HK1243001A1 - 选择性地活化调节性t细胞用於治疗自身免疫病的修饰的il-2变体 - Google Patents
选择性地活化调节性t细胞用於治疗自身免疫病的修饰的il-2变体 Download PDFInfo
- Publication number
- HK1243001A1 HK1243001A1 HK18102706.1A HK18102706A HK1243001A1 HK 1243001 A1 HK1243001 A1 HK 1243001A1 HK 18102706 A HK18102706 A HK 18102706A HK 1243001 A1 HK1243001 A1 HK 1243001A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- protein
- cells
- peg
- variant
- polyethylene glycol
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2013—IL-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Transplantation (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462070016P | 2014-08-11 | 2014-08-11 | |
| US62/070,016 | 2014-08-11 | ||
| PCT/US2015/044462 WO2016025385A1 (en) | 2014-08-11 | 2015-08-10 | Modified il-2 variants that selectively activate regulatory t cells for the treatment of autoimmune diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1243001A1 true HK1243001A1 (zh) | 2018-07-06 |
Family
ID=55304526
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK18102706.1A HK1243001A1 (zh) | 2014-08-11 | 2015-08-10 | 选择性地活化调节性t细胞用於治疗自身免疫病的修饰的il-2变体 |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US10035836B1 (enExample) |
| EP (2) | EP3482766B1 (enExample) |
| JP (2) | JP6640834B2 (enExample) |
| KR (1) | KR20170035910A (enExample) |
| CN (2) | CN113234138A (enExample) |
| AU (1) | AU2015301936B2 (enExample) |
| CA (1) | CA2955006C (enExample) |
| EA (1) | EA034925B1 (enExample) |
| ES (2) | ES2717831T3 (enExample) |
| HK (1) | HK1243001A1 (enExample) |
| HU (2) | HUE051414T2 (enExample) |
| IL (1) | IL250059B (enExample) |
| MX (2) | MX373296B (enExample) |
| NZ (1) | NZ728175A (enExample) |
| PL (2) | PL3482766T3 (enExample) |
| SG (1) | SG11201700629TA (enExample) |
| SI (2) | SI3180020T1 (enExample) |
| WO (1) | WO2016025385A1 (enExample) |
| ZA (1) | ZA201700381B (enExample) |
Families Citing this family (86)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL3482766T3 (pl) | 2014-08-11 | 2020-11-16 | Delinia, Inc. | Modyfikowane warianty il-2, które selektywnie aktywują limfocyty t regulatorowe do leczenia chorób autoimmunologicznych |
| MX2017012966A (es) | 2015-04-10 | 2018-06-06 | Amgen Inc | Muteinas de interleuquina 2 para la expansion de celulas t regulatorias. |
| CN117659160A (zh) | 2015-09-11 | 2024-03-08 | 小利兰·斯坦福大学托管委员会 | 生物相关正交细胞因子/受体对 |
| RU2766200C1 (ru) | 2015-10-01 | 2022-02-09 | Хит Байолоджикс, Инк. | Композиции и способы для соединения внеклеточных доменов типа i и типа ii в качестве гетерологичных химерных белков |
| US20170204154A1 (en) | 2016-01-20 | 2017-07-20 | Delinia, Inc. | Molecules that selectively activate regulatory t cells for the treatment of autoimmune diseases |
| KR20250133490A (ko) * | 2016-05-04 | 2025-09-05 | 암젠 인크 | T-조절 세포의 증식을 위한 인터류킨-2 뮤테인 |
| WO2017202786A1 (en) * | 2016-05-25 | 2017-11-30 | F. Hoffmann-La Roche Ag | Materials and methods relating to dosage regimen design |
| EA201991142A1 (ru) * | 2016-11-08 | 2019-10-31 | Варианты il-2 для лечения аутоиммунных заболеваний | |
| IL268346B2 (en) | 2017-02-06 | 2024-08-01 | Orionis Biosciences BV | Targeted chimeric proteins and uses thereof |
| KR102745835B1 (ko) | 2017-02-27 | 2024-12-24 | 샤턱 랩스 인코포레이티드 | Tigit- 및 light-기반 키메라 단백질 |
| CA3054132A1 (en) | 2017-02-27 | 2018-08-30 | Shattuck Labs, Inc. | Csf1r-based chimeric proteins |
| CN118184797A (zh) | 2017-02-27 | 2024-06-14 | 沙塔克实验室有限公司 | 基于vsig8的嵌合蛋白 |
| CA3056630A1 (en) | 2017-03-15 | 2018-09-20 | Pandion Therapeutics, Inc. | Targeted immunotolerance |
| JP2020521452A (ja) | 2017-05-24 | 2020-07-27 | パンディオン・セラピューティクス・インコーポレイテッド | 標的化免疫寛容 |
| JP7325341B2 (ja) | 2017-07-11 | 2023-08-14 | シンソークス，インク． | 非天然ヌクレオチドの組み込み及びその方法 |
| BR112020002272A2 (pt) * | 2017-08-03 | 2020-07-28 | Synthorx, Inc. | conjugados de citocina para o tratamento de doenças autoimunes |
| CA3077380A1 (en) | 2017-09-27 | 2019-04-04 | Sigilon Therapeutics, Inc. | Methods, compositions, and implantable elements comprising active cells |
| EP3713592A4 (en) | 2017-11-21 | 2022-01-12 | The Board of Trustees of the Leland Stanford Junior University | INTERLEUKIN-2 PARTIAL AGONISTS |
| USRE50550E1 (en) | 2017-12-06 | 2025-08-26 | Pandion Operations, Inc. | IL-2 muteins and uses thereof |
| US10174091B1 (en) | 2017-12-06 | 2019-01-08 | Pandion Therapeutics, Inc. | IL-2 muteins |
| US10946068B2 (en) | 2017-12-06 | 2021-03-16 | Pandion Operations, Inc. | IL-2 muteins and uses thereof |
| MA51291A (fr) | 2017-12-19 | 2020-10-28 | Xencor Inc | Protéines de fusion il-2 fc modifiées |
| WO2019131964A1 (ja) * | 2017-12-27 | 2019-07-04 | 協和発酵キリン株式会社 | Ｉｌ－２改変体 |
| WO2019148089A1 (en) | 2018-01-26 | 2019-08-01 | Orionis Biosciences Inc. | Xcr1 binding agents and uses thereof |
| CN112074267B (zh) | 2018-02-05 | 2024-06-28 | 奥里尼斯生物科学公司股份有限公司 | 成纤维细胞结合剂及其用途 |
| WO2019158764A1 (en) | 2018-02-16 | 2019-08-22 | Iltoo Pharma | Use of interleukin 2 for treating sjögren's syndrome |
| EP3762406A2 (en) * | 2018-03-09 | 2021-01-13 | Askgene Pharma, Inc. | Cytokine prodrugs |
| US11359000B2 (en) | 2018-03-28 | 2022-06-14 | Bristol-Myers Squibb Company | Interleukin-2/Interleukin-2 receptor alpha fusion proteins and methods of use |
| CN111918665B (zh) * | 2018-03-28 | 2024-11-26 | 阿森迪斯药物肿瘤股份有限公司 | Il-2缀合物 |
| UY38160A (es) | 2018-04-04 | 2019-11-29 | Sigilon Therapeutics Inc | Partículas implantables y métodos relacionados |
| US20210145889A1 (en) | 2018-04-04 | 2021-05-20 | Sigilon Therapeutics, Inc. | Methods, compositions, and implantable elements comprising stem cells |
| BR112020025287A2 (pt) | 2018-06-25 | 2021-03-09 | University Of Washington | Projeto de novo de miméticos de interleucina potentes e seletivos |
| WO2020007937A1 (en) | 2018-07-03 | 2020-01-09 | Iltoo Pharma | Use of interleukin-2 for treating systemic sclerosis |
| CA3106520A1 (en) * | 2018-07-13 | 2020-01-16 | Il-2Rx, Inc. | Compounds, compositions, methods, and uses for treating cancer and immunological disorders |
| US12459980B2 (en) | 2018-07-25 | 2025-11-04 | AskGene Pharma, Inc. | IL-21 prodrugs and methods of use thereof |
| AU2019317353B2 (en) * | 2018-08-06 | 2022-02-17 | Medikine, Inc. | IL-2 receptor binding compounds |
| JP7307500B2 (ja) * | 2018-08-06 | 2023-07-12 | メディカイン、インコーポレイテッド | Ｉｌ－２受容体結合化合物 |
| WO2020035482A1 (en) | 2018-08-13 | 2020-02-20 | Iltoo Pharma | Combination of interleukin-2 with an interleukin 1 inhibitor, conjugates and therapeutic uses thereof |
| US10780121B2 (en) | 2018-08-29 | 2020-09-22 | Shattuck Labs, Inc. | FLT3L-based chimeric proteins |
| WO2020056066A1 (en) * | 2018-09-11 | 2020-03-19 | Ambrx, Inc. | Interleukin-2 polypeptide conjugates and their uses |
| UY38389A (es) | 2018-09-27 | 2020-04-30 | Sigilon Therapeutics Inc | Dispositivos implantables para terapia celular y métodos relacionados |
| US12410225B2 (en) | 2018-11-08 | 2025-09-09 | Orionis Biosciences, Inc | Modulation of dendritic cell lineages |
| SG11202103045SA (en) | 2018-11-20 | 2021-04-29 | Univ Washington | Split interleukin mimetics and their use |
| CN111378026A (zh) * | 2018-12-27 | 2020-07-07 | 天津键凯科技有限公司 | 一种制备结合位点可控的peg化生物分子的方法 |
| CN113660946A (zh) | 2019-02-06 | 2021-11-16 | 新索思股份有限公司 | Il-2缀合物及其使用方法 |
| CA3129317A1 (en) | 2019-02-15 | 2020-08-20 | Integral Molecular, Inc. | Antibodies comprising a common light chain and uses thereof |
| KR20210128443A (ko) | 2019-02-15 | 2021-10-26 | 인테그럴 몰큘러 인코포레이티드 | 클라우딘 6 항체 및 이의 용도 |
| AU2020252119B2 (en) * | 2019-03-29 | 2025-09-04 | Centre National De La Recherche Scientifique - Cnrs | Interleukin-2 variants with modified biological activity |
| CN114126638A (zh) * | 2019-04-26 | 2022-03-01 | 普罗林科斯有限责任公司 | 缓慢释放的细胞因子偶联物 |
| CA3141327A1 (en) | 2019-05-20 | 2020-11-26 | Pandion Operations, Inc. | Madcam targeted immunotolerance |
| CN120795117A (zh) * | 2019-06-14 | 2025-10-17 | 科优基因公司 | 用于癌症治疗的新型白介素-2变体 |
| KR20220051177A (ko) | 2019-07-26 | 2022-04-26 | 비스테라, 인크. | 인터류킨-2 작용제 및 이의 용도 |
| JP7758662B2 (ja) | 2019-09-10 | 2025-10-22 | シンソークス， インコーポレイテッド | Ｉｌ－２コンジュゲートおよび自己免疫疾患を治療するための使用方法 |
| CN114853874B (zh) * | 2019-09-10 | 2024-05-17 | 中国医学科学院北京协和医院 | 靶向调节t细胞的长效白介素-2及其在治疗自身免疫病中的应用 |
| CA3160466A1 (en) * | 2019-11-05 | 2021-05-14 | Medikine, Inc. | Dual il-2r and il-7r binding compounds |
| CN115087664A (zh) | 2019-11-05 | 2022-09-20 | 麦地金公司 | IL-2Rβγc结合化合物 |
| TW202128961A (zh) * | 2019-11-20 | 2021-08-01 | 美商安維塔生物科學股份有限公司 | 細胞激素融合蛋白及其醫藥組合物及治療應用 |
| IL321567A (en) | 2019-12-13 | 2025-08-01 | Synthekine Inc | Il-2 orthologs and methods of use |
| CN111018961B (zh) * | 2019-12-17 | 2022-03-18 | 北京志道生物科技有限公司 | 白介素-2衍生物 |
| JP2023514010A (ja) | 2020-01-10 | 2023-04-05 | ブライト ピーク セラピューティクス エージー | 修飾ｉｌ－２ポリペプチドおよびその使用 |
| CN115362168A (zh) | 2020-01-14 | 2022-11-18 | 辛德凯因股份有限公司 | 偏向化il2突变蛋白方法和组合物 |
| IL294388A (en) | 2020-01-14 | 2022-08-01 | Synthekine Inc | Il2 orthologs and methods of use |
| CN113121670B (zh) * | 2020-01-15 | 2022-11-22 | 天津键凯科技有限公司 | 二取代peg化白细胞介素2及其制备方法、应用 |
| US20230102464A1 (en) * | 2020-01-15 | 2023-03-30 | Jenkem Technology Co., Ltd. (Tianjin) | Method for preparing pegylated biomolecule with controllable binding sites |
| WO2021158623A1 (en) | 2020-02-03 | 2021-08-12 | Medikine, Inc. | IL-7Rαγc BINDING COMPOUNDS |
| WO2021168079A1 (en) | 2020-02-21 | 2021-08-26 | Pandion Operations, Inc. | Tissue targeted immunotolerance with a cd39 effector |
| MX2022010990A (es) * | 2020-03-05 | 2022-10-07 | Univ Leland Stanford Junior | Variantes dise?adas de il-2. |
| US20230090069A1 (en) | 2020-03-06 | 2023-03-23 | Centre Hospitalier Universitaire De Nimes | Low dose human interleukin-2 for the treatment of amyotrophic lateral sclerosis |
| TW202203973A (zh) | 2020-04-22 | 2022-02-01 | 美商默沙東藥廠 | 對介白素-2受體βγc二聚體具偏性且結合至非肽、水溶性聚合物之人類介白素-2結合物 |
| US11897930B2 (en) | 2020-04-28 | 2024-02-13 | Anwita Biosciences, Inc. | Interleukin-2 polypeptides and fusion proteins thereof, and their pharmaceutical compositions and therapeutic applications |
| TW202210502A (zh) | 2020-06-03 | 2022-03-16 | 丹麥商阿森迪斯腫瘤製藥有限公司 | 新穎il-2序列及其用途 |
| CN115768788A (zh) * | 2020-07-09 | 2023-03-07 | Eutilex股份有限公司 | Il-2变体 |
| MX2023005030A (es) | 2020-10-29 | 2023-05-16 | Bristol Myers Squibb Co | Proteinas de fusion para el tratamiento de enfermedades. |
| CA3197344A1 (en) * | 2020-11-04 | 2022-05-12 | William J. Dower | Il-2r.beta.yc binding compounds and uses thereof |
| KR20230129018A (ko) | 2020-12-04 | 2023-09-05 | 비스테라, 인크. | 인터류킨-2 작용제를 사용하는 방법 |
| EP4314033A4 (en) * | 2021-03-31 | 2025-04-23 | Anwita Biosciences, Inc. | FUSION PROTEINS, PHARMACEUTICAL COMPOSITIONS AND THERAPEUTIC APPLICATIONS |
| MX2023012131A (es) * | 2021-04-16 | 2024-01-11 | Orionis Biosciences Inc | Construcciones de il-2. |
| US11999771B2 (en) | 2022-04-07 | 2024-06-04 | Medikine, Inc. | IL-7Rαγc ligand immunoglobulin fusion proteins |
| WO2024056154A1 (en) | 2022-09-12 | 2024-03-21 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Interleukin-2 for use in treating autism spectrum disorder |
| WO2024103860A1 (zh) * | 2022-11-18 | 2024-05-23 | 南京诺艾新生物技术有限公司 | 受体亲和力偏好性的定点偶联聚乙二醇化白介素-2突变体及其用途 |
| CN120282987A (zh) | 2022-11-30 | 2025-07-08 | 因特格尔莫来库乐有限公司 | 包括双特异性型式的针对紧密连接蛋白6的抗体 |
| WO2024121173A1 (en) | 2022-12-05 | 2024-06-13 | Centre Hospitalier Universitaire De Nimes | Low dose human interleukin-2 for the treatment of amyotrophic lateral sclerosis in a subgroup of patients |
| CN120529914A (zh) | 2023-01-09 | 2025-08-22 | 奥德赛治疗股份有限公司 | 抗tnfr2抗原结合蛋白及其用途 |
| CN119708194A (zh) * | 2023-09-28 | 2025-03-28 | 南京诺艾新生物技术有限公司 | Il-22突变体及其制备方法与应用 |
| WO2025129120A2 (en) | 2023-12-15 | 2025-06-19 | Port Therapeutics, Inc. | Use of thermal bioswitches for treating autoimmune diseases |
| WO2025217240A1 (en) | 2024-04-10 | 2025-10-16 | Odyssey Therapeutics, Inc. | Anti-tnfr2 antigen-binding proteins and uses thereof |
Family Cites Families (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4853332A (en) | 1982-10-19 | 1989-08-01 | Cetus Corporation | Structural genes, plasmids and transformed cells for producing cysteine depleted muteins of biologically active proteins |
| US5206344A (en) * | 1985-06-26 | 1993-04-27 | Cetus Oncology Corporation | Interleukin-2 muteins and polymer conjugation thereof |
| US5466447A (en) | 1988-06-29 | 1995-11-14 | Amgen Inc. | Method for treating psoriasis |
| EP0378666A4 (en) * | 1988-07-05 | 1992-01-22 | Amgen Inc. | Interleukin ii analogs |
| US5089261A (en) | 1989-01-23 | 1992-02-18 | Cetus Corporation | Preparation of a polymer/interleukin-2 conjugate |
| US4902502A (en) | 1989-01-23 | 1990-02-20 | Cetus Corporation | Preparation of a polymer/interleukin-2 conjugate |
| US6541610B1 (en) | 1989-09-05 | 2003-04-01 | Immunex Corporation | Fusion proteins comprising tumor necrosis factor receptor |
| US5650150A (en) | 1990-11-09 | 1997-07-22 | Gillies; Stephen D. | Recombinant antibody cytokine fusion proteins |
| US5281698A (en) | 1991-07-23 | 1994-01-25 | Cetus Oncology Corporation | Preparation of an activated polymer ester for protein conjugation |
| CA2188871C (en) | 1993-09-21 | 2001-01-23 | Robert I. Abels | Method for treating psoriasis |
| JP2002505086A (ja) | 1998-02-25 | 2002-02-19 | レキシジェン ファーマシューティカルズ コーポレイション | 抗体ベースの融合タンパク質の循環半減期の増強 |
| DZ2788A1 (fr) * | 1998-05-15 | 2003-12-01 | Bayer Ag | Agonistes et antagonistes selectifs à IL-2. |
| US6955807B1 (en) * | 1998-05-15 | 2005-10-18 | Bayer Pharmaceuticals Corporation | IL-2 selective agonists and antagonists |
| US6348192B1 (en) | 1999-05-11 | 2002-02-19 | Bayer Corporation | Interleukin-2 mutein expressed from mammalian cells |
| SK782002A3 (en) | 1999-07-21 | 2003-08-05 | Lexigen Pharm Corp | FC fusion proteins for enhancing the immunogenicity of protein and peptide antigens |
| AU2001238595A1 (en) | 2000-02-22 | 2001-09-03 | Shearwater Corporation | N-maleimidyl polymer derivatives |
| US20020022030A1 (en) * | 2000-04-26 | 2002-02-21 | Philippa Marrack | Product and process for regulation of T cell responses |
| US6689353B1 (en) | 2000-06-28 | 2004-02-10 | Bayer Pharmaceuticals Corporation | Stabilized interleukin 2 |
| CA2422294C (en) * | 2000-09-14 | 2012-12-04 | Beth Israel Deaconess Medical Center, Inc. | Modulation of il-2- and il-15-mediated t cell responses |
| RU2003129528A (ru) | 2001-03-07 | 2005-04-10 | Мерк Патент ГмбХ (DE) | Способ экспрессии белков, содержащих в качестве компонента гибридный изотип антитела |
| JP4444652B2 (ja) * | 2001-07-11 | 2010-03-31 | マキシゲン・ホールディングズ・リミテッド | Ｇ−ｃｓｆ結合体 |
| DE60222914T2 (de) | 2001-07-27 | 2008-07-24 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Systeme zur stellengerichteten in-vivo-mutagenese mit oligonukleotiden |
| JP2005507870A (ja) | 2001-08-13 | 2005-03-24 | ユニバーシティ・オブ・サザン・カリフォルニア | 低毒性のインターロイキン−２突然変異体 |
| EP2354791A1 (en) | 2001-12-04 | 2011-08-10 | Merck Patent GmbH | Immunocytokines with modulated selectivity |
| ATE525395T1 (de) | 2003-06-12 | 2011-10-15 | Lilly Co Eli | Fusions proteine von glp-1-analoga |
| WO2005007121A2 (en) | 2003-07-18 | 2005-01-27 | Massachusetts Institute Of Technology | Mutant interleukin-2(il-2) polypeptides |
| CA2678736A1 (en) * | 2003-07-21 | 2005-02-17 | Transgene S.A. | Novel multifunctional il-2 - il-18 fusion proteins |
| CN1930300A (zh) * | 2004-03-05 | 2007-03-14 | 希龙公司 | 预测患者治疗药物耐受性的体外试验系统 |
| CA2557677A1 (en) | 2004-03-05 | 2005-10-06 | Chiron Corporation | In vitro test system for predicting patient tolerability of therapeutic agents |
| EP1846020B1 (en) | 2005-01-27 | 2013-08-21 | Novartis Vaccines and Diagnostics, Inc. | Methods for treating renal cell carcinoma |
| DE602005001688T2 (de) | 2005-02-07 | 2008-04-10 | Novartis Vaccines and Diagnostics, Inc., Emeryville | Aufbereitung von Aldesleukin zur pharmazeutischen Verwendung |
| FR2918770B1 (fr) | 2007-07-10 | 2009-09-11 | Essilor Int | Afficheur destine a etre integre a une paire de lunettes. |
| WO2009061853A2 (en) | 2007-11-05 | 2009-05-14 | Massachusetts Institute Of Technology | Mutant interleukin-2 (il-2) polypeptides |
| KR20090103209A (ko) * | 2008-03-27 | 2009-10-01 | (주)한국비엠아이 | 사람 인터루킨-2 동종체 |
| DE102008023820A1 (de) | 2008-05-08 | 2009-11-12 | Aicuris Gmbh & Co. Kg | Mittel zur Behandlung und/oder Prophylaxe einer Autoimmunerkrankung und zur Bildung von Regulatorischen T-Zellen |
| US20110274650A1 (en) | 2009-01-21 | 2011-11-10 | Amgen Inc. | Compositions and methods of treating inflammatory and autoimmune diseases |
| PL2542590T5 (pl) | 2010-03-05 | 2020-08-10 | The Johns Hopkins University | Kompozycje i sposoby dla ukierunkowanych immunomodulatorowych przeciwciał i białek fuzyjnych |
| CU23923B1 (es) | 2010-11-12 | 2013-07-31 | Ct De Inmunología Molecular | Polipéptidos derivados de la il-2 con actividad agonista |
| RS61854B1 (sr) | 2010-11-12 | 2021-06-30 | Nektar Therapeutics | Konjugati il-2 dela i polimera |
| CN102462837B (zh) | 2010-11-19 | 2016-08-03 | 生物林格斯Ip有限公司 | 抗炎组合物 |
| CA2860170C (en) | 2010-12-22 | 2022-06-14 | The Board Of Trustees Of The Leland Stanford Junior University | Superagonists and antagonists of interleukin-2 |
| CN102174111B (zh) | 2011-01-25 | 2013-01-09 | 江苏省弗泰生物科技有限公司 | 人白介素2-Fc融合蛋白及其用途 |
| CN105440123B (zh) * | 2011-02-10 | 2020-10-09 | 罗切格利卡特公司 | 突变体白介素-2多肽 |
| BR112013023151A2 (pt) | 2011-03-11 | 2020-09-15 | Assistance Publique - Hôpitaux De Paris | interleucina-2 para uso no tratamento de desordem auto-imune, !muno-relacionada ou inflamatória e método para determinar se um regime ou dose de il-2 tem de ser modificado |
| EA201892619A1 (ru) | 2011-04-29 | 2019-04-30 | Роше Гликарт Аг | Иммуноконъюгаты, содержащие мутантные полипептиды интерлейкина-2 |
| US20150073043A1 (en) * | 2012-01-19 | 2015-03-12 | Institut Pasteur Of Shanghai, Chinese Academy Of Sciences | Use of phosphorylation pathway-related factor in regulating function of regulatory t cell |
| US9844582B2 (en) | 2012-05-22 | 2017-12-19 | Massachusetts Institute Of Technology | Synergistic tumor treatment with extended-PK IL-2 and therapeutic agents |
| US20140044675A1 (en) | 2012-08-10 | 2014-02-13 | Roche Glycart Ag | Interleukin-2 fusion proteins and uses thereof |
| CN103193879A (zh) * | 2013-02-07 | 2013-07-10 | 深圳市亚太兴实业有限公司 | 一种聚乙二醇修饰的重组人白介素2的制备方法 |
| US9546203B2 (en) | 2013-03-14 | 2017-01-17 | Amgen Inc. | Aglycosylated Fc-containing polypeptides with cysteine substitutions |
| US10544187B2 (en) | 2013-03-15 | 2020-01-28 | Xencor, Inc. | Targeting regulatory T cells with heterodimeric proteins |
| CN103193887B (zh) | 2013-04-03 | 2015-02-04 | 江苏众红生物工程创药研究院有限公司 | 一种重组猪白细胞介素2-Fc融合蛋白及其编码基因和表达方法 |
| WO2014201378A1 (en) | 2013-06-13 | 2014-12-18 | Massachusetts Institute Of Technology | Synergistic tumor treatment with extended-pk il -2 and adoptive cell therapy |
| SI3102595T1 (sl) | 2014-02-06 | 2019-02-28 | F. Hoffmann-La Roche Ag | Fuzijske beljakovine z interlevkinom-2 in njihova uporaba |
| US10150802B2 (en) | 2014-04-24 | 2018-12-11 | The Board Of Trustees Of The Leland Stanford Junior University | Superagonists, partial agonists and antagonists of interleukin-2 |
| KR20150133576A (ko) | 2014-05-20 | 2015-11-30 | 삼성전자주식회사 | 화학적 개질된 표적화 단백질 및 그의 이용 |
| KR102493543B1 (ko) | 2014-07-21 | 2023-01-30 | 데리니아, 인크. | 자가면역 질환의 치료를 위한 조절 t 세포를 선택적으로 활성화시키는 분자 |
| PL3482766T3 (pl) | 2014-08-11 | 2020-11-16 | Delinia, Inc. | Modyfikowane warianty il-2, które selektywnie aktywują limfocyty t regulatorowe do leczenia chorób autoimmunologicznych |
| WO2016025647A1 (en) | 2014-08-12 | 2016-02-18 | Massachusetts Institute Of Technology | Synergistic tumor treatment with il-2, a therapeutic antibody, and a cancer vaccine |
| AU2015328163B2 (en) | 2014-10-09 | 2020-10-15 | Dana-Farber Cancer Institute, Inc. | Multiple-variable IL-2 dose regimen for treating immune disorders |
-
2015
- 2015-08-10 PL PL18215282T patent/PL3482766T3/pl unknown
- 2015-08-10 EP EP18215282.7A patent/EP3482766B1/en active Active
- 2015-08-10 AU AU2015301936A patent/AU2015301936B2/en not_active Ceased
- 2015-08-10 US US15/327,813 patent/US10035836B1/en active Active
- 2015-08-10 HK HK18102706.1A patent/HK1243001A1/zh unknown
- 2015-08-10 WO PCT/US2015/044462 patent/WO2016025385A1/en not_active Ceased
- 2015-08-10 CN CN202110571465.2A patent/CN113234138A/zh active Pending
- 2015-08-10 EA EA201790371A patent/EA034925B1/ru active IP Right Revival
- 2015-08-10 SI SI201530637T patent/SI3180020T1/sl unknown
- 2015-08-10 EP EP15831523.4A patent/EP3180020B1/en active Active
- 2015-08-10 HU HUE18215282A patent/HUE051414T2/hu unknown
- 2015-08-10 ES ES15831523T patent/ES2717831T3/es active Active
- 2015-08-10 KR KR1020177001917A patent/KR20170035910A/ko not_active Ceased
- 2015-08-10 MX MX2017000833A patent/MX373296B/es active IP Right Grant
- 2015-08-10 NZ NZ728175A patent/NZ728175A/en not_active IP Right Cessation
- 2015-08-10 PL PL15831523T patent/PL3180020T3/pl unknown
- 2015-08-10 CN CN201580053284.3A patent/CN107106654B/zh not_active Expired - Fee Related
- 2015-08-10 CA CA2955006A patent/CA2955006C/en active Active
- 2015-08-10 SG SG11201700629TA patent/SG11201700629TA/en unknown
- 2015-08-10 JP JP2017507401A patent/JP6640834B2/ja not_active Expired - Fee Related
- 2015-08-10 SI SI201531284T patent/SI3482766T1/sl unknown
- 2015-08-10 ES ES18215282T patent/ES2807260T3/es active Active
- 2015-08-10 HU HUE15831523A patent/HUE043038T2/hu unknown
-
2017
- 2017-01-11 IL IL250059A patent/IL250059B/en active IP Right Grant
- 2017-01-17 ZA ZA2017/00381A patent/ZA201700381B/en unknown
- 2017-01-18 MX MX2020004206A patent/MX2020004206A/es unknown
-
2019
- 2019-12-26 JP JP2019235716A patent/JP6941664B2/ja not_active Expired - Fee Related
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN107106654B (zh) | 选择性地活化调节性t细胞用于治疗自身免疫病的修饰的il-2变体 | |
| CN106795213B (zh) | 选择性地活化调节性t细胞用于治疗自身免疫病的分子 | |
| US11535657B2 (en) | Molecules that selectively activate regulatory T cells for the treatment of autoimmune diseases | |
| HK1261663A1 (en) | Molecules that selectively activate regulatory t cells for the treatment of autoimmune diseases | |
| EA041387B1 (ru) | Молекулы, которые избирательно активируют регуляторные t-клетки для лечения аутоиммунных заболеваний |