HK1222793A1 - 用於抑制含布罗莫结构域的蛋白质的方法和组合物 - Google Patents

用於抑制含布罗莫结构域的蛋白质的方法和组合物 Download PDF

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HK1222793A1
HK1222793A1 HK16110964.3A HK16110964A HK1222793A1 HK 1222793 A1 HK1222793 A1 HK 1222793A1 HK 16110964 A HK16110964 A HK 16110964A HK 1222793 A1 HK1222793 A1 HK 1222793A1
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substituted
unsubstituted
hydrogen
compound
alkyl
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‧凡卡亞拉帕提
H‧凡卡亚拉帕提
‧吉岡
M‧吉冈
‧斯特羅唯爾
J‧W‧斯特罗唯尔
‧帕迪亞
J‧K‧帕迪亚
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康威基内有限公司
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  • Chemical & Material Sciences (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Endocrinology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychiatry (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
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  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HK16110964.3A 2013-03-14 2014-03-13 用於抑制含布罗莫结构域的蛋白质的方法和组合物 HK1222793A1 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361781988P 2013-03-14 2013-03-14
US61/781,988 2013-03-14
PCT/US2014/025289 WO2014159837A1 (en) 2013-03-14 2014-03-13 Methods and compositions for inhibition of bromodomain-containing proteins

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HK1222793A1 true HK1222793A1 (zh) 2017-07-14

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US (3) US9695179B2 (https=)
EP (1) EP2968360B1 (https=)
JP (1) JP6464139B2 (https=)
KR (1) KR20150135359A (https=)
CN (1) CN105407894A (https=)
AU (1) AU2014244426B2 (https=)
BR (1) BR112015022417A2 (https=)
CA (1) CA2905451A1 (https=)
EA (1) EA201591746A1 (https=)
HK (1) HK1222793A1 (https=)
MX (1) MX367420B (https=)
WO (1) WO2014159837A1 (https=)

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RU2640115C2 (ru) 2011-11-01 2017-12-26 Ресверлоджикс Корп. Фармацевтические композиции замещенных хиназолинонов
US9765039B2 (en) 2012-11-21 2017-09-19 Zenith Epigenetics Ltd. Biaryl derivatives as bromodomain inhibitors
US9073878B2 (en) 2012-11-21 2015-07-07 Zenith Epigenetics Corp. Cyclic amines as bromodomain inhibitors
AU2013365926B9 (en) 2012-12-21 2019-01-17 Zenith Epigenetics Ltd. Novel heterocyclic compounds as bromodomain inhibitors
JP6669499B2 (ja) 2013-02-15 2020-03-18 カラ ファーマシューティカルズ インコーポレイテッド 治療用化合物
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JP2016510000A (ja) 2013-02-20 2016-04-04 カラ ファーマシューティカルズ インコーポレイテッド 治療用化合物およびその使用
JP6464139B2 (ja) 2013-03-14 2019-02-06 コンバージーン・リミテッド・ライアビリティ・カンパニーＣｏｎｖｅｒｇｅｎｅ Ｌｌｃ ブロモドメイン含有タンパク質の阻害のための方法および組成物
MX366703B (es) 2013-03-15 2019-07-22 Incyte Holdings Corp Heterociclos tricíclicos como inhibidores de la proteína bet.
US9745319B2 (en) 2013-03-15 2017-08-29 Araxes Pharma Llc Irreversible covalent inhibitors of the GTPase K-Ras G12C
UY35464A (es) 2013-03-15 2014-10-31 Araxes Pharma Llc Inhibidores covalentes de kras g12c.
CN105102452B (zh) * 2013-04-26 2018-01-26 百济神州有限公司 取代的5‑(3,5‑二甲基异噁唑‑4‑基)二氢吲哚‑2‑酮类衍生物
EA027139B1 (ru) 2013-04-26 2017-06-30 Бейджин, Лтд. Замещенные 5-(3,5-диметилизоксазол-4-ил)индолин-2-оны
EP3010918B1 (en) 2013-06-21 2018-08-15 Zenith Epigenetics Ltd. Novel substituted bicyclic compounds as bromodomain inhibitors
CA2915838C (en) 2013-06-21 2023-04-18 Zenith Epigenetics Corp. Bicyclic bromodomain inhibitors
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