SI3180020T1 - Modificirane variante IL-2, ki selektivno aktivirajo regulatorne celice T, za zdravljenje avtoimunih bolezni - Google Patents
Modificirane variante IL-2, ki selektivno aktivirajo regulatorne celice T, za zdravljenje avtoimunih bolezniInfo
- Publication number
- SI3180020T1 SI3180020T1 SI201530637T SI201530637T SI3180020T1 SI 3180020 T1 SI3180020 T1 SI 3180020T1 SI 201530637 T SI201530637 T SI 201530637T SI 201530637 T SI201530637 T SI 201530637T SI 3180020 T1 SI3180020 T1 SI 3180020T1
- Authority
- SI
- Slovenia
- Prior art keywords
- variants
- cells
- modified
- treatment
- autoimmune diseases
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2013—IL-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Transplantation (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462070016P | 2014-08-11 | 2014-08-11 | |
| PCT/US2015/044462 WO2016025385A1 (en) | 2014-08-11 | 2015-08-10 | Modified il-2 variants that selectively activate regulatory t cells for the treatment of autoimmune diseases |
| EP15831523.4A EP3180020B1 (en) | 2014-08-11 | 2015-08-10 | Modified il-2 variants that selectively activate regulatory t cells for the treatment of autoimmune diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI3180020T1 true SI3180020T1 (sl) | 2019-04-30 |
Family
ID=55304526
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI201531284T SI3482766T1 (sl) | 2014-08-11 | 2015-08-10 | Spremenjene variante IL-2, ki selektivno aktivirajo regulatorne T celice za zdravljenje avtoimunskih bolezni |
| SI201530637T SI3180020T1 (sl) | 2014-08-11 | 2015-08-10 | Modificirane variante IL-2, ki selektivno aktivirajo regulatorne celice T, za zdravljenje avtoimunih bolezni |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI201531284T SI3482766T1 (sl) | 2014-08-11 | 2015-08-10 | Spremenjene variante IL-2, ki selektivno aktivirajo regulatorne T celice za zdravljenje avtoimunskih bolezni |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US10035836B1 (sl) |
| EP (2) | EP3482766B1 (sl) |
| JP (2) | JP6640834B2 (sl) |
| KR (1) | KR20170035910A (sl) |
| CN (2) | CN107106654B (sl) |
| AU (1) | AU2015301936B2 (sl) |
| CA (1) | CA2955006C (sl) |
| EA (1) | EA034925B1 (sl) |
| ES (2) | ES2807260T3 (sl) |
| HK (1) | HK1243001A1 (sl) |
| HU (2) | HUE043038T2 (sl) |
| IL (1) | IL250059B (sl) |
| MX (2) | MX2017000833A (sl) |
| NZ (1) | NZ728175A (sl) |
| PL (2) | PL3482766T3 (sl) |
| SG (1) | SG11201700629TA (sl) |
| SI (2) | SI3482766T1 (sl) |
| WO (1) | WO2016025385A1 (sl) |
| ZA (1) | ZA201700381B (sl) |
Families Citing this family (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2807260T3 (es) | 2014-08-11 | 2021-02-22 | Delinia Inc | Variantes de IL-2 modificadas que activan selectivamente las células T reguladoras para el tratamiento de enfermedades autoinmunes |
| IL283764B2 (en) | 2015-04-10 | 2024-01-01 | Amgen Inc | Interleukin for the expansion of myotonic control T-2 cells |
| WO2017044464A1 (en) | 2015-09-11 | 2017-03-16 | The Board Of Trustees Of The Leland Stanford Junior University | Biologically relevant orthogonal cytokine/receptor pairs |
| SG10201913576RA (en) | 2015-10-01 | 2020-02-27 | Heat Biologics Inc | Compositions and methods for adjoining type i and type ii extracellular domains as heterologous chimeric proteins |
| US20170204154A1 (en) | 2016-01-20 | 2017-07-20 | Delinia, Inc. | Molecules that selectively activate regulatory t cells for the treatment of autoimmune diseases |
| EP3808764A1 (en) * | 2016-05-04 | 2021-04-21 | Amgen Inc. | Interleukin-2 muteins for the expansion of t-regulatory cells |
| BR112018074152A8 (pt) * | 2016-05-25 | 2023-01-31 | Hoffmann La Roche | Métodos para determinar um regime de dosagem, métodos para tratar um indivíduo, método para otimizar o tratamento terapeuticamente, agente terapêutico e sistema de rede para determinar uma dose eficaz ou um regime de dosagem para um indivíduo sendo tratado com um agente terapêutico |
| EA201991142A1 (ru) * | 2016-11-08 | 2019-10-31 | Варианты il-2 для лечения аутоиммунных заболеваний | |
| CN110546160A (zh) | 2017-02-06 | 2019-12-06 | 奥里尼斯生物科学公司 | 靶向嵌合蛋白及其用途 |
| IL268198B1 (en) | 2017-02-27 | 2024-06-01 | Shattuck Labs Inc | based chimeric proteins - TIGIT and LIGHT |
| EP3585409A4 (en) | 2017-02-27 | 2020-12-02 | Shattuck Labs, Inc. | CHEMERICAL PROTEINS BASED ON CSF1R |
| US11192933B2 (en) | 2017-02-27 | 2021-12-07 | Shattuck Labs, Inc. | VSIG8-based chimeric proteins |
| CA3056630A1 (en) | 2017-03-15 | 2018-09-20 | Pandion Therapeutics, Inc. | Targeted immunotolerance |
| US10676516B2 (en) | 2017-05-24 | 2020-06-09 | Pandion Therapeutics, Inc. | Targeted immunotolerance |
| JP7325341B2 (ja) | 2017-07-11 | 2023-08-14 | シンソークス，インク． | 非天然ヌクレオチドの組み込み及びその方法 |
| JP2020529976A (ja) * | 2017-08-03 | 2020-10-15 | シンソークス，インク． | 自己免疫疾患の処置のためのサイトカイン抱合体 |
| WO2019067766A1 (en) | 2017-09-27 | 2019-04-04 | Sigilon Therapeutics, Inc. | METHODS, COMPOSITIONS AND IMPLANTABLE ELEMENTS COMPRISING ACTIVE CELLS |
| US10174092B1 (en) | 2017-12-06 | 2019-01-08 | Pandion Therapeutics, Inc. | IL-2 muteins |
| US10946068B2 (en) | 2017-12-06 | 2021-03-16 | Pandion Operations, Inc. | IL-2 muteins and uses thereof |
| CA3086199A1 (en) * | 2017-12-19 | 2019-06-27 | Xencor, Inc. | Engineered il-2 fc fusion proteins |
| US20210060169A1 (en) | 2017-12-27 | 2021-03-04 | Kyowa Kirin Co., Ltd. | Il-2 variant |
| AU2019215440A1 (en) | 2018-02-05 | 2020-08-27 | Orionis Biosciences, Inc. | Fibroblast binding agents and use thereof |
| WO2019158764A1 (en) | 2018-02-16 | 2019-08-22 | Iltoo Pharma | Use of interleukin 2 for treating sjögren's syndrome |
| JP2021515599A (ja) * | 2018-03-09 | 2021-06-24 | アスクジーン・ファーマ・インコーポレイテッドＡｓｋＧｅｎｅ Ｐｈａｒｍａ， Ｉｎｃ． | 新規のサイトカインプロドラッグ |
| TW202003551A (zh) | 2018-03-28 | 2020-01-16 | 美商必治妥美雅史谷比公司 | 介白素-2/介白素-2受體阿法融合蛋白及其使用方法 |
| AU2019246389A1 (en) | 2018-03-28 | 2020-08-27 | Ascendis Pharma Oncology Division A/S | IL-2 conjugates |
| CN112203646A (zh) | 2018-04-04 | 2021-01-08 | 西吉隆医疗股份有限公司 | 可植入颗粒和相关方法 |
| US20210145889A1 (en) | 2018-04-04 | 2021-05-20 | Sigilon Therapeutics, Inc. | Methods, compositions, and implantable elements comprising stem cells |
| WO2020007937A1 (en) | 2018-07-03 | 2020-01-09 | Iltoo Pharma | Use of interleukin-2 for treating systemic sclerosis |
| AU2019301697A1 (en) * | 2018-07-13 | 2021-01-07 | Il-2Rx, Inc. | Compounds, compositions, methods, and uses for treating cancer and immunological disorders |
| CN112585160A (zh) | 2018-08-06 | 2021-03-30 | 麦地金公司 | Il-2受体结合化合物 |
| JP7307500B2 (ja) * | 2018-08-06 | 2023-07-12 | メディカイン、インコーポレイテッド | Ｉｌ－２受容体結合化合物 |
| US20210236599A1 (en) | 2018-08-13 | 2021-08-05 | Iltoo Pharma | Combination of interleukin-2 with an interleukin 1 inhibitor, conjugates and therapeutic uses thereof |
| US10780121B2 (en) | 2018-08-29 | 2020-09-22 | Shattuck Labs, Inc. | FLT3L-based chimeric proteins |
| CA3111576A1 (en) * | 2018-09-11 | 2020-03-19 | Ambrx, Inc. | Interleukin-2 polypeptide conjugates and their uses |
| UY38389A (es) | 2018-09-27 | 2020-04-30 | Sigilon Therapeutics Inc | Dispositivos implantables para terapia celular y métodos relacionados |
| EA202190593A1 (ru) * | 2018-11-20 | 2021-11-18 | Юниверсити Оф Вашингтон | Расщепленные миметики интерлейкина и их применение |
| CN111378026A (zh) * | 2018-12-27 | 2020-07-07 | 天津键凯科技有限公司 | 一种制备结合位点可控的peg化生物分子的方法 |
| JP2022519271A (ja) | 2019-02-06 | 2022-03-22 | シンソークス， インコーポレイテッド | Ｉｌ－２コンジュゲートおよびその使用方法 |
| US11254736B2 (en) | 2019-02-15 | 2022-02-22 | Integral Molecular, Inc. | Antibodies comprising a common light chain and uses thereof |
| EA202192146A1 (ru) | 2019-02-15 | 2021-11-09 | Интиграл Молекьюлар, Инк. | Антитела к клаудину 6 и их применение |
| EP3946424A1 (en) * | 2019-03-29 | 2022-02-09 | Institut Curie | Interleukin-2 variants with modified biological activity |
| KR20220035333A (ko) | 2019-05-20 | 2022-03-22 | 팬디온 오퍼레이션스, 인코포레이티드 | Madcam 표적 면역관용 |
| EP3983433A4 (en) * | 2019-06-14 | 2023-08-09 | Cugene Inc. | NOVEL INTERLEUKIN-2 VARIANTS FOR CANCER TREATMENT |
| CN114853874B (zh) * | 2019-09-10 | 2024-05-17 | 中国医学科学院北京协和医院 | 靶向调节t细胞的长效白介素-2及其在治疗自身免疫病中的应用 |
| CA3160466A1 (en) * | 2019-11-05 | 2021-05-14 | Medikine, Inc. | Dual il-2r and il-7r binding compounds |
| MX2022005411A (es) | 2019-11-05 | 2022-08-10 | Medikine Inc | COMPUESTOS DE UNIÓN A IL-2RßYC. |
| TW202128961A (zh) * | 2019-11-20 | 2021-08-01 | 美商安維塔生物科學股份有限公司 | 細胞激素融合蛋白及其醫藥組合物及治療應用 |
| BR112022011513A2 (pt) * | 2019-12-13 | 2022-08-23 | Synthekine Inc | Ortólogos de il-2 e métodos de uso |
| CN114478743A (zh) * | 2019-12-17 | 2022-05-13 | 北京志道生物科技有限公司 | 白介素-2衍生物 |
| KR20220140514A (ko) | 2020-01-10 | 2022-10-18 | 브라이트 피크 테라퓨틱스 아게 | 변형된 il-2 폴리펩타이드 및 그의 용도 |
| IL294388A (en) | 2020-01-14 | 2022-08-01 | Synthekine Inc | il2 orthologs and methods of use |
| US11491205B2 (en) | 2020-01-14 | 2022-11-08 | Synthekine, Inc. | Biased IL2 muteins methods and compositions |
| CN113121671A (zh) * | 2020-01-15 | 2021-07-16 | 天津键凯科技有限公司 | 一种制备结合位点可控的peg化生物分子的方法 |
| CN113121670B (zh) * | 2020-01-15 | 2022-11-22 | 天津键凯科技有限公司 | 二取代peg化白细胞介素2及其制备方法、应用 |
| BR112022015002A2 (pt) | 2020-02-03 | 2022-12-06 | Medikine Inc | Ligante de il-7r-alfa/gama/c, composto, composição farmacêutica, método para tratar uma doença em um paciente e ácido nucleico |
| US11981715B2 (en) | 2020-02-21 | 2024-05-14 | Pandion Operations, Inc. | Tissue targeted immunotolerance with a CD39 effector |
| IL295811A (en) * | 2020-03-05 | 2022-10-01 | Univ Leland Stanford Junior | designed variants of il-2 |
| TW202146041A (zh) | 2020-03-06 | 2021-12-16 | 尼姆大學醫學中心 | 用於肌肉萎縮性脊髓側索硬化症之治療的低劑量人類介白素-2 |
| WO2021216478A1 (en) * | 2020-04-22 | 2021-10-28 | Merck Sharp & Dohme Corp. | HUMAN INTERLEUKIN-2 CONJUGATES BIASED FOR THE INTERLEUKIN-2 RECEPTOR BETA GAMMAc DIMER AND CONJUGATED TO A NONPEPTIDIC, WATER-SOLUBLE POLYMER |
| US11897930B2 (en) | 2020-04-28 | 2024-02-13 | Anwita Biosciences, Inc. | Interleukin-2 polypeptides and fusion proteins thereof, and their pharmaceutical compositions and therapeutic applications |
| US20230242607A1 (en) * | 2020-07-09 | 2023-08-03 | Eutilex Co., Ltd. | Il-2 variants |
| MX2023005030A (es) | 2020-10-29 | 2023-05-16 | Bristol Myers Squibb Co | Proteinas de fusion para el tratamiento de enfermedades. |
| US11999771B2 (en) | 2022-04-07 | 2024-06-04 | Medikine, Inc. | IL-7Rαγc ligand immunoglobulin fusion proteins |
| WO2024056154A1 (en) | 2022-09-12 | 2024-03-21 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Interleukin-2 for use in treating autism spectrum disorder |
| WO2024103860A1 (zh) * | 2022-11-18 | 2024-05-23 | 南京诺艾新生物技术有限公司 | 受体亲和力偏好性的定点偶联聚乙二醇化白介素-2突变体及其用途 |
| WO2024121173A1 (en) | 2022-12-05 | 2024-06-13 | Centre Hospitalier Universitaire De Nimes | Low dose human interleukin-2 for the treatment of amyotrophic lateral sclerosis in a subgroup of patients |
Family Cites Families (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4853332A (en) | 1982-10-19 | 1989-08-01 | Cetus Corporation | Structural genes, plasmids and transformed cells for producing cysteine depleted muteins of biologically active proteins |
| US5206344A (en) * | 1985-06-26 | 1993-04-27 | Cetus Oncology Corporation | Interleukin-2 muteins and polymer conjugation thereof |
| US5466447A (en) | 1988-06-29 | 1995-11-14 | Amgen Inc. | Method for treating psoriasis |
| EP0378666A4 (en) * | 1988-07-05 | 1992-01-22 | Amgen Inc. | Interleukin ii analogs |
| US5089261A (en) | 1989-01-23 | 1992-02-18 | Cetus Corporation | Preparation of a polymer/interleukin-2 conjugate |
| US4902502A (en) | 1989-01-23 | 1990-02-20 | Cetus Corporation | Preparation of a polymer/interleukin-2 conjugate |
| US6541610B1 (en) | 1989-09-05 | 2003-04-01 | Immunex Corporation | Fusion proteins comprising tumor necrosis factor receptor |
| US5650150A (en) | 1990-11-09 | 1997-07-22 | Gillies; Stephen D. | Recombinant antibody cytokine fusion proteins |
| US5281698A (en) | 1991-07-23 | 1994-01-25 | Cetus Oncology Corporation | Preparation of an activated polymer ester for protein conjugation |
| AU5134693A (en) | 1993-09-21 | 1995-04-10 | Amgen, Inc. | Method for treating psoriasis |
| HUP0100813A3 (en) | 1998-02-25 | 2003-08-28 | Lexigen Pharmaceuticals Corp L | Enhancing the circulating half-life of antibody-based fusion proteins |
| DZ2788A1 (fr) | 1998-05-15 | 2003-12-01 | Bayer Ag | Agonistes et antagonistes selectifs à IL-2. |
| US6955807B1 (en) | 1998-05-15 | 2005-10-18 | Bayer Pharmaceuticals Corporation | IL-2 selective agonists and antagonists |
| US6348192B1 (en) | 1999-05-11 | 2002-02-19 | Bayer Corporation | Interleukin-2 mutein expressed from mammalian cells |
| SK782002A3 (en) | 1999-07-21 | 2003-08-05 | Lexigen Pharm Corp | FC fusion proteins for enhancing the immunogenicity of protein and peptide antigens |
| AU2001238595A1 (en) | 2000-02-22 | 2001-09-03 | Shearwater Corporation | N-maleimidyl polymer derivatives |
| US20020022030A1 (en) * | 2000-04-26 | 2002-02-21 | Philippa Marrack | Product and process for regulation of T cell responses |
| US6689353B1 (en) | 2000-06-28 | 2004-02-10 | Bayer Pharmaceuticals Corporation | Stabilized interleukin 2 |
| DE60138222D1 (de) * | 2000-09-14 | 2009-05-14 | Beth Israel Hospital | Modulierung von il-2 und il-15 vermittelten t zellantworten |
| ES2393733T3 (es) | 2001-03-07 | 2012-12-27 | Merck Patent Gmbh | Tecnología de expresión para proteínas que contienen una fracción de anticuerpo de isotipo híbrido |
| EP1425304B9 (en) * | 2001-07-11 | 2010-09-08 | Maxygen, Inc. | G-csf conjugates |
| JP2005500841A (ja) | 2001-07-27 | 2005-01-13 | アメリカ合衆国 | オリゴヌクレオチドを用いるインビボ部位指定変異誘発のためのシステム |
| EP1476180A4 (en) | 2001-08-13 | 2005-04-20 | Univ Southern California | INTERLEUKIN-2 MUTANTS WITH REDUCED TOXICITY |
| CN100390282C (zh) * | 2001-12-04 | 2008-05-28 | 默克专利有限公司 | 具有调节的选择性的il-2融合蛋白 |
| MXPA05013565A (es) | 2003-06-12 | 2006-03-09 | Lilly Co Eli | Proteinas de fusion analogas al glp-1. |
| WO2005007121A2 (en) | 2003-07-18 | 2005-01-27 | Massachusetts Institute Of Technology | Mutant interleukin-2(il-2) polypeptides |
| DK1648931T3 (da) * | 2003-07-21 | 2011-03-07 | Transgene Sa | Multifunktionelle cytokiner |
| WO2005091956A2 (en) | 2004-03-05 | 2005-10-06 | Chiron Corporation | In vitro test system for predicting patient tolerability of therapeutic agents |
| CN1930300A (zh) * | 2004-03-05 | 2007-03-14 | 希龙公司 | 预测患者治疗药物耐受性的体外试验系统 |
| JP2008528621A (ja) | 2005-01-27 | 2008-07-31 | ノバルティス ヴァクシンズ アンド ダイアグノスティクス インコーポレイテッド | 腎細胞ガンを処置するための方法 |
| DE602005001688T2 (de) | 2005-02-07 | 2008-04-10 | Novartis Vaccines and Diagnostics, Inc., Emeryville | Aufbereitung von Aldesleukin zur pharmazeutischen Verwendung |
| FR2918770B1 (fr) | 2007-07-10 | 2009-09-11 | Essilor Int | Afficheur destine a etre integre a une paire de lunettes. |
| US8906356B2 (en) | 2007-11-05 | 2014-12-09 | Massachusetts Institute Of Technology | Mutant interleukin-2 (IL-2) polypeptides |
| KR20090103209A (ko) * | 2008-03-27 | 2009-10-01 | (주)한국비엠아이 | 사람 인터루킨-2 동종체 |
| DE102008023820A1 (de) | 2008-05-08 | 2009-11-12 | Aicuris Gmbh & Co. Kg | Mittel zur Behandlung und/oder Prophylaxe einer Autoimmunerkrankung und zur Bildung von Regulatorischen T-Zellen |
| CA2749539C (en) | 2009-01-21 | 2022-07-19 | Amgen Inc. | Compositions and methods comprising interleukin-2 mutants for treating inflammatory and autoimmune diseases |
| IL300733A (en) | 2010-03-05 | 2023-04-01 | Univ Johns Hopkins | Compositions and methods for antibodies and fusion proteins targeting immune modulation |
| CU23923B1 (es) | 2010-11-12 | 2013-07-31 | Ct De Inmunología Molecular | Polipéptidos derivados de la il-2 con actividad agonista |
| WO2012065086A1 (en) | 2010-11-12 | 2012-05-18 | Nektar Therapeutics | Conjugates of an il-2 moiety and a polymer |
| CN102462837B (zh) | 2010-11-19 | 2016-08-03 | 生物林格斯Ip有限公司 | 抗炎组合物 |
| WO2012088446A1 (en) | 2010-12-22 | 2012-06-28 | Board Of Trustees Of The Leland Stanford Junior University | Superagonists and antagonists of interleukin-2 |
| CN102174111B (zh) | 2011-01-25 | 2013-01-09 | 江苏省弗泰生物科技有限公司 | 人白介素2-Fc融合蛋白及其用途 |
| HUE029139T2 (hu) * | 2011-02-10 | 2017-02-28 | Roche Glycart Ag | Mutáns interleukin-2 polipeptidek |
| US9669071B2 (en) | 2011-03-11 | 2017-06-06 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Method for stimulating T lymphocytes with IL-2 |
| EA201892619A1 (ru) | 2011-04-29 | 2019-04-30 | Роше Гликарт Аг | Иммуноконъюгаты, содержащие мутантные полипептиды интерлейкина-2 |
| CN103212064B (zh) * | 2012-01-19 | 2016-02-17 | 中国科学院上海巴斯德研究所 | 磷酸化途径相关因子在调控调节性t细胞功能中的应用 |
| WO2013177187A2 (en) | 2012-05-22 | 2013-11-28 | Massachusetts Institute Of Technology | Synergistic tumor treatment with extended-pk il-2 and therapeutic agents |
| US20140044675A1 (en) | 2012-08-10 | 2014-02-13 | Roche Glycart Ag | Interleukin-2 fusion proteins and uses thereof |
| CN103193879A (zh) * | 2013-02-07 | 2013-07-10 | 深圳市亚太兴实业有限公司 | 一种聚乙二醇修饰的重组人白介素2的制备方法 |
| US9580486B2 (en) | 2013-03-14 | 2017-02-28 | Amgen Inc. | Interleukin-2 muteins for the expansion of T-regulatory cells |
| WO2014145907A1 (en) | 2013-03-15 | 2014-09-18 | Xencor, Inc. | Targeting t cells with heterodimeric proteins |
| CN103193887B (zh) | 2013-04-03 | 2015-02-04 | 江苏众红生物工程创药研究院有限公司 | 一种重组猪白细胞介素2-Fc融合蛋白及其编码基因和表达方法 |
| WO2014201378A1 (en) | 2013-06-13 | 2014-12-18 | Massachusetts Institute Of Technology | Synergistic tumor treatment with extended-pk il -2 and adoptive cell therapy |
| LT3102595T (lt) | 2014-02-06 | 2019-01-25 | F. Hoffmann-La Roche Ag | Interleukino-2 sulieti baltymai ir jų panaudojimas |
| US10150802B2 (en) | 2014-04-24 | 2018-12-11 | The Board Of Trustees Of The Leland Stanford Junior University | Superagonists, partial agonists and antagonists of interleukin-2 |
| KR20150133576A (ko) | 2014-05-20 | 2015-11-30 | 삼성전자주식회사 | 화학적 개질된 표적화 단백질 및 그의 이용 |
| IL289475B2 (en) | 2014-07-21 | 2023-10-01 | Delinia Inc | Molecules that activate T cells are selectively regulated for the treatment of autoimmune diseases |
| ES2807260T3 (es) | 2014-08-11 | 2021-02-22 | Delinia Inc | Variantes de IL-2 modificadas que activan selectivamente las células T reguladoras para el tratamiento de enfermedades autoinmunes |
| WO2016025645A1 (en) | 2014-08-12 | 2016-02-18 | Massachusetts Institute Of Technology | Synergistic tumor treatment with il-2, a therapeutic antibody, and an immune checkpoint blocker |
| EP3204119B1 (en) | 2014-10-09 | 2021-06-09 | Dana-Farber Cancer Institute, Inc. | Multiple-variable il-2 dose regimen for treating immune disorders |
-
2015
- 2015-08-10 ES ES18215282T patent/ES2807260T3/es active Active
- 2015-08-10 MX MX2017000833A patent/MX2017000833A/es active IP Right Grant
- 2015-08-10 EP EP18215282.7A patent/EP3482766B1/en active Active
- 2015-08-10 SI SI201531284T patent/SI3482766T1/sl unknown
- 2015-08-10 SG SG11201700629TA patent/SG11201700629TA/en unknown
- 2015-08-10 CA CA2955006A patent/CA2955006C/en active Active
- 2015-08-10 AU AU2015301936A patent/AU2015301936B2/en active Active
- 2015-08-10 EP EP15831523.4A patent/EP3180020B1/en active Active
- 2015-08-10 HU HUE15831523A patent/HUE043038T2/hu unknown
- 2015-08-10 CN CN201580053284.3A patent/CN107106654B/zh active Active
- 2015-08-10 ES ES15831523T patent/ES2717831T3/es active Active
- 2015-08-10 HU HUE18215282A patent/HUE051414T2/hu unknown
- 2015-08-10 SI SI201530637T patent/SI3180020T1/sl unknown
- 2015-08-10 PL PL18215282T patent/PL3482766T3/pl unknown
- 2015-08-10 PL PL15831523T patent/PL3180020T3/pl unknown
- 2015-08-10 KR KR1020177001917A patent/KR20170035910A/ko not_active Application Discontinuation
- 2015-08-10 WO PCT/US2015/044462 patent/WO2016025385A1/en active Application Filing
- 2015-08-10 JP JP2017507401A patent/JP6640834B2/ja active Active
- 2015-08-10 NZ NZ728175A patent/NZ728175A/en unknown
- 2015-08-10 CN CN202110571465.2A patent/CN113234138A/zh active Pending
- 2015-08-10 EA EA201790371A patent/EA034925B1/ru active IP Right Revival
- 2015-08-10 US US15/327,813 patent/US10035836B1/en active Active
-
2017
- 2017-01-11 IL IL250059A patent/IL250059B/en active IP Right Grant
- 2017-01-17 ZA ZA2017/00381A patent/ZA201700381B/en unknown
- 2017-01-18 MX MX2020004206A patent/MX2020004206A/es unknown
-
2018
- 2018-02-26 HK HK18102706.1A patent/HK1243001A1/zh unknown
-
2019
- 2019-12-26 JP JP2019235716A patent/JP6941664B2/ja active Active
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HK1243001A1 (zh) | 選擇性地活化調節性t細胞用於治療自身免疫病的修飾的il-2變體 | |
| IL289475A (en) | Molecules that activate t cells are selectively regulated for the treatment of autoimmune diseases | |
| ZA201804458B (en) | Molecules that selectively activate regulatory t cells for the treatment of autoimmune diseases | |
| IL266178A (en) | Variants of il-2 for the treatment of autoimmune diseases | |
| HK1245827B (zh) | 受控激活或消除治療性細胞的方法 | |
| EP3227330C0 (en) | TDP-43 BINDING POLYPEPTIDES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | |
| HK1256795A1 (zh) | 可用於治療自身免疫疾病的二吡唑基衍生物 | |
| SI3122358T1 (sl) | Kombinacije FGFR- in CMET-inhibitorjev za zdravljenje raka | |
| PL3277280T3 (pl) | Izomiosmina do zastosowania w leczeniu chorób autoimmunologicznych | |
| PL3129483T3 (pl) | Terapia skojarzona do leczenia chorób autoimmunologicznych | |
| PT3122349T (pt) | Composições para o tratamento da autodigestão | |
| GB201414023D0 (en) | Treatment of autoimmune diseases | |
| GB201514909D0 (en) | Treatment of autoimmune diseases |