HK1211177A1 - Cloned non-human animals free of selective markers - Google Patents

Cloned non-human animals free of selective markers Download PDF

Info

Publication number
HK1211177A1
HK1211177A1 HK15112184.4A HK15112184A HK1211177A1 HK 1211177 A1 HK1211177 A1 HK 1211177A1 HK 15112184 A HK15112184 A HK 15112184A HK 1211177 A1 HK1211177 A1 HK 1211177A1
Authority
HK
Hong Kong
Prior art keywords
genetically modified
recombinase
human animal
somatic cells
free
Prior art date
Application number
HK15112184.4A
Other languages
English (en)
Chinese (zh)
Inventor
‧龔
G‧C‧龚
‧萊
K‧V‧莱
‧瓦倫澤拉
D‧M‧瓦伦泽拉
Original Assignee
瑞泽恩制药公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49725406&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1211177(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 瑞泽恩制药公司 filed Critical 瑞泽恩制药公司
Publication of HK1211177A1 publication Critical patent/HK1211177A1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0273—Cloned vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D19/00—Instruments or methods for reproduction or fertilisation
    • A61D19/04—Instruments or methods for reproduction or fertilisation for embryo transplantation
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/873—Techniques for producing new embryos, e.g. nuclear transfer, manipulation of totipotent cells or production of chimeric embryos
    • C12N15/877—Techniques for producing new mammalian cloned embryos
    • C12N15/8771—Bovine embryos
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/873—Techniques for producing new embryos, e.g. nuclear transfer, manipulation of totipotent cells or production of chimeric embryos
    • C12N15/877—Techniques for producing new mammalian cloned embryos
    • C12N15/8778—Swine embryos
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/20—Animal model comprising regulated expression system
    • A01K2217/203—Animal model comprising inducible/conditional expression system, e.g. hormones, tet
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/01—Animal expressing industrially exogenous proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/007—Vectors comprising a special translation-regulating system cell or tissue specific
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2999/00—Further aspects of viruses or vectors not covered by groups C12N2710/00 - C12N2796/00 or C12N2800/00
    • C12N2999/007—Technological advancements, e.g. new system for producing known virus, cre-lox system for production of transgenic animals

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Environmental Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Wood Science & Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Developmental Biology & Embryology (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Transplantation (AREA)
  • Reproductive Health (AREA)
  • Public Health (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
HK15112184.4A 2012-11-28 2013-11-26 Cloned non-human animals free of selective markers HK1211177A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261730771P 2012-11-28 2012-11-28
US61/730,771 2012-11-28
PCT/US2013/072088 WO2014085501A1 (en) 2012-11-28 2013-11-26 Cloned non-human animals free of selective markers

Publications (1)

Publication Number Publication Date
HK1211177A1 true HK1211177A1 (en) 2016-05-20

Family

ID=49725406

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15112184.4A HK1211177A1 (en) 2012-11-28 2013-11-26 Cloned non-human animals free of selective markers

Country Status (16)

Country Link
US (1) US20140221734A1 (enExample)
EP (1) EP2925122A1 (enExample)
JP (2) JP6154479B2 (enExample)
KR (1) KR20150089004A (enExample)
CN (1) CN104918484A (enExample)
AU (1) AU2013352235A1 (enExample)
BR (1) BR112015012408A2 (enExample)
CA (1) CA2891163A1 (enExample)
HK (1) HK1211177A1 (enExample)
IL (1) IL238771A0 (enExample)
MX (1) MX353279B (enExample)
MY (1) MY193790A (enExample)
RU (1) RU2015122802A (enExample)
SG (1) SG11201503752SA (enExample)
WO (1) WO2014085501A1 (enExample)
ZA (1) ZA201503305B (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2844174T3 (es) 2013-09-18 2021-07-21 Kymab Ltd Métodos, células y organismos
US11246299B2 (en) 2015-03-04 2022-02-15 Pormedtec Co., Ltd. Disease model pig exhibiting stable phenotype, and production method thereof
CN105200086A (zh) * 2015-10-22 2015-12-30 中国农业科学院北京畜牧兽医研究所 一种无选择标记的多基因复合性状基因工程猪的制备方法
ES2953925T3 (es) * 2015-11-04 2023-11-17 Fate Therapeutics Inc Ingeniería genómica de células pluripotentes
CA3099441A1 (en) * 2018-06-13 2019-12-19 Regeneron Pharmaceuticals, Inc. A rodent model of fibrodysplasia ossificans progressiva
CN109504708A (zh) * 2018-12-03 2019-03-22 江苏集萃药康生物科技有限公司 一种筛选标记自我删除的基因打靶载体及方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1375654A3 (en) * 1998-11-02 2008-01-16 GTC Biotherapeutics, Inc. Transgenic and cloned mammals
US7049480B1 (en) * 2000-09-01 2006-05-23 Avigenics, Inc. Methods of enucleating an avian oocyte or zygote using two-photon laser scanning microscopy
JPWO2006035741A1 (ja) * 2004-09-29 2008-05-15 伸弥 山中 Ｅｓ細胞特異的発現遺伝子及びその利用
WO2009121999A1 (es) * 2008-04-04 2009-10-08 Consejo Superior De Investigaciones Científicas Promotor especifico de celulas troncales
WO2011020005A1 (en) * 2009-08-14 2011-02-17 Regeneron Pharmaceuticals, Inc. miRNA-REGULATED DIFFERENTIATION-DEPENDENT SELF-DELETING CASSETTE
CN102628061A (zh) * 2012-04-09 2012-08-08 西北农林科技大学 一种hbd3 乳腺特异性表达载体及构建的重组细胞

Also Published As

Publication number Publication date
JP2016502407A (ja) 2016-01-28
ZA201503305B (en) 2016-05-25
AU2013352235A1 (en) 2015-05-28
KR20150089004A (ko) 2015-08-04
JP6154479B2 (ja) 2017-06-28
CN104918484A (zh) 2015-09-16
IL238771A0 (en) 2015-06-30
WO2014085501A1 (en) 2014-06-05
MX2015006810A (es) 2015-09-07
RU2015122802A (ru) 2017-01-10
SG11201503752SA (en) 2015-06-29
JP6227747B2 (ja) 2017-11-08
MY193790A (en) 2022-10-27
EP2925122A1 (en) 2015-10-07
US20140221734A1 (en) 2014-08-07
CA2891163A1 (en) 2014-06-05
MX353279B (es) 2018-01-05
BR112015012408A2 (pt) 2017-07-11
JP2017060502A (ja) 2017-03-30

Similar Documents

Publication Publication Date Title
HK1211177A1 (en) Cloned non-human animals free of selective markers
MX353134B (es) Ratones con receptor de linfocitos t modificados geneticamente.
WO2012158986A3 (en) Methods for site-specific genetic modification in stem cells using xanthomonas tal nucleases (xtn) for the creation of model organisms
WO2015200805A3 (en) Methods and compositions for targeted genetic modifications and methods of use
MX2021014368A (es) Metodos y composiciones para la modificacion dirigida de un genoma.
Jena et al. Handmade cloned and parthenogenetic goat embryos–A comparison of different culture media and donor cells
JP2013176400A5 (enExample)
JP2016529904A5 (enExample)
SG10201808935WA (en) Targeted modification of rat genome
JP2015533284A5 (enExample)
PH12014502574A1 (en) Methods and compositions for rna-directed target dna modification and for rna-directed modulation of transcription
WO2012071393A3 (en) Method for producing pluripotent stem cells
HK1256687A1 (zh) 对用於产生能生育的 xy 雌性小鼠的多能细胞的选择
JP2016502407A5 (enExample)
IL307495B1 (en) Preparations and methods for producing genetically modified animals
PH12017501589A1 (en) Etv2 and uses thereof
WO2012029784A1 (ja) マウス系統を樹立する方法
JP2018506984A5 (enExample)
MX2018000071A (es) Musculo cardiaco humanizado.
WO2009088189A3 (ko) 형질전환된 복제개의 생산방법
EP4349980A3 (en) Methods and compositions for the targeted modification of a genome
Shah et al. tem Cell and Cloning Research in Farm Animals: A Special Focus on Buffalo.
Riaz et al. Therapeutic cloning by xenotransplanted oocytes, supplemented with species specific reprogramming factors
Park et al. In Vitro Production of Human Erythropoietin (hEPO) Transgenic Bovine Embryos by Somatic Cell Nuclear Transfer
CN101434949A (zh) 克隆和转基因动物的生产方法