EA034925B1 - Модифицированные варианты il-2, которые селективно активируют регуляторные т-клетки, для лечения аутоиммунных заболеваний - Google Patents
Модифицированные варианты il-2, которые селективно активируют регуляторные т-клетки, для лечения аутоиммунных заболеваний Download PDFInfo
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- EA034925B1 EA034925B1 EA201790371A EA201790371A EA034925B1 EA 034925 B1 EA034925 B1 EA 034925B1 EA 201790371 A EA201790371 A EA 201790371A EA 201790371 A EA201790371 A EA 201790371A EA 034925 B1 EA034925 B1 EA 034925B1
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Classifications
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- C07K14/52—Cytokines; Lymphokines; Interferons
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
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- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
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Landscapes
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| PCT/US2015/044462 WO2016025385A1 (en) | 2014-08-11 | 2015-08-10 | Modified il-2 variants that selectively activate regulatory t cells for the treatment of autoimmune diseases |
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| EP3482766B1 (en) | 2014-08-11 | 2020-05-20 | Delinia, Inc. | Modified il-2 variants that selectively activate regulatory t cells for the treatment of autoimmune diseases |
| IL304950A (en) | 2015-04-10 | 2023-10-01 | Amgen Inc | Interleukin for the expansion of myotonic control T-2 cells |
| CN117659160A (zh) | 2015-09-11 | 2024-03-08 | 小利兰·斯坦福大学托管委员会 | 生物相关正交细胞因子/受体对 |
| CN116063566A (zh) | 2015-10-01 | 2023-05-05 | 热生物制品有限公司 | 作为异源嵌合蛋白邻接i型和ii型胞外结构域的组合物和方法 |
| US20170204154A1 (en) | 2016-01-20 | 2017-07-20 | Delinia, Inc. | Molecules that selectively activate regulatory t cells for the treatment of autoimmune diseases |
| KR20240115933A (ko) * | 2016-05-04 | 2024-07-26 | 암젠 인크 | T-조절 세포의 증식을 위한 인터류킨-2 뮤테인 |
| EP3465494A1 (en) * | 2016-05-25 | 2019-04-10 | Hoffmann-La Roche AG | Materials and methods relating to dosage regimen design |
| CN110167957A (zh) | 2016-11-08 | 2019-08-23 | 德里尼亚公司 | 用于治疗自身免疫疾病的il-2变体 |
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| CN110234345A (zh) | 2017-02-27 | 2019-09-13 | 沙塔克实验室有限公司 | 制备和使用基于细胞外结构域的嵌合蛋白的方法 |
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