A (en) Reduction of serum lipid levels and agents and compositions useful therefor

Legal Events

Date Code Title Description
PE Patent expired