JP2013176400A5 - - Google Patents
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- Publication number
- JP2013176400A5 JP2013176400A5 JP2013127052A JP2013127052A JP2013176400A5 JP 2013176400 A5 JP2013176400 A5 JP 2013176400A5 JP 2013127052 A JP2013127052 A JP 2013127052A JP 2013127052 A JP2013127052 A JP 2013127052A JP 2013176400 A5 JP2013176400 A5 JP 2013176400A5
- Authority
- JP
- Japan
- Prior art keywords
- rat
- pluripotent
- cell
- cells
- culture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000004027 cell Anatomy 0.000 claims 52
- 238000000034 method Methods 0.000 claims 17
- 101100257359 Caenorhabditis elegans sox-2 gene Proteins 0.000 claims 8
- 101100257363 Mus musculus Sox2 gene Proteins 0.000 claims 8
- 102100028072 Fibroblast growth factor 4 Human genes 0.000 claims 6
- 101001060274 Homo sapiens Fibroblast growth factor 4 Proteins 0.000 claims 6
- 210000004602 germ cell Anatomy 0.000 claims 6
- 102000001267 GSK3 Human genes 0.000 claims 5
- 108060006662 GSK3 Proteins 0.000 claims 5
- 239000003112 inhibitor Substances 0.000 claims 5
- 239000002829 mitogen activated protein kinase inhibitor Substances 0.000 claims 5
- NFVJNJQRWPQVOA-UHFFFAOYSA-N n-[2-chloro-5-(trifluoromethyl)phenyl]-2-[3-(4-ethyl-5-ethylsulfanyl-1,2,4-triazol-3-yl)piperidin-1-yl]acetamide Chemical compound CCN1C(SCC)=NN=C1C1CN(CC(=O)NC=2C(=CC=C(C=2)C(F)(F)F)Cl)CCC1 NFVJNJQRWPQVOA-UHFFFAOYSA-N 0.000 claims 5
- 108090000623 proteins and genes Proteins 0.000 claims 5
- 229940124647 MEK inhibitor Drugs 0.000 claims 4
- 102000002260 Alkaline Phosphatase Human genes 0.000 claims 3
- 108020004774 Alkaline Phosphatase Proteins 0.000 claims 3
- 108091008794 FGF receptors Proteins 0.000 claims 3
- 102000044168 Fibroblast Growth Factor Receptor Human genes 0.000 claims 3
- 101000881866 Homo sapiens Developmental pluripotency-associated protein 3 Proteins 0.000 claims 3
- 101710126211 POU domain, class 5, transcription factor 1 Proteins 0.000 claims 3
- 101710150336 Protein Rex Proteins 0.000 claims 3
- 241000862969 Stella Species 0.000 claims 3
- 210000002459 blastocyst Anatomy 0.000 claims 3
- 238000012239 gene modification Methods 0.000 claims 3
- 230000005017 genetic modification Effects 0.000 claims 3
- 235000013617 genetically modified food Nutrition 0.000 claims 3
- 102100028073 Fibroblast growth factor 5 Human genes 0.000 claims 2
- 101001060267 Homo sapiens Fibroblast growth factor 5 Proteins 0.000 claims 2
- 206010043276 Teratoma Diseases 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 2
- 210000001654 germ layer Anatomy 0.000 claims 2
- 239000001963 growth medium Substances 0.000 claims 2
- 230000035755 proliferation Effects 0.000 claims 2
- 239000002464 receptor antagonist Substances 0.000 claims 2
- 229940044551 receptor antagonist Drugs 0.000 claims 2
- 208000001608 teratocarcinoma Diseases 0.000 claims 2
- 102000018918 Activin Receptors Human genes 0.000 claims 1
- 108010052946 Activin Receptors Proteins 0.000 claims 1
- 102000005606 Activins Human genes 0.000 claims 1
- 108010059616 Activins Proteins 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 239000000488 activin Substances 0.000 claims 1
- 239000005557 antagonist Substances 0.000 claims 1
- 238000004113 cell culture Methods 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 238000003780 insertion Methods 0.000 claims 1
- 230000037431 insertion Effects 0.000 claims 1
- 210000001161 mammalian embryo Anatomy 0.000 claims 1
- 230000000644 propagated effect Effects 0.000 claims 1
- 230000001902 propagating effect Effects 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0615327.4 | 2006-08-01 | ||
| GBGB0615327.4A GB0615327D0 (en) | 2006-03-30 | 2006-08-01 | Culture medium containing kinase inhibitors and uses thereof |
| GBGB0700479.9A GB0700479D0 (en) | 2006-08-01 | 2007-01-10 | Culture medium containing kinase inhibitors, and uses thereof |
| GB0700479.9 | 2007-01-10 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009522328A Division JP5456467B2 (ja) | 2006-08-01 | 2007-08-01 | ラットおよび他種由来の多能性細胞 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013176400A JP2013176400A (ja) | 2013-09-09 |
| JP2013176400A5 true JP2013176400A5 (enExample) | 2014-01-09 |
Family
ID=37809760
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009522328A Expired - Fee Related JP5456467B2 (ja) | 2006-08-01 | 2007-08-01 | ラットおよび他種由来の多能性細胞 |
| JP2013127052A Pending JP2013176400A (ja) | 2006-08-01 | 2013-06-17 | ラットおよび他種由来の多能性細胞 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009522328A Expired - Fee Related JP5456467B2 (ja) | 2006-08-01 | 2007-08-01 | ラットおよび他種由来の多能性細胞 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US8431395B2 (enExample) |
| EP (1) | EP2049654A2 (enExample) |
| JP (2) | JP5456467B2 (enExample) |
| CN (2) | CN101657535B (enExample) |
| AU (1) | AU2007280216B2 (enExample) |
| GB (3) | GB0615327D0 (enExample) |
| WO (1) | WO2008015418A2 (enExample) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7682828B2 (en) | 2003-11-26 | 2010-03-23 | Whitehead Institute For Biomedical Research | Methods for reprogramming somatic cells |
| US8357666B2 (en) * | 2005-08-01 | 2013-01-22 | Nupotential, Inc. | Reprogramming a cell by inducing a pluripotent gene through RNA interference |
| US9074180B2 (en) * | 2006-03-30 | 2015-07-07 | The University Court Of The University Of Edinburgh | Culture medium containing kinase inhibitors, and uses thereof |
| CN105861443A (zh) * | 2007-04-07 | 2016-08-17 | 怀特黑德生物医学研究所 | 体细胞重编程 |
| US9080145B2 (en) | 2007-07-01 | 2015-07-14 | Lifescan Corporation | Single pluripotent stem cell culture |
| EP2198012B1 (en) * | 2007-07-18 | 2014-12-31 | Cellartis AB | Cardiomyocyte-like cell clusters derived from hbs cells |
| CA3114827C (en) | 2007-07-31 | 2023-09-05 | Lifescan, Inc. | Differentiation of human embryonic stem cells to pancreatic endocrine |
| EP3078738B1 (en) | 2007-08-31 | 2020-05-20 | Whitehead Institute for Biomedical Research | Wnt pathway stimulation in reprogramming somatic cells |
| ES2690554T3 (es) * | 2008-03-17 | 2018-11-21 | The Scripps Research Institute | Enfoques químicos y genéticos combinados para la generación de células madre pluripotentes inducidas |
| AU2009234423A1 (en) * | 2008-04-07 | 2009-10-15 | Nupotential, Inc. | Reprogramming a cell by inducing a pluripotent gene through RNA interference |
| CN105671065A (zh) | 2008-06-13 | 2016-06-15 | 怀特黑德生物医学研究所 | 细胞编程和重编程 |
| AU2009267137A1 (en) | 2008-06-30 | 2010-01-07 | Centocor Ortho Biotech Inc. | Differentiation of pluripotent stem cells |
| US8735156B2 (en) | 2008-12-01 | 2014-05-27 | The Board Of Regents Of The University Of Texas System | Production and use of rat spermatogonial stem cell lines |
| ES2645869T3 (es) * | 2008-12-17 | 2017-12-11 | The Scripps Research Institute | Generación y mantenimiento de células madre |
| US20110088107A1 (en) * | 2009-04-24 | 2011-04-14 | Yaqub Hanna | Compositions and methods for deriving or culturing pluripotent cells |
| ES2638464T3 (es) * | 2009-10-16 | 2017-10-20 | The Scripps Research Institute | Inducción de células pluripotentes |
| CN102762717A (zh) * | 2009-12-01 | 2012-10-31 | 日本国立癌症研究中心 | 使用大鼠胚胎干细胞构建嵌合大鼠的方法 |
| WO2011081222A1 (ja) * | 2009-12-29 | 2011-07-07 | 武田薬品工業株式会社 | 膵ホルモン産生細胞の製造法 |
| AU2011235212B2 (en) | 2010-03-31 | 2014-07-31 | The Scripps Research Institute | Reprogramming cells |
| JPWO2011125948A1 (ja) * | 2010-04-02 | 2013-07-11 | 独立行政法人理化学研究所 | Ｅｓ細胞の製造方法 |
| EP3399026B1 (en) | 2010-06-14 | 2024-06-26 | The Scripps Research Institute | Reprogramming of cells to a new fate |
| CN102344490B (zh) * | 2010-07-30 | 2014-03-05 | 中国科学院上海生命科学研究院 | 抗小鼠Stk40的多克隆抗体及其制备 |
| WO2012020845A1 (ja) * | 2010-08-09 | 2012-02-16 | 武田薬品工業株式会社 | 膵ホルモン産生細胞の製造法 |
| US10214722B2 (en) * | 2010-09-07 | 2019-02-26 | Technion Research & Development Foundation Limited | Methods for expanding and maintaining human pluripotent stem cells (PSCs) in an undifferentiated state in a single cell suspension culture |
| JP6090855B2 (ja) * | 2010-11-17 | 2017-03-08 | 国立大学法人京都大学 | 心筋細胞および／または心筋前駆細胞増殖剤ならびに心筋細胞および／または心筋前駆細胞の増殖方法 |
| CN106893692B (zh) | 2010-12-22 | 2021-11-26 | 菲特治疗公司 | 用于单细胞分选与增强ipsc重新编程的细胞培养平台 |
| EP2668286A4 (en) * | 2011-01-24 | 2015-07-01 | Univ Ben Gurion | METHOD FOR EVALUATING A MENTAL DISEASE |
| ES2902650T3 (es) | 2011-06-21 | 2022-03-29 | Novo Nordisk As | Inducción eficiente de endodermo definitivo a partir de células madre pluripotentes |
| HUE068728T2 (hu) | 2011-08-05 | 2025-01-28 | Regeneron Pharma | Humanizált univerzális könnyûláncú egerek |
| MX378871B (es) | 2011-12-20 | 2025-03-10 | Regeneron Pharma | Ratones con cadena ligera humanizada. |
| JP6275120B2 (ja) | 2012-04-25 | 2018-02-07 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | 大きい標的化ベクターによるヌクレアーゼ媒介標的化 |
| JP6475172B2 (ja) | 2013-02-20 | 2019-02-27 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | ラットの遺伝子組換え |
| EP3456831B1 (en) | 2013-04-16 | 2021-07-14 | Regeneron Pharmaceuticals, Inc. | Targeted modification of rat genome |
| WO2014197934A1 (en) | 2013-06-14 | 2014-12-18 | The University Of Queensland | Renal progenitor cells |
| MX388127B (es) | 2013-12-11 | 2025-03-19 | Regeneron Pharma | Metodos y composiciones para la modificacion dirigida de un genoma. |
| SG10201807292YA (en) | 2014-03-04 | 2018-09-27 | Fate Therapeutics Inc | Improved reprogramming methods and cell culture platforms |
| WO2015155738A2 (en) | 2014-04-09 | 2015-10-15 | Christopher Rudd | Use of gsk-3 inhibitors or activators which modulate pd-1 or t-bet expression to modulate t cell immunity |
| JP6652334B2 (ja) | 2014-05-31 | 2020-02-19 | Ｊｃｒファーマ株式会社 | ウリジンとｎ−アセチル−ｄ−マンノサミンとを含有する培地 |
| BR112016028564A2 (pt) | 2014-06-06 | 2018-01-30 | Regeneron Pharma | método para modificar um locus-alvo em uma célula. |
| SG10201911411YA (en) | 2014-06-26 | 2020-02-27 | Regeneron Pharma | Methods and compositions for targeted genetic modifications and methods of use |
| CA3176380A1 (en) | 2014-11-21 | 2016-05-26 | Regeneron Pharmaceuticals, Inc. | Methods and compositions for targeted genetic modification using paired guide rnas |
| BR112017013104A2 (pt) | 2014-12-19 | 2018-05-15 | Regeneron Pharma | métodos para modificar um locus genômico alvo em uma célula, para intensificar a recombinação homóloga em um locus genômico alvo em uma célula e para produzir uma geração f0 de um animal não humano. |
| CA2981277A1 (en) * | 2015-03-30 | 2016-10-06 | Ajinomoto Co., Inc. | Human serum albumin-containing culture medium for growth of neural stem cells |
| AU2016338680B2 (en) | 2015-10-16 | 2022-11-17 | Fate Therapeutics, Inc. | Platform for the induction and maintenance of ground state pluripotency |
| MA45479A (fr) | 2016-04-14 | 2019-02-20 | Janssen Biotech Inc | Différenciation de cellules souches pluripotentes en cellules de l'endoderme de l'intestin moyen |
| JP2019537729A (ja) | 2016-09-28 | 2019-12-26 | オルガノボ インコーポレイテッド | アッセイにおける人工腎臓組織の使用 |
| WO2019208787A1 (ja) * | 2018-04-27 | 2019-10-31 | 株式会社カネカ | 原始腸管細胞の製造方法 |
| SG11202104941YA (en) * | 2018-11-21 | 2021-06-29 | Agency Science Tech & Res | Generation of mature kupffer cells |
| CN111238897B (zh) * | 2020-02-18 | 2023-03-28 | 上海市皮肤病医院 | 生物标本的处理方法与处理剂 |
| CN116096860A (zh) * | 2020-07-02 | 2023-05-09 | 阿塞尔塔有限公司 | 来自延迟胚胎的哺乳动物牲畜多能干细胞系 |
| EP4386082A4 (en) * | 2021-08-10 | 2025-08-20 | Kaneka Corp | PROCESS FOR THE PRODUCTION OF PLURIPOTENT STEM CELLS |
| CN115927166A (zh) * | 2022-12-06 | 2023-04-07 | 云南省第一人民医院 | 一种大鼠原始内胚层干细胞分离建系的方法 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9308271D0 (en) | 1993-04-21 | 1993-06-02 | Univ Edinburgh | Method of isolating and/or enriching and/or selectively propagating pluripotential animal cells and animals for use in said method |
| WO1995006716A1 (en) | 1993-08-30 | 1995-03-09 | Northwestern University | Rat pluripotent embryonic stem cells and method of obtaining and using same |
| EP0941310A1 (en) | 1996-10-11 | 1999-09-15 | THE TEXAS A&M UNIVERSITY SYSTEM | Methods for the generation of primordial germ cells and transgenic animal species |
| US6214795B1 (en) * | 1996-11-12 | 2001-04-10 | Praecis Pharmaceuticals, Inc. | Peptide compounds useful for modulating FGF receptor activity |
| EP0986635A4 (en) | 1997-01-10 | 2001-11-07 | Life Technologies Inc | SERUM SUBSTITUTE FOR EMBRYONIC STEM CELLS |
| WO1999027076A1 (en) * | 1997-11-25 | 1999-06-03 | Arc Genomic Research | Pluripotent embryonic stem cells and methods of obtaining them |
| GB9819912D0 (en) | 1998-09-11 | 1998-11-04 | Univ Edinburgh | Propagation and/or derivation of embryonic stem cells |
| US7455983B2 (en) * | 2000-01-11 | 2008-11-25 | Geron Corporation | Medium for growing human embryonic stem cells |
| US20020045260A1 (en) * | 2000-10-17 | 2002-04-18 | Shih-Chieh Hung | Method of isolating mesenchymal stem cells |
| JP2002176973A (ja) | 2000-12-14 | 2002-06-25 | Shigeo Saito | 哺乳動物胚性幹細胞とその樹立方法並びにその継代培養方法 |
| DE60301953T2 (de) | 2002-03-05 | 2006-07-27 | Artemis Pharmaceuticals Gmbh | Durch inzucht erzeugte von embryonalen stammzellen abgeleitete mäuse |
| GB0210539D0 (en) | 2002-05-08 | 2002-06-19 | Univ Edinburgh | Control of es cell self renewal and lineage specification, and medium therefor |
| US7338957B2 (en) | 2003-08-28 | 2008-03-04 | Irm Llc | Compounds and compositions as protein kinase inhibitors |
| KR101221302B1 (ko) * | 2003-12-23 | 2013-01-11 | 비아싸이트, 인크. | 완전 내배엽 |
| KR101386690B1 (ko) | 2004-03-04 | 2014-04-22 | 도쿠리츠교세이호진 고쿠리츠간켄큐센터 | 래트 배아 줄기 세포 |
| JP2007530654A (ja) | 2004-03-30 | 2007-11-01 | ファイザー・プロダクツ・インク | シグナル伝達阻害剤の組合せ |
| WO2005110438A2 (en) * | 2004-04-15 | 2005-11-24 | Massachusetts Institute Of Technology | Methods and products related to the intracellular delivery of polysaccharides |
| US20080268533A1 (en) | 2004-08-25 | 2008-10-30 | University Of Georgia Research Foundation, Inc. | Methods and Compositions Utilizing Myc and Gsk3Beta to Manipulate the Pluripotency of Embryonic Stem Cells |
| MX2007015610A (es) | 2005-06-10 | 2008-02-21 | Irm Llc | Compuestos que mantienen la fluripotencia de las celulas totipotentes embrionarias. |
| US20070128669A1 (en) | 2005-11-28 | 2007-06-07 | Institute For Chemical Genomics | Serum-free expansion of cells in culture |
| US9074180B2 (en) | 2006-03-30 | 2015-07-07 | The University Court Of The University Of Edinburgh | Culture medium containing kinase inhibitors, and uses thereof |
| US20090281418A1 (en) * | 2006-04-03 | 2009-11-12 | Koninklijke Philips Electomics N.V. | Determining tissue surrounding an object being inserted into a patient |
| EP2018167A4 (en) | 2006-05-15 | 2010-07-14 | Irm Llc | COMPOSITIONS AND METHODS AS INHIBITORS OF FGF RECEPTOR KINASES |
-
2006
- 2006-08-01 GB GBGB0615327.4A patent/GB0615327D0/en not_active Ceased
-
2007
- 2007-01-10 GB GBGB0700479.9A patent/GB0700479D0/en not_active Ceased
- 2007-08-01 AU AU2007280216A patent/AU2007280216B2/en not_active Ceased
- 2007-08-01 WO PCT/GB2007/002913 patent/WO2008015418A2/en not_active Ceased
- 2007-08-01 US US11/832,317 patent/US8431395B2/en not_active Expired - Fee Related
- 2007-08-01 CN CN200780036720.1A patent/CN101657535B/zh not_active Expired - Fee Related
- 2007-08-01 GB GB0716426A patent/GB2451523B/en not_active Expired - Fee Related
- 2007-08-01 JP JP2009522328A patent/JP5456467B2/ja not_active Expired - Fee Related
- 2007-08-01 CN CN201410720584.XA patent/CN104531610A/zh active Pending
- 2007-08-01 EP EP07766403A patent/EP2049654A2/en not_active Withdrawn
-
2013
- 2013-04-05 US US13/857,449 patent/US20130333058A1/en not_active Abandoned
- 2013-06-17 JP JP2013127052A patent/JP2013176400A/ja active Pending
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