GB0615327D0 - Culture medium containing kinase inhibitors and uses thereof - Google Patents
Culture medium containing kinase inhibitors and uses thereofInfo
- Publication number
- GB0615327D0 GB0615327D0 GBGB0615327.4A GB0615327A GB0615327D0 GB 0615327 D0 GB0615327 D0 GB 0615327D0 GB 0615327 A GB0615327 A GB 0615327A GB 0615327 D0 GB0615327 D0 GB 0615327D0
- Authority
- GB
- United Kingdom
- Prior art keywords
- culture medium
- medium containing
- kinase inhibitors
- containing kinase
- inhibitor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 239000001963 growth medium Substances 0.000 title 1
- 229940043355 kinase inhibitor Drugs 0.000 title 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 title 1
- 108091008794 FGF receptors Proteins 0.000 abstract 1
- 102000044168 Fibroblast Growth Factor Receptor Human genes 0.000 abstract 1
- 102000001267 GSK3 Human genes 0.000 abstract 1
- 108060006662 GSK3 Proteins 0.000 abstract 1
- 229940124647 MEK inhibitor Drugs 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000002829 mitogen activated protein kinase inhibitor Substances 0.000 abstract 1
- NFVJNJQRWPQVOA-UHFFFAOYSA-N n-[2-chloro-5-(trifluoromethyl)phenyl]-2-[3-(4-ethyl-5-ethylsulfanyl-1,2,4-triazol-3-yl)piperidin-1-yl]acetamide Chemical compound CCN1C(SCC)=NN=C1C1CN(CC(=O)NC=2C(=CC=C(C=2)C(F)(F)F)Cl)CCC1 NFVJNJQRWPQVOA-UHFFFAOYSA-N 0.000 abstract 1
- 239000004017 serum-free culture medium Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
- A61K49/0008—Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0273—Cloned vertebrates
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0603—Embryonic cells ; Embryoid bodies
- C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/101—Bovine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/103—Ovine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/108—Swine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/16—Activin; Inhibin; Mullerian inhibiting substance
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/235—Leukemia inhibitory factor [LIF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/70—Enzymes
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Environmental Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Reproductive Health (AREA)
- Chemical & Material Sciences (AREA)
- Gynecology & Obstetrics (AREA)
- Developmental Biology & Embryology (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Biodiversity & Conservation Biology (AREA)
- Animal Husbandry (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pathology (AREA)
- Rheumatology (AREA)
- Toxicology (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Priority Applications (25)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0615327.4A GB0615327D0 (en) | 2006-03-30 | 2006-08-01 | Culture medium containing kinase inhibitors and uses thereof |
| GBGB0700479.9A GB0700479D0 (en) | 2006-08-01 | 2007-01-10 | Culture medium containing kinase inhibitors, and uses thereof |
| AU2007232393A AU2007232393A1 (en) | 2006-03-30 | 2007-03-30 | Culture medium containing kinase inhibitors. and uses thereof |
| TW096111227A TW200815597A (en) | 2006-03-30 | 2007-03-30 | Culture medium containing kinase inhibitors, and uses thereof |
| EP07732217A EP1999249B8 (en) | 2006-03-30 | 2007-03-30 | Culture medium containing kinase inhibitors. and uses thereof |
| PCT/GB2007/001163 WO2007113505A2 (en) | 2006-03-30 | 2007-03-30 | Culture medium containing kinase inhibitors. and uses thereof |
| AT07732217T ATE530637T1 (de) | 2006-03-30 | 2007-03-30 | Kulturmedium mit kinasehemmern und verwendung |
| GB0706239A GB2436737B (en) | 2006-03-30 | 2007-03-30 | Culture medium containing kinase inhibitors,and uses thereof |
| JP2009502219A JP5680850B2 (ja) | 2006-03-30 | 2007-03-30 | キナーゼインヒビターを含む培養培地およびその使用 |
| US11/694,351 US9074180B2 (en) | 2006-03-30 | 2007-03-30 | Culture medium containing kinase inhibitors, and uses thereof |
| CA002645170A CA2645170A1 (en) | 2006-03-30 | 2007-03-30 | Culture medium containing kinase inhibitors, and uses thereof |
| EP11182239A EP2457995A1 (en) | 2006-03-30 | 2007-03-30 | Culture medium containing kinase inhibitors, and uses thereof |
| PCT/GB2007/002913 WO2008015418A2 (en) | 2006-08-01 | 2007-08-01 | Pluripotent cells from rat and other species |
| CN200780036720.1A CN101657535B (zh) | 2006-08-01 | 2007-08-01 | 源于大鼠及其它动物的多潜能细胞 |
| EP07766403A EP2049654A2 (en) | 2006-08-01 | 2007-08-01 | Pluripotent cells from rat and other species |
| GB0716426A GB2451523B (en) | 2006-08-01 | 2007-08-01 | Pluripotent cells from rat and other species |
| CN201410720584.XA CN104531610A (zh) | 2006-08-01 | 2007-08-01 | 源于大鼠及其它动物的多潜能细胞 |
| AU2007280216A AU2007280216B2 (en) | 2006-08-01 | 2007-08-01 | Pluripotent cells from rat and other species |
| US11/832,317 US8431395B2 (en) | 2006-08-01 | 2007-08-01 | Pluripotent cells from rat and other species |
| JP2009522328A JP5456467B2 (ja) | 2006-08-01 | 2007-08-01 | ラットおよび他種由来の多能性細胞 |
| IL193495A IL193495A0 (en) | 2006-03-30 | 2008-08-17 | Culture medium containing kinase inhibitors and uses thereof |
| US12/581,981 US20100041137A1 (en) | 2006-03-30 | 2009-10-20 | Culture medium containing kinase inhibitors, and uses thereof |
| JP2013011454A JP5728036B2 (ja) | 2006-03-30 | 2013-01-24 | キナーゼインヒビターを含む培養培地およびその使用 |
| US13/857,449 US20130333058A1 (en) | 2006-08-01 | 2013-04-05 | Pluripotent Cells From Rat and Other Species |
| JP2013127052A JP2013176400A (ja) | 2006-08-01 | 2013-06-17 | ラットおよび他種由来の多能性細胞 |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0606392.9A GB0606392D0 (en) | 2006-03-30 | 2006-03-30 | Culture medium containing kinase inhibitors, and uses thereof |
| GBGB0615327.4A GB0615327D0 (en) | 2006-03-30 | 2006-08-01 | Culture medium containing kinase inhibitors and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB0615327D0 true GB0615327D0 (en) | 2006-09-13 |
Family
ID=37809760
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GBGB0615327.4A Ceased GB0615327D0 (en) | 2006-03-30 | 2006-08-01 | Culture medium containing kinase inhibitors and uses thereof |
| GBGB0700479.9A Ceased GB0700479D0 (en) | 2006-08-01 | 2007-01-10 | Culture medium containing kinase inhibitors, and uses thereof |
| GB0716426A Expired - Fee Related GB2451523B (en) | 2006-08-01 | 2007-08-01 | Pluripotent cells from rat and other species |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GBGB0700479.9A Ceased GB0700479D0 (en) | 2006-08-01 | 2007-01-10 | Culture medium containing kinase inhibitors, and uses thereof |
| GB0716426A Expired - Fee Related GB2451523B (en) | 2006-08-01 | 2007-08-01 | Pluripotent cells from rat and other species |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US8431395B2 (enExample) |
| EP (1) | EP2049654A2 (enExample) |
| JP (2) | JP5456467B2 (enExample) |
| CN (2) | CN104531610A (enExample) |
| AU (1) | AU2007280216B2 (enExample) |
| GB (3) | GB0615327D0 (enExample) |
| WO (1) | WO2008015418A2 (enExample) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7682828B2 (en) * | 2003-11-26 | 2010-03-23 | Whitehead Institute For Biomedical Research | Methods for reprogramming somatic cells |
| US8357666B2 (en) * | 2005-08-01 | 2013-01-22 | Nupotential, Inc. | Reprogramming a cell by inducing a pluripotent gene through RNA interference |
| WO2007113505A2 (en) * | 2006-03-30 | 2007-10-11 | The University Court Of The University Of Edinburgh | Culture medium containing kinase inhibitors. and uses thereof |
| MX348010B (es) | 2007-04-07 | 2017-05-23 | Whitehead Inst Biomedical Res | Reprogramacion de celulas somaticas. |
| US9080145B2 (en) | 2007-07-01 | 2015-07-14 | Lifescan Corporation | Single pluripotent stem cell culture |
| CN101918541A (zh) * | 2007-07-18 | 2010-12-15 | 塞拉提斯股份公司 | 衍生自hBS细胞的心肌细胞样细胞簇 |
| RU2473685C2 (ru) | 2007-07-31 | 2013-01-27 | Лайфскен, Инк. | Дифференцировка человеческих эмбриональных стволовых клеток |
| WO2009032194A1 (en) | 2007-08-31 | 2009-03-12 | Whitehead Institute For Biomedical Research | Wnt pathway stimulation in reprogramming somatic cells |
| JP5951254B2 (ja) * | 2008-03-17 | 2016-07-13 | ザ スクリプス リサーチ インスティテュート | 人工多能性幹細胞を作製するための化学的手法と遺伝的手法の組み合わせ法 |
| CN102083982A (zh) * | 2008-04-07 | 2011-06-01 | 纽珀滕索有限公司 | 通过rna干扰引入复能基因而重编程细胞 |
| WO2009152529A2 (en) | 2008-06-13 | 2009-12-17 | Whitehead Institute For Biomedical Research Nine Cambridge Center | Programming and reprogramming of cells |
| CA2729121C (en) | 2008-06-30 | 2019-04-09 | Centocor Ortho Biotech Inc. | Differentiation of pluripotent stem cells |
| US8735156B2 (en) | 2008-12-01 | 2014-05-27 | The Board Of Regents Of The University Of Texas System | Production and use of rat spermatogonial stem cell lines |
| SG172160A1 (en) * | 2008-12-17 | 2011-07-28 | Scripps Research Inst | Generation and maintenance of stem cells |
| EP2421956A4 (en) * | 2009-04-24 | 2013-10-02 | Whitehead Biomedical Inst | COMPOSITIONS AND METHODS FOR OBTAINING OR CULTURING PLURIPOTENTER CELLS |
| MX389666B (es) | 2009-10-16 | 2025-03-19 | Scripps Research Inst | Induccion de celulas pluripotentes. |
| WO2011068103A1 (ja) | 2009-12-01 | 2011-06-09 | 独立行政法人国立がん研究センター | ラット胚性幹細胞を用いたキメララットの作製法 |
| EP2505639B1 (en) * | 2009-12-29 | 2018-09-19 | Takeda Pharmaceutical Company Limited | Method for manufacturing pancreatic-hormone-producing cells |
| CA2800498C (en) | 2010-03-31 | 2021-11-16 | The Scripps Research Institute | Reprogramming cells |
| EP2554659A4 (en) * | 2010-04-02 | 2013-09-25 | Riken | PROCESS FOR PREPARING ES CELLS |
| WO2011159726A2 (en) | 2010-06-14 | 2011-12-22 | The Scripps Research Institute | Reprogramming of cells to a new fate |
| CN102344490B (zh) * | 2010-07-30 | 2014-03-05 | 中国科学院上海生命科学研究院 | 抗小鼠Stk40的多克隆抗体及其制备 |
| AU2011290123B2 (en) * | 2010-08-09 | 2016-11-10 | Takeda Pharmaceutical Company Limited | Method of producing pancreatic hormone-producing cells |
| CA3150342A1 (en) * | 2010-09-07 | 2012-03-15 | Technion Research & Development Foundation Limited | Novel methods and culture media for culturing pluripotent stem cells |
| EP2640829A4 (en) * | 2010-11-17 | 2014-06-11 | Univ Kyoto | CARDIOMYOCYTE AND / OR CARDIOVORA CELL PROLIFERATING AGENTS AND METHOD FOR PROLIFERATING CARDIOMYOCYTES AND / OR CARDIOVORA CELLS |
| US9732319B2 (en) | 2010-12-22 | 2017-08-15 | Fate Therapeutics, Inc. | Cell culture platform for single cell sorting and enhanced reprogramming of iPSCs |
| EP2668286A4 (en) * | 2011-01-24 | 2015-07-01 | Univ Ben Gurion | METHOD FOR EVALUATING A MENTAL DISEASE |
| WO2012175633A1 (en) | 2011-06-21 | 2012-12-27 | Novo Nordisk A/S | Efficient induction of definitive endoderm from pluripotent stem cells |
| ES2872081T3 (es) | 2011-08-05 | 2021-11-02 | Regeneron Pharma | Ratones con cadena ligera universal humanizada |
| SMT201900296T1 (it) | 2011-12-20 | 2019-07-11 | Regeneron Pharma | Topi di catena leggera umanizzata |
| ES2683071T3 (es) | 2012-04-25 | 2018-09-24 | Regeneron Pharmaceuticals, Inc. | Direccionamiento mediado por nucleasas con grandes vectores de direccionamiento |
| MX2015010841A (es) | 2013-02-20 | 2016-05-09 | Regeneron Pharma | Modificacion genetica de ratas. |
| DK3456831T3 (da) | 2013-04-16 | 2021-09-06 | Regeneron Pharma | Målrettet modifikation af rottegenom |
| NZ715302A (en) | 2013-06-14 | 2021-12-24 | Univ Queensland | Renal progenitor cells |
| MX388127B (es) | 2013-12-11 | 2025-03-19 | Regeneron Pharma | Metodos y composiciones para la modificacion dirigida de un genoma. |
| CN120536341A (zh) | 2014-03-04 | 2025-08-26 | 菲特治疗公司 | 改良的重编程方法和细胞培养平台 |
| WO2015155738A2 (en) | 2014-04-09 | 2015-10-15 | Christopher Rudd | Use of gsk-3 inhibitors or activators which modulate pd-1 or t-bet expression to modulate t cell immunity |
| JP6652334B2 (ja) * | 2014-05-31 | 2020-02-19 | Jcrファーマ株式会社 | ウリジンとn−アセチル−d−マンノサミンとを含有する培地 |
| DK3152312T3 (da) | 2014-06-06 | 2020-04-06 | Regeneron Pharma | Fremgangsmåder og sammensætninger til modifikation af et mållocus |
| DK3161128T3 (en) | 2014-06-26 | 2018-11-05 | Regeneron Pharma | METHODS AND COMPOSITIONS FOR TARGETED GENTICAL MODIFICATIONS AND PROCEDURES FOR USE THEREOF |
| EP3221457B1 (en) | 2014-11-21 | 2019-03-20 | Regeneron Pharmaceuticals, Inc. | Methods and compositions for targeted genetic modification using paired guide rnas |
| MX388784B (es) | 2014-12-19 | 2025-03-20 | Regeneron Pharma | Métodos y composiciones para la modificación genética dirigida a través de direccionamiento múltiple de una sola etapa. |
| EP3279318A4 (en) * | 2015-03-30 | 2018-08-29 | Ajinomoto Co., Inc. | Human serum albumin-containing culture medium for growth of neural stem cells |
| CN117737124A (zh) | 2015-10-16 | 2024-03-22 | 菲特治疗公司 | 用于诱导和维护基态多能性的平台 |
| WO2017180361A1 (en) | 2016-04-14 | 2017-10-19 | Janssen Biotech, Inc. | Differentiation of pluripotent stem cells to intestinal midgut endoderm cells |
| AU2017335841A1 (en) | 2016-09-28 | 2019-04-04 | Organovo, Inc. | Use of engineered renal tissues in assays |
| US20210246429A1 (en) * | 2018-04-27 | 2021-08-12 | Kaneka Corporation | Method for producing primitive gut tube cells |
| EP3884042A4 (en) * | 2018-11-21 | 2022-08-24 | Agency For Science, Technology And Research | GENERATION OF TIRES AND COPPER CELLS |
| CN111238897B (zh) * | 2020-02-18 | 2023-03-28 | 上海市皮肤病医院 | 生物标本的处理方法与处理剂 |
| AU2021300644A1 (en) * | 2020-07-02 | 2023-03-02 | Accellta Ltd. | Mammalian livestock pluripotent stem cells from delayed embryos |
| WO2023017806A1 (ja) * | 2021-08-10 | 2023-02-16 | 株式会社カネカ | 多能性幹細胞の製造方法 |
| CN115927166A (zh) * | 2022-12-06 | 2023-04-07 | 云南省第一人民医院 | 一种大鼠原始内胚层干细胞分离建系的方法 |
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|---|---|---|---|---|
| GB9308271D0 (en) | 1993-04-21 | 1993-06-02 | Univ Edinburgh | Method of isolating and/or enriching and/or selectively propagating pluripotential animal cells and animals for use in said method |
| EP0716690A1 (en) | 1993-08-30 | 1996-06-19 | Northwestern University | Rat pluripotent embryonic stem cells and method of obtaining and using same |
| AU4984697A (en) * | 1996-10-11 | 1998-05-11 | The Texas A & M University System | Methods for the generation of primordial germ cells and transgenic animal species |
| US6214795B1 (en) * | 1996-11-12 | 2001-04-10 | Praecis Pharmaceuticals, Inc. | Peptide compounds useful for modulating FGF receptor activity |
| JP2001508302A (ja) | 1997-01-10 | 2001-06-26 | ライフ テクノロジーズ,インコーポレイテッド | 胚性幹細胞血清置換 |
| WO1999027076A1 (en) * | 1997-11-25 | 1999-06-03 | Arc Genomic Research | Pluripotent embryonic stem cells and methods of obtaining them |
| GB9819912D0 (en) | 1998-09-11 | 1998-11-04 | Univ Edinburgh | Propagation and/or derivation of embryonic stem cells |
| US7455983B2 (en) * | 2000-01-11 | 2008-11-25 | Geron Corporation | Medium for growing human embryonic stem cells |
| US20020045260A1 (en) * | 2000-10-17 | 2002-04-18 | Shih-Chieh Hung | Method of isolating mesenchymal stem cells |
| JP2002176973A (ja) | 2000-12-14 | 2002-06-25 | Shigeo Saito | 哺乳動物胚性幹細胞とその樹立方法並びにその継代培養方法 |
| ATE306810T1 (de) | 2002-03-05 | 2005-11-15 | Artemis Pharmaceuticals Gmbh | Durch inzucht erzeugte von embryonalen stammzellen abgeleitete mäuse |
| GB0210539D0 (en) | 2002-05-08 | 2002-06-19 | Univ Edinburgh | Control of es cell self renewal and lineage specification, and medium therefor |
| US7338957B2 (en) | 2003-08-28 | 2008-03-04 | Irm Llc | Compounds and compositions as protein kinase inhibitors |
| EP2722387B1 (en) * | 2003-12-23 | 2019-12-11 | Viacyte, Inc. | Definitive endoderm |
| KR101386690B1 (ko) | 2004-03-04 | 2014-04-22 | 도쿠리츠교세이호진 고쿠리츠간켄큐센터 | 래트 배아 줄기 세포 |
| BRPI0509580A (pt) | 2004-03-30 | 2007-11-27 | Pfizer Prod Inc | combinações de inibidores de transdução de sinal |
| WO2005110438A2 (en) * | 2004-04-15 | 2005-11-24 | Massachusetts Institute Of Technology | Methods and products related to the intracellular delivery of polysaccharides |
| WO2006026473A2 (en) | 2004-08-25 | 2006-03-09 | University Of Georgia Research Foundation, Inc. | METHODS AND COMPOSITIONS UTILIZING MYC AND GSK3ß TO MANIPULATE THE PLURIPOTENCY OF EMBRYONIC STEM CELLS |
| AU2006257859B2 (en) | 2005-06-10 | 2009-12-10 | Irm Llc | Compounds that maintain pluripotency of embryonic stem cells |
| ATE446509T1 (de) * | 2005-11-28 | 2009-11-15 | Choongwae Pharma Corp | Serumfreie expansion von zellen in kultur |
| WO2007113505A2 (en) * | 2006-03-30 | 2007-10-11 | The University Court Of The University Of Edinburgh | Culture medium containing kinase inhibitors. and uses thereof |
| CN101410060A (zh) * | 2006-04-03 | 2009-04-15 | 皇家飞利浦电子股份有限公司 | 测定插入患者体内的对象周围的组织 |
| JP2009537520A (ja) | 2006-05-15 | 2009-10-29 | アイアールエム・リミテッド・ライアビリティ・カンパニー | Fgf受容体キナーゼ阻害剤のための組成物および方法 |
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2006
- 2006-08-01 GB GBGB0615327.4A patent/GB0615327D0/en not_active Ceased
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2007
- 2007-01-10 GB GBGB0700479.9A patent/GB0700479D0/en not_active Ceased
- 2007-08-01 GB GB0716426A patent/GB2451523B/en not_active Expired - Fee Related
- 2007-08-01 CN CN201410720584.XA patent/CN104531610A/zh active Pending
- 2007-08-01 WO PCT/GB2007/002913 patent/WO2008015418A2/en not_active Ceased
- 2007-08-01 JP JP2009522328A patent/JP5456467B2/ja not_active Expired - Fee Related
- 2007-08-01 US US11/832,317 patent/US8431395B2/en not_active Expired - Fee Related
- 2007-08-01 CN CN200780036720.1A patent/CN101657535B/zh not_active Expired - Fee Related
- 2007-08-01 AU AU2007280216A patent/AU2007280216B2/en not_active Ceased
- 2007-08-01 EP EP07766403A patent/EP2049654A2/en not_active Withdrawn
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2013
- 2013-04-05 US US13/857,449 patent/US20130333058A1/en not_active Abandoned
- 2013-06-17 JP JP2013127052A patent/JP2013176400A/ja active Pending
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| Publication number | Publication date |
|---|---|
| AU2007280216A1 (en) | 2008-02-07 |
| US20080066197A1 (en) | 2008-03-13 |
| GB2451523A (en) | 2009-02-04 |
| CN104531610A (zh) | 2015-04-22 |
| GB0716426D0 (en) | 2007-10-10 |
| CN101657535B (zh) | 2016-03-02 |
| JP5456467B2 (ja) | 2014-03-26 |
| CN101657535A (zh) | 2010-02-24 |
| AU2007280216B2 (en) | 2012-12-20 |
| US20130333058A1 (en) | 2013-12-12 |
| EP2049654A2 (en) | 2009-04-22 |
| US8431395B2 (en) | 2013-04-30 |
| GB2451523A8 (en) | 2009-02-18 |
| WO2008015418A3 (en) | 2008-04-10 |
| GB0700479D0 (en) | 2007-02-21 |
| JP2009545302A (ja) | 2009-12-24 |
| WO2008015418A2 (en) | 2008-02-07 |
| JP2013176400A (ja) | 2013-09-09 |
| GB2451523B (en) | 2010-03-17 |
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